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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Metabolic Inflammation and Adipose Tissue

edited by

Dariusz Szukiewicz

submission deadline 31 Mar 2027 | Viewed by 20 | Submission Open

Keywords: metabolic inflammation; chronic low-grade inflammation; metabolic syndrome; obesity; adipocyte dysfunction; adipose tissue dysfunction; visceral obesity; immunometabolic disorders; insulin resistance; adipokine profile

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms of Cranium–Brain Interactions in Brain Health and Neurological Disease

edited by Meenakshi Umar

submission deadline 31 Mar 2027 | Viewed by 19 | Submission Open

Keywords: cranium–brain interactions; cranial bone marrow; meninges; neurovascular biology; neuroimmune signaling; neuroinflammation; blood–brain barrier; molecular signaling; cranial development; neurological disorders

(This special issue belongs to the Section Molecular Neurobiology)

Microscopy for Molecular Sciences: Recent Advances in Imaging and Analysis

edited by

Rawil Fakhrullin

and

Ilnur Ishmukhametov

submission deadline 31 Mar 2027 | Viewed by 19 | Submission Open

Keywords: molecular interactions via microscopy; scanning probe microscopy; optical microscopy; spectral microimaging; correlative microscopy; machine learning; image analysis; high-content screening

(This special issue belongs to the Section Molecular Biophysics)

Crystal Polymorphism in Nanostructured Materials

edited by Diego Germán Lamas and Analía Leticia Soldati

submission deadline 31 Mar 2027 | Viewed by 17 | Submission Open

Keywords: crystal polymorphism; nanostructured materials; metastable phases; phase stability and transformations; surface and interfacial energies; X-ray diffraction and total scattering; in situ and operando characterization; synchrotron, electron, and neutron techniques; first-principles and atomistic modeling; structure–property relationships

(This special issue belongs to the Section Materials Science)

Synthesis and Characterization of Shape Memory Polymers

edited by Bonifacio Alvarado-Tenorio

submission deadline 31 Mar 2027 | Viewed by 17 | Submission Open

Keywords: molecular design of shape-memory polymers; shape-memory polymer synthesis; stimuli-responsive polymer networks; shape-memory polymer nanocomposites; polymer crystallization and phase transitions; thermomechanical characterization; molecular structure-property relationships; two-way and triple-shape memory effects

(This special issue belongs to the Section Materials Science)

Long COVID: From Medical Conditions to Molecular Mechanisms

edited by Sándor Szabó and Veronika Müller

submission deadline 31 Mar 2027 | Viewed by 14 | Submission Open

Keywords: long COVID; pathophysiological mechanisms; molecular and cellular mechanisms; cytokine dysregulation; vascular factors; endothelial vs. epithelial cell damage; hormonal changes; gene activation; pro-oncogenic changes; prevalence; clinical manifestations

(This special issue belongs to the Section Molecular Biology)

Recent Molecular Insights into Parasitic Infections and Evolution

edited by Juan Antonio Venegas

submission deadline 31 Mar 2027 | Viewed by 12 | Submission Open

Keywords: molecular parasitology; parasitic infections; molecular virulence of parasites; molecular evasion of the immune response; parasitic signal transducer systems; molecular evolution of parasites; molecular pathogenesis of parasites; host–parasite interactions at the molecular level; molecular drug resistance

(This special issue belongs to the Section Molecular Biology)

Computer-Aided Drug Discovery, Including Cheminformatics and Computational Chemistry

edited by

Yorley Duarte

submission deadline 31 Mar 2027 | Viewed by 11 | Submission Open

Keywords: computer-aided drug discovery; computational chemistry; cheminformatics; molecular modeling; molecular docking; virtual screening; molecular dynamics; drug design; artificial intelligence; machine learning

(This special issue belongs to the Section Molecular Informatics)

Advances in Cell and Tissue Ultrastructure: Molecular Mechanisms and Biomedical Applications

edited by Katarzyna Haczkiewicz-Leśniak

submission deadline 31 Mar 2027 | Viewed by 10 | Submission Open

Keywords: cell ultrastructure; tissue ultrastructure; ultrastructural pathology; glomerulonephritis; organelles architecture; neuromuscular disorders; cryo-TEM; advanced electron microscopy techniques; spheroids; gold nanoparticles; vesicles morphology

