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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Transcatheter Aortic Valve Implantation (TAVI): Recent Advances and Future Prospects
edited by Suvitesh Luthra and Richard Jabbour
submission deadline 20 Apr 2027 | Viewed by 99 | Submission Open
Keywords: transcatheter; surgical; aortic valve; TAVI; aortic stenosis; clinical outcomes research
(This special issue belongs to the Section Cardiology)
Advances in Prediction, Prevention, and Management of Pregnancy and Childbirth Complications
edited by Ioannis Kyvernitakis
submission deadline 20 Apr 2027 | Viewed by 99 | Submission Open
Keywords: preterm birth; prevention; high-risk pregnancy; prediction; fetal medicine; fetal growth restriction; twin pregnancy
(This special issue belongs to the Section Obstetrics & Gynecology)
New Frontiers in Kidney Transplantation: Innovation, Organ Preservation, and Clinical Outcomes
edited by Obi O. Ekwenna
submission deadline 20 Apr 2027 | Viewed by 92 | Submission Open
Keywords: kidney transplantation; robotic kidney transplantation; organ preservation; machine perfusion; living donor protection; deceased donor transplantation; xenotransplantation; cryobiology; biomimetic organ preserva-tion; transplant innovation; clinical outcomes; precision medicine; transplant immunology; health disparities
(This special issue belongs to the Section Nephrology & Urology)
Challenges and Advances in Thyroid and Parathyroid Surgery
edited by
submission deadline 20 Apr 2027 | Viewed by 84 | Submission Open
Keywords: thyroid surgery; parathyroid surgery; surgical innovation; multigland disease; postoperative quality of life
(This special issue belongs to the Section General Surgery)
Urological Oncology: Clinical Diagnosis, Treatment, and Prognostic Management
edited by Matteo Vittori and Valerio Iacovelli
submission deadline 20 Apr 2027 | Viewed by 81 | Submission Open
Keywords: urological oncology; prostate cancer; bladder cancer; renal cell carcinoma; upper tract urothelial carcinoma; urological malignancies; biomarkers; imaging; precision oncology; risk stratification; prognostic factors; robotic surgery; minimally invasive surgery; systemic therapy; immunotherapy; artificial intelligence
(This special issue belongs to the Section Nephrology & Urology)
Current Trends in Minimally Invasive Gynecologic Surgery
edited by Raanan Meyer
submission deadline 20 Apr 2027 | Viewed by 78 | Submission Open
Keywords: minimally invasive gynecology; endometriosis; uterine fibroids; isthmocele; fertility sparing surgery; hysteroscopy; gynecological surgery; laparoscopic surgery; deeply infiltrating endometriosis; ERAS protocols; artificial intelligence in surgery; patient-reported outcomes
(This special issue belongs to the Section Obstetrics & Gynecology)
Current Advances in Glaucoma: From Pathophysiology to Clinical Management submission deadline 23 Apr 2027 | Viewed by 50 | Submission Open
Keywords: glaucoma; intraocular pressure; optic neuropathy; glaucoma diagnosis; ocular imaging; glaucoma treatment; glau-coma surgery; neuroprotection; clinical translational research; treatment adherence; real-world evidence; phar-macoepidemiology; artificial intelligence; quality of life
(This special issue belongs to the Section Ophthalmology)
Clinics and Management of Allergic and Inflammatory Skin Disorders submission deadline 25 Apr 2027 | 5 articles | Viewed by 7418 | Submission Open
Keywords: allergic dermatoses; chronic inflammatory dermatoses; atopic dermatosis; contact dermatitis; chronic urticria; rosacea; psoriasis; hidradenitis suppurativa; diagnosis; comorbidities; management
(This special issue belongs to the Section Dermatology)
New Advances in the Management of Voice Disorders: 2nd Edition submission deadline 25 Apr 2027 | 6 articles | Viewed by 6061 | Submission Open
Keywords: voice disorders; laryngology; laryngoscope; acoustic analysis; dysphonia; voice surgery; diagnosis; treatment; rehabilitation; vocal folds; voice assessment/measures
(This special issue belongs to the Section Otolaryngology)
Colorectal Cancer: Early Detection, Treatment Advances and Patient Outcomes
edited by , and Federica Giordano
