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Diagnosis and Treatment of Ocular Surface and Corneal Diseases
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Diagnosis and Treatment of Ocular Surface and Corneal Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 4079

Special Issue Editor

Dr. Adrian Gericke

E-Mail Website
Guest Editor
Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany
Interests: cornea; glaucoma; retina; ocular perfusion; membrane receptors; redox signaling
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Diseases of the ocular surface, including the cornea, exert a major impact on visual acuity and the quality of life of affected patients. For an intact ocular surface, a well-regulated tear secretion, proper innervation, an abundant reservoir of corneal and conjunctival stem cells, and an intact immune system are required. Advanced age, prolonged wearing of contact lenses, excessive use of digital devices, and the intake of certain drugs are risk factors for ocular surface diseases, which constitute an increasing burden for healthcare systems. To counteract this trend and to improve treatment for ocular surface diseases, it is vital to identify and understand their pathophysiology and the consequences for healthcare systems. Therefore, we encourage submissions of clinical research articles pertaining to treatment options, prevention, and epidemiological aspects of ocular surface diseases.


Prof. Dr. Adrian Gericke
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cornea
  • conjunctiva
  • ocular surface
  • stem cells
  • immune system
  • epidemiology
  • healthcare system

Published Papers (2 papers)

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Research

7 pages, 241 KiB  
Article
Prevalence of Herpesvirus DNA in Corneal Transplant Recipients
by Julia Bing Bu, Stephanie D. Grabitz, Norbert Pfeiffer and Joanna Wasielica-Poslednik
J. Clin. Med. 2023, 12(1), 289; https://doi.org/10.3390/jcm12010289 - 30 Dec 2022
Cited by 5 | Viewed by 2446
Abstract
Purpose: Graft failure after penetrating keratoplasty (PK) is a serious complication, especially in eyes with herpetic keratitis (HK). This study evaluated the prevalence and graft survival of herpes simplex virus type 1 (HSV-1) and varicella zoster virus (VZV) DNA in recipient corneas during [...] Read more.
Purpose: Graft failure after penetrating keratoplasty (PK) is a serious complication, especially in eyes with herpetic keratitis (HK). This study evaluated the prevalence and graft survival of herpes simplex virus type 1 (HSV-1) and varicella zoster virus (VZV) DNA in recipient corneas during PK. Methods: The retrospective study was performed at the Department of Ophthalmology at University Hospital in Mainz, Germany. We analyzed data from every patient who underwent PK between January 2020 and June 2021. According to our clinical routine, we performed HSV-1 and VZV polymerase chain reaction (PCR) on all excised corneal buttons regardless of the primary clinical diagnosis. Results: We included 112 eyes of 112 consecutive patients who underwent PK. At the time of PK, 91 (81.25%) patients had no history of HK and 21 (18.75%) patients did. The recipient corneas of 91 patients without a history of HK tested positive for HSV-1 DNA in 12 (13.2%) eyes, for VZV DNA in 3 (3.3%) eyes, and for HSV-1 and VZV DNA simultaneously in 2 (2.2%) eyes. The recipient corneas of 21 patients with a preoperative history of HK tested positive for HSV-1 DNA in 13 (61.9%) eyes and VZV DNA in 1 (4.8%) eye. All patients with positive herpes DNA and no history of HK prior to PK received antiherpetic treatment and had a 100% graft survival rate after 1 year. Conclusions: We found herpesvirus DNA in 18.7% of recipient corneas without clinical suspicion or history of herpes keratitis. This suggests the need of routine HSV-1 and VZV PCR testing in all explanted corneas regardless of clinical suspicion, to detect, treat and prevent possible recurrence of herpes infection in corneal grafts and support graft survival. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Ocular Surface and Corneal Diseases)
9 pages, 3704 KiB  
Communication
A Simple Repair Algorithm for Descemet’s Membrane Detachment Performed at the Slit Lamp
by Fan Li, Zhe Zhu, Lubo Fan, Gengrong Yi, Xiaowei Zhu and Naiyang Li
J. Clin. Med. 2022, 11(23), 7001; https://doi.org/10.3390/jcm11237001 - 27 Nov 2022
Viewed by 1159
Abstract
Our study aims to investigate a simple repair algorithm for Descemet’s membrane detachment (DMD) following phacoemulsification with Pentacam and anterior segment optical coherence tomography (AS-OCT). Twelve patients with DMD were included in this retrospective study. All cases had persistent corneal edema after phacoemulsification [...] Read more.
Our study aims to investigate a simple repair algorithm for Descemet’s membrane detachment (DMD) following phacoemulsification with Pentacam and anterior segment optical coherence tomography (AS-OCT). Twelve patients with DMD were included in this retrospective study. All cases had persistent corneal edema after phacoemulsification and no improved response to conservative treatment. The repair algorithm consisted of delineating the DMD with the Pentacam and AS-OCT, paracentesis, and intracameral air bubble performed at the slit lamp, followed by immediate supine position. At one month, the final status of Descemet’s membrane (DM), best-corrected visual acuity, and incidence of complications were noted. DMD was involved in the visual axis in all cases. The mean interval between phacoemulsification and repair was 5.3 ± 1.2 days. Complete reattachment of DM and corneal clarity occurred in all 12 eyes. Eleven (91.7%) eyes underwent one repair procedure, while one eye (8.3%) underwent a repeat procedure. No adverse events were found. Minor post-intervention complications included temporary increased intraocular pressure due to pupillary block in one eye (8.3%). In conclusion, our modified and simplified repair algorithm for DMD can be performed safely as an outpatient procedure, with accurate delineation using a Pentacam and AS-OCT. It may provide new insight into the timely diagnosis, evaluation, and management of DMD. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Ocular Surface and Corneal Diseases)
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