(This special issue belongs to the Section Molecular Biology)

Molecular Psychiatry: From Genetics to Psychopharmacology

edited by

Jarosław Jozwiak

submission deadline 31 Mar 2027 | Viewed by 10 | Submission Open

Keywords: molecular psychiatry; psychiatric genetics; neurodevelopmental disorders; psychopharmacology; precision psychiatry

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Organ Damage Induced by Anabolic-Androgenic Steroids

edited by

Vittorio Fineschi

submission deadline 31 Mar 2027 | Viewed by 9 | Submission Open

Keywords: anabolic androgenic steroids; AASs; sudden cardiac death; SCD; doping in sport; molecular analysis; toxicology; testosterone; toxicity; autopsy

(This special issue belongs to the Section Molecular Biology)

Sportomics and the Molecular Athlete: Metabolic Stress, Nutrition and Safety in High-Performance Athletes

edited by Luiz-Claudio Cláudio Cameron

submission deadline 31 Mar 2027 | Viewed by 8 | Submission Open

Keywords: sportomics; metabolic stress; personalized nutrition; sex and gender athlete-based analysis; precision sports medicine; athlete safety; unintentional doping; environmental stress; n-of-1 elite-athlete studies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Active Ingredients and Health Effects of Plant Extracts and Functional Food

edited by Cong Teng

submission deadline 31 Mar 2027 | Viewed by 7 | Submission Open

Keywords: plant extract; polysaccharides; protein; polyphenols; functional ingredients; structural characterization; health activities

(This special issue belongs to the Section Bioactives and Nutraceuticals)

MicroRNAs and mRNA in Human Health and Disease, 2nd Edition

edited by

Paulina Gil-Kulik

submission deadline 31 Mar 2027 | Viewed by 7 | Submission Open

Keywords: stem cells; mesenchymal stem cells; gene expression; microRNA; mRNA

(This special issue belongs to the Section Molecular Biology)

Advanced Research in Mitochondrial Function

edited by Juan Pablo Muñoz

submission deadline 31 Mar 2027 | Viewed by 7 | Submission Open

Keywords: mitochondrial dysfunction; breast cancer; oxidative stress; endocrine-disrupting chemicals

(This special issue belongs to the Section Molecular Biology)

The Dynamic Membrane State: From Lipid Composition and Biophysical Organization to Cellular Function

edited by Marco Cavaglià

submission deadline 31 Mar 2027 | Viewed by 6 | Submission Open

Keywords: membrane lipids; membrane biophysics; lipidomics; lipid–protein interactions; membrane asymmetry; organelle membranes; lipid divide; bioelectricity; molecular dynamics; synthetic membranes

(This special issue belongs to the Section Molecular Biophysics)

State-of-the-Art "Physical Chemistry and Chemical Physics" in China

edited by Chen Wu

submission deadline 31 Mar 2027 | Viewed by 6 | Submission Open

Keywords: molecular dynamics; reaction mechanisms; operando characterization; interfacial and surface science; molecular catalysis; electrochemistry and energy conversion; quantum and computational chemistry; machine learning; AI-enabled chemical discovery; biomolecular physical chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Skeletal Muscle: Metabolism, Aging and Treatment Strategies

edited by Johan Lindqvist

submission deadline 31 Mar 2027 | Viewed by 6 | Submission Open

Keywords: skeletal muscle; whole-body energy homeostasis; aging; muscle metabolism; sarcopenia; skeletal muscle disease

(This special issue belongs to the Section Molecular Biology)

Plasma–Surface and Plasma–Cell Interactions: Molecular Mechanisms and Applications

edited by

Andrei Vasile Nastuta

submission deadline 31 Mar 2027 | Viewed by 6 | Submission Open

Keywords: plasma medicine; plasma theranostics; plasma pharmacology; plasma oncology; plasma bioengineering; plasma agriculture; plasma and food; plasma and automotive; plasma and aerospace; plasma diagnostics; plasma material processing; plasma polymerization and coating; simulation of plasma phenomena during interaction with matter

