Pushing Boundaries in Cardiac Resynchronization Therapy: Clinical Innovations Transforming Heart Failure Management

Dear Colleagues,

Cardiac resynchronization therapy (CRT) has revolutionized heart failure management, particularly in patients with dyssynchrony. Since its introduction, CRT has advanced significantly, improving survival rates and quality of life for millions worldwide. However, despite careful patient selection, nearly one-third of CRT recipients fail to respond to therapy. The reasons for CRT nonresponse are multifaceted, including left ventricular (LV) scar burden, suboptimal LV stimulation sites, and inadequate electrical or mechanical dyssynchrony. While patients with left bundle branch block (LBBB) generally experience favorable outcomes, those without LBBB consistently exhibit poor responses to resynchronization therapy. Furthermore, many individuals, especially those with advanced heart failure, present with mixed conduction disorders—complex abnormalities that standard CRT systems alone cannot fully correct. This Special Issue explores the latest advancements and innovations in resynchronization therapy, including novel preoperative and intraoperative decision-making algorithms aimed at optimizing treatment for a broader patient population with diverse conduction disorders. We invite you to contribute your latest research findings or review articles to this Special Issue and help shape the future of resynchronization therapy.

Prof. Dr. István Szokodi
Dr. Attila Kónyi
Guest Editors

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