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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Sepsis and Septic Shock: From Molecular Mechanisms to Novel Therapies—2nd Edition

edited by

Markus A. Weigand

and Michael Adamzik

submission deadline 30 Jul 2025 | Viewed by 338 | Submission Open

Keywords: sepsis; septic shock; mechanistic insight; epigenetics; immunometabolism; biomarkers; therapy approach; stratification; precision diagnostics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biology and Diagnosis on Biliary and Pancreatic Cancers

edited by Francesco Vasuri and Luca Saragoni

submission deadline 30 Jul 2025 | Viewed by 275 | Submission Open

Keywords: biliary cancer; pancreatic cancer; histological diagnoses; cytological diagnoses; chromosome aneuploidy; specific genetic mutations

(This special issue belongs to the Section Molecular Oncology)

Protein Design and Engineering in Biochemistry

edited by Om Prakash Narayan

submission deadline 30 Jul 2025 | Viewed by 197 | Submission Open

Keywords: protein engineering; molecular biology; biochemical tools; computational protein design; directed evolution; CRISPR/Cas9; synthetic biology; biomaterials; protein therapeutics; regenerative medicine

(This special issue belongs to the Section Molecular Biology)

Artificial Intelligence in Nano- and Bio-Technology Systems: Focus on Molecular Research

edited by

Abbas Amini

submission deadline 30 Jul 2025 | Viewed by 184 | Submission Open

Keywords: artificial intelligence; nanotechnology; biotechnology; medicine; energy systems; blockchain

(This special issue belongs to the Section Molecular Nanoscience)

The Brain’s Regeneration Potential: The Role of Neural Progenitor Cells in Neuropsychiatric Therapy

edited by

Beatriz Caballero

and

Yaiza Potes

submission deadline 30 Jul 2025 | Viewed by 174 | Submission Open

Keywords: neural stem cells; neural progenitor cells; neuropsychiatric disorders; neurodegeneration; neurogenesis; neuroplasticity; melatonin; psychoactive drugs

(This special issue belongs to the Section Molecular Neurobiology)

Research Progress and Therapeutic Targets of Chronic Kidney Disease

edited by

Stefanos Roumeliotis

submission deadline 30 Jul 2025 | Viewed by 168 | Submission Open

Keywords: blood pressure; cardiovascular disease; chronic kidney disease; diabetes; hypertension; inflammation; oxidative stress; sodium glucose transporter-2; vascular calcification

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neuroblastoma: Molecular Pathology, Diagnostics and Therapeutics

edited by

Simona Dedoni

submission deadline 30 Jul 2025 | Viewed by 164 | Submission Open

Keywords: neuroblastoma; solid cancer; immature nerve cells; molecular mechanism; biomarker; tumor heterogeneity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Elucidating How Chondrocytes Maintain Cartilage Stability

edited by James A. Martin

submission deadline 30 Jul 2025 | Viewed by 156 | Submission Open

Keywords: chondrocytes; articular cartilage; chondrogenesis; osteoarthritis; mechano-transduction; aging; extracellular matrix

(This special issue belongs to the Section Molecular Biology)

The Roles of Oxidative Stress in Metabolic Syndrome

edited by

Maria Magdalena Quetglas-Llabrés

and

Margalida Monserrat-Mesquida

submission deadline 30 Jul 2025 | Viewed by 142 | Submission Open

Keywords: oxidative stress; metabolic syndrome; inflammation; antioxidants; human chronic diseases; cardiometabolic diseases; nutrition; lifestyle

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancing Liver Health: State of the Art and Recent Research Advances

edited by

Chase Wehrle

submission deadline 30 Jul 2025 | Viewed by 142 | Submission Open

Keywords: liver; liver cancer and malignancy; liver transplantation; inflammation and immunity; liver health and ageing; molecular genomics; cellular senescence; metabolic dysfunction-associated liver disease; cirrhosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Forensics at Trial

edited by

Guido Viel

submission deadline 30 Jul 2025 | Viewed by 142 | Submission Open

Keywords: forensic science; molecular biology; evidence; proof; justice; trial; forensic pathology; forensic genetics; forensic histology; forensic toxicology

(This special issue belongs to the Section Molecular Toxicology)

Advanced Molecular Research in Brain Tumors

edited by

Shiv K. Gupta

submission deadline 30 Jul 2025 | Viewed by 140 | Submission Open

Keywords: targeted therapy; blood– brain barrier; GBM; glioma; immune checkpoint blockers; TME

(This special issue belongs to the Section Molecular Oncology)