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Advances in Therapeutic Cancer Vaccines and Combination Immunotherapy

edited by Praveen Neeli

submission deadline 31 Mar 2027 | Viewed by 4 | Submission Open

Keywords: therapeutic cancer vaccines; neoantigens; DNA and mRNA vaccines; nanoparticle delivery; antigen presentation; tumor immune microenvironment; immune-checkpoint blockade; combination immunotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biology and Chemistry of Medicinal Plants: From Resources to Applications

edited by

Mohamed Bouhrim

submission deadline 31 Mar 2027 | Viewed by 4 | Submission Open

Keywords: medicinal plants; phytochemistry; bioactive compounds; ethnopharmacology; molecular mechanisms; phytotherapy; diabetes mellitus; metabolic disorders; oxidative stress; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Recent Advances in Cancer Biomarkers: Diagnosis, Prognosis, and Clinical Implications

edited by

Jongwan Kim

and

Paola Palumbo

submission deadline 31 Mar 2027 | Viewed by 3 | Submission Open

Keywords: cancer biomarkers; multi-omics; liquid biopsy; precision oncology; early diagnosis

(This special issue belongs to the Section Molecular Oncology)

Cardiovascular Diseases: Molecular Mechanisms of Cardiac Injury and Remodeling

edited by

Parisa Aghagolzadeh

submission deadline 31 Mar 2027 | Viewed by 2 | Submission Open

Keywords: cardiovascular disease; cardiac injury; cardiac remodeling; heart failure; fibrosis; inflammation; noncoding RNAs; omics; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Food Colloidal Interfacial Engineering and Their Applications

edited by

Parham Joolaei Ahranjani

and

Giovanna Ferrentino

submission deadline 31 Mar 2027 | Viewed by 1 | Submission Open

Keywords: food colloids; molecular interactions; food interfaces; protein–polysaccharide complexes; pickering emulsions; interfacial adsorption; colloidal delivery systems; bioactive encapsulation; interfacial rheology; molecular modelling

(This special issue belongs to the Section Molecular Biophysics)

Immune and Inflammatory Underpinnings of Neurodevelopmental and Neuropsychiatric Disorders

edited by

Antonella Gagliano

and

Francesca Cucinotta

submission deadline 31 Mar 2027 | Viewed by 1 | Submission Open

Keywords: neurodevelopmental disorders; neuroinflammation; PANS; neuroimmunology; pathogenetic pathways; autism spectrum disorder; attention deficit/hyperactivity disorder; tourette’s disorder; microglia; cytokines; autoimmunity; immunogenetics

(This special issue belongs to the Section Molecular Neurobiology)

Identification, Mechanism of Action, and Applications of Bioactive Molecules from Natural Source

edited by

Widad Ben Bakrim

submission deadline 31 Mar 2027 | Submission Open

Keywords: natural products; phytochemistry; mechanisms of action; molecular docking; metabolomics; biological activity; pharmacological applications; green extraction; nutraceuticals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Microbial Modulation in Human Immune and Metabolic Systems: Emerging Mechanisms and Translational Opportunities

edited by

Hooi-Leng Ser

submission deadline 1 Apr 2027 | Viewed by 182 | Submission Open

Keywords: host–microbe interactions; immune regulation; metabolic homeostasis; microbial metabolites; dysbiosis; microbiome interventions; translational microbiology

(This special issue belongs to the Section Molecular Microbiology)

Plant–Microbe Interactions: 2nd Edition

edited by Jian Jin

submission deadline 20 Apr 2027 | 6 articles | Viewed by 14877 | Submission Open

Keywords: plant; crop; rhizosphere microbiome; microbial colonization; quorum sensing; endophytic microbes

(This special issue belongs to the Section Molecular Plant Sciences)

Anti-Cancer Drugs: Natural Products, Synthetic Compounds and Potential Pharmacological Effects and Applications

edited by Kaiqun Ren and Hui Zou

submission deadline 20 Apr 2027 | 4 articles | Viewed by 14181 | Submission Open

Keywords: cancer; natural product; synthetic compounds; mechanism; structural modification; pharmacological action

