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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Cellular Mechanisms of Scaffold-Based Tissue Engineering

edited by

Inseon Kim

submission deadline 31 Mar 2027 | 1 articles | Viewed by 609 | Submission Open

Keywords: scaffold; tissue engineering; extracellular matrix; biomaterials; 3D bioprinting; mechanobiology; stem cell differentiation; cultivated meat

(This special issue belongs to the Section Molecular Biology)

Podocyte Research: Molecular Insights and Clinical Applications

edited by

Hans Lorenzo

submission deadline 31 Mar 2027 | Viewed by 607 | Submission Open

Keywords: podocytes; glomerular filtration barrier; slit diaphragm; podocyte injury; proteinuria; focal segmental glomerulosclerosis; nephrotic syndrome; cell death; non-coding RNAs; therapeutic targets

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms in Glomerular and Renal Diseases

edited by Eleni Stamellou and

Evangelia Dounousi

submission deadline 31 Mar 2027 | 1 articles | Viewed by 581 | Submission Open

Keywords: glomerulonephritis (GN); podocytopathies; IgA (IgAN); chronic kindey disease (CKD); membra-nous nephropathy; focal segmental glomerulosclerosis (FSGS)

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Immune Regulation in Prostate Cancer

edited by Nigel Peter Murray

submission deadline 31 Mar 2027 | 1 articles | Viewed by 565 | Submission Open

Keywords: prostate cancer; immunosupressision; molecular changes; tumour microenvironment; anti-tumour immune changes; next-generation methods of molecular investigation

(This special issue belongs to the Section Molecular Oncology)

Emerging Biomarkers in Airway Diseases: From Epigenetic Regulation to Cellular Stress Pathways

edited by

Giusy Daniela Albano

submission deadline 31 Mar 2027 | 1 articles | Viewed by 544 | Submission Open

Keywords: airway diseases; asthma; chronic obstructive pulmonary disease; chronic rhinosinusitis; virus-associated airway disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Nanoscience Approaches to Neurodevelopmental Disorders

edited by

Khairunnuur Fairuz Azman

submission deadline 31 Mar 2027 | Viewed by 521 | Submission Open

Keywords: neurodevelopment; molecular neuroscience; neurotrophic signaling; epigenetics; synaptic plasticity; neuroinflammation; neurodevelopmental disorders; biomarkers; nanoneuroscience; nanotechnology

(This special issue belongs to the Section Molecular Neurobiology)

Advanced Strategies for Melanoma Immunotherapy

edited by

Andrzej Mackiewicz

and

Piotr Rutkowski

submission deadline 31 Mar 2027 | Viewed by 516 | Submission Open

Keywords: melanoma immunotherapy; immune Checkpoint Inhibitors; combination therapies; biomarkers; tumor microenvironment

(This special issue belongs to the Section Molecular Immunology)

Kidney Transplantation: Current Framework and New Perspectives

edited by Alberto Rosati

submission deadline 31 Mar 2027 | 1 articles | Viewed by 498 | Submission Open

Keywords: renal transplantation; organ donation; living donation; transplant survival; organ preservation; healthcare costs; acute and chronic rejection; immune tolerance; xenotransplantation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancing Mental Disorder Therapies: Drug Repositioning and Translational Insights from Animal Models

edited by Claudia Bregonzio and Mariela Fernanda Pérez

submission deadline 31 Mar 2027 | Viewed by 491 | Submission Open

Keywords: anxiety; depression; Parkinson's disease; Alzheimer; schizophrenia; neurotransmitter imbalance; novel treatments; new pharmacological targets; preclinical studies

(This special issue belongs to the Section Molecular Neurobiology)

Calcium Dynamics in Disease: Mechanisms and Therapeutic Opportunities

edited by

Valeria Magnelli

submission deadline 31 Mar 2027 | Viewed by 485 | Submission Open

Keywords: calcium signaling; homeostasis; deregulation; calcium imbalance

(This special issue belongs to the Section Biochemistry)

