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Special Issue "Ulcerative Colitis: Current and Emerging Treatment Strategies"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepato-Pancreato-Biliary Medicine".

Deadline for manuscript submissions: 15 October 2019

Special Issue Editor

Guest Editor
Prof. Dr. Sandro Ardizzone

Gastrointestinal Unit, ASST Fatebenefratelli Sacco - Department of Biochemical and Clinical Sciences "L. Sacco", University of Milan, Milano 20157, Italy
Website | E-Mail
Interests: IBD; therapy; immunomodulation; biologic therapy; cell-based therapy

Special Issue Information

Dear Colleagues,

Ulcerative colitis (UC) is one of the two forms of inflammatory bowel disease (IBD) with a high prevalence in Western countries, whose incidence is gradually increasing in newly industrialised countries in Africa, Asia, and South America. For many years salicylates, systemic and topical steroids and immunosuppressants were the cornerstones of UC drug therapy, without however significantly affecting the clinical course of the disease and, above all, without impacting its natural history.

Although its etiology is unknown, in the last 20 years considerable progress has been made in understanding its complex pathogenesis. In particular, the identification of specific cytokines (TNFa, integrins, etc) has allowed us to define specific therapeutic targets and the relative production of anti-TNFa monoclonal antibodies (infliximab, adalimumab, golimumab) and anti-integrins (vedolizumab) , currently available in Europe and North America.

However, although these therapies have allowed us to effectively treat a larger patient audience with "difficult" UC, such as steroid-dependent patients, steroid-refractoriness, and extraintestinal manifestations, there are still various unmet needs, such as failure or loss of response, and the increased risk, albeit mild, of infections or neoplasia, which require further pharmacological treatments that are possibly faster, more effective and safe. Thus, particular emphasis tends to be placed on some of the most recent biological therapies, which are proving promising in the treatment of IBD, with therapeutic target alternatives to the selective blocking of specific cytokines, such as interleukin 12/23 and SMAD7 inhibitors, and low molecular weight drugs (small molecule drugs (SMDs)), such as inhibitors of JAK kinases, sphingosine 1 phosphate (S1P) and phosphodiesterase 4. Furthermore, particular interest is also placed on cell-based therapies (stem cell transplantation). 

Considering, therefore, the progressive enrichment of the therapeutic armament, this Special Issue, will consider the conventional therapy and the emerging treatments of UC in an attempt to place them in specific clinical contexts, in order to optimize their choice both in terms of effectiveness and safety.

Prof. Dr. Sandro Ardizzone
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Ulcerative colitis
  • Conventional therapy
  • Emerging treatment
  • Salicylates
  • Systemic and topical steroids
  • Immunosuppressants
  • Monoclonal anti-TNFa antibodies
  • Monoclonal anti-integrine antibodies
  • Small molecules
  • Cell-based therapies

Published Papers

This special issue is now open for submission.
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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