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Addressing the Atrial Fibrillation Epidemic: New Insights and Approaches to Prevention and Therapy

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: closed (20 June 2024) | Viewed by 2742

Special Issue Editors

Dr. Julian Müller

E-Mail Website
Guest Editor
Clinic for Interventional Electrophysiology, Heart Centre Bad Neustadt, Von-Guttenberg-Straße 11, 97616 Bad Neustadt an der Saale, Germany
Interests: electrophysiology; atrial fibrillation; ventricular tachycardia; ablation
Dr. Heiko Lehrmann

E-Mail Website
Guest Editor
Clinic for Interventional Electrophysiology, Heart Centre Bad Neustadt, Von-Guttenberg-Straße 11, 97616 Bad Neustadt an der Saale, Germany
Interests: atrial fibrillation; zero fluoroscopy; ablation; ventricular tachycardia

Special Issue Information

Dear Colleagues,

Atrial fibrillation (AF) is the most common arrhythmia wordwide and its prevalence is dramatically increasing. Despite technological advantages and upcoming new ablation strategies, ablation rates are still suboptimal. Several non-invasive measures and prevention are required to increase AF therapy success.

The aim of this Special Issue is to provide a comprehensive summery of possible approaches for arrhythmia prevention and non-invasive (pharmalogical)/interventional techniques for AF therapies. Colleagues and researchers working in the field of prevention and clinical electrophysiology are welcome to submit original articles or reviews to this Special Issue. 

Dr. Julian Müller
Dr. Heiko Lehrmann
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiac arrhytmias
  • catheter ablation
  • new technologies
  • prevention
  • atrial fibrillation

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Published Papers (2 papers)

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Research

10 pages, 787 KiB  
Article
The Role of Galectin-3 Levels for Predicting Paroxysmal Atrial Fibrillation in Patients with Embolic Stroke of Undetermined Source
by Bekir Çalapkorur, Erkan Demirci, Oğuzhan Baran, Ersin Kasım Ulusoy, Derya Koçer, Selami Demirelli, Mustafa Gök and Ziya Şimşek
J. Clin. Med. 2024, 13(11), 3175; https://doi.org/10.3390/jcm13113175 - 29 May 2024
Viewed by 775
Abstract
Background/Objectives: Paroxysmal atrial fibrillation (PAF) is an important cause that is thought main potential factor in Embolic stroke of undetermined source (ESUS). Extended Holter ECG is an expensive and time-consuming examination. It needs another tools for predicting PAF in ESUS patients. In this [...] Read more.
Background/Objectives: Paroxysmal atrial fibrillation (PAF) is an important cause that is thought main potential factor in Embolic stroke of undetermined source (ESUS). Extended Holter ECG is an expensive and time-consuming examination. It needs another tools for predicting PAF in ESUS patients. In this study, serum galectin-3 levels, ECG parameters (PR interval, P wave time and P wave peak time) LA volume index, LA global peak strain and atrial electromechanical conduction time values were investigated for predicting PAF. Methods: 150 patients with ESUS and 30 volunteers for the control group were recruited to study. 48–72 h Holter ECG monitoring was used for detecting PAF. Patients were divided into two groups (ESUS + PAF and ESUS-PAF) according to the development of PAF in Holter ECG monitoring. Results: 30 patients with ESUS whose Holter ECG monitoring showed PAF, were recruited to the ESUS + PAF group. Other 120 patients with ESUS were recruited to the ESUS-PAF group. PA lateral, PA septum, and PA tricuspid were higher in the ESUS + PAF group (p < 0.001 for all). Serum galectin-3 levels were significantly higher in ESUS + PAF than in ESUS-PAF and control groups (479.0 pg/mL ± 435.8 pg/mL, 297.8 pg/mL ± 280.3 pg/mL, and 125.4 ± 87.0 pg/mL, p < 0.001, respectively). Serum galectin-3 levels were significantly correlated with LAVI, PA lateral, and global peak LA strain (r = 0.246, p = 0.001, p = 0.158, p = 0.035, r = −0.176, p = 0.018, respectively). Conclusion: Serum galectin-3 levels is found higher in ESUS patients which developed PAF and Serum galectin-3 levels are associated LA adverse remodeling in patients with ESUS. Full article
(This article belongs to the Special Issue Addressing the Atrial Fibrillation Epidemic: New Insights and Approaches to Prevention and Therapy)
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14 pages, 2015 KiB  
Article
Recurrent Atrial Fibrillation Ablation after Initial Successful Pulmonary Vein Isolation
by Julian Müller, Karin Nentwich, Artur Berkovitz, Kai Sonne, Olena Kozlova, Sebastian Barth, Alexandru Deacanu, Christian Waechter, Philipp Halbfass, Heiko Lehrmann and Thomas Deneke
J. Clin. Med. 2023, 12(22), 7177; https://doi.org/10.3390/jcm12227177 - 19 Nov 2023
Cited by 2 | Viewed by 1541
Abstract
Background: Pulmonary vein isolation (PVI) is an effective treatment option for patients with symptomatic atrial fibrillation (AF). However, the electrical recovery of pulmonary veins (PVs) is the main trigger for AF recurrences. This study investigates the characteristics of patients admitted for redo AF [...] Read more.
Background: Pulmonary vein isolation (PVI) is an effective treatment option for patients with symptomatic atrial fibrillation (AF). However, the electrical recovery of pulmonary veins (PVs) is the main trigger for AF recurrences. This study investigates the characteristics of patients admitted for redo AF ablation, the PV reconnection rates depending on previous ablation modalities and the impact of different ablation strategies for redo procedures. Methods: Consecutive patients undergoing first redo AF ablation were included. Patients were grouped according to the electrical recovery of at least one PV. The impacts of the technique for first AF ablation on PV reconnection rates and patients with and without PV reconnection were compared. Different ablation strategies for redo procedures were compared and its recurrence rates after a mean follow-up of 25 ± 20 months were investigated. Results: A total of 389 patients (68 ± 10 years; 57% male; 39% paroxysmal AF) underwent a first redo. The median time between the first and redo procedure was 40 ± 39 months. Radiofrequency was used in 278 patients, cryoballoon was used in 85 patients and surgical AF ablation was performed on 26 patients. In total, 325 patients (84%) had at least one PV reconnected, and the mean number of reconnected PVs was 2.0 ± 1.3, with significant differences between ablation approaches (p for all = 0.002); this was mainly due to differences in the left inferior PV and right superior PV reconnections. The presence of PV reconnection during redo was not associated with better long-term success compared to completely isolated PVs (67% vs. 67%; log-rank p = 0.997). Overall, the different ablation strategies for redos were comparable regarding AF recurrences during follow-up (p = 0.079), with the ablation approach having no impact in the case of left atrial low voltage or without. Conclusions: PV reconnections after initial successful PVI are common among all techniques of AF ablation. Long-term rhythm control off antiarrhythmic drugs was possible in 2/3 of all patients after the redo procedure; however, different ablation strategies with extra-PV trigger ablation did not improve long-term success. Patients with recurrent AF after PVI constitute a challenging group of patients. Full article
(This article belongs to the Special Issue Addressing the Atrial Fibrillation Epidemic: New Insights and Approaches to Prevention and Therapy)
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