Exploring Tolerance Mechanisms in Plants Under Stress

edited by

Lujun Yu

submission deadline 30 Jul 2025 | Viewed by 140 | Submission Open

Keywords: stress; tolerance; gene family; phytohormones; mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Gene Mining and Germplasm Innovation for the Important Traits in Rice (Second Edition)

edited by

Shimin Zuo

and

Yongmei Bao

submission deadline 30 Jul 2025 | Viewed by 134 | Submission Open

Keywords: rice; gene mining; important traits; molecular design; gene editing; germplasm innovation

(This special issue belongs to the Section Molecular Plant Sciences)

Neurohormones in Cardiac Fibrosis and Heart Failure

edited by

Helmy M. Siragy

submission deadline 30 Jul 2025 | Viewed by 125 | Submission Open

Keywords: heart failure; neurohormones; cardiac fibrosis; angiotensin II; aldosterone; endothelin; catecholamines

(This special issue belongs to the Section Molecular Biology)

Venoms and Ion Channels (3rd Edition)

edited by

Steve Peigneur

submission deadline 30 Jul 2025 | Viewed by 123 | Submission Open

Keywords: sodium channels; potassium channels; calcium channels; trp channels; acetylcholine receptors; cone snail venom peptides; spider venom peptides; sea anemone toxins; scorpion toxins; snake toxins

(This special issue belongs to the Section Molecular Toxicology)

Advances in Ovarian Cancer Metastasis and Chemotherapy Resistance

edited by

Carmela Ricciardelli

and

Noor A. Lokman

submission deadline 30 Jul 2025 | Viewed by 118 | Submission Open

Keywords: ovarian cancer; metastasis; biomarkers; chemotherapy resistance; tumor microenvironment; peritoneal– cancer cell interactions; proteomics; novel therapeutic targets

(This special issue belongs to the Section Molecular Oncology)

Advanced Research in Immune Cell Therapy

edited by

Alexander Huang

submission deadline 30 Jul 2025 | Viewed by 116 | Submission Open

Keywords: molecular biology; bioinformatics; proteomics; molecular mechanisms; genomics

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms Underlying Skin Diseases

edited by Maria Lucia Dell'Anna

submission deadline 30 Jul 2025 | Viewed by 112 | Submission Open

Keywords: pigmentation; lipid signaling; immune cells; inflammation; skin barrier; oxidative damage; mitochondria

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Compounds in Cancer: Targeting Immune Cells and Signalling Pathways

edited by

Tomasz Jędrzejewski

submission deadline 30 Jul 2025 | Viewed by 112 | Submission Open

Keywords: natural compounds; cancer; inflammation; signalling pathways; antineoplastic agents; macrophage; T cells; molecular mechanism of pharmacological action; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights into Environmental Toxicology in Cancer

edited by

Silvia Vivarelli

submission deadline 30 Jul 2025 | Viewed by 111 | Submission Open

Keywords: environmental carcinogenesis; toxic exposure; exposome; occupational cancer risk; biomarkers of exposure; new approach methodologies (NAMs)

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms Study of Functional Foods and Nutrients in Human Health Interventions

edited by

Rui Jiao

submission deadline 30 Jul 2025 | Viewed by 109 | Submission Open

Keywords: functional foods; molecular mechanisms; nutrient bioavailability; chronic disease prevention; health interventions

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights in Biomodelling

edited by

Jacques Demongeot

submission deadline 30 Jul 2025 | Viewed by 108 | Submission Open

Keywords: biomodelling; biomathematics; bioinformatics; biostatistics; biophysics; theoretical biology; theoretical ecology; mathematical biology; theoretical physics; physical chemistry

(This special issue belongs to the Section Molecular Informatics)

Theranostic Application of Reactive Oxygen Species-Sensitive Nanocarriers

edited by

Young-Il Jeong

submission deadline 30 Jul 2025 | Viewed by 106 | Submission Open

Keywords: ROS generation; ROS detection; ROS-sensitive nanoparticles; Photodynamic therapy (PDT)

(This special issue belongs to the Section Molecular Nanoscience)

Studying Multi-Target Drug Approaches and Posttranslational Modification (PTM) Therapies

edited by

Guo-Ping Zhou

submission deadline 30 Jul 2025 | Viewed by 106 | Submission Open

Keywords: multi-target therapy; network analysis tools; multi-label proteins; web-server predictor; posttranslational modifications (PTMs); 3D structures; rational drug design

(This special issue belongs to the Section Molecular Informatics)