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Imaging for Cancer Theranostics

edited by

Hak Soo Choi

and Kai Bao

submission deadline 20 Apr 2027 | 3 articles | Viewed by 8309 | Submission Open

Keywords: molecular imaging; cancer theranostics; precision medicine; targeted therapy; diagnostic imaging; theranostic agents; multimodal imaging; molecular probes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomaterials and Antibacterial Materials for Medical Applications

edited by

Shixiong Yi

submission deadline 20 Apr 2027 | 2 articles | Viewed by 2147 | Submission Open

Keywords: biomaterial science; photodynamic antibacterial materials; photothermal antibacterial materials; advanced antibacterial materials; antimicrobial nanostructured materials; polymer-based biomaterials; infected wound dressings

(This special issue belongs to the Section Materials Science)

Immunoregulation of Abnormal Cell Proliferation: Molecular Mechanisms and Therapeutic Strategies

edited by

Xingkang Wu

submission deadline 20 Apr 2027 | 1 articles | Viewed by 1093 | Submission Open

Keywords: immune microenvironment; cell proliferation; molecular mechanisms; therapeutic strategies; tumor; autoimmune disease; psoriasis; rheumatoid arthritis; lupus erythematosus; type 1 diabetes; inflammatory bowel disease

(This special issue belongs to the Section Molecular Immunology)

Biomaterials for Dental and Orthopedic Applications, 2nd Edition

edited by

Lia Rimondini

submission deadline 20 Apr 2027 | 1 articles | Viewed by 1029 | Submission Open

Keywords: personalized biomaterials; dental and orthopedic applications; tissue regeneration; 3D biorinting

(This special issue belongs to the Section Materials Science)

Integrative Multi-Omics in Neurodegenerative Diseases: Mechanisms, Biomarkers and Therapeutic Targets

edited by

Abdullah Sheikh

submission deadline 20 Apr 2027 | Viewed by 37 | Submission Open

Keywords: multi-omics; neurodegenerative diseases; systems biology; biomarkers; precision medicine; transcriptomics; proteomics; metabolomics; epigenomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Multidrug-Resistant Bacteria Across One Health Interfaces: Molecular Mechanisms, Dissemination, and Innovative Control Strategies

edited by

Clara Mariana Gonçalves Lima

submission deadline 20 Apr 2027 | Viewed by 33 | Submission Open

Keywords: antimicrobial resistance; virulence factors; biofilms; multidrug-resistant bacteria; antimicrobial agents

(This special issue belongs to the Section Molecular Microbiology)

Thyroid-Related Diseases: Molecular Pathology, Diagnosis and Treatment (3rd Edition)

edited by

Vincenzo Fiorentino

and

Maurizio Martini

submission deadline 20 Apr 2027 | Viewed by 3 | Submission Open

Keywords: thyroid disease; thyroid nodules; thyroid cancer; thyroid carcinoma; thyroid radiology; thyroid–gut axis; autoimmune thyroid disorders; thyroid hormone; molecular mechanisms; molecular tests

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Cellular and Molecular Mechanisms in the Progression of Cardiovascular Diseases

edited by

Eglė Mazgelytė

submission deadline 22 Apr 2027 | Viewed by 71 | Submission Open

Keywords: cardiovascular diseases; molecular mechanisms; cellular signaling; inflammation; oxidative stress; cardiac remodeling; endothelial dysfunction; biomarkers; precision medicine; translational cardiovascular research

(This special issue belongs to the Section Molecular Biology)

Molecular Genetics and Genomics of Aquatic Crustaceans

edited by

Xianhong Meng

, Falin Zhou and Lingbo Ma

submission deadline 23 Apr 2027 | 4 articles | Viewed by 3781 | Submission Open

Keywords: genome sequencing; epigenomics; CRISPR/Cas9 gene editing; transcriptomics; gene expression profiling; genome-wide association studies (GWASs); quantitative trait loci (QTL) mapping; genomic selection; marker-assisted selection (MAS); molecular markers

(This special issue belongs to the Section Molecular Genetics and Genomics)

Neurodegenerative Diseases: Molecular Mechanisms and Therapies, 4th Edition

edited by

Zhidong Zhou

and

Alexandre Hiroaki Kihara

submission deadline 23 Apr 2027 | 1 articles | Viewed by 1299 | Submission Open

Keywords: neurodegeneration; neurodegenerative diseases; protein aggregation; pathogenesis; therapy; mitochondria; neuroinflammation; oxidative stress; cell therapy; clinical trial

