Clinical Perspectives on Obesity and Bariatric Surgery: Outcomes and Complications

Dear Colleagues,

This Special Issue brings together leading experts in gastroenterology, hepatology, and metabolic surgery to address the pressing challenges of obesity and its management through bariatric interventions. With obesity now affecting more than 650 million adults worldwide and driving comorbidities such as type 2 diabetes, cardiovascular disease, and MASLD/MASH, bariatric surgery remains the most effective therapy for sustained weight loss and metabolic improvement. However, outcomes vary widely, and understanding the predictors of success and the spectrum of complications is critical to advancing patient care.

The issue highlights cutting-edge research on predictors of surgical response, including emerging roles of intestinal adaptation, nutrient sensing, and metabolic phenotyping. Longitudinal studies on weight loss trajectories, diabetes remission, and quality of life provide updated benchmarks for patient counseling. Equally important, the issue covers early and late complications—such as leaks, strictures, malnutrition, and hypoglycemia—and explores endoscopic and surgical strategies for management, reinforcing the importance of multidisciplinary care.

Finally, the collection emphasizes precision medicine approaches to obesity care, including the integration of biomarkers, advanced imaging, and digital health technologies to optimize patient selection and long-term monitoring. By balancing benefits with risks, this issue provides a comprehensive resource for clinicians, researchers, and trainees committed to improving outcomes in obesity and bariatric surgery. It underscores the need for innovation, collaboration, and evidence-based practice to reduce complications while extending the life-saving benefits of these interventions to a broader patient population.

Dr. Dilhana S. Badurdeen
Guest Editor

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