Management and Treatment in Angioedema

Dear Colleagues,

In the last decade, our knowledge regarding angioedema has taken a significant number of steps forward. Recurrent angioedema without wheals is now recognized as a clinical entity. The Hereditary Angioedema Working Group (HAWK) classification allowed the scientific community to go beyond the semantic confusion that dominated this topic for decades. In the last few years, the identification of new types of hereditary angioedema has required a continuous update of the classification. Recently, additional mechanisms have been involved in angioedema pathogenesis, including the uncontrolled activation of factor XII, generation of vasoactive mediators that induce dysregulation of endothelial functions, and bidirectional interactions between mast cell-derived mediators and the plasma contact system. This fervid research activity has promoted the identification of new diagnostic tools, and many new therapies, some of them available in many countries, and others progressing at different research stages.

As it often happens, each answer opens the way for a new question. Despite major advances in our understanding of recurrent angioedema, many unsolved questions remain, leaving several unmet needs for patients and caregivers.

In this Special Issue, we will more closely examine recent innovations and advancements in the knowledge of pathogenetic mechanisms, with a focus about genetics. Moreover, we will also address the management of different forms of angioedema, with special attention to idiopathic types, and their approach in clinical and emergency settings, both for diagnostic and therapeutic approaches.

Dr. Maria Bova, MD
Dr. Mar Guilarte, MD
Guest Editors

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