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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms of Allergy and Asthma: 3rd Edition

edited by

Bilal Alashkar Alhamwe

and

Daniel P. Potaczek

submission deadline 20 Oct 2025 | 8 articles | Viewed by 15416 | Submission Open

Keywords: allergy; asthma; epigenetics/epigenomics; genetics/genomics; inflammation; molecular biology

(This special issue belongs to the Section Molecular Biology)

Research and Application of Platelet-Rich Plasma (PRP)

edited by

Tomoyuki Kawase

submission deadline 20 Oct 2025 | 4 articles | Viewed by 15062 | Submission Open

Keywords: platelet-rich plasma; platelet-rich fibrin; platelets; exosome; mitochondria; growth factors; tissue regeneration

(This special issue belongs to the Section Molecular Biology)

Targeting RNA Molecules

edited by

Constantinos Stathopoulos

submission deadline 20 Oct 2025 | 3 articles | Viewed by 12971 | Submission Open

Keywords: riboswitch; noncoding RNA; antibiotics; resistance; bacteria; antimicrobial resistance

(This special issue belongs to the Section Molecular Biology)

Ion Channels as a Potential Target in Pharmaceutical Designs 2.0

edited by

Sheng-Nan Wu

submission deadline 20 Oct 2025 | 9 articles | Viewed by 11833 | Submission Open

Keywords: ion currents; current kinetics; gating properties; voltage-dependent hysteresis; frequency-dependent regulation; small-molecule modulator

(This special issue belongs to the Section Molecular Biology)

Exosomes—3rd Edition

edited by

Abdelnaby Khalyfa

submission deadline 20 Oct 2025 | 5 articles | Viewed by 10875 | Submission Open

Keywords: extracellular vesicles (EVs); exosomes; cancer; sleep cardiovascular diseases; lung disease and upper airways; obesity; sleep and end-organ morbidity

(This special issue belongs to the Section Molecular Biology)

The Role of Mesenchymal Stem Cells in Organ Repair and Tissue Regeneration

edited by

Sara Cruciani

submission deadline 20 Oct 2025 | 6 articles | Viewed by 8490 | Submission Open

Keywords: stem cells; differentiation; cell therapy; tissue regeneration; cell mechanisms; regenerative medicine; immunomodulation

(This special issue belongs to the Section Molecular Biology)

Molecular Research and Treatment in Multiple Sclerosis

edited by Nada Starčević Čizmarević and

Borut Peterlin

submission deadline 20 Oct 2025 | 4 articles | Viewed by 7760 | Submission Open

Keywords: multiple sclerosis; neuroinflammation; neurodegeneration; genetics; molecular research; biomarkers; neuroimaging; therapy

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Cancer and Molecular Imaging

edited by Mi-Ae Park

submission deadline 20 Oct 2025 | 3 articles | Viewed by 6565 | Submission Open

Keywords: molecular imaging; radiology; cancer detection; precision medicine; cancer mechanisms

(This special issue belongs to the Section Molecular Biology)

Zebrafish as a Model for Biomedical Studies—2nd Edition

edited by

Pierre-Olivier Angrand

submission deadline 20 Oct 2025 | 4 articles | Viewed by 6103 | Submission Open

Keywords: zebrafish; cancer; metabolic diseases; neurological disorders; infectious diseases; xenografts; drug discovery

(This special issue belongs to the Section Molecular Biology)

Extracellular Vesicles: The Biology and Therapeutic Applications, 2nd Edition

edited by

Tamás Visnovitz

submission deadline 20 Oct 2025 | 2 articles | Viewed by 5975 | Submission Open

Keywords: extracellular vesicles (EVs); exosomes; release; uptake; bio-distribution; methods; biomarkers; therapeutic applications

(This special issue belongs to the Section Molecular Biology)

Molecular Aspects of Cartilage Biology

edited by

Michela Geminiani

submission deadline 20 Oct 2025 | 3 articles | Viewed by 5788 | Submission Open

Keywords: cartilage biology; tissue regeneration; molecular mechanisms; chondrocytes; cartilage disorders; therapeutic interventions; biomaterials

(This special issue belongs to the Section Molecular Biology)

Exploring the Molecular Basis of Cellular Responses to Microgravity-Induced Oxidative Stress

edited by

Caterina Morabito

and

Simone Guarnieri

submission deadline 20 Oct 2025 | 2 articles | Viewed by 4575 | Submission Open

Keywords: microgravity; reactive oxygen species (ROS); oxidative damage; cellular antioxidant systems; cell metabolism; cell responses; molecular pathways; simulated microgravity; protective countermeasures

(This special issue belongs to the Section Molecular Biology)

Extraction, Identification and Quantification of Bioactive Molecules

edited by

Francesca Scionti

and Rosario Mare

submission deadline 20 Oct 2025 | 2 articles | Viewed by 3814 | Submission Open

Keywords: extracts; botanicals; nutraceuticals; bioactive molecules; spectrometry; spectrophotometer; chromatography; western blotting; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

