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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Multiple Myeloma: Therapeutic and Management Strategies
edited by Terri Parker
submission deadline 20 Jan 2026 | 2 articles | Viewed by 871 | Submission Open
Keywords: multiple myeloma; frontline treatment; monoclonal antibodies; sequencing of treatment; immunotherapy; CAR T; Bi-specific T cell engagers; toxicity management
(This special issue belongs to the Section Hematology)
Obesity-Related Metabolic and Cardiovascular Disorders
edited by and Federica Vinciguerra
submission deadline 20 Jan 2026 | 1 articles | Viewed by 799 | Submission Open
Keywords: obesity; type 2 diabetes mellitus; insulin resistance; metabolic syndrome; cardiovascular disease; lipid disorder; adipose tissue dysfunction; visceral adiposity; cardiometabolic risk; endothelial dysfunction; health disparities; gut microbiota; bariatric surgery; precision medicine
(This special issue belongs to the Section Cardiovascular Medicine)
Recent Advances and Future Perspectives of Subarachnoid Hemorrhage
edited by Alexandros Doukas and Athanasios K. Petridis
submission deadline 20 Jan 2026 | 1 articles | Viewed by 785 | Submission Open
Keywords: subarachnoid hemorrhage; neuromonitoring; neurocritical care; neurointerventions; neurointensive care
(This special issue belongs to the Section Clinical Neurology)
Cardiopulmonary Resuscitation in the Emergency Care Unit
edited by , Felipe Fernández-Méndez, and
submission deadline 20 Jan 2026 | 1 articles | Viewed by 719 | Submission Open
Keywords: cardiopulmonary resuscitation; advanced life support; new technologies; special circumstances; emergency care unit
(This special issue belongs to the Section Emergency Medicine)
Current Status and Future of Urological Surgery
edited by , Davide De Marchi and
submission deadline 20 Jan 2026 | 1 articles | Viewed by 637 | Submission Open
Keywords: urological surgery; robotic-assisted surgery; minimally invasive surgery; artificial intelligence; augmented reality; surgical navigation; endourology; laparoscopic urology; reconstructive urology; functional urology; bph treatment; urinary incontinence; prostate cancer surgery; bladder cancer surgery; surgical innovation; digital surgery
(This special issue belongs to the Section Nephrology & Urology)
Cardiometabolic Insights into Metabolic Dysfunction: From Mechanisms to Therapeutic Strategies
edited by Alessandro Andreis, and
submission deadline 20 Jan 2026 | 1 articles | Viewed by 609 | Submission Open
Keywords: cardiovascular complications; pharmacological; interventional strategies; cardiology; endocrinology; hepatology
(This special issue belongs to the Section Cardiology)
Haemophilia: Current Treatment and Clinical Outcomes, Challenges and Opportunities: 2nd Edition
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 443 | Submission Open
Keywords: haemophilia A and B; FVIII EHL; FIX EHL; prophylaxis; emicizumab; health-related quality of life; population pharmacokinetics
(This special issue belongs to the Section Hematology)
Beyond the Kidney: Managing Chronic Kidney Disease in the Era of Cardio-Metabolic-Kidney Syndrome submission deadline 20 Jan 2026 | Viewed by 427 | Submission Open
Keywords: chronic kidney disease; disease-modifying therapy; physical exercise; cardio-metabolic-kidney syndrome; SGLT2 in-hibitors; MRA; renal nutrition; innovative therapies; low protein diet
(This special issue belongs to the Section Nephrology & Urology)
Clinical Comparisons of Nonpharmaceutical and Pharmaceutical Analgesia
edited by and
submission deadline 20 Jan 2026 | Viewed by 427 | Submission Open
Keywords: acute pain; chronic pain; postoperative pain; non-pharmaceutical; pharmaceutical; analgesia; clinical
(This special issue belongs to the Section Anesthesiology)
Clinical Updates and Current Challenges in Obstetrical Anesthesia
edited by Michael Froelich
submission deadline 20 Jan 2026 | Viewed by 421 | Submission Open
Keywords: obstetrical anesthesia; clinical innovation; practice guidelines; neuraxial techniques; enhanced recovery; risk stratification; maternal safety; multimodal analgesia; health systems innovation; global and low-resource care
