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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Plant Cell Wall: Structural Dynamics, Functions, and Future Innovations

edited by

Ioannis-Dimosthenis Adamakis

and

Kosmas Haralampidis

submission deadline 30 Aug 2025 | Viewed by 56 | Submission Open

Keywords: plant cell wall; biosynthesis; biomass; abiotic stress; biotic stress; renewable resources; biotechnology; climate change

(This special issue belongs to the Section Molecular Plant Sciences)

Bioactive Peptides: Microbial Fermentation-Driven Synthesis and Multifunctional Applications in Health and Industry

edited by

Yongjun Wei

submission deadline 30 Aug 2025 | Viewed by 55 | Submission Open

Keywords: bioactive peptides; foods; probiotics; fermentation; pharmaceutical; herbs

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Eukaryotic DNA Replication—from Bench to Bedside

edited by Heinz-Peter Nasheuer

submission deadline 30 Aug 2025 | Viewed by 54 | Submission Open

Keywords: genome stability; cell cycle; DNA replication; chromatin replication; replication origins— selection; licensing and firing; replication forks— smoothly progressing and under stress; role of DNA replication in cancer and other human diseases; disease treatment opportunities

(This special issue belongs to the Section Molecular Genetics and Genomics)

Trees Genetics, Genomics, and Molecular Breeding

edited by

Hengfu Yin

submission deadline 30 Aug 2025 | Viewed by 54 | Submission Open

Keywords: trees genetics; genomics; molecular; regulatory mechanism; genetic improvement

(This special issue belongs to the Section Molecular Plant Sciences)

New Insight into Biomaterials for Tissue Engineering and Regenerative Medicine

edited by

Diana Torge

submission deadline 30 Aug 2025 | Viewed by 53 | Submission Open

Keywords: biomaterials; tissue regeneration; regenerative medicine; bone regeneration; periodontal disease; morphology; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Electrochemistry and Emerging Contaminants: Molecular Insights for Innovative Solutions

edited by

Miguel A. Esteso

submission deadline 30 Aug 2025 | Viewed by 51 | Submission Open

Keywords: electrochemistry; chemical reactions; removal; environmental pollution

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Insights into Agrifood Waste Valorization: From By-Products to Sustainable Resources

edited by

Elena Dreassi

and

Annalaura Brai

submission deadline 30 Aug 2025 | Viewed by 50 | Submission Open

Keywords: antioxidants; by-products; antimicrobials; nutraceuticals; food industry; circular economy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Health Targeting Cardiovascular and Cerebrovascular Diseases: Molecular Aspects

edited by

Byeong-Wook Song

submission deadline 30 Aug 2025 | Viewed by 49 | Submission Open

Keywords: cardiovascular disease; cerebrovascular disease; cell therapy; gene therapy; extracellular vesicles; regenerative medicine; brain– heart axis; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Chessboard: How Plants and Insects Outsmart Each Other

edited by

Mateusz Labudda

submission deadline 30 Aug 2025 | Viewed by 46 | Submission Open

Keywords: acarology; biotic stress; entomology nitric oxide; oxidative stress; phytopathology; reactive nitrogen species; reactive oxygen species

(This special issue belongs to the Section Molecular Plant Sciences)

Activation of the Blood–Brain Barrier and Neurological Dysfunction: 2nd Edition

edited by

Monique F. Stins

submission deadline 30 Aug 2025 | Viewed by 46 | Submission Open

Keywords: blood– brain barrier; neuro-infectious diseases; microbes; traumatic brain injury; Alzheimer’ s disease; Parkinson’ s disease; schizophrenia; cerebral vasculature; vascular heterogeneity; white matter; gray matter; therapeutic delivery; opening the BBB; neuro vascular unit

(This special issue belongs to the Section Molecular Neurobiology)

Feature Papers in ‘Physical Chemistry and Chemical Physics’: Fourth Edition

edited by

Dongho Kim

submission deadline 30 Aug 2025 | Viewed by 45 | Submission Open

Keywords: heterogeneous structures; alignment and surface phenomena; quantum theory; mathematical physics; statistical and classical mechanics; molecular structure; chemical kinetics; laser physics; dynamics; kinetics; photochemistry; spectroscopy; exciton dynamics; statistical mechanics; thermodynamics; electrochemistry; catalysis; surface science; quantum mechanics; theoretical developments; fundamental aspects of catalysis; solar energy conversion; polymer dynamics

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

The Latest Molecular Research on Renal Disease

edited by Niels Henrik Buus

submission deadline 30 Aug 2025 | Viewed by 44 | Submission Open

Keywords: renal disease; chronic kidney disease; renal regeneration; kidney injury

