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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Diagnosis and Treatment of Amyloidosis
edited by Michael Rosenzweig
submission deadline 31 Dec 2025 | 9 articles | Viewed by 23741
Keywords: amyloidosis; transthyretin (TTR); autologous stem cell transplantation (ASCT); chemotherapy; immunotherapy; cardiomyopathy; nephropathy; neuropathy
(This special issue belongs to the Section Cardiology)
Symptoms and Treatment of Parkinson’s Disease
edited by and Nikolaos Papagiannakis
submission deadline 31 Dec 2025 | 6 articles | Viewed by 21703
Keywords: Parkinson’ s disease; non-motor symptoms; clinical progression; cognitive assessment; genetics; remote monitoring; biomarkers; personalized medicine; device-aided treatments; disease-modifying therapies
(This special issue belongs to the Section Clinical Neurology)
Interdisciplinary Approach on the Oral Cavity Management Due to Musculoskeletal Conditions
edited by Cosmin Sinescu, and
submission deadline 31 Dec 2025 | 5 articles | Viewed by 21556
Keywords: rehabilitation medicine; biomechanics; bruxism assessment; general medicine; dental medicine; biomedical imaging; musculoskeletal disorders; shoulder girdle; cervical region; physical therapy; therapeutic exercise; postural correction; dynamic balance; pediatric rehabilitation; sports medicine; quality of life research; general conditions with resonance in the oro-maxillo-facial sphere
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Management of Prosthetic Joint Infection (PJI)
edited by Daniel Pérez-Prieto
submission deadline 31 Dec 2025 | 7 articles | Viewed by 13915
Keywords: prosthetic joint infection; debridement; biofilm; wound healing; multidisciplinary team; osteomyelitis
(This special issue belongs to the Section Orthopedics)
Challenges in the Field of Psycho-Oncology: Insights from Research
edited by , , Tânia Brandão and Ricardo Teixeira
submission deadline 31 Dec 2025 | 3 articles | Viewed by 7333
Keywords: cancer; psycho-oncology; survivorship care; psychological distress; quality of life; sustainable development goals; global health; health disparities
(This special issue belongs to the Section Oncology)
New Trends and Challenges in Critical Care Management
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 5344
Keywords: critical care; intensive care; extracorporeal organ support; mechanical ventilation; personalized medicine; artificial intelligence; infections; antimicrobial resistance; COVID-19
(This special issue belongs to the Section Intensive Care)
Rare Respiratory Diseases: A Personal and a Public Health Problem: 3rd Edition
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 4572
Keywords: rare diseases; rare respiratory diseases; alpha-1 antitrypsin deficiency; primary ciliary dyskinesia; cystic fibrosis; idiopathic pulmonary fibrosis; lymphangioleiomyomatosis; interstitial lung diseases; pulmonary arterial hypertension
(This special issue belongs to the Section Respiratory Medicine)
Acute Kidney Injury: Latest Advances and Prospects
edited by and Kianoush Kashani
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4324
Keywords: acute kidney injury (AKI); sepsis; septic shock; renal replacement therapy; intensive care; specialized interventions; biomarkers; risk factors; “ Green Practice” ; nephrology; epidemiology; multidisciplinary approach
(This special issue belongs to the Section Nephrology & Urology)
Clinical Updates on Knee and Hip Arthroplasty
edited by Amarildo Smakaj and Elena Gasbarra
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4214
Keywords: knee arthroplasty; hip arthroplasty; total joint replacement; minimally invasive arthroplasty; implant durability; postoperative rehabilitation; revision arthroplasty; prosthesis-related complications; periprosthetic joint infection; implant loosening
(This special issue belongs to the Section Orthopedics)
Clinical Therapeutic Advances in Bone Fractures
edited by Simon Hackl and Eva Simone Steinhausen
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3582
Keywords: stem cells; biomechanics; fracture fixation; orthobiologics; rehabilitation; personalized medicine; 3D printing; im-plant coating; nonunion; fracture-related infection
(This special issue belongs to the Section Orthopedics)
Emerging Clinical Insights into Adolescent Behavioral Development and Mental Health
edited by and Anne-Marie Iselin
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2871
Keywords: adolescence; behavioral development; clinical maladjustment; adolescents’ mental health; innovative clinical approach; adolescents’ emotional problems; clinical settings; innovative developmental research; adolescents’ symptoms
(This special issue belongs to the Section Mental Health)
Pregnancy Complications and Maternal-Perinatal Outcomes
