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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of the Endocannabinoid System in Reward- and Addiction-Related Neuroplasticity

edited by

Francisco Navarrete-Rueda

and

María S. García Gutiérrez

submission deadline 20 Sep 2025 | 1 articles | Viewed by 830 | Submission Open

Keywords: endocannabinoid system; neuroplasticity; reward; addiction; biomarker; therapeutic approach

(This special issue belongs to the Section Molecular Neurobiology)

Novel Statistical Methods in Gene Expression Analysis, Functional Genomics, Genetics, and Biochemistry

edited by Łukasz Huminiecki

submission deadline 20 Sep 2025 | 1 articles | Viewed by 804 | Submission Open

Keywords: multi-omics; statistics; gene expression analysis

(This special issue belongs to the Section Molecular Informatics)

Glioblastoma: Molecular Pathogenesis and Treatment

edited by

Maurizio Martini

and

Vincenzo Fiorentino

submission deadline 20 Sep 2025 | 1 articles | Viewed by 800 | Submission Open

Keywords: glioblastoma; molecular therapy; pathogenesis; immunotherapy; brain tumor

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanostructures: From Synthesis, Modification to Biomedical Applications

edited by Kleoniki Giannousi and

Catherine Dendrinou-Samara

submission deadline 20 Sep 2025 | 1 articles | Viewed by 799 | Submission Open

Keywords: nanostructures; post-synthetic methods; multi-drug resistant bacteria; amyloidopathies; neurodegeneration; photocatalysis; biosensors

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Mechanism and Treatment of Diabetes Mellitus and Its Complications

edited by

Bernd Stratmann

submission deadline 20 Sep 2025 | 3 articles | Viewed by 758 | Submission Open

Keywords: MODY; LADA; diabetes late complications; molecular mechanisms; omics; polyneuropathy; microvascular disease; macrovascular disease; liver disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

3D Technology in Biomedicine: Studying Molecular Mechanisms in Health and Disease

edited by Flavia Carton

submission deadline 20 Sep 2025 | 1 articles | Viewed by 713 | Submission Open

Keywords: 3D technologies; biomedicine; molecular biology; in vitro/ex vivo models; regenerative medicine; human diseases

(This special issue belongs to the Section Materials Science)

Advanced Research on Female Reproductive Physiology

edited by Tomoko Fujiwara and

Masanori Ono

submission deadline 20 Sep 2025 | 1 articles | Viewed by 706 | Submission Open

Keywords: circadian rhythm; diet; hypothalamus; lifestyle habits; ovary; pituitary; preconception care; reproduction function; reproductive behavior; uterus

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Genetic and Epigenetic Insights into Extracellular Vesicles

edited by

Dimitrios Vlachakis

and

George P. Chrousos

submission deadline 20 Sep 2025 | Viewed by 705 | Submission Open

Keywords: exosomes; extracellular vesicles; cell– cell communication; endocrinology

(This special issue belongs to the Section Biochemistry)

miRNAs in Cancers: From Molecular Biology to Treatment

edited by

Laura Mosca

submission deadline 20 Sep 2025 | 1 articles | Viewed by 675 | Submission Open

Keywords: cancer; miRNA; epigenetic

(This special issue belongs to the Section Molecular Biology)

Cell Biology and Biochemistry Regulation Mediated by Natural Compounds

edited by

Amélia M. Silva

submission deadline 20 Sep 2025 | Viewed by 674 | Submission Open

Keywords: cellular targets; natural compounds; nutraceuticals; health-promoting effects; enzymatic activity; cell-based assays; in vivo; nanoencapsulation; delivery of natural compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Anti-Cancer Drugs, 2nd Edition

edited by

Christiana Neophytou

submission deadline 20 Sep 2025 | 1 articles | Viewed by 668 | Submission Open

Keywords: combination therapy in cancer; small-molecule inhibitors in cancer; anti-cancer agents derived from natural sources; immunotherapy advances in cancer therapy; targeting metastatic dormancy; modulation of the tumor microenvironment; 3D model approaches in cancer research; predictive biomarkers for cancer chemoresistance