New Insights into Airway Smooth Muscle: From Function to Dysfunction

edited by

Hiroaki Kume

submission deadline 20 Oct 2025 | 2 articles | Viewed by 3473 | Submission Open

Keywords: contraction; proliferation; migration; airway hyperresponsiveness; airway remodeling; β 2-adrenergic receptors; muscarinic receptor; Th2 inflammation; non-Th2 inflammation; oxidative stress; lysophospholipids; intracellular signal transduction processes; Ca2+ signaling; interactions with other cells (inflammatory cells and epithelium); asthma; COPD

(This special issue belongs to the Section Molecular Biology)

Microbiome and Metabolome in the Gastrointestinal Tract, 3rd Edition

edited by

Ioannis Alexandros Charitos

submission deadline 20 Oct 2025 | 1 articles | Viewed by 3431 | Submission Open

Keywords: microbiome; dysbiosis; microbiology; immunity; cytokine/chemokine networks; microbiota axes pathways; toxic substances; autoimmunity

(This special issue belongs to the Section Molecular Biology)

Physiological and Molecular Responses to Biotic and Abiotic Stressors in Marine Organisms

edited by

Chiara Lauritano

and Miriam Ruocco

submission deadline 20 Oct 2025 | 3 articles | Viewed by 3302 | Submission Open

Keywords: stress responses; marine organisms; enzymatic pathways; multiple stressors; stress markers; epigenetic response; physiological response

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Osteogenesis

edited by

Roberto Sacco

and

Carlos Fernando Mourão

submission deadline 20 Oct 2025 | 2 articles | Viewed by 3154 | Submission Open

Keywords: osteogenesis; bone reconstruction; bone regeneration; bone disease

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular and Physiological Responses of Insects to Biotic, Abiotic and Xenobiotic Constraints

edited by

Farman Ullah

Shuo Yan

and Yaobin Lu

submission deadline 20 Oct 2025 | 3 articles | Viewed by 2940 | Submission Open

Keywords: climatic changes; chemical insecticides; insect adaptation mechanisms; resistance mechanisms; ecosystem services; insect ecology; thermal stress adaptations

(This special issue belongs to the Section Molecular Biology)

Virus-Host Interplay: Mechanisms and Novel Therapeutic Strategies

edited by

Jinsung Yang

submission deadline 20 Oct 2025 | 1 articles | Viewed by 2791 | Submission Open

Keywords: virus; autophagy; therapeutics; virus– host interaction; virus– receptor interaction; signaling

(This special issue belongs to the Section Molecular Biology)

Research on Mitochondrial Genetics and Epigenetics

edited by Arianna Montanari

submission deadline 20 Oct 2025 | 2 articles | Viewed by 2704 | Submission Open

Keywords: mitochondrial DNA dynamics; retrograde regulation; epigenetic modulators; mitochondrial diseases; cellular homeostasis

(This special issue belongs to the Section Molecular Biology)

Structural and Functional Insights into Membrane Transporters: A Tribute to Dr. Ernest Wright

edited by Jeff Abramson

submission deadline 20 Oct 2025 | 2 articles | Viewed by 2652 | Submission Open

Keywords: membrane transporters; membrane protein; glucose transport; cell membrane; interface reaction

(This special issue belongs to the Section Molecular Biology)

Signaling in Respiratory Diseases

edited by Tonio Pera

submission deadline 20 Oct 2025 | 1 articles | Viewed by 2597 | Submission Open

Keywords: asthma; COPD; cystic fibrosis; GPCR; pharmacology; inflammation; airway remodeling

(This special issue belongs to the Section Molecular Biology)

Advancing Occupational Health Through Omics Technologies

edited by

Silvia Vivarelli

submission deadline 20 Oct 2025 | 1 articles | Viewed by 2485 | Submission Open

Keywords: omics technologies; occupational health; biomarkers; personalized risk assessment; workplace exposures; genomics; proteomics; psychosocial factors; disease susceptibility; preventive medicine

(This special issue belongs to the Section Molecular Biology)

Stem Cells in Tissue Engineering

edited by Ichiro Takada

submission deadline 20 Oct 2025 | 2 articles | Viewed by 2323 | Submission Open

Keywords: stem cells; transcription factors; transcription co-regulators; chromatin remodeling factors; chromatin receptors; nuclear maintenance and differentiation; iPS cells; iPS-T/NK; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Analytical Techniques for Biological and Medical Research: 2nd Edition

edited by

Angela Di Capua

and

Maria Assunta Acquavia

submission deadline 20 Oct 2025 | 1 articles | Viewed by 2285 | Submission Open

Keywords: HPLC; GC; electrophoresis; mass spectrometry; plant materials; validation; metabolomics; proteomics; protein– ligand interaction.