submission deadline 25 Apr 2027 | 3 articles | Viewed by 5838 | Submission Open
Keywords: colorectal cancer; early detection; prevention; innovation; screening; precision medicine; biomarkers; genetic profile
(This special issue belongs to the Section Oncology)
Helicobacter pylori-Associated Intestinal Diseases and Beyond submission deadline 25 Apr 2027 | 4 articles | Viewed by 4746 | Submission Open
Keywords: IBD; Hp; stomach; celiac disease; diverticulosis; diverticulitis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Clinical Advances in Psoriasis and Psoriatic Arthritis: 2nd Edition
edited by and Alessandra Narcisi
submission deadline 25 Apr 2027 | 3 articles | Viewed by 4669 | Submission Open
Keywords: psoriasis; psoriatic arthritis; inflammatory skin disease; inflammatory autoimmune disease; immunotherapy; autoimmunity; comorbidities; therapeutic; diagnosis; treatment; management; biologics
(This special issue belongs to the Section Dermatology)
Updates on Neuromuscular Diseases
edited by
submission deadline 25 Apr 2027 | 6 articles | Viewed by 4203 | Submission Open
Keywords: neuromuscualr disorders; myopathies; neuropathies; neuromuscualr junction disorders; neurogenetics
(This special issue belongs to the Section Clinical Neurology)
Chronic Obstructive Pulmonary Disease (COPD): Treatment and Management—Second Edition
edited by and Alfredo Antonio Chetta
submission deadline 25 Apr 2027 | 3 articles | Viewed by 3094 | Submission Open
Keywords: chronic obstructive pulmonary disease (COPD); treatable traits; precision medicine; COPD comorbidities; COPD mortality
(This special issue belongs to the Section Respiratory Medicine)
Personalized Therapy and Clinical Outcome for Vasculitis
edited by
submission deadline 25 Apr 2027 | 2 articles | Viewed by 3065 | Submission Open
Keywords: immune-mediated systemic vasculitis; personalized therapy; treatment; outcome; biomarkers; risk factors; management; multidisciplinary care
(This special issue belongs to the Section Immunology & Rheumatology)
Clinical Advancements in Orthopedic Trauma Treatments
edited by
submission deadline 25 Apr 2027 | 6 articles | Viewed by 3046 | Submission Open
Keywords: fractures; osteoporosis; fixation; trauma; fracture healing; osteosynthesis; pain
(This special issue belongs to the Section Orthopedics)
Current Advances and Future Perspectives of Sepsis and Septic Shock
edited by Filippo Mearelli and Gianni Biolo
submission deadline 25 Apr 2027 | 2 articles | Viewed by 2642 | Submission Open
Keywords: sepsis; epidemiology; biomarkers; diagnosis; predictive models; prognostication
(This special issue belongs to the Section Emergency Medicine)
Gastrointestinal Cancer: Outcomes and Therapeutic Management—2nd Edition
edited by Maximos Frountzas
submission deadline 25 Apr 2027 | 4 articles | Viewed by 2387 | Submission Open
Keywords: surgical oncology; gastrointestinal cancer; esophageal; gastric; hepatic; biliary; pancreatic; colon; rectal; neoplasm
(This special issue belongs to the Section Oncology)
The New Perspective in Transcatheter Aortic Valve Implantation (TAVI)
edited by Salvatore Giordano, Arturo Giordano and Nicola Corcione
submission deadline 25 Apr 2027 | 3 articles | Viewed by 2202 | Submission Open
Keywords: transcatheter aortic valve implantation (TAVI); structural heart intervention; aortic stenosis; valve technology and durability; imaging and procedural optimization
(This special issue belongs to the Section Cardiovascular Medicine)
Knee Arthroplasty: Recent Advances and Future Challenges
edited by Matteo Marullo
submission deadline 25 Apr 2027 | 4 articles | Viewed by 2197 | Submission Open
Keywords: knee arthroplasty; implant design; robotic surgery; revision surgery; biomechanics; clinical outcomes; perioperative care; fast-track surgery; digital orthopedics; partial knee replacement
(This special issue belongs to the Section Orthopedics)
Early Palliative Care for Patients with Advanced Cancer
edited by
submission deadline 25 Apr 2027 | Viewed by 2163 | Submission Open
Keywords: palliative care; early integration; cancer care transitions; communication; symptom management; end of life
(This special issue belongs to the Section Oncology)