Peripheral Neuropathy: Exploring Pathogenic Pathways and Therapeutic Approaches

edited by Yuehling Hsieh

submission deadline 31 Mar 2027 | Viewed by 479 | Submission Open

Keywords: peripheral neuropathy; biochemical mechanisms; biomarkers; nerve regeneration; therapeutic approaches; pain management; denervated muscle atrophy; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathogenic Escherichia coli: Cellular Biology, Mechanisms of Pathogenesis, Therapeutic Approaches and Strategies for Disease Intervention

edited by

Jorge Goldstein

submission deadline 31 Mar 2027 | Viewed by 465 | Submission Open

Keywords: enterohemorrhagic E. coli; EHEC; Shiga toxin-producing E. coli; STEC; HUS; inflammation; kidney; blood; brain; pathogenesis; antibodies; extraintestinal pathogenic E. coli; E. coli pathotypes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Unraveling the Host–Virus Interplay in Viral Infection: Molecular Mechanisms and Therapeutic Horizons

edited by

Agustín Valenzuela-Fernández

and

Romina Cabrera-Rodríguez

submission deadline 31 Mar 2027 | Viewed by 461 | Submission Open

Keywords: host–virus interplay; viral infection; molecular mechanisms; antiviral defenses; molecular tools for diagnosis and therapies

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Combinatorial Strategies in Anti-Obesity Therapeutics

edited by

James Ernest Blevins

submission deadline 31 Mar 2027 | Viewed by 446 | Submission Open

Keywords: obesity; high-fat diet; rodents; pharmacotherapy; body weight; food intake

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Dermatological Perspectives on Connective Tissue Diseases

edited by

Yoshihide Asano

submission deadline 31 Mar 2027 | Viewed by 443 | Submission Open

Keywords: connective tissue diseases; systemic sclerosis; systemic lupus erythematosus; dermatomyo-sitis; rheumatoid arthritis; Sjögren’s syndrome; skin immunology; fibrosis; cytokines; targeted therapy

(This special issue belongs to the Section Molecular Biology)

The Role of miRNAs in Healthy Lungs and Chronic Lung Diseases

edited by Victor Ruiz

submission deadline 31 Mar 2027 | Viewed by 438 | Submission Open

Keywords: miRNA; DROSHA; DICER; DGCR8; ADAR; pulmonary fibrosis; COPD; asthma; lung neoplasm

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Pathophysiology of Peripheral Neuropathies and Neuromuscular Disorders

edited by

Eleonora Galosi

submission deadline 31 Mar 2027 | Viewed by 438 | Submission Open

Keywords: peripheral neuropathies; neuromuscular disorders; small fiber neuropathy; neuropathic pain; nerve regeneration; molecular pathways; next-generation sequencing

(This special issue belongs to the Section Molecular Neurobiology)

Current Research on the Structural Biology of Membrane Proteins

edited by

Izuru Kawamura

submission deadline 31 Mar 2027 | Viewed by 426 | Submission Open

Keywords: NMR; X-ray diffraction; cryo-electron microscopy; membrane protein; structure; dynamics; molecular dynamics simulation; vibrational spectroscopy

(This special issue belongs to the Section Molecular Biophysics)

DNA Damage, Genome Stability and the Human Disease

edited by

Fiammetta Verni

submission deadline 31 Mar 2027 | Viewed by 425 | Submission Open

Keywords: DNA damage; human diseases; DNA repair; genomic instability; therapeutic strategies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Recent Molecular Insights into Alzheimer's Disease

edited by

Giulia Sita

submission deadline 31 Mar 2027 | Viewed by 424 | Submission Open

Keywords: neurodegeneration; neuroprotection; pharmacology; toxicology; Alzheimer’s disease; neuroinflammation; aging

