Brain Tumors and Neuroinflammation

Dear Colleagues,

Inflammation plays a significant role in gliomagenesis, malignant progression, metastasis, and clinical symptomatology. The central nervous system (CNS) microenvironment plays a major role in this process, with contributions from factors such as oxidative stress, interleukins, cyclooxygenases, inflammatory pathway transcription factors, metabolic alterations, microsatellite instability, etc. Other cellular factors such as reactive astrocytes, microglia and macrophages, and other members of the immunologic response also factor into tumor progression and response to treatment. Recent preclinical and clinical studies attempting to harness the immune system to improve response to treatment have helped to improve our understanding of the role of the immune response in tumor progression and response to treatment in the brain. This Special Issue will focus on preclinical and clinical data regarding our understanding the interaction between brain tumors and neuroinflammation.

Dr. David Ryan Ormond
Guest Editor

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