(This special issue belongs to the Section Obstetrics & Gynecology)
Innovations and Evolution of Extracorporeal Organ Support in Critical Care
edited by , and Antonella Tosi
submission deadline 20 Jan 2026 | Viewed by 305 | Submission Open
Keywords: critical care; extracorporeal organ support; critical care nephrology; cardiology; ARDS; sepsis; blood purification; liver support
(This special issue belongs to the Section Intensive Care)
Metabolic Dysregulation Across the Spectrum from Anorexia Nervosa to Obesity
edited by Andriana C. Kaliora
submission deadline 20 Jan 2026 | Viewed by 301 | Submission Open
Keywords: metabolic dysregulation; anorexia nervosa; obesity; environmental factors in metabolic health; gut microbiota and metabolism; hormonal regulation of appetite; inflammation and metabolic disorders; dietary influence on metabolism
(This special issue belongs to the Section Endocrinology & Metabolism)
Innovations in Infertility Treatment and Assisted Reproductive Technologies (ARTs)
edited by Diana Alecsandru
submission deadline 20 Jan 2026 | Viewed by 299 | Submission Open
Keywords: infertility; assisted reproductive technology (ARTs); fertility preservation; in vitro fertilization (IVF); reproductive endocrinology
(This special issue belongs to the Section Obstetrics & Gynecology)
Bronchoscopy and Interventional Pulmonology
edited by Bryan S. Benn and
submission deadline 20 Jan 2026 | Viewed by 283 | Submission Open
Keywords: navigation-guided bronchoscopy; Robotic-guided bronchoscopy; 3D imaging integration; lung nodule/peripheral pulmonary lesion marking; transbronchial lung cryobiopsy and interstitial lung disease; malignant and benign central airway obstruction and stenosis; airway stents; pleuroscopic procedures; bronchoscopic lung volume reduction
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances in Urologic Oncology: 2nd Edition
edited by Saum Ghodoussipour
submission deadline 20 Jan 2026 | 1 articles | Viewed by 267 | Submission Open
Keywords: bladder cancer; kidney cancer; prostate cancer; testis cancer; penile cancer; minimally invasive; cancer treatment
(This special issue belongs to the Section Nephrology & Urology)
From Dual Diagnosis to Dual Disorder(s): Bridging Comorbidity and Integrated Clinical Understanding submission deadline 20 Jan 2026 | Viewed by 266 | Submission Open
Keywords: dual diagnosis; dual disorder; psychiatric comorbidity; addiction; integrated care; self-medication; substance use; mental illness; treatment models
(This special issue belongs to the Section Mental Health)
Advances in Chronic Pain Research and Therapy
edited by Elena Makovac
submission deadline 20 Jan 2026 | Viewed by 196 | Submission Open
Keywords: chronic pain; pain perception; brain-body interactions; therapeutic effectiveness; integrated approach
(This special issue belongs to the Section Clinical Rehabilitation)
Recent Management of Hip Fractures
edited by
submission deadline 20 Jan 2026 | Viewed by 191 | Submission Open
Keywords: hip fracture; internal fixation; hemiarthroplasty; arthroplasty and fixation; osteoporosis management; fracture prevention; multidisciplinary care; surgical treatment; rehabilitation strategies
(This special issue belongs to the Section Orthopedics)
Clinical Application of Echocardiography in Heart Disease: 2nd Edition
edited by
submission deadline 20 Jan 2026 | Viewed by 191 | Submission Open
Keywords: transthoracic echocardiography; transesophageal echocardiography; stress echocardiography; valve disease; coronary artery disease; myocardial disease; pericardial disease; aortic disease; congenital heart disease
(This special issue belongs to the Section Cardiology)
Therapeutic Strategies for Obesity and Diabetes in Cardiovascular Disease Patients
edited by Davide D'Andrea
submission deadline 20 Jan 2026 | Viewed by 188 | Submission Open
Keywords: obesity; diabetes; cardiovascular complications; diabetes management; pharmacological treatment; bariatric surgery; regular monitoring
(This special issue belongs to the Section Cardiovascular Medicine)
Preventive Strategies and Novel Treatments for Rheumatoid Arthritis
edited by
submission deadline 20 Jan 2026 | Viewed by 184 | Submission Open