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 2298
Keywords: pregnancy; high-risk; GDM; preeclampsia; fetal growth restriction; diabetes; placenta; ultrasound
(This special issue belongs to the Section Obstetrics & Gynecology)
Updates on Treatment of Chronic Kidney Disease: Novel Approaches and Future Directions
edited by Pietro C. Dattolo and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1945
Keywords: chronic kidney disease; CKD treatment; SGLT2 inhibitors; GLP-1 receptor agonists; non-steroidal MRAs; precision medicine; renal replacement therapy; novel therapeutics; clinical trials; nephrology
(This special issue belongs to the Section Nephrology & Urology)
Clinical Updates on Prenatal Diagnosis
edited by Valentina D'Ambrosio
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1784
Keywords: fetal anomalies; twin pregnancy; fetal therapy; prenatal genetic testing; genome sequencies
(This special issue belongs to the Section Obstetrics & Gynecology)
Novel Advanced Imaging in Cardiology: Current Status and Future Directions
edited by and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1695
Keywords: cardiac imaging; cardiac magnetic resonance; echocardiography; computed tomography; trans-thoracic echocardiography global longitudinal strain (GLS) analyses; radiomics
(This special issue belongs to the Section Cardiovascular Medicine)
Children and Adolescent Mood Disorders: Risks and Treatment submission deadline 31 Dec 2025 | Viewed by 1570
Keywords: emotional dysregulation; mood disorders; adolescence; anxiety; depression; addiction; psychotherapy; pharmacological treatments; prevention programs
(This special issue belongs to the Section Mental Health)
Recent Progress and Future Directions in Orthopedic Oncology
edited by and Carmine Zoccali
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1040
Keywords: orthopedic oncology; bone tumors; limb-sparing surgery; reconstruction techniques; 3D-printed implants; navigation and robotics; precision medicine in musculoskeletal oncology
(This special issue belongs to the Section Orthopedics)
Clinical Challenges and Advances in Dry Eye Disease and Meibomian Gland Dysfunction submission deadline 31 Dec 2025 | 1 articles | Viewed by 842
Keywords: dry eye disease; ocular surface; corneal disease; conjunctival disease; ocular biomarkers; patient-centered care; advanced diagnostics; regenerative medicine; artificial intelligence; therapeutic innovations
(This special issue belongs to the Section Ophthalmology)
Advances in Gene Therapy for Retinal Diseases
edited by Tahreem Aman Mir
submission deadline 31 Dec 2025 | Viewed by 246
Keywords: gene therapy; inherited retinal degenerations; age-related macular degeneration; diabetic retinopathy
(This special issue belongs to the Section Ophthalmology)
Clinical Trends in Diagnostic Radiology
edited by Wolfram Schwindt, Benjamin Noto and Anne Helfen
submission deadline 31 Dec 2025 | Viewed by 233
Keywords: diagnostic imaging; radiology; nuclear medicine; hybrid imaging; artificial intelligence; radiomics; quantitative imaging; theranostics; imaging biomarkers; clinical applications
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Progress in the Multimodal Treatment of Pancreatic Disease
edited by
submission deadline 31 Dec 2025 | Viewed by 177
Keywords: pancreatic diseases; pancreatic cancer; multimodal treatment; neoadjuvant therapy; imaging techniques; minimally invasive surgery; immunotherapy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Optimizing Outcomes in Deep Vein Thrombosis: A Focus on Interventional Management
edited by Adam Gwozdz
submission deadline 31 Dec 2025 | Viewed by 156
Keywords: deep vein thrombosis; post-thrombotic syndrome; venous patency; emerging technology; vascular surgery
(This special issue belongs to the Section Vascular Medicine)
Broadening the Knowledge of Autism Spectrum Disorder in Adulthood: Advances in Diagnosis, Assessment and Treatment
edited by
submission deadline 5 Jan 2026 | 1 articles | Viewed by 3259 | Submission Open
Keywords: autism spectrum disorder; adulthood; autism; comorbidity; gender; age-adjusted
(This special issue belongs to the Section Mental Health)
Advances in Diagnosis and Management of Pancreatobiliary Disorders—2nd Edition
edited by
submission deadline 9 Jan 2026 | 5 articles | Viewed by 4163 | Submission Open
Keywords: pancreas diseases; pancreatic tumors; biliary tract diseases and neoplams; ERCP; EUS; cholangioscopy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Clinical Advances in Pancreatobiliary Diseases
edited by
submission deadline 9 Jan 2026 | 1 articles | Viewed by 1271 | Submission Open
Keywords: pancreatobiliary diseases; EUS; ERCP; interventional endoscopy; targeted therapy; pancreatobiliary cancer
