Takotsubo Syndrome: Insights into Pathophysiology, Diagnosis, and Management
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 84
Special Issue Editors
Interests: interventional cardiology; percutaneous coronary intervention (PCI); acute myocardial infarction; acute coronary syndromes; transcatheter interventions; structural interventions; cardiovascular diseases; advanced coronary imaging techniques
Interests: cardiovascular disease prevention; atherosclerotic plaque vulnerability; heart failure
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Special Issue Information
Dear Colleagues,
Takotsubo syndrome (TTS) is an acute, reversible cardiomyopathy characterized by transient left ventricular dysfunction, typically in the absence of obstructive coronary artery disease. It often presents with chest pain and ECG changes mimicking acute coronary syndrome (ACS) and is frequently precipitated by physical or emotional stress. Although the exact pathophysiology remains unclear, proposed mechanisms include catecholamine-mediated myocardial stunning, microvascular dysfunction, and autonomic dysregulation.
Despite its transient nature, TTS is associated with significant complications, including acute heart failure, arrhythmias, thromboembolic events, and recurrence. Advances in imaging modalities, biomarker discovery, and risk stratification are refining diagnostic accuracy and prognostic assessment. However, optimal management strategies remain debated, particularly regarding long-term outcomes and preventive approaches.
This Special Issue aims to explore recent advances in the clinical pathophysiology, diagnosis, and clinical management of TTS. We welcome original research, reviews, and case studies that contribute to a deeper understanding of disease mechanisms, risk factors, novel diagnostic tools, and emerging therapeutic strategies.
Dr. Andreas Mitsis
Dr. Nikolaos Kadoglou
Guest Editors
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Keywords
- takotsubo syndrome
- stress cardiomyopathy
- acute heart failure
- cardiac imaging
- catecholamine surge
- myocardial dysfunction
- echocardiography
- biomarker discovery
- cardiovascular risk
- clinical management
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