Keywords: rheumatoid arthritis; antibodies; biologics; JAK; environment; susceptibility; therapeutic strategies
(This special issue belongs to the Section Immunology & Rheumatology)
Current Trends and Future Challenges in Heart Failure
edited by Oren Caspi and
submission deadline 20 Jan 2026 | Viewed by 182 | Submission Open
Keywords: heart failure; guideline-directed therapy; digital health; biomarkers; multidisciplinary care; artificial intelligence; cardiorenal syndrome; remote hemodynamic monitoring; cardiac amyloidosis; exercise rehabilitation
(This special issue belongs to the Section Cardiology)
Emerging Trends in Multiple Myeloma
edited by
submission deadline 20 Jan 2026 | Viewed by 179 | Submission Open
Keywords: multiple myeloma; personalized medicine; high-risk disease; cellular therapies; refractory disease
(This special issue belongs to the Section Hematology)
Clinical Update on Aortic Valve Disease Treatments
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 167 | Submission Open
Keywords: aortic valve disease; minimally invasive surgery; transcatheter procedures; echocardiography; diagnosis; therapy; innovation
(This special issue belongs to the Section Cardiology)
Clinical Advances, Opportunities, and Challenges in Digestive Diseases of the Foregut
edited by Valentin Mocanu and
submission deadline 20 Jan 2026 | Viewed by 155 | Submission Open
Keywords: obesity; achalasia; reflux; malrotation; therapeutic endoscopy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Lung Transplantation: Current Challenges and New Perspectives
edited by Reinaldo E. Rampolla and Pedro A. Catarino
submission deadline 20 Jan 2026 | Viewed by 150 | Submission Open
Keywords: lung transplantation; interstitial lung diseases; pulmonary hypertension; chronic obstructive pulmonary disease; bronchiectasis; extra corporeal membrane oxygenation; robotic lung transplantation
(This special issue belongs to the Section Respiratory Medicine)
New Clinical Perception of Cardiac Rehabilitation
edited by and Mario Pacileo
submission deadline 20 Jan 2026 | Viewed by 137 | Submission Open
Keywords: cardiac rehabilitation; digital health; exercise therapy; cardiovascular prevention; chronic disease management; psychosocial support; personalized medicine
(This special issue belongs to the Section Clinical Rehabilitation)
Surgical Management of Vascular Diseases: Challenges and Innovations in the 21st Century
edited by Reinhardt T. Grundmann
submission deadline 20 Jan 2026 | Viewed by 131 | Submission Open
Keywords: abdominal aortic aneurysm; carotid stenosis; peripheral vascular disease; endovascular therapy; open surgery; vascular disease and cancer outcomes; clinical trial; meta-analysis; surgical innovation
(This special issue belongs to the Section Cardiovascular Medicine)
Pulmonary Disease and Comorbidities, Clinical and Epidemiological Studies: From Neonates to Adults
edited by
submission deadline 20 Jan 2026 | Viewed by 127 | Submission Open
Keywords: pulmonary disorders; comorbidity; neonatal lung disease; pediatric pulmonology; adult respiratory disease; chronic respiratory conditions; clinical epidemiology; pulmonary function testing; diagnostic imaging; lung biomarkers; risk factors
(This special issue belongs to the Section Respiratory Medicine)
The Association Between Cancer and Cardiovascular Diseases: Insights After a Quarter of the Century
edited by Tomer Ziv-Baran and Elena Izkhakov
submission deadline 20 Jan 2026 | Viewed by 126 | Submission Open
Keywords: cancer survivors; cardiovascular disease; cardio-oncology; chemotherapy; radiation therapy; immunotherapy; multidisciplinary approach
(This special issue belongs to the Section Epidemiology & Public Health)
Personalized Modern Oncological Strategies for Breast Cancer Treatment
edited by Vlad Alexandru Gata, Maximilian Muntean and
submission deadline 22 Jan 2026 | Viewed by 115 | Submission Open
Keywords: breast cancer; targeted and immune therapies; predictive biomarkers; surgical de-escalation; MRI of the breast; breast reconstruction
(This special issue belongs to the Section General Surgery)
Application of Artificial Intelligence in Cardiology submission deadline 23 Jan 2026 | 6 articles | Viewed by 5842 | Submission Open