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Advance in Chronic Total Occlusion Percutaneous Coronary Intervention
edited by Anbukarasi Maran and Kevin Croce
submission deadline 9 Jan 2026 | Viewed by 166 | Submission Open
Keywords: chronic total occlusion (CTO); percutaneous coronary intervention (PCI); innovative techniques; guidewire technology; retrograde PCI; interventional cardiology  
(This special issue belongs to the Section Cardiovascular Medicine)
Heart Disease and Chronic Inflammatory Conditions: New Insights
edited by Ofer Kobo and Gilad Margolis
submission deadline 10 Jan 2026 | 4 articles | Viewed by 15276 | Submission Open
Keywords: heart diseases; chronic inflammatory; rheumatoid arthritis; cardiovascular disease; inflammatory bowel disease
(This special issue belongs to the Section Cardiology)
Clinical Guidelines in Critical Care Medicine
edited by , and Daniela Bandic-Pavlovic
submission deadline 10 Jan 2026 | 3 articles | Viewed by 7489 | Submission Open
Keywords: critical illness; immunocompromised host; biomarkers; thrombocytopenia; blood coagulation disorders; multiple trauma; diagnostic imaging
(This special issue belongs to the Section Intensive Care)
Heart Failure and Coronary Artery Diseases: Cardiovascular Complications and Comorbidities submission deadline 10 Jan 2026 | 3 articles | Viewed by 5294 | Submission Open
Keywords: heart failure; acute myocardial infarction; coronary artery diseases; cardiac imaging; biomarkers; artificial intelligence
(This special issue belongs to the Section Cardiovascular Medicine)
From Acute Injury to Personalized Prevention—Developing Modern Strategies submission deadline 10 Jan 2026 | 2 articles | Viewed by 2766 | Submission Open
Keywords: orthopedics; acute injury; personalized prevention; innovative methodologies; musculoskeletal disorders; musculoskeletal injury; conservative therapy; functional testing; intervention
(This special issue belongs to the Section Orthopedics)
Advancements in Spinal Oncology: The Current Landscape
edited by Aladine Elsamadicy and
submission deadline 10 Jan 2026 | 2 articles | Viewed by 2237 | Submission Open
Keywords: spinal oncology; patient outcomes; primary bone tumor; spine metastases; intradural tumors
(This special issue belongs to the Section Clinical Neurology)
Advanced Physiotherapy Practice in Patients with Musculoskeletal Disorders submission deadline 10 Jan 2026 | 1 articles | Viewed by 1113 | Submission Open
Keywords: differential diagnosis; physiotherapy; rehabilitation; multidisciplinary; effectiveness; musculoskeletal disorders; screening for referral; manual therapy; exercise; cognitive behavioral therapy; pain neuroscience
(This special issue belongs to the Section Clinical Rehabilitation)
Pelvic Organ Prolapse: Clinical Advances and Challenges submission deadline 10 Jan 2026 | 1 articles | Viewed by 647 | Submission Open
Keywords: pelvic organ prolapse; pessary treatment; uterus-preserving prolapse surgery; clinical management; clinical treatment
(This special issue belongs to the Section Obstetrics & Gynecology)
Advances in Vascular and Endovascular Surgery: Second Edition
edited by and Afshin Assadian
submission deadline 11 Jan 2026 | 4 articles | Viewed by 4373 | Submission Open
Keywords: vascular surgery; endovascular surgery; aortic surgery; peripheral arterial disease; vascular imaging; EVAR; FEVAR; vascular access; vascular education; aneurysms
(This special issue belongs to the Section Vascular Medicine)
Clinical Updates in Physiotherapy for Musculoskeletal Disorders submission deadline 15 Jan 2026 | 11 articles | Viewed by 33777 | Submission Open
Keywords: musculoskeletal disorders; physiotherapy interventions; lifestyle; psychoneuroimmunology; chronic pain; inflammation; physical therapy
(This special issue belongs to the Section Clinical Rehabilitation)
Physical Therapy in Neurorehabilitation submission deadline 15 Jan 2026 | 8 articles | Viewed by 23988 | Submission Open
Keywords: physical therapy; transcutaneous electrical nerve stimulation (TENS); muscle strengthening; balance exercising; pain; quality of life; neurodegenerative disorders; neuromuscular disorders; stroke; demyelinating disorders
(This special issue belongs to the Section Clinical Neurology)
Innovative Systemic Treatments for Atopic Dermatitis
edited by
submission deadline 15 Jan 2026 | 5 articles | Viewed by 21038 | Submission Open
Keywords: atopic dermatitis; atopic eczema; JAK inhibitors; anti-IL-4; anti-IL-13; dupilumab; tralokinumab; lebrikizumab; abrocitinib; upadacitinib; baricitinib
(This special issue belongs to the Section Dermatology)
Clinical Application of Biomarkers in Cancers
edited by
submission deadline 15 Jan 2026 | 3 articles | Viewed by 17501 | Submission Open
Keywords: cancer biomarkers; early detection; personalized therapy; biomarker validation; advanced technologies; clinical implementation