Advanced Diagnostics, Management, and Rare Unusual Clinical Consequences of Blunt or Penetrating Abdominal, Pelvic, Thoracic, and Vascular Injuries
edited by and Zbigniew Pasieka
submission deadline 25 Apr 2027 | 3 articles | Viewed by 1707 | Submission Open
Keywords: blunt trauma; penetrating trauma; abdominal injuries; thoracic injuries; pelvic fractures; arterial and vascular trauma; blunt aortic injury (BTAI); thoracic endovascular aortic repair (TEVAR); visceral macrovascular trauma; emergency surgery; damage control resuscitation
(This special issue belongs to the Section General Surgery)
Advances in Anticoagulant and Antiplatelet Therapy for Coronary Artery Disease: 2nd Edition
edited by
submission deadline 25 Apr 2027 | 2 articles | Viewed by 1654 | Submission Open
Keywords: platelet; anticoagulant therapy; antiplatelet therapy; coronary artery disease (CAD); atrial fibrillation (AF); thromboembolic events; myocardial ischemic; bleeding events; aspirin; clopidogrel; cardiovascular and cerebrovascular diseases; diagnosis and treatment; percutaneous coronary intervention; acute coronary syndrome
(This special issue belongs to the Section Cardiology)
Kidney Transplantation: From Donor Selection to Recipient Outcomes
edited by Basma Merhi and Reginald Gohh
submission deadline 25 Apr 2027 | 1 articles | Viewed by 982 | Submission Open
Keywords: kidney transplantation; end-stage renal disease (ESRD); living-donor kidney transplantation; deceased-donor kidney transplantation; organ shortage; dialysis waiting time; transplant candidate evaluation; immunosuppression
(This special issue belongs to the Section Nephrology & Urology)
Bariatric Surgery: Clinical Advances and Future Directions submission deadline 25 Apr 2027 | 1 articles | Viewed by 972 | Submission Open
Keywords: metabolic surgery; bariatric surgery; reflux; laparoscopy; conversion surgery; obesity
(This special issue belongs to the Section General Surgery)
Advances in Percutaneous Coronary Intervention: Techniques, Tools and Outcomes
edited by Takashi Ashikaga
submission deadline 25 Apr 2027 | 1 articles | Viewed by 866 | Submission Open
Keywords: percutaneous coronary intervention; orbital atherectomy; coronary artery calcification; intravascular ultrasound (IVUS); optical coherence tomography (OCT)
(This special issue belongs to the Section Cardiovascular Medicine)
Management of Complex Orthopaedic Trauma and Bone Infection
edited by
submission deadline 25 Apr 2027 | 1 articles | Viewed by 721 | Submission Open
Keywords: complex orthopaedic trauma; fracture-related infection (FRI); bone and implant-associated infection; chronic osteomyelitis; post-traumatic infection; biofilm-associated infection; advanced fracture management; limb reconstruction; nonunion and delayed union; multidisciplinary trauma care
(This special issue belongs to the Section Orthopedics)
Percutaneous Coronary Interventions in Acute Coronary Syndromes: Techniques, Imaging and Clinical Outcomes
edited by Ioannis Skalidis
submission deadline 25 Apr 2027 | 1 articles | Viewed by 618 | Submission Open
Keywords: PCI; acute coronary syndrome; STEMI; NSTEMI; myocardial infarction; intravascular imaging; IVUS; OCT; coro-nary physiology; QFR; multivessel disease; antithrombotic therapy
(This special issue belongs to the Section Cardiology)
Clinical Advances in Intracranial Tumors Surgery
edited by Michael J. Karsy and
submission deadline 25 Apr 2027 | 1 articles | Viewed by 463 | Submission Open
Keywords: intracranial tumors; surgical innovations; minimally invasive surgery; awake mapping; fluorescence-guided surgery; intraoperative imaging; robotic surgery; artificial intelligence; perioperative care; patient-centered outcomes
(This special issue belongs to the Section Clinical Neurology)
Advances and Updates in Fetal Medicine
edited by Roy Zigron and
submission deadline 25 Apr 2027 | 1 articles | Viewed by 404 | Submission Open
Keywords: fetal medicine; maternal medicine; obstetric ultrasound; twin pregnancy; pre-eclampsia; prematurity
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Updates of Pediatric Craniofacial Surgery
edited by Federica Tosi
submission deadline 25 Apr 2027 | Viewed by 374 | Submission Open