Keywords: artificial intelligence; cardiology; clinical practice; valvular heart disease; arrhythmias; device therapy; machine learning
(This special issue belongs to the Section Cardiology)
Clinical Advances and New Challenges in Laparoscopic Surgery
edited by Ionut Bogdan Diaconescu and Matei Bratu
submission deadline 23 Jan 2026 | Viewed by 149 | Submission Open
Keywords: laparoscopic surgery; trauma surgery; surgical oncology; abdominal surgery; colorectal surgery; general surgery; minimally invasive surgery; gastrointestinal surgery; hernia surgery; surgery; advance laparoscopic surgery; cancer surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Advances in Glaucoma: Current Status and Prospects
edited by Rubén Sánchez-Jean, and Federico Sáenz-Francés San Baldomero
submission deadline 24 Jan 2026 | 2 articles | Viewed by 4559 | Submission Open
Keywords: glaucoma surgery; new techniques; minimally invasive glaucoma surgery; intraocular pressure; optometry; IOLs designs
(This special issue belongs to the Section Ophthalmology)
Pediatric Pulmonology: Recent Developments and Emerging Trends
edited by Athina L. Papadopoulou
submission deadline 25 Jan 2026 | 5 articles | Viewed by 20691 | Submission Open
Keywords: definition of breath sounds; lung– gut axis pathophysiology; disease endotypes and phenotypes; asthma management in children; bronchiolitis spectrum; pediatric bronchopulmonary dysplasia; pulmonary function testing in pediatric patients; pediatric sleep-disordered breathing; neonatal respiratory distress syndrome; childhood interstitial lung diseases; pulmonary hypertension in children; biomarkers in pediatric lung diseases; allergy and the lungs; diagnostic and therapeutic challenges in bronchoscopy; gene therapy in cystic fibrosis
(This special issue belongs to the Section Clinical Pediatrics)
Clinical Risks and Perinatal Outcomes in Pregnancy and Childbirth: 2nd Edition
edited by Apostolos Mamopoulos and
submission deadline 25 Jan 2026 | 6 articles | Viewed by 16495 | Submission Open
Keywords: pregnancy complications; perinatal outcomes; childbirth; hypertension; diabetes; fetal growth restriction; stillbirth; preterm delivery
(This special issue belongs to the Section Obstetrics & Gynecology)
Personalized Medicine for the Management of Non-Communicable Disease (NCDs)
edited by , Giulio Geraci and
submission deadline 25 Jan 2026 | 8 articles | Viewed by 15441 | Submission Open
Keywords: personalized medicine; precision medicine; non-communicable disease; cardiovascular disease; cancer; diabetes; chronic obstructive pulmonary disease; cognitive impairment; atherosclerosis; lipids; inflammation; immunity; therapy
(This special issue belongs to the Section Epidemiology & Public Health)
Clinical Updates on Cardiac and Vascular Toxicities from Antineoplastic Drugs and Beyond
edited by
submission deadline 25 Jan 2026 | 5 articles | Viewed by 13589 | Submission Open
Keywords: cardiotoxicity; vascular toxicity; cardio-oncology; immune checkpoint inhibitors; anthracyclines; tyrosine kinase inhibitors; HER2; proteasome inhibitors; platinum; antimetabolites; microtubule inhibitors
(This special issue belongs to the Section Cardiovascular Medicine)
Male Fertility in the Modern Age: Challenges and Opportunities
edited by
submission deadline 25 Jan 2026 | 2 articles | Viewed by 13546 | Submission Open
Keywords: male infertility; semen parameters; sperm selection; IVF/ICSI
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Keratoconus: Current Status and Prospects
edited by and Isabel Lema
submission deadline 25 Jan 2026 | 3 articles | Viewed by 11419 | Submission Open
Keywords: keratoconus; prevention; diagnostic; biomarker discovery; genetics; exposome; treatment; personalized medicine; major challenges; technological advances
(This special issue belongs to the Section Ophthalmology)
Prevention, Diagnosis and Treatment of Oral Mucosal Diseases
edited by
submission deadline 25 Jan 2026 | 3 articles | Viewed by 10893 | Submission Open
Keywords: oral mucosal diseases; oral mucositis; oral precancerous lesions; oral cancer; oral potentially malignant disorders; OPMDs; oral leukoplakia
