Human Drug Transporters: From Molecular Mechanisms to Drug Development
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 169
Special Issue Editor
Special Issue Information
Dear Colleagues,
We would like to announce a new Special Issue entitled “Human Drug Transporters: From Molecular Mechanisms to Drug Development”.
Over the last few decades, several mechanisms have been identified to act as a defence against natural and man-made toxic compounds. However, these mechanisms can also contribute to drug resistance, which is a major challenge in the field of pharmaceutics. Polyspecific membrane transporters found in all major tissue barriers are important players in this so-called “chemoimmunity system”. Among them, certain ABC transporters and SLC transporters, e.g., OATP and MATE proteins, can play a crucial role in drug targeting and availability, significantly modifying drug ADME-Tox parameters. Consequently, drug regulatory authorities have mandated the evaluation of these interactions in the development of new pharmaceutical agents.
The aim of this Special Issue is to collect papers that contribute to a better characterisation of these transporters and drug interactions.
We invite academic and industrial researchers and investigators to submit original articles or reviews to this Special Issue. The objective is to present novel findings on fundamental molecular mechanisms, innovative methods for the enhanced characterisation of relevant transporters, and a more profound comprehension of the impact of mutations and the context of drug–drug interactions.
Potential topics include, but are not limited to, the following:
- Studies concerning the structure–function relationship of multidrug transporters;
- The effect of mutations, including clinically relevant mutations, on protein function;
- The influence of membrane lipids on transporter activities;
- New experimental methods to study a particular transporter or complex models involving more than one transporter;
- Investigation of the role of transporters in important clinical drug toxicities;
- In silico studies, provided that experimental data are also included in the study.
Dr. Ágnes Telbisz
Guest Editor
Manuscript Submission Information
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Keywords
- human drug transporters
- multidrug resistance
- drug–drug interaction
- ABC transporters
- SLC transporters
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