(This special issue belongs to the Section Molecular Oncology)

New Research Progresses on Multifaceted Cholinergic Signaling

edited by Taher Darreh-Shori

submission deadline 20 Sep 2025 | Viewed by 664 | Submission Open

Keywords: cholinergic signaling; choline acetyltransferase (ChAT); nicotinic acetylcholine receptors (AChRs); muscarinic acetylcholine receptors (mAChRs); mitochondrial acetylcholine receptors; cholinergic anti-inflammatory pathway; cholinergic signaling in cancer; cholinergic signaling in mitochondria; cholinergic signaling in ALS; cholinergic signaling in dementia; cholinergic signaling in COVID-19

(This special issue belongs to the Section Molecular Neurobiology)

Host-Pathogen Interactions during Persistent Bacterial Infections, 2nd Edition

edited by

Bettina Löffler

submission deadline 20 Sep 2025 | 1 articles | Viewed by 624 | Submission Open

Keywords: bacteria; intracellular adaptation; metabolic adaptation; metabolic host reprogramming; host– pathogen interaction; chronic infections; regulation of virulence

(This special issue belongs to the Section Molecular Microbiology)

Fiber Plants: Genetics and Genomics, Molecular Mechanisms and Potential Applications—Novel Materials, Functional Foods and Beyond

edited by

Jian Zhang

and

Michael Deyholos

submission deadline 20 Sep 2025 | 1 articles | Viewed by 600 | Submission Open

Keywords: fiber plant; genetics; genomics; bioactive products; natural fibers; fatty acids; medical products; environmental and ecological effects of fiber plants

(This special issue belongs to the Section Molecular Plant Sciences)

Emerging Topics in Macromolecular Crystallography

edited by

Zhongzhou Chen

and

Giuseppe Zanotti

submission deadline 20 Sep 2025 | 1 articles | Viewed by 564 | Submission Open

Keywords: macromolecular crystallography; structural biology; artificial intelligence; structure determination; molecular mechanism; functions; drug discovery; protein; nucleic acid; carbohydrates

(This special issue belongs to the Section Macromolecules)

Role of Glia in Human Health and Disease

edited by

Daniele Lana

and

Hajime Hirase

submission deadline 20 Sep 2025 | 1 articles | Viewed by 544 | Submission Open

Keywords: astrocytes; microglia; oligodendrocytes; Schwann cells; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Upper and Lower Airway Diseases in Allergy and Immunology: From Bench to Bedside

edited by

Giovanni Paoletti

Giulia Costanzo

and

Enrico Marco Heffler

submission deadline 20 Sep 2025 | 1 articles | Viewed by 530 | Submission Open

Keywords: unified airway disease; allergic rhinitis; asthma; chronic rhinosinusitis; eosinophilic; airway inflammation; airway epithelial barrier; immune dysregulation; respiratory microbiome; biomarkers; allergy and immunology

(This special issue belongs to the Section Molecular Immunology)

Roles and Function of Extracellular Vesicles in Diseases: 3rd Edition

edited by

Won Jong Rhee

submission deadline 20 Sep 2025 | Viewed by 509 | Submission Open

Keywords: extracellular vesicle; exosome; disease; roles and function

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Natural Products in Human Health and Disease

edited by

Sung-Joon Lee

and Ji Hae Lee

submission deadline 20 Sep 2025 | Viewed by 486 | Submission Open

Keywords: natural substances; phytochemicals; chronic diseases; aging

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Lipoproteins—Opportunities for the Development of Nanotherapeutics in Chronic Disease

edited by

Thomas Grewal

submission deadline 20 Sep 2025 | Viewed by 479 | Submission Open

Keywords: lipoproteins; LDL; HDL; nanotherapeutics; chronic disease; targeted therapy; drug delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Medicinal Mechanism and Application of Biologically Active Compounds in Melanoma