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Interventional Cardiology—Challenges and Solutions
edited by
submission deadline 25 Jan 2026 | 4 articles | Viewed by 5220 | Submission Open
Keywords: chronic total occlusion; highly calcified coronary or lower extremity arteries; stentless percutaneous coronary intervention; chronic limb threatening ischemia; instent restenosis in the extremity artery diseases; endovascular therapy for pulmonary thromboembolism; transcatheter aortic valve replacemment for the bicuspid aortic valve; transcatheter aortic valve replacement for the valve-in-valve procedure; endovascular therapy for tricospid valve regurgitation; transcatheter edge-to-edge repair for mitral valve regurgitation
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Advances in Treatment for Venous Thromboembolism
edited by and Georgia Kaiafa
submission deadline 25 Jan 2026 | 3 articles | Viewed by 5207 | Submission Open
Keywords: venous thromboembolism; anticoagulation; cancer-associated thrombosis; thrombosis in MPNs; thrombosis in multiple myeloma; antiphospholipidic syndrome; thrombosis in PNH; thrombosis in hemoglobinopathies; thrombophilia; pregnancy and thrombophilia; reversal of anticoagulants; thromboprophylaxis
(This special issue belongs to the Section Hematology)
Foot and Ankle Surgery: Current Advances and Prospects
edited by
submission deadline 25 Jan 2026 | 4 articles | Viewed by 5079 | Submission Open
Keywords: foot and ankle surgery; foot pathologies; ankle disease and trauma; diabetic foot; epidemiology; clinical anatomy; foot orthoses; weight-bearing CT
(This special issue belongs to the Section Orthopedics)
Autism Spectrum Disorder: Diagnosis, Treatment, and Management
edited by
submission deadline 25 Jan 2026 | 1 articles | Viewed by 4371 | Submission Open
Keywords: adult autism (including autism spectrum disorders); neurodevelopmental disorders; clinical diagnostics; digital diagnostics; artificial intelligence; multimodal treatments
(This special issue belongs to the Section Mental Health)
Clinical Diagnostic and Therapeutic Approaches in Cardiac Amyloidosis
edited by Grigorios Giamouzis
submission deadline 25 Jan 2026 | 1 articles | Viewed by 3539 | Submission Open
Keywords: cardiac amyloidosis; transthyretin amyloidosis; hypertrophic cardiomyopathy; cardiac imaging; heart failure
(This special issue belongs to the Section Cardiology)
Clinical Updates in Cardiac Electrophysiology: 2nd Edition
edited by Kenneth C. Bilchick
submission deadline 25 Jan 2026 | 1 articles | Viewed by 3432 | Submission Open
Keywords: arrhythmias; atrial fibrillation; cardiac electrophysiology; heart rhythm disorders; ablation; ventricular tachycardia; remote monitoring; digital health; artificial intelligence; cardiac magnetic resonance
(This special issue belongs to the Section Cardiology)
Inflammatory Bowel Diseases: Clinical Advances and Emerging Therapies submission deadline 25 Jan 2026 | 2 articles | Viewed by 3029 | Submission Open
Keywords: inflammatory bowel disease (IBD); ulcerative colitis; Crohn’ s disease; gut inflammation; bowel perforation
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advancements in Individualized Plastic and Reconstructive Surgery: Second Edition
edited by , Peter Niclas Broer and Denis C. Ehrl
submission deadline 25 Jan 2026 | 2 articles | Viewed by 2076 | Submission Open
Keywords: patient-specific reconstructive procedures; microsurgical precision techniques; autologous tissue transplantation; digital imaging and customization; biomaterials in reconstructive surgery; tissue engineering for plastic reconstruction; flap surgery innovations; personalized cleft surgery; personalized aesthetic surgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Shoulder and Elbow Surgery: Clinical Updates and Perspectives
edited by Taku Hatta, Akihiko Hasegawa and Takuma Yuri
submission deadline 25 Jan 2026 | 2 articles | Viewed by 1126 | Submission Open
Keywords: rotator cuff injuries; shoulder arthroplasty; elbow surgery; shoulder surgery; shoulder and elbow disease; arthroscopic surgery; orthopedic surgery
(This special issue belongs to the Section Orthopedics)
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