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Molecular Biology of Haematology

edited by Valéria Tavares

submission deadline 23 Apr 2027 | 1 articles | Viewed by 877 | Submission Open

Keywords: haematopoiesis; molecular biology; genomics; epigenomics; computational biology; hematologic neoplasms; biomarkers; liquid biopsy; precision medicine

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Innate Immunity and Disease Resistance in Animals

edited by

Sutian Wang

submission deadline 23 Apr 2027 | Viewed by 482 | Submission Open

Keywords: innate immunity; pathogenic microorganism; animals; pathogenesis; mechanism of disease-resistance; disease-resistant/therapeutic target

(This special issue belongs to the Section Molecular Immunology)

Biosynthetic Pathways, Regulation, and Metabolic Engineering of Plant Bioactive Compounds

edited by

Fei Zhou

submission deadline 25 Apr 2027 | Viewed by 14 | Submission Open

Keywords: plant bioactive compounds; specialized metabolism; biosynthetic pathways; metabolic regulation; metabolic engineering; synthetic biology; heterologous production; multi-omics

(This special issue belongs to the Section Molecular Plant Sciences)

Novel Biomarkers and Therapeutics for Alzheimer's Disease

edited by

Lindsay H. Burns

submission deadline 28 Apr 2027 | Viewed by 6 | Submission Open

Keywords: Alzheimer’s disease; biomarkers; neuroprotection; secretase modulators; homeostasis regulators; mitochondrial enhancers; neuroinflammation; tau; small molecules; stem cells; RNAi

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Approaches in Molecular and Cellular Cancer Biology: Translating Basic Research to the Clinic

edited by

Rafael Coveñas Rodríguez

and

Maruan Hijazi Vega

submission deadline 29 Apr 2027 | Viewed by 73 | Submission Open

Keywords: cell signaling; proteomics; phosphoproteomics; mass spectrometry; kinase inhibitors; kinase activity; signaling networks; computational biology; peptide receptor antagonists; anticancer and cancer peptides

(This special issue belongs to the Section Molecular Oncology)

Male Infertility: Emerging Trends and Future Directions

edited by

Monica Muratori

and

Oumaima Ammar

submission deadline 29 Apr 2027 | Viewed by 73 | Submission Open

Keywords: male infertility; epigenetics; multi-omics; spermatogenesis; assisted reproduction; phytotherapy; artificial intelligence

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Inflammasomes

edited by

Roberto Negro

submission deadline 30 Apr 2027 | 3 articles | Viewed by 4602 | Submission Open

Keywords: inflammasome; pyroptosis; innate immunity; cancer; neurodegenerative diseases; microbiota; gasdermin; ninjurin; drug screening; personalized treatments; multi-omics analysis

(This special issue belongs to the Section Molecular Immunology)

Antibiotics Science: Molecular Insights, Detection Strategies, Resistance Challenges and Interdisciplinary Applications

edited by

Lidia Magerusan

submission deadline 30 Apr 2027 | 4 articles | Viewed by 4412 | Submission Open

Keywords: antibiotics; antibiotic molecular design and synthesis; antibiotic action mechanism; antibiotics resistance; environmental contamination; therapeutic monitoring; antibiotic sensing and detection; food and environmental safety

(This special issue belongs to the Section Molecular Microbiology)

Skin Cancer: A Focus from Pathophysiology to Novel Therapeutic Strategies

edited by

Piotr Sobolewski

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2951 | Submission Open

Keywords: skin cancer; melanoma; keratinocyte carcinoma; pathophysiology; biomarkers; immunotherapy; targeted therapy; nanomedicine; resistance; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Toxicity Caused by Environmental Pollutants

edited by Ivan Girón-Perez

submission deadline 30 Apr 2027 | 4 articles | Viewed by 2846 | Submission Open

Keywords: environmental pollutant; molecular toxicity; immunotoxicology; neurotoxicity

(This special issue belongs to the Section Molecular Toxicology)

From Mechanisms to Medicine: Cellular Insights into Pulmonary Hypertension

edited by

Swati Dabral

submission deadline 30 Apr 2027 | 3 articles | Viewed by 2841 | Submission Open

Keywords: vascular remodeling; cellular mechanisms; hypoxia; growth factors; inflammation

(This special issue belongs to the Section Molecular Biology)

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