Keywords: pediatric craniofacial surgery; craniosynostosis; near-infrared spectroscopy; blood transfusion; perioperative monitoring; pediatric anesthesia; hemodynamic management; tissue oxygenation
(This special issue belongs to the Section Clinical Pediatrics)
Clinical Management of Type 1 Diabetes: 2nd Edition
edited by Carmen Quirós
submission deadline 25 Apr 2027 | Viewed by 367 | Submission Open
Keywords: type 1 diabetes; continuous glucose monitoring; hybrid closed loop; hypoglycemia; physical activity; new onset type 1 diabetes; pre-stage 3 type 1 diabetes; smart insulin pens
(This special issue belongs to the Section Endocrinology & Metabolism)
Recent Clinical Perspectives on Chronic Kidney Disease
edited by Luca Visconti
submission deadline 25 Apr 2027 | Viewed by 318 | Submission Open
Keywords: chronic kidney disease; nephrology; hemodialysis; renal impairment; renal replacement therapy; new therapeutic approaches in CKD; clinical trials; renal complications
(This special issue belongs to the Section Nephrology & Urology)
New Insights into Physical Therapy: 2nd Edition submission deadline 25 Apr 2027 | Viewed by 207 | Submission Open
Keywords: physical rehabilitation; new technologies; virtual reality; augmented reality; telerehabilitation; clinical pilates; blood flow restriction; manual therapy; motor imagery; electrophysical modalities; therapeutic exercises; neurology; mus-culoskeletal; geriatric; respiratory; acute illness; cardiovascular
(This special issue belongs to the Section Clinical Rehabilitation)
Multimodality Imaging in Congenital and Pediatric Heart Disease
edited by Massimiliano Cantinotti
submission deadline 25 Apr 2027 | Viewed by 143 | Submission Open
Keywords: congenital heart disease; echocardiography; cardiac magnetic resonance; computed tomography; imaging; multimodality imaging
(This special issue belongs to the Section Cardiology)
Artificial Intelligence in Ocular Imaging: Clinical Applications and Perspectives
edited by , and Alfonso Vasquez-Perez
submission deadline 25 Apr 2027 | Viewed by 136 | Submission Open
Keywords: artificial intelligence; machine learning; deep learning; ocular imaging; screening; corneal ectasia; diabetic retinopathy; AMD; macular oedema; glaucoma detection
(This special issue belongs to the Section Ophthalmology)
Clinical Management of Scoliosis, Spinal Deformities, and Related Spinal Disorders
edited by Simon Benedict Roberts
submission deadline 25 Apr 2027 | Viewed by 115 | Submission Open
Keywords: scoliosis; spinal deformity; spinal disorders; computer-assisted navigation; surgical robotics; artificial intelligence; minimally invasive surgery; spine surgery
(This special issue belongs to the Section Orthopedics)
Artificial Intelligence in Clinical Radiology Practice: Transforming Medical Imaging and Reporting Workflows
edited by and Amna A. Ajam
submission deadline 25 Apr 2027 | Viewed by 80 | Submission Open
Keywords: artificial intelligence; diagnostic radiology; clinical workflow integration; deep learning image reconstruction; computer-assisted triage; large language models
(This special issue belongs to the Section Nuclear Medicine & Radiology)
The Evolving Landscape of Multiple Sclerosis: New Insights into Biomarkers and Treatment
edited by , and Maddalena Sparaco
submission deadline 25 Apr 2027 | Viewed by 79 | Submission Open
Keywords: multiple sclerosis; precision medicine; biomarkers; neuroimaging; disease-modifying therapies; neurodegeneration; disease progression
(This special issue belongs to the Section Clinical Neurology)
Advances in Cataract, Corneal and Refractive Surgery
edited by , Sheraz M. Daya and Arthur B. Cummings
submission deadline 25 Apr 2027 | Viewed by 72 | Submission Open
Keywords: cataract surgery; corneal surgery; refractive surgery; laser surgery; presbyopia surgery; robotic surgery; cell transplantation; intraocular lens; LASIK; Lenticule Extraction/KLEx
(This special issue belongs to the Section Ophthalmology)
Clinical Advances in Physiotherapy for Neurorehabilitation
edited by and
submission deadline 25 Apr 2027 | Viewed by 67 | Submission Open