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cutaneous Biology, Molecular Dermatology and Dermatopathology, 2nd Edition

edited by

Bijan Safai

submission deadline 30 Aug 2025 | Viewed by 44 | Submission Open

Keywords: molecular dermatology; targeted therapy; cutaneous oncology; immunodermatology; cutaneous biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Adsorbing Materials

edited by Mounia Achak

submission deadline 30 Aug 2025 | Viewed by 43 | Submission Open

Keywords: adsorption process; adsorbing materials; bio-based adsorbents; regeneration and reusability; pollutant removal; wastewater treatment; industrial and environmental applications

(This special issue belongs to the Section Materials Science)

The Role of Natural Compound for Reversing Cancer Therapy Resistance

edited by

Tae Woo Kim

submission deadline 30 Aug 2025 | Viewed by 40 | Submission Open

Keywords: cancer; natural compound; cell death; radioresistance; chemoresistance

(This special issue belongs to the Section Molecular Pharmacology)

Cardiovascular Diseases: Molecular Mechanisms, Biomarkers, and Therapies: 2nd Edition

edited by

Cristina Maria Sena

submission deadline 30 Aug 2025 | Viewed by 39 | Submission Open

Keywords: cardiovascular diseases; oxidative stress; inflammation; risk factors; biomarkers; omics technology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nutrition from Cereal Foods: Molecular Insights into Nutrition, Metabolism and Health Regulation

edited by Genyi Zhang

submission deadline 30 Aug 2025 | Viewed by 38 | Submission Open

Keywords: molecular breeding; cereal crops; bioactive compounds; metabolic syndrome; inflammation; gut health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Ruminant Physiology: Digestion, Metabolism, and Endocrine System

edited by Rui Hu

submission deadline 30 Aug 2025 | Viewed by 37 | Submission Open

Keywords: ruminant physiology; digestive health; metabolic regulation; endocrine signaling; rumen microbiome; nutrient partitioning; methane mitigation; epigenetic modulation; nutritional stress adaptation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms of Hemostasis, Thrombosis and Thrombo-Inflammation: 3rd Edition

edited by

Johan W. M. Heemskerk

submission deadline 30 Aug 2025 | Viewed by 35 | Submission Open

Keywords: atherosclerosis; coagulation; complement; endothelial cells; extracellular vesicles; fibrinolysis; immune thrombosis; inflammation; leukocytes; platelets; proteomics; red blood cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cellular Pathways and Cytokine Networks in Tuberous Sclerosis: Mechanisms and Therapeutic Targets

edited by Uchenna John Unachukwu

submission deadline 30 Aug 2025 | Viewed by 33 | Submission Open

Keywords: mTOR signaling dysregulation; neurocristopathy; cytokine crosstalk; TSC1/TSC2 complex; epigenetic modifiers; metabolic reprogramming; molecular biomarkers; spatial transcriptomics

(This special issue belongs to the Section Molecular Biology)

Advancements in the Electrochemical Detection of Biomolecules: From Sensing to Environmental Applications

edited by

Habibulla Imran

submission deadline 30 Aug 2025 | Viewed by 29 | Submission Open

Keywords: biomolecules; nanomaterials; biorecognition; biomolecular detection; electrochemical

(This special issue belongs to the Section Molecular Biophysics)

Chemical Elicitors and Microbial Metabolites: Synergistic Mechanisms in Plant Systemic Resistance Induction

edited by Heewan Kang

submission deadline 30 Aug 2025 | Viewed by 27 | Submission Open

Keywords: chemical elicitors; Bacillus spp.; microbial metabolites; amino acids; defense induction; resistance mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Pathways and Mechanisms of Lung Injury: From Environmental Agents to Clinical Implications

edited by

Maria Lisa Garavaglia

and Cristina Porta

submission deadline 30 Aug 2025 | Viewed by 25 | Submission Open

Keywords: lung injury; lung cancer; pulmonary fibrosis; chronic obstructive pulmonary disease; acute respiratory distress syndrome; environmental pollutants and toxins; molecular and cellular mechanisms; biomarkers; therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Modulating the Niche: Targeting the Tumor Microenvironment for Enhanced Therapy

edited by

Dong Min Lee

submission deadline 30 Aug 2025 | Viewed by 24 | Submission Open

Keywords: microenvironment dynamics; immune modulation; biomarker discovery; tumor microenvironment; extracellular matrix; cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Teleost in Biomedical Research

edited by

Antonino Germanà

and

Marialuisa Aragona

submission deadline 31 Aug 2025 | 2 articles | Viewed by 6542 | Submission Open

Keywords: fish; teleost; experimental model; translational research; biomedicine; comparative studies