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Chronic Kidney Disease

edited by

Sohel Julovi

submission deadline 20 Oct 2025 | 1 articles | Viewed by 1952 | Submission Open

Keywords: CKD; CVD; CKD-MBD; oxidative stress; inflammation; fibrosis; biochemical markers

(This special issue belongs to the Section Molecular Biology)

Regulation of Ion Channels and Transporters

edited by

Susumu Ohya

submission deadline 20 Oct 2025 | 2 articles | Viewed by 1928 | Submission Open

Keywords: ion channels; ion transporters; cardiovascular disease; inflammatory disease; cancers; neurogenerative disease; disease microenvironment; drug discovery; drug resistance

(This special issue belongs to the Section Molecular Biology)

Next-Gen Tissue Engineering in Disease Modelling, Drug Discovery and Immunotherapeutics

edited by

Hugo Ronaldo Freitas Caires

submission deadline 20 Oct 2025 | 1 articles | Viewed by 1400 | Submission Open

Keywords: tissue engineering; 3D cell culture; biomaterials; disease modelling; immunotherapy; cell-based therapies; organ-on-a-chip

(This special issue belongs to the Section Molecular Biology)

Yeast Modeling in Metabolism and Cell Cycle Research

edited by

Teodora Emilia Coldea

submission deadline 20 Oct 2025 | Viewed by 866 | Submission Open

Keywords: yeast modeling; metabolism; cell cycle development; microbial fermentation; bioactive compounds; probiotics; drug targets

(This special issue belongs to the Section Molecular Biology)

Advanced Research on the Detection of Small Metabolites in Biological Fluids

edited by

Stefania Garzoli

submission deadline 20 Oct 2025 | Viewed by 577 | Submission Open

Keywords: metabolomic; biological fluids; GC/MS; HPLC/MS; NMR

(This special issue belongs to the Section Molecular Biology)

Molecular Pathways of Proteostasis in Aging and Diseases

edited by Emmanouil Kyriakakis

submission deadline 20 Oct 2025 | 1 articles | Viewed by 575 | Submission Open

Keywords: proteostasis; aging; neurodegenerative diseases; UPR; autophagy; ER stress; HSR; longevity; healthspan; quality control mechanisms; muscle atrophy; cardiovascular disease

(This special issue belongs to the Section Molecular Biology)

Ribonucleotides in Genomic DNA: Molecular Mechanisms and Biological Implications

edited by

Francesca Storici

submission deadline 20 Oct 2025 | Viewed by 526 | Submission Open

Keywords: ribonucleotides in DNA; genomic RNA incorporation; ribonucleotide excision repair; ribonucleotide reductase; genome stability; function of ribonucleotides in DNA; DNA polymerase fidelity; ribonucleotide-induced mutations; ribonucleotide misincorporation; ribonucleotide in DNA structure

(This special issue belongs to the Section Molecular Biology)

Advancements in Protein Engineering and Structure Determination

edited by Ivan Campeotto and Shabir Najmudin

submission deadline 20 Oct 2025 | Viewed by 482 | Submission Open

Keywords: protein engineering; protein structure; protein design; protein modelling; protein stability

(This special issue belongs to the Section Molecular Biology)

Innovative Delivery Technologies for Nucleic Acid Therapeutics: From In Vitro to In Vivo Applications

edited by Karim Daliri

submission deadline 20 Oct 2025 | Viewed by 320 | Submission Open

Keywords: nucleic acid therapeutics; nucleic acid delivery; mRNA; siRNA; ASOs; plasmid DNA; CRISPR/Cas9

(This special issue belongs to the Section Molecular Biology)

RNA Modifications in Response to Physical Activity: Implications for Rehabilitation and Disease Management

edited by Roberto Tedeschi and Francesca Gorini

submission deadline 20 Oct 2025 | Viewed by 302 | Submission Open

Keywords: RNA modifications; non-coding RNAs (ncRNAs); physical activity; gene expression; rehabilitation and disease management; epigenetic regulation; exercise-induced RNA expression; miRNA in inflammation control

(This special issue belongs to the Section Molecular Biology)

Molecular Pathways, Microbiome, and Chronic Inflammatory Skin Diseases: Bridging the Gap

edited by

Oliver Seifert

submission deadline 25 Oct 2025 | Viewed by 123 | Submission Open

Keywords: psoriasis; skin microbiome; chronic inflammatory skin diseases; molecular pathogenesis; biomarkers

(This special issue belongs to the Section Molecular Biology)

Current Insights into the Role of Exosomes in Intercellular Communication

edited by

Orit Uziel

submission deadline 30 Oct 2025 | 11 articles | Viewed by 29781 | Submission Open

Keywords: exosomes; extravesicles; intracellular communication

(This special issue belongs to the Section Molecular Biology)