edited by Rosanna Avola and Adriana C. E. Graziano

submission deadline 20 Sep 2025 | Viewed by 463 | Submission Open

Keywords: biologically active compounds; medicinal mechanism; cancer; melanoma; chemoprevention; anticancer effect; immunomodulation; apoptosis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Research Advances in Antibiotic Resistance

edited by

José Pascual Abad

and

Irma Marín

submission deadline 20 Sep 2025 | Viewed by 458 | Submission Open

Keywords: antibiotic resistance; resistant pathogenic microorganisms; One Health; prevalence of antibiotic-resistant microorganisms; multidrug resistance; antibiotic resistance levels; alternative anti-infectious strategies and compounds; antibiotic-resistant genes; mechanisms of antimicrobial resistance

(This special issue belongs to the Section Molecular Microbiology)

Novel Therapeutic Advances in Pancreatic Cancer

edited by

Enza Lonardo

submission deadline 20 Sep 2025 | Viewed by 455 | Submission Open

Keywords: pancreatic cancer; therapeutic advancements; tumor microenvironment; personalized medicine; biomarkers; liquid biopsy; targeted therapies; immunotherapy; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Plant Breeding and Genetics: New Findings and Perspectives

edited by

Andrés J. Cortés

submission deadline 20 Sep 2025 | 1 articles | Viewed by 454 | Submission Open

Keywords: quantitative genetics; classical plant breeding; marker-assisted selection; genomic selection; speed breeding; gene editing and biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Chemicals Impacts on the Reproductive System

edited by

Giovanna Liguori

and

Anna Costagliola

submission deadline 20 Sep 2025 | Viewed by 447 | Submission Open

Keywords: endocrine disruptors; environmental pollution; female reproduction; male reproduction

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Pathology, Diagnostics, and Therapeutics in Optic Neuropathies

edited by Tsz Kin Ng

submission deadline 20 Sep 2025 | 1 articles | Viewed by 445 | Submission Open

Keywords: optic neuropathies; glaucoma; optic nerve; retinal ganglion cells; neuroprotection; biomarkers; pathophysiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Choroid Plexus in Neurological Health

edited by

Telma Quintela

submission deadline 20 Sep 2025 | Viewed by 443 | Submission Open

Keywords: choroid plexus; cerebrospinal fluid; neurological health; blood– CSF barrier; central nervous system

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Epilepsy and Antiepileptic Drugs, 3rd Edition

edited by

Jarogniew J. Luszczki

submission deadline 20 Sep 2025 | Viewed by 437 | Submission Open

Keywords: antiepileptic drugs: classic; novel; second and third generations; antiseizure medications: novel therapeutic options; cannabinoids in epilepsy; animal models of epilepsy: from animals to humans; clinical trials in epilepsy: novel potentially efficacious drugs; interactions between antiepileptic drugs: pharmacodynamic and pharmacokinetic aspects; interactions of antiepileptic drugs with other drugs: pharmacodynamic and pharmacokinetic aspects; adverse effects of antiseizure medication; treatment of epilepsy in specific populations (elderly; childbearing women; children); drug-resistant epilepsy in preclinical conditions; epileptogenesis: all pathophysiological and molecular aspects

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research of Human Fertility

edited by

Angeliki Tiptiri-Kourpeti

and Byron Asimakopoulos

submission deadline 20 Sep 2025 | Viewed by 431 | Submission Open

Keywords: human reproduction; fertility preservation; ART; infertility; IVF

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Drug Resistance Mechanisms in Human Cancer Cells to Anticancer Drugs

edited by

Daekyu Sun

submission deadline 20 Sep 2025 | Viewed by 414 | Submission Open

Keywords: cancer therapy; targeted therapy; combination therapy; drug resistance; resensitization; DNA repair; DNA damage response; DNA repair inhibitors; synthetic lethality; chemoradiation