Drugs—from Chemical Structure to Biological Activity

edited by

Sravani Sana

submission deadline 30 Jul 2025 | Viewed by 101 | Submission Open

Keywords: hit molecule; lead optimization; drug design; virtual screening; molecule descriptors; structure– activity relationship; pharmacokinetic/ADME profile; in vitro biological activity

(This special issue belongs to the Section Molecular Pharmacology)

Nanomedicine for Diagnostic and Therapeutic Application

edited by

Nicola D'Avanzo

and Antonella Barone

submission deadline 30 Jul 2025 | Viewed by 97 | Submission Open

Keywords: polymeric nanoparticles; lipid nanoparticles; diagnostic; theranostic; targeted drug delivery; nonovesicles; prescion medicine

(This special issue belongs to the Section Molecular Nanoscience)

Reproductive Immunology: Pathological Mechanisms, Genetics, and Immunotherapy

edited by

Ming Zhang

submission deadline 30 Jul 2025 | Viewed by 93 | Submission Open

Keywords: genital tract; fertilization; embryo development; fetus development; immune

(This special issue belongs to the Section Molecular Immunology)

Harnessing Bioinformatics for miRNA Research: Methods, Insights and Applications

edited by Maria Rosaria Tumolo and Saverio Sabina

submission deadline 30 Jul 2025 | Viewed by 93 | Submission Open

Keywords: microRNA; bioinformatics; hub genes; miRNA target prediction; miRNA regulatory networks; miRNA-based biomarkers; artificial intelligence in miRNA research; multi-omics approaches

(This special issue belongs to the Section Molecular Informatics)

Advances in Molecular Biology of Ovarian Cancer

edited by

Stefania Scicchitano

and Cinzia Garofalo

submission deadline 30 Jul 2025 | Viewed by 91 | Submission Open

Keywords: ovarian cancer; signaling pathways; transcription factors; cancer metabolism; chemoresistance; tumor microenvironment; ovarian cancer stem cells; cancer therapies

(This special issue belongs to the Section Molecular Oncology)

Molecular Research on Gene Editing in Agricultural Crops

edited by

Xiaoli Shi

submission deadline 30 Jul 2025 | Viewed by 87 | Submission Open

Keywords: genome editing; molecular insights; agricultural crops

(This special issue belongs to the Section Molecular Plant Sciences)

Acute Myeloid Leukemia: From Molecular Insights to Therapeutic Innovations

edited by

Lukasz Szymanski

submission deadline 30 Jul 2025 | Viewed by 86 | Submission Open

Keywords: acute myeloid leukemia; AML; epigenetic Mechanisms; genetics; epigenetic regulation

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Role of Locus Coeruleus in Regulating Sudden Cortical States and Preventing Neurodegeneration

edited by

Francesco Fornai

submission deadline 30 Jul 2025 | Viewed by 86 | Submission Open

Keywords: reticular formation; norepinephrine; neuroplasticity; neuroprotection; neurodegenerations; adrenergic receptors; dementia; parkinson's disease; autism; affective disorders; addiction; psychostimulants

(This special issue belongs to the Section Molecular Neurobiology)

New Advances in Natural Product Synthesis and Emerging Biotechnology Applications

edited by Katarzyna Kotwica-Mojzych

submission deadline 30 Jul 2025 | Viewed by 85 | Submission Open

Keywords: natural compounds; natural product synthesis; chemical analysis; molecular technologies; biotechnology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Contribution of Astrocytes and Microglia for the Development of Neurological Disorders

edited by Rommy Von Bernhardi

submission deadline 30 Jul 2025 | Viewed by 78 | Submission Open

Keywords: aging; astrocytes; glial cells; microglia; neurodegenerative diseases; neuron-glia interaction; neuroimmune response; neuroinflammation

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research on Porous Polymers for Advanced Separation and Analytical Applications

edited by

Dmitrij Bondarev

submission deadline 30 Jul 2025 | Viewed by 75 | Submission Open

Keywords: microporous polymers; molecular imprinting; ion imprinting; separation; porous surfaces; spectroscopy; chromatography

(This special issue belongs to the Section Macromolecules)

Plasticity in Multiple Sclerosis: From Molecular to System Level, from Adaptation to Maladaptation

edited by Gloria Dalla Costa and Laura Cacciaguerra

submission deadline 30 Jul 2025 | Viewed by 75 | Submission Open

Keywords: multiple sclerosis; neuroplasticity; remyelination; synaptic adaptations

(This special issue belongs to the Section Molecular Neurobiology)