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Neuropharmacology in Neurodegenerative Disorders

edited by

Ichiro Kawahata

submission deadline 31 Mar 2027 | Viewed by 419 | Submission Open

Keywords: neuropharmacology; neurodegenerative disorders; cognitive dysfunction; motor dysfunction; drug discovery; neuroprotection; neurogenesis; brain plasticity; biomarkers; AI (artificial intelligence)

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Pharmacological Targets and Therapeutic Strategies in Diabetes and Obesity

edited by

Roma Patel

submission deadline 31 Mar 2027 | 1 articles | Viewed by 403 | Submission Open

Keywords: diabetes; obesity; molecular pharmacology; therapeutic targets; insulin resistance; β-cell dysfunction; metabolic signaling pathways; adipose tissue biology; drug–target interactions

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Medicinal Value of Plant Extracts

edited by

Myrna Déciga-Campos

and

Rosa Ventura-Martínez

submission deadline 31 Mar 2027 | Viewed by 401 | Submission Open

Keywords: medicinal plant; essential oil; cancer; diabetes; pain; inflammation; neurodegenerative diseases; metabolites; bioactive compounds; toxicity; safety; mutagenicity; genotoxicity; biological evaluations; efficacy; molecular

(This special issue belongs to the Section Molecular Pharmacology)

Virus Detection and Analysis: Molecular Investigations

edited by

Hayes Kam-Hei Luk

submission deadline 31 Mar 2027 | Viewed by 383 | Submission Open

Keywords: virus; molecular detection; nucleic acid amplification; molecular typing; next generation sequencing; metagenomics; point-of-care testing

(This special issue belongs to the Section Molecular Microbiology)

Plant-Based Early Therapeutics for Parasitic Infections Combined with Functional Modern Diagnosis Methods

edited by

Lee Tian Chang

submission deadline 31 Mar 2027 | Viewed by 382 | Submission Open

Keywords: active phytocompounds; antiparasitic agents; artificial intelligence; early diagnosis early treatment; life cycle; medicinal plants; parasite and vector; phytogenic feed additives; vision recognition

(This special issue belongs to the Section Molecular Plant Sciences)

Latest Research Progress of Biomaterial Modification

edited by

Manuel José Lis

submission deadline 31 Mar 2027 | Viewed by 380 | Submission Open

Keywords: functionalization of carbohydrates; molecular aggregation; simulation of biopolymers; biopolymeric microcapsules; biopolymeric devices

(This special issue belongs to the Section Materials Science)

Updates on Oral Potentially Malignant Disorders: From Pathogenesis to Treatment

edited by

Takahiro Abe

submission deadline 31 Mar 2027 | Viewed by 364 | Submission Open

Keywords: oral potentially malignant disorders; oral leukoplakia; oral erythroplakia; oral lichen planus/oral lichenoid lesions; oral submucous fibrosis; oral epithelial dysplasia; malignant transformation risk; biomarkers; imaging/diagnostic support; genomic or epigenomic factor

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Roles of Phytochemicals in Molecular Signaling Networks

edited by

Jui-Hung Yen

submission deadline 31 Mar 2027 | Viewed by 363 | Submission Open

Keywords: phytochemicals; molecular signaling pathways; inflammation; apoptosis; chronic diseases; cancer; cardiovascular diseases; structure–activity relationships

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Decoding Protein Structure and Protein Dynamics in Cancer

edited by

Umesh Kalathiya

and

Monikaben Padariya

submission deadline 31 Mar 2027 | Viewed by 363 | Submission Open

Keywords: protein structures; oncogenes; post-translational modifications (PTMs); cancer; proteomics; computational biology; structural biology; molecular modeling; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Mechanisms and Pathways of Actions for Nutritional Effects on Brain Health

edited by

Fahimeh Martami

submission deadline 31 Mar 2027 | Viewed by 360 | Submission Open

Keywords: brain health; neuroplasticity; neurotransmission; neuroinflammation; oxidative stress; brain metabolism