(This special issue belongs to the Section Molecular Biology)

Effect of Diet on Human Neurocognitive Function

edited by

Radosław Zajdel

submission deadline 31 Aug 2025 | 2 articles | Viewed by 4659 | Submission Open

Keywords: cognition; cognitive impairment; dietary pattern; nutrients; nervous cells

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Therapeutic Targets and Approaches to Manage Inflammation: Disappointing Past, Current Efforts and Faint Hopes

edited by Natasha Irrera

submission deadline 31 Aug 2025 | 3 articles | Viewed by 3662 | Submission Open

Keywords: inflammation; inflammatory pathways; resolution of inflammation; inflammasome; molecular pathways; anti-inflammatory response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Cellular Mechanisms of Spinal Cord Injury and Repair

edited by Victoria Moreno-Manzano

submission deadline 31 Aug 2025 | 3 articles | Viewed by 3474 | Submission Open

Keywords: spinal cord injury; molecular changes; neuronal degeneration; circuit regeneration; transcriptomics; cell imaging; single-cell analysis; cell communication; behavior; functional outputs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bio-Nano Interactions—3rd Edition

edited by

Massimiliano Magro

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2011 | Submission Open

Keywords: nanoparticles; proteins; smart nanomaterial surfaces; selective protein binding; nanomaterials; abiotic material; biological systems; bio-inspired inorganic materials and DNA nanotechnologies

(This special issue belongs to the Section Molecular Nanoscience)

Chitosan Materials: Recent Advances in Modification, Properties and Application

edited by

Gabriela Dudek

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1978 | Submission Open

Keywords: chitosan materials; biomedical applications; agriculture and food industry; water treatment and environmental applications; nanotechnology and advanced materials

(This special issue belongs to the Section Macromolecules)

Inflammatory Bowel Disease: From Genetics to Treatment

edited by Dalin Li

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1878 | Submission Open

Keywords: genetic predisposition; inflammatory bowel disease; genome-wide association study Crohn's disease; ulcerative colitis; bowel disease

(This special issue belongs to the Section Molecular Genetics and Genomics)

Mast Cell Disorders: From Molecular Mechanisms to Therapeutic Approaches

edited by Ehud Razin and

Sagi Tshori

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1269 | Submission Open

Keywords: mastocytosis; mast cell activation syndrome; mast cell disorders; theurapeutic approaches; molecular mechanisms; tumor neovascularization; inflammatory diseases; asthma

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cellular and Molecular Study of Neurodevelopmental and Neurological Disorders

edited by

Kazuhito Toyooka

submission deadline 31 Aug 2025 | 1 articles | Viewed by 848 | Submission Open

Keywords: autism spectrum disorder; ADHD; schizophrenia; intellectual disability; Alzheimer’ s disease; Parkinson’ s disorder; traumatic brain injury; epilepsy; neurodevelopmental disorders; neurological diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Natural Compounds in Neuroscience and Neurodegenerative Disease Therapeutics

edited by

Sarmistha Mitra

submission deadline 31 Aug 2025 | Viewed by 629 | Submission Open

Keywords: natural products; bioactive metabolites; secondary metabolites; neuronal development; neurotrophins; neuromedicine; neurodegeneration; memory disorders

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Identification of Novel Biomarkers Towards Improved Diagnosis and Management of Peripheral Vascular Diseases

edited by

Daniel P. Zalewski

submission deadline 31 Aug 2025 | Viewed by 628 | Submission Open

Keywords: vascular pathophysiology; peripheral atherosclerosis; aneurysm; venous disorders; congenital vascular malformations; molecular biomarkers; diagnostic biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Aspects of Reproductive Medicine

edited by Wei Chen

submission deadline 31 Aug 2025 | 1 articles | Viewed by 614 | Submission Open

Keywords: spermatogenesis; oogenesis; microenvironment; organ interactions; molecular regulation; gametogenesis; signaling pathways; reproductive disorders

(This special issue belongs to the Section Molecular Biology)

Molecular Research in Asthma and Allergy

edited by

Sylwia Smolińska

submission deadline 31 Aug 2025 | 1 articles | Viewed by 599 | Submission Open

Keywords: asthma; allergy; molecular mechanisms; exposome; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Vitamin K in Disease Mechanisms and Therapy

edited by Maria Kokozidou

submission deadline 31 Aug 2025 | Viewed by 484 | Submission Open

Keywords: vitamins K; vitamins K-soluble proteins; vitamin K-dependent clotting factors; matrix Gla protein; calcification of blood vessels; vascular stiffness; cardiac output; stroke volume