New Insights into Lectins

edited by Yuichiro Sato

submission deadline 30 Jul 2025 | Viewed by 73 | Submission Open

Keywords: lectin; carbohydrate-binding specificity; virus; antiviral activity; cancer; anticancer activity; glycan-targeted therapy

(This special issue belongs to the Section Molecular Biology)

Natural Products in Drug Discovery for Anticancer Treatment

edited by

Magdalena Bartnik

and Adrianna Sławińska-Brych

submission deadline 31 Jul 2025 | 4 articles | Viewed by 13105 | Submission Open

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Medicinal Chemistry: From Drug Design to Drug Development

edited by

Chiara Brullo

and

Andrea Spallarossa

submission deadline 31 Jul 2025 | 4 articles | Viewed by 8397 | Submission Open

Keywords: medicinal chemistry; biological targets; drug synthesis; drug discovery; pharmaceutical chemistry; structure-activity relationships

(This special issue belongs to the Section Molecular Pharmacology)

Research Advances in the Bioinformatics of Genome Editing and Gene Function Analysis

edited by

Hidemasa Bono

submission deadline 31 Jul 2025 | 4 articles | Viewed by 7428 | Submission Open

Keywords: genome editing; functional genomics; genome analysis; transcriptome analysis; metagenome analysis; meta-analysis; bioinformatics; large language model (LLM); public databases

(This special issue belongs to the Section Molecular Informatics)

Molecular Toxicology on the Environmental Impact of Pharmaceuticals

edited by

Anna Weronika Sobańska

submission deadline 31 Jul 2025 | 4 articles | Viewed by 4752 | Submission Open

Keywords: pharmaceutic; cosmetic preparations; cosmetic products; cosmetic compounds; molecular mechanisms; environmental toxicity and/or persistence; mobility in soil/water compartment; bioconcentration or bioaccumulation

(This special issue belongs to the Section Molecular Toxicology)

Cheminformatics in Drug Discovery and Green Synthesis

edited by

Ana Amić

submission deadline 31 Jul 2025 | 5 articles | Viewed by 3613 | Submission Open

Keywords: cheminformatics; drug discovery; databases; in silico methods; green chemistry

(This special issue belongs to the Section Molecular Informatics)

Heterocyclic Compounds: Synthesis, Design, and Biological Activity

edited by

Josef Jampilek

submission deadline 31 Jul 2025 | 3 articles | Viewed by 1877 | Submission Open

Keywords: heterocycles; bioactive molecules and materials; pharmacophore; design; targeting; computer studies; synthesis and analysis; natural compounds; carbohydrates; physicochemical properties; biological screening

(This special issue belongs to the Section Biochemistry)

Advancements in Cancer Biomarkers

edited by

Christos Mikropoulos

submission deadline 31 Jul 2025 | 3 articles | Viewed by 1841 | Submission Open

Keywords: biomarkers; ctDNA; mircroRNA; proteomics; gene methylation; TIL; transcriptomics; micro RNA; tumor microenvironment; gene methylation; proteomics

(This special issue belongs to the Section Molecular Oncology)

Mechanisms of Diabetic Cardiomyopathy

edited by Martin Michel

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1735 | Submission Open

Keywords: diabetes; cardiomyopathy; animal models; novel treatments; pathophyiology; SGLT2 inhibitors; neprilysin inhibitors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Review Papers in Molecular Immunology, 3rd Edition

edited by

Manlio Ferrarini

and

Vincenzo Barnaba

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1731 | Submission Open

Keywords: molecular immunology; review; immune cells

(This special issue belongs to the Section Molecular Immunology)

Dysregulation of Bone Health–a Matter of Several Culprits

edited by Ana Gomes

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1437 | Submission Open

Keywords: bone metabolism; osteoporosis; osteopenia; low-impact fractures; osteoimmunology; leptin; lung disorders; cancer; renal disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Structure-Based Design of Drugs and Biologically Active Molecules Based on Computer-Aided Drug Discovery

edited by

Cleydson Breno Rodrigues dos Santos

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1355 | Submission Open

Keywords: drug design; virtual screening; bioinformatics; chemoinformatics; quantum chemistry

(This special issue belongs to the Section Molecular Informatics)

Molecular Diagnosis in Cardiovascular Diseases

edited by Calogera Pisano,

Carmela Rita Balistreri

and Giuseppe Raffa

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1310 | Submission Open

Keywords: cardiac diseases; molecular diagnosis; aortopathy; aneurysm; dissection; heart failure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 551-600 on page 12 of 68.

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