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Molecular Research on Snake Venoms

edited by

Isadora Sousa De Oliveira

and

Eliane Candiani Arantes

submission deadline 31 Mar 2027 | Viewed by 359 | Submission Open

Keywords: snake venoms; venomics; toxin diversity; toxin evolution; structure–function relationships; bioactive peptides; antivenom development; recombinant toxins; molecular mechanisms of toxicity

(This special issue belongs to the Section Molecular Biology)

miRNA in Physiology and Pathophysiology

edited by

Ivan Jovanović

submission deadline 31 Mar 2027 | Viewed by 357 | Submission Open

Keywords: microRNAs; gene regulation; physiology; pathophysiology; biomarkers; complex diseases; cancer

(This special issue belongs to the Section Molecular Genetics and Genomics)

New Advances in Infection Immunology

edited by

Arturo Contis-Montes De Oca

submission deadline 31 Mar 2027 | Viewed by 348 | Submission Open

Keywords: neuro-infection; innate immunity; immunopathology; microbiome-immune axis; chronic in-flammation

(This special issue belongs to the Section Molecular Immunology)

Immune Responses as the Central Determinant of Gene Therapy Outcomes

edited by

Manoj Pandey

submission deadline 31 Mar 2027 | Viewed by 346 | Submission Open

Keywords: innate and adaptive immune sensing; TLR signaling; complement activation; antigen presentation; T‑cell cytotoxicity; humoral immunity (IgG, IgM, IgA); pediatric immunology; rare disease; lysosomal storage disease; neuroinflammation; immunomodulatory therapies; complement inhibitors

(This special issue belongs to the Section Molecular Immunology)

Antibiotic Resistance: Recent Developments and Future Prospects

edited by

Awais Ghaffar

submission deadline 31 Mar 2027 | 1 articles | Viewed by 339 | Submission Open

Keywords: antimicrobial resistance detection; microbial ecology; shotgun metagenomics; genome-resolved metagenomics; microbiome analysis; resistome characterization; One Health

(This special issue belongs to the Section Molecular Pharmacology)

Endometriosis: Contemporary Insights and Emerging Perspectives

edited by

Márcia Mendonça Carneiro

submission deadline 31 Mar 2027 | Viewed by 339 | Submission Open

Keywords: endometrisis; infertility; chronic pelvic pain

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Infectious Disease Detection: Novel Assays and Biomarkers

edited by

Leonardo M. Leony

submission deadline 31 Mar 2027 | Viewed by 336 | Submission Open

Keywords: in vitro diagnostics (IVD); imunoassays; nucleic acid testing; serology; point-of-care testing (PoCT)

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Small Molecules and Antibodies for Targeted Cancer Therapies

edited by Chitra Subramanian

submission deadline 31 Mar 2027 | Viewed by 335 | Submission Open

Keywords: targeted therapy; small molecules; antibodies; drug resistance; metastasis; cancer treatment; mechanism of resistance

(This special issue belongs to the Section Molecular Pharmacology)

Novel Therapeutic Strategies Targeting Cancer Stem Cells

edited by Luciano Vellón

submission deadline 31 Mar 2027 | Viewed by 334 | Submission Open

Keywords: cancer stem cells; machine learning; deep learning; therapeutic response; molecular markers; cancer

(This special issue belongs to the Section Molecular Oncology)

Sarcomeric Proteins in Health and Disease: Progress and Prospects

edited by

Thomas C. Irving

submission deadline 31 Mar 2027 | Viewed by 330 | Submission Open

Keywords: sarcomeric proteins; muscle contraction; sarcomere

(This special issue belongs to the Section Molecular Biophysics)

Computational Models in Oncology: From Tumor Initiation to Progression to Treatment

edited by

Vladimir Simic

submission deadline 31 Mar 2027 | Viewed by 322 | Submission Open

Keywords: computational models; tumor growth; computational oncology; multiscale modeling; cancer progression; treatment response modeling; mathematical modeling

(This special issue belongs to the Section Molecular Informatics)