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Physiological and Pathological Hypoxia: The Battle between the Protective and Deleterious Effects of Oxygen Deprivation

edited by

Michele Samaja

Michele Maffia

Rita Paroni

and Giacomo Strapazzon

submission deadline 31 Aug 2025 | Viewed by 431 | Submission Open

Keywords: physiological hypoxia; pathological hypoxia; hypoxia; signalling pathway; inflammation; oxygen transport

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Insights into Novel Food Packaging Materials: Properties, Molecular Mechanisms, and Advanced Applications

edited by

Di Wang

and

Qingjun Kong

submission deadline 31 Aug 2025 | 1 articles | Viewed by 407 | Submission Open

Keywords: food packaging; food materials; nano materials; degradable materials; edible materials; coating; shelf life; food preservation; postharvest control

(This special issue belongs to the Section Materials Science)

Cutting Edge Advances in Antitumor Properties of Natural Products

edited by

Francesca Giordano

and

Maria Luisa Panno

submission deadline 31 Aug 2025 | Viewed by 401 | Submission Open

Keywords: natural product; cancer; cell signaling; cell death and differentiation; oxidative stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced Research on Cancer Stem Cells

edited by

Ilze Štrumfa

submission deadline 31 Aug 2025 | Viewed by 374 | Submission Open

Keywords: cancer stem cells; tumour microenvironment; pancreatic cancer; glioblastoma; gastric cancer; breast cancer; lung cancer; colorectal cancer; renal cancer; liver cancer; melanoma; leukemia; lymphoma

(This special issue belongs to the Section Molecular Oncology)

Role of MicroRNAs in Human Diseases: 2nd Edition

edited by

Lorenzo F. Sempere

submission deadline 31 Aug 2025 | 1 articles | Viewed by 243 | Submission Open

Keywords: microRNAs; miRNAs; miRs; preclinical models; target interaction; regulatory networks; oncology; cancer biology; cardiovascular disease; neurodegenerative conditions; diagnostic applications; therapeutic development and clinical trials

(This special issue belongs to the Section Molecular Genetics and Genomics)

Nanoparticles in Molecular Pharmaceutics

edited by

Qingxin Mu

submission deadline 31 Aug 2025 | Viewed by 217 | Submission Open

Keywords: nanoparticles; molecular pharmaceutics; drug delivery; nanomedicine; nanoformulation

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Diagnosis and Treatment of Colorectal Cancer

edited by Steven T. Brower and Robert Pergolizzi

submission deadline 31 Aug 2025 | Viewed by 216 | Submission Open

Keywords: colorectal cancer; biomarkers; epigenetics; targeted therapy; chemoresistance; personalized cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Microbial Genomics in the Omics Era

edited by

Surajit De Mandal

submission deadline 31 Aug 2025 | Viewed by 202 | Submission Open

Keywords: microbe; bioinformatics; DNA; RNA; protein; sequencing; structure; omics

(This special issue belongs to the Section Molecular Microbiology)

Zebrafish: A Model Organism for Human Health and Disease: 2nd Edition

edited by

Jyotshna Kanungo

submission deadline 31 Aug 2025 | Viewed by 175 | Submission Open

Keywords: zebrafish; drug discovery; high-throughput screens; genome editing/CRISPR mutants; cancer; neuronal disorders; drug toxicity; drug effect mechanisms; developmental disorders

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Alzheimer’s Disease

edited by Sudip Dhakal

submission deadline 31 Aug 2025 | Viewed by 171 | Submission Open

Keywords: Alzheimer’ s disease; amyloid beta; tauopathy; autophagy; stress response; mitochondrial dysfunction; cognitive decline; biomarkers; disease models

(This special issue belongs to the Section Molecular Neurobiology)

The Translation Process, Molecular Mechanism, and Recognition Methods of Post-Translational Modifications of Proteins

edited by

Hao Lin

submission deadline 31 Aug 2025 | Viewed by 158 | Submission Open

Keywords: DNA replication; repair; and transcription; post-translational modifications; chromatin; acetylation; methylation; phosphorylation; ubiquitination and ubiquitin-like modifiers; histone modifications

(This special issue belongs to the Section Molecular Biology)

Role of MicroRNAs in Health and Diseases

edited by

Roberto Madeddu

submission deadline 31 Aug 2025 | Viewed by 156 | Submission Open

Keywords: miRNA; cancer; biomarkers; function; miRNA target

(This special issue belongs to the Section Molecular Genetics and Genomics)

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