Keywords: artificial intelligence; digital health; gait analysis; instrumented assessment; movement analysis; multiple sclerosis; neurological disorders; neurorehabilitation; Parkinson’s disease; physical therapy; quantitative assessment; robotic rehabilitation; stroke; virtual reality
(This special issue belongs to the Section Clinical Rehabilitation)
Rehabilitation and Treatment of Post-COVID-19 Condition submission deadline 26 Apr 2027 | 3 articles | Viewed by 3334 | Submission Open
Keywords: post-COVID-19 condition; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); comorbidities; interdisciplinary; multimodal; digital medicine; rehabilitation; treatment; health-related quality of life; disability; return to work
(This special issue belongs to the Section Clinical Rehabilitation)
Recent Clinical Updates on Movement Disorders
edited by Vladimira Vuletic, Dejan Georgiev and
submission deadline 28 Apr 2027 | Viewed by 129 | Submission Open
Keywords: movement disorders; Parkinson’s disease; dystonia; functional movement disorders; autonomic dysfunction; dysautonomia; deep brain stimulation; non-motor symptoms; neurophysiology; clinical phenotyping
(This special issue belongs to the Section Clinical Neurology)
One Airway, Many Specialists: Multidisciplinary Innovation in Thoraco-Pulmonary Diseases—Insights from the XXIII SIET National Meeting
edited by Federico Raveglia, and
submission deadline 30 Apr 2027 | Viewed by 330 | Submission Open
Keywords: thoraco-pulmonary diseases; endoscopy; thoracic surgery; airway oncology; pleural diseases; mediastinal disorders; digital medicine; artificial intelligence; anesthesiology; radiology; respiratory; diagnosis, treatment and prognosis
(This special issue belongs to the Section Respiratory Medicine)
Current Clinical Research in Oral and Maxillofacial Surgery
edited by
submission deadline 1 May 2027 | Viewed by 60 | Submission Open
Keywords: oral and maxillofacial surgery; microvascular reconstruction; free flap; digital surgical planning; artificial intelligence; head and neck oncology
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Otolaryngologic Disorders: Focus on Clinical Practice
edited by and
submission deadline 4 May 2027 | Viewed by 11 | Submission Open
Keywords: surgical techniques; clinical outcomes and safety; rhinology and sinus disorders; multidisciplinary and patient-centered approaches; epidemiological studies; diagnostic biomarkers; nasal airway evaluation; trends in otolaryngological procedures and resource utilization
(This special issue belongs to the Section Otolaryngology)
Artificial Intelligence (AI) in Dental Clinical Practice
edited by and Keiichiro Watanabe
submission deadline 5 May 2027 | 9 articles | Viewed by 10832 | Submission Open
Keywords: artificial intelligence; dental diagnostics; machine learning; deep learning; digital dentistry; clinical decision support; diagnostic automation; data transparency; evidence-based dentistry
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Updates on Physiotherapy in Pain Management
edited by and George Gioftsos
submission deadline 10 May 2027 | 4 articles | Viewed by 4979 | Submission Open
Keywords: pain management; physiotherapy; chronic pain; rehabilitation; pain assessment; patient outcomes; musculoskeletal; central sensitization; pain sensitivity; analgesia; pain modulation; exercise therapy; pain education; telerehabilitation; health-related quality of life; pain coping strategies
(This special issue belongs to the Section Clinical Rehabilitation)
Rehabilitation Strategies for Chronic Musculoskeletal Pain
edited by Ana Isabel de la Llave Rincon and
submission deadline 10 May 2027 | 2 articles | Viewed by 3260 | Submission Open
Keywords: pain; musculoskeletal; rehabilitation; treatment; classification
(This special issue belongs to the Section Clinical Rehabilitation)
Advances in Physical Therapy for Healthy Aging: Innovative and Functional Rehabilitation Approaches submission deadline 10 May 2027 | 3 articles | Viewed by 2392 | Submission Open
Keywords: physical therapy; healthy aging; functional rehabilitation; therapeutic exercise; motor control; pelvic floor rehabilitation; preventive interventions
(This special issue belongs to the Section Clinical Rehabilitation)
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