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insights into Transplantation and Machine Perfusion

edited by

Joan Roselló-Catafau

and

Arnau Panisello-Roselló

submission deadline 20 Sep 2025 | Viewed by 407 | Submission Open

Keywords: transplantation (liver; kidney; and other organs); primary failure; ischemia-reperfusion injury; static graft preservation; HOPE; NMP; cell signaling; glycocalyx; metabolomics; mitochondria; sterile inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Biomarkers in Pancreatic Diseases

edited by

Laura Gaman

and

Mihaela Badea

submission deadline 20 Sep 2025 | Viewed by 402 | Submission Open

Keywords: pancreatic disease; pancreatic cancer; pancreatitis; biomarker; RNA

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism of Extracellular Vesicles in Human Diseases

edited by Eszter Ágnes Tóth

submission deadline 20 Sep 2025 | 1 articles | Viewed by 397 | Submission Open

Keywords: extracellular vesicles; intercellular communication; disease pathophysiology; biomarkers; nanoscience; biomolecular interactions

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms, Emerging Biomarkers, Novel Therapies and Personalized Treatment in Celiac Disease (CD)

edited by María Isabel Torres

submission deadline 20 Sep 2025 | Viewed by 395 | Submission Open

Keywords: celiac disease; gluten sensitivity; immune response; emerging biomarkers; novel therapies; microbiome modulation; personalized treatment

(This special issue belongs to the Section Molecular Immunology)

Recent Research of Protein Structure Prediction and Design

edited by

Alexandre G. De Brevern

submission deadline 20 Sep 2025 | Viewed by 393 | Submission Open

Keywords: protein design; multidomain proteins; AlphaFold2; protein folding; deep learning

(This special issue belongs to the Section Biochemistry)

The Function of Glial Cells in the Nervous System: 2nd Edition

edited by Krista Minéia Wartchow

submission deadline 20 Sep 2025 | 1 articles | Viewed by 382 | Submission Open

Keywords: glial cells; glial– neuronal interaction; glial biomarkers; neurodegenerative diseases; therapeutic approaches

(This special issue belongs to the Section Molecular Neurobiology)

Antimicrobial Agents: Synthesis and Design

edited by

Silvana Alfei

submission deadline 20 Sep 2025 | Viewed by 379 | Submission Open

Keywords: multi-drug resistant Gram-negative and Gram-positive pathogens; clinically relevant superbugs; severe and almost untreatable infections; immunocompromised individuals; synthetic antimicrobial cationic macromolecules; synthetic cationic dendrimers; polymers; and copolymers; polymerizing strategies; quaternary ammonium and phosphonium salts; amino-acid modified macromolecules; electrostatic interactions and membrane permeabilization; membrane disruptors; drug delivery systems; cationic bola-amphiphiles

(This special issue belongs to the Section Molecular Microbiology)

Natural Compounds for Skeletal Muscle Health and Regeneration

edited by

Khurshid Ahmad

submission deadline 20 Sep 2025 | Viewed by 375 | Submission Open

Keywords: skeletal muscle; natural compounds; molecular mechanism; muscle regeneration; computational analysis; experimental analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Bioactive Peptides: Mechanisms of Action and Biosynthesis

edited by

Eduardo Costa

and

Sara Silva

submission deadline 20 Sep 2025 | Viewed by 368 | Submission Open

Keywords: mechanisms of action; biosynthesis; bioactive peptides (BAPs); innate immunity; synthetic peptides; therapeutic applications; antimicrobial peptides (AMPs)

(This special issue belongs to the Section Biochemistry)

Major Histocompatibility Complex Antigens in Disease

edited by Jerzy K. Kulski and Charles E. Larsen

submission deadline 20 Sep 2025 | Viewed by 360 | Submission Open

Keywords: major histocompatibility complex; immune response; human leukocyte antigen (HLA); immune function; disease susceptibility; pathogen resistance; antigenic transposable elements; cancer

(This special issue belongs to the Section Molecular Immunology)

