Signaling in Respiratory Diseases

Dear Colleagues,

In health and disease, lung function is regulated by various forms of signaling. Receptors expressed on the cell surface serve to transduce extracellular signals initiated by the binding of neurotransmitters, hormones, cytokines and exocrine or paracrine factors, as well as therapeutic drugs, to their respective receptors. The scope of this Special Issue encompasses molecular signaling in the lung in relation to various aspects of respiratory diseases. This includes both the signaling involved in disease pathogenesis and signaling that is potentially therapeutic or regenerative. Studies focused on signaling that regulates relevant functions—including, but not limited to—receptor function and/or desensitization, inflammation, cell proliferation, migration, differentiation, smooth muscle contraction, angiogenesis, mucosal barrier function, tissue remodeling, fibrosis, emphysema and lung mechanics. While the emphasis of this issue is primarily on G protein-coupled receptor signaling, studies exploring other forms of signal transduction, including nuclear receptors, receptor tyrosine kinases and receptor serine/threonine kinases, are also welcome.

Dr. Tonio Pera
Guest Editor

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• asthma
• COPD
• cystic fibrosis
• GPCR
• pharmacology
• inflammation
• airway remodeling