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Special Issue "Molecular Mechanisms of Cancer Chemoprevention"
Deadline for manuscript submissions: closed (31 December 2019).
Interests: cancer prevention; animal models; translational research
Special Issues and Collections in MDPI journals
Interests: liver carcinogenesis; cancer chemoprevention; chronic hepatitis; metabolic syndrome; retinoid; phytochemicals; clinical trial
Special Issues and Collections in MDPI journals
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Interests: colorectal carcinogenesis; inflammatory bowel disease; ulcerative colitis; Crohn’s disease; cancer chemiprevention; animal model
On the basis of the data that are now available in the GLOBOCAN series of IARC, there were 18.10 million new cases of cancer and 9.60 million cancer deaths in 2018. The number of people suffering from cancer is increasing year by year, and many types of cancer, such as pancreatic cancer, are still intractable. Thus, it is desperately desired to establish new cancer prevention methods and further develop cancer treatment methods. Given that the number of cancer survivors has also increased dramatically, the number of people at high risk for cancer that are a target for cancer prevention is assumed to increase in the future. However, dissemination and implementation of cancer prevention knowledge is not enough. One of the reasons is that the study of cancer prevention is still insufficient. Therefore, it is necessary to classify cancer preventive medicines from the viewpoint of their molecular mechanisms and to confirm their validity with evidence obtained from clinical and epidemiological studies. As shown for the development of cancer-targeting drugs, it is possible to specifically select molecules that can be effective targets for cancer prevention, sufficiently analyze the related molecular mechanisms, and establish a cancer prevention method.
Taking into consideration the various biological processes that can eliminate cancer cells, several systems can be examined to develop cancer prevention strategies, such as activation of DNA repair genes in mutated cells, induction of apoptosis in uncontrolled cells, and elimination of cancer cells by activation of the immune system. Moreover, elimination of cancer cells from a normal cell society by cell competition can also be considered. In these processes, it is thought that many molecules interact to maintain homeostasis. Also, many molecules have already been identified as potential target molecules of cancer chemoprevention; they include adiponectin, angiotensin II receptor, carbonic anhydrase, cyclooxygenase, HMG-CoA reductase, inducible nitric oxide synthetase, NADPH oxidase, lipoprotein lipase, plasminogen activator-1.
As mentioned above, this Special Issue entitled “Molecular Mechanisms in Cancer Prevention” will cover many of the biochemical, molecular, immunological, and cellular mechanisms implicated in the development of cancer. Recent studies have shown that the biological background of diabetes and the biological background of cancer are similar. We welcome submissions both from specialists of diseases that increase the risk of cancer developement and from cancer specialists.
Dr. Michihiro Mutoh
Prof. Dr. Masahito Shimizu
Prof. Takuji Tanaka
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- molecular targets
- cancer high-risk groups