Research on Stem Cells in Neurological Disorders: Disease Modeling and Therapy

edited by

Xiaohua Jiang

submission deadline 31 Mar 2027 | Viewed by 311 | Submission Open

Keywords: disease modeling; molecular regulation; therapeutic intervention; neurological disorders

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Cellular Mechanisms Underlying Chronic Pain

edited by Patrícia Rodrigues

submission deadline 31 Mar 2027 | Viewed by 303 | Submission Open

Keywords: chronic pain; neuroinflammation; oxidative stress; ion channels; GPCR channels; nociception; peripheral sensitization; central sensitization; pain biomarkers; molecular signaling

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Approaches to Aquatic Animal Health: Immunobiology, Infectious Diseases, Antimicrobial Resistance and One Health

edited by

Partho Debnath

submission deadline 31 Mar 2027 | 1 articles | Viewed by 303 | Submission Open

Keywords: aquatic animal health; molecular immunology; infectious diseases; antimicrobial resistance; One Health; whole-genome sequencing; host–pathogen interactions; comparative genomics; molecular diagnostics; molecular epidemiology

(This special issue belongs to the Section Molecular Immunology)

Oxidative Stress and the Kidney: From Physiological Homeostasis to Pathophysiology and Nutraceutical Interventions

edited by

Daniele La Russa

and

Daniela Pellegrino

submission deadline 31 Mar 2027 | Viewed by 299 | Submission Open

Keywords: oxidative stress; nutraceuticals; CVD risk; CKD; antioxidant

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Effects and Applications of Nanoparticles in Plant Physiology

edited by

Fan Zhang

submission deadline 31 Mar 2027 | Viewed by 297 | Submission Open

Keywords: nano-enabled agriculture; nanotoxicology; molecular mechanisms; nanosafety; micro/nanoparticle stresses; combined risk

(This special issue belongs to the Section Molecular Plant Sciences)

Research in Cannabinoid Therapeutics: Novel Insights and Products

edited by

Daniela Sedan

and Dario Andrinolo

submission deadline 31 Mar 2027 | Viewed by 293 | Submission Open

Keywords: cannabinoids; acidic cannabinoids; entourage effect; full spectrum; endocannabinoid system; endocannabinoidome; endocannabinoids; endocannabinoid-like compounds; cannabis derivatives; endocannabinoidome receptors

(This special issue belongs to the Section Molecular Neurobiology)

Impact of Maternal Diet and Nutrition on Infant Neurodevelopment

edited by

Ana Sofia Vallés

submission deadline 31 Mar 2027 | Viewed by 288 | Submission Open

Keywords: nutrition; neurodevelopment; molecular mechanisms; epigenetics; neuroinflammation; metabolic programming; brain development; developmental origins of health and disease; pregnancy; maternal diet

(This special issue belongs to the Section Bioactives and Nutraceuticals)

State-of-the-Art Molecular Neurobiology in Malaysia

edited by

Mohamad Fairuz Yahaya

submission deadline 31 Mar 2027 | Viewed by 285 | Submission Open

Keywords: molecular neurobiology; traumatic brain injury; stroke; synaptic plasticity; biomarkers; neurotherapeutics; neurodegeneration; neuroinflammation; traumatic brain injury; stroke; synaptic plasticity; biomarkers; neurotherapeutics

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Structural, Dynamic, and Functional Biophysics of Membrane Proteins

edited by

F. Luis González Flecha

submission deadline 31 Mar 2027 | Viewed by 278 | Submission Open

Keywords: cryo-EM; x-ray crystallography and scattering; NMR spectroscopy; neutron scattering and reflectometry; single-molecule biophysics; molecular dynamics simulations; membrane protein dynamics; free energy analysis; mechanistic models of transport and signaling; membrane mimetics (nanodiscs, SMALPs, etc)

(This special issue belongs to the Section Molecular Biophysics)

Displaying special issue 2901-2950 on page 59 of 62.

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