Fluorescence Techniques for Exploring Protein Oligomerization

edited by

Valerica Raicu

submission deadline 20 Sep 2025 | Viewed by 357 | Submission Open

Keywords: protein oligomerization; Fö rster Resonance Energy Transfer (FRET); quantifying protein interactions; single molecule fluorescence; super-resolution microscopy; fluorescence fluctuation spectroscopy

(This special issue belongs to the Section Biochemistry)

Mitochondrial Energy Metabolism in Cells and Tissues

edited by

Alexander Remels

submission deadline 20 Sep 2025 | Viewed by 356 | Submission Open

Keywords: mitochondria; mitophagy; mitochondrial biogenesis; mitochondrial dynamics; fusion; fission; energy metabolism

(This special issue belongs to the Section Molecular Biology)

Application of Mass Spectrometry and Chromatography in Drug Monitoring

edited by Carsten Müller

submission deadline 20 Sep 2025 | Viewed by 353 | Submission Open

Keywords: therapeutic drug monitoring; method validation; pharmacometrics; pediatric clinical pharmacology; laboratory developed tests; clinical mass spectrometry; functional tests; isobars; triple quad mass spectrometry; HR-MS; biomarker; drugs of abuse; therapeutic drugs; metabolites

(This special issue belongs to the Section Biochemistry)

The Future of Drug Discovery and Development, 2nd Edition

edited by

William C. (Trey) Putnam

submission deadline 20 Sep 2025 | Viewed by 345 | Submission Open

Keywords: drug discovery; drug development; biotechnology; target identification; target validation; regulatory affairs; regulatory sciences; drug commercialization; pharmaceutical market access; drug screening; novel nonclinical models/approaches; advanced manufacturing; continuous manufacturing; process analytical technology; adaptive clinical trials; in silico laboratory and clinical development; rolling submissions; accelerated approvals; real-world evidence

(This special issue belongs to the Section Molecular Pharmacology)

Role and Application of Stem Cells in Regenerative Medicine (Volume 5)

edited by

Oriana Trubiani

Francesca Diomede

and

Jacopo Pizzicannella

submission deadline 20 Sep 2025 | Viewed by 344 | Submission Open

Keywords: mesenchymal stem cells; tissue regeneration; regenerative medicine; immunomodulatory process

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Epigenetics of Metabolic Diseases

edited by

Makrina Karaglani

submission deadline 20 Sep 2025 | Viewed by 336 | Submission Open

Keywords: epigenetics; metabolic diseases; DNA methylation; histone modifications; non-coding RNAs; obesity; diabetes; metabolic syndrome

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Defects of Naturally Occurring Mutations

edited by Ya-Xiong Tao

submission deadline 20 Sep 2025 | Viewed by 336 | Submission Open

Keywords: protein misfolding; loss of function; gain of function; pharmacological chaperone; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Recent Progress in Extracellular Vesicles

edited by

Regina Golan-Gerstl

submission deadline 20 Sep 2025 | Viewed by 333 | Submission Open

Keywords: extracellular vesicles (EVs); macrovesicles; exosomes; cell– cell comunication

(This special issue belongs to the Section Molecular Biology)

Molecular Diagnostic and Therapeutic Advances of Type 2 Diabetes and Obesity

edited by

Thozhukat Sathyapalan

Stephen Atkin

and

Alexandra E. Butler

submission deadline 20 Sep 2025 | Viewed by 330 | Submission Open

Keywords: type 2 diabetes; obesity; diabetes complications; cardiovascular disease; dyslipidemia; non-alcoholic fatty liver disease; metabolic syndrome; retinopathy; nephropathy; neuropathy; pharmacotherapy; insulin resistance

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Basis and Latest Therapeutic Strategies for Genetic Diseases in Children

edited by

Alessandro Mussa

and Chiara Leoni

submission deadline 20 Sep 2025 | Viewed by 323 | Submission Open

Keywords: rare diseases; genetic disease; gene therapy; drug development; drug repurposing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 1451-1500 on page 30 of 68.

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