(This special issue belongs to the Section Clinical Laboratory Medicine)
Current Trends and Prospects of Critical Emergency Medicine
edited by Quincy K. Tran
submission deadline 15 Jan 2026 | 8 articles | Viewed by 10961 | Submission Open
Keywords: critically ill patients; critical care; resuscitation; emergency medicine; trends; prospects; outcomes
(This special issue belongs to the Section Emergency Medicine)
Advances in Pulmonary Disease Management and Innovation in Treatment submission deadline 15 Jan 2026 | 6 articles | Viewed by 10738 | Submission Open
Keywords: severe asthma; COPD; sleep-related breathing disorders; respiratory tract infections; innovative respiratory therapies; translational pulmonary research; pulmonary vascular disease; interstitial lung disease; eHealth in respiratory care
(This special issue belongs to the Section Respiratory Medicine)
Pulmonary Embolism—Current and Novel Approaches
edited by Roy Beigel and Shlomi Matetzky
submission deadline 15 Jan 2026 | 3 articles | Viewed by 6545 | Submission Open
Keywords: pulmonary embolism; treatment; coagulation; venous thrombosis; thrombolysis; anticoagulation; risk stratification
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances in Assessment Measures and Theoretical Models of Caregivers' Sensitivity and Contingency: 2nd Edition
edited by
submission deadline 15 Jan 2026 | 3 articles | Viewed by 5539 | Submission Open
Keywords: clinical caregiving; sensitivity assessment; contingency modeling; caregiver– patient interactions; mental health outcomes; novel assessment measures; therapeutic responsiveness; caregiver interventions; clinical well-being; care recipient support
(This special issue belongs to the Section Intensive Care)
Clinical Advances in Minimally Invasive Urologic Surgery
edited by , Fabio Crocerossa and
submission deadline 15 Jan 2026 | 4 articles | Viewed by 5271 | Submission Open
Keywords: urology; uro-oncology; uro-gynecology; robotic surgery; laparoscopy; robot-assisted; artificial intelligence
(This special issue belongs to the Section Nephrology & Urology)
Clinical Management and Treatment of Psoriasis
edited by
submission deadline 15 Jan 2026 | 3 articles | Viewed by 5136 | Submission Open
Keywords: psoriasis; biological drugs; personalized medicine; comorbidities; real-world evidence
(This special issue belongs to the Section Dermatology)
Safety in Spinal Surgery
edited by Simon B. Roberts and
submission deadline 15 Jan 2026 | 1 articles | Viewed by 4991 | Submission Open
Keywords: spinal surgery; patients with spinal deformity; inherent risks; risk management; surgery safety
(This special issue belongs to the Section General Surgery)
Clinical Advances in the Diagnosis and Treatment of Cardiac Arrhythmias
edited by Fabrizio Guarracini and
submission deadline 15 Jan 2026 | 3 articles | Viewed by 4350 | Submission Open
Keywords: cardiac arrhythmias; antiarrhythmic agents; pacemakers; cardiac resynchronization; catheter ablation; electrophysiology
(This special issue belongs to the Section Cardiology)
Recent Clinical Advances in Percutaneous Coronary Intervention
edited by and Luke Pickup
submission deadline 15 Jan 2026 | 2 articles | Viewed by 3294 | Submission Open
Keywords: complex PCI; calcium modification; left main stem; stent; coronary artery disease; atherectomy; mechanical circula-tory support device; Impella; DCB; intra-coronary imaging; IVUS; OCT
(This special issue belongs to the Section Cardiology)
Up-to-Date Research in Liver Transplantation
edited by
submission deadline 15 Jan 2026 | 2 articles | Viewed by 2983 | Submission Open
Keywords: liver transplantation; acute or chronic liver diseases; hepatitis C virus infection; hepatocellular carcinoma (HCC); cirrhosis; intrahepatic (ICCA); perihilar (PCCA) cholangiocarcinoma; unresectable liver metastases; acute or chronic liver failure (ACLF); acute alcoholic hepatitis (AAH)
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Pediatric Nephrology: Advances in the Diagnosis and Management of Pediatric Kidney Disorders submission deadline 15 Jan 2026 | 3 articles | Viewed by 2949 | Submission Open
Keywords: diagnosis; management; treatment; kidney disorders; chronic kidney disease; biomarkers; genetic testing; kidney; children; newborn
(This special issue belongs to the Section Nephrology & Urology)
Diagnosis and Management of Aortic Diseases: Drafting from Theoretical Aspects to Clinical Practice—2nd Edition
edited by
submission deadline 15 Jan 2026 | 2 articles | Viewed by 2164 | Submission Open
Keywords: aortic disease; aortic aneurysm; aortic dissection; aortic surgery; diagnosis and management
(This special issue belongs to the Section Cardiovascular Medicine)
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