Research in Membrane Transporters—Unveiling the Molecular Mechanisms and Practical Application

edited by

Ewa Maciaszczyk-Dziubinska

and Donata Wawrzycka

submission deadline 30 Oct 2025 | 5 articles | Viewed by 9363 | Submission Open

Keywords: membrane transporters; transporter function; transporter regulation; transporter-mediated drug transport; transport-related diseases; biomolecular studies; pharmacokinetics; membrane proteostasis

(This special issue belongs to the Section Molecular Biology)

Radiation-Induced DNA Damage and Toxicity

edited by

Mohammad Asif Sherwani

and

Muhammad Maqbool

submission deadline 30 Oct 2025 | 3 articles | Viewed by 3538 | Submission Open

Keywords: radiation; DNA damage; toxicity; immune response

(This special issue belongs to the Section Molecular Biology)

Molecular Biology of Extremophiles: Recent Advances

edited by

Paulina Corral

submission deadline 30 Oct 2025 | 2 articles | Viewed by 2049 | Submission Open

Keywords: extremophiles; multi-omics approaches; secondary metabolites; bioactive compounds; genome mining; phylogeny and evolution; bioprospecting

(This special issue belongs to the Section Molecular Biology)

Radiobiology—New Advances

edited by

Marco Calvaruso

and

Luigi Minafra

submission deadline 30 Oct 2025 | 1 articles | Viewed by 1629 | Submission Open

Keywords: radiobiology; radiotherapy; radiosensitizing agents; radioresistance; DNA damage; FLASH radiotherapy; particle therapy

(This special issue belongs to the Section Molecular Biology)

Extracellular Vesicles: Advances in Multi-Omics

edited by

Leo Kei Iwai

submission deadline 30 Oct 2025 | 1 articles | Viewed by 1494 | Submission Open

Keywords: extracellular vesicles; omics; mass spectrometry; molecular targets; biomarker

(This special issue belongs to the Section Molecular Biology)

The Impact of Environmental Factors on Male Reproductive Development and Disorders

edited by

Gennaro Lettieri

submission deadline 30 Oct 2025 | Viewed by 408 | Submission Open

Keywords: spermatozoa; DNA; protamine; male reproductive health; pollution; endocrine disruption; heavy metals

(This special issue belongs to the Section Molecular Biology)

Enzymes Involved in Amino Acid Metabolism: Molecular Structure and Function

edited by

Barbara Cellini

and Mirco Dindo

submission deadline 30 Oct 2025 | Viewed by 217 | Submission Open

Keywords: amino acids; enzyme; human disease; protein engineering; protein dynamics

(This special issue belongs to the Section Molecular Biology)

The Role of miRNAs in Healthy Lungs and Chronic Lung Diseases

edited by Victor Ruiz

submission deadline 30 Oct 2025 | Viewed by 151 | Submission Open

Keywords: miRNA; DROSHA; DICER; DGCR8; ADAR; pulmonary fibrosis; COPD; asthma; lung neoplasm

(This special issue belongs to the Section Molecular Biology)

Research on Inflammation and Autophagy

edited by

Irene Paterniti

and

Michela Campolo

submission deadline 30 Oct 2025 | Viewed by 96 | Submission Open

Keywords: inflammation; autophagy; mTOR signaling; inflammasome; oxidative stress; acute and chronic inflammatory diseases

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Pathways of Epithelial-Mesenchymal Transition

edited by

Noemi Monti

submission deadline 30 Oct 2025 | Viewed by 79 | Submission Open

Keywords: metastasis; fibrosis; tumor microenvironment; molecular pathways; EMT reversion

(This special issue belongs to the Section Molecular Biology)

Human Drug Transporters: From Molecular Mechanisms to Drug Development

edited by Ágnes Telbisz

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1257 | Submission Open

Keywords: human drug transporters; multidrug resistance; drug– drug interaction; ABC transporters; SLC transporters

(This special issue belongs to the Section Molecular Biology)

Antisense Oligonucleotides: Versatile Tools with Broad Applications

edited by

Suxiang Chen

submission deadline 31 Oct 2025 | 1 articles | Viewed by 727 | Submission Open

Keywords: antisense oligonucleotide; RNase H; splice switching; exon skipping; therapeutics; pesticide

(This special issue belongs to the Section Molecular Biology)

Natural and Synthetic Modified Nucleic Acids: Their Properties, Functions and Applications

edited by

Malgorzata Sierant

submission deadline 31 Oct 2025 | 1 articles | Viewed by 594 | Submission Open

Keywords: DNA; RNA; nucleic acid analogues; modified nucleosides; modified nucleosides identification techniques; nucleoside modifying enzymes; gene therapy; therapeutic nucleic acids; biomedical applications; drug delivery

(This special issue belongs to the Section Molecular Biology)

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