Molecular Pathways of Proteostasis in Aging and Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (20 October 2025) | Viewed by 1404
Special Issue Editor
Special Issue Information
Dear Colleagues,
Proteostasis—the maintenance of cellular protein homeostasis—is crucial for preserving the stability and functionality of the proteome. This dynamic process involves protein synthesis, folding, trafficking, and degradation, all finely balanced by complex regulatory networks. However, during aging and in various diseases, proteostasis often becomes impaired, leading to the accumulation of misfolded proteins and toxic aggregates. This disruption is particularly evident in neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Huntington’s, where protein misfolding and aggregation play central roles in pathogenesis. Additionally, proteostasis imbalance contributes to muscle atrophy, heart dysfunction, and other age-related disorders for which effective treatments remain limited.
As Guest Editor of this Special Issue of IJMS, titled “Molecular Pathways of Proteostasis in Aging and Diseases”, I invite submissions exploring the molecular mechanisms governing proteostasis and its regulation during aging and disease progression. Topics may include protein quality control systems, the unfolded protein response, the role of chaperones, and mechanisms underlying protein aggregation. Studies investigating strategies to enhance proteostasis for promoting healthy aging are particularly welcome. We encourage original research articles, reviews, perspectives, and methodological reports that advance our understanding of how proteostasis can be modulated to mitigate disease and enhance longevity.
Dr. Emmanouil Kyriakakis
Guest Editor
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Keywords
- proteostasis
- aging
- neurodegenerative diseases
- UPR
- autophagy
- ER stress
- HSR
- longevity
- healthspan
- quality control mechanisms
- muscle atrophy
- cardiovascular disease
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