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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Dietary Polyphenols and Human Health
edited by
submission deadline 20 Nov 2026 | 2 articles | Viewed by 1198 | Submission Open
Keywords: natural polyphenols; health and disease; neurodegenerative diseases; gut microbiota; lowest effective dose; molecular mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Pathogenesis and Treatment Approaches of Hematological Malignancies
edited by
submission deadline 20 Nov 2026 | 1 articles | Viewed by 1183 | Submission Open
Keywords: leukemia; lymphoma; minimal residual disease (MRD); cancer genomic profiling (CGP); molecular targeted therapy
(This special issue belongs to the Section Molecular Oncology)
Biophysical Studies of Protein Structure-Function Relationships
edited by , and Velia Minicozzi
submission deadline 20 Nov 2026 | 1 articles | Viewed by 1081 | Submission Open
Keywords: protein structure; molecular dynamics; computational modeling; drug discovery
(This special issue belongs to the Section Molecular Biophysics)
Metal-Organic Frameworks: Pioneering New Solutions for Biomedical Challenges submission deadline 20 Nov 2026 | 1 articles | Viewed by 977 | Submission Open
Keywords: MOFs; biomedical advances; drug delivery; personalized medicine; biomedical imaging; bio-sensor; smart MOFs; nanomedicine; cancer therapy
(This special issue belongs to the Section Materials Science)
Molecular Understanding Involved in Age-Related Diseases submission deadline 20 Nov 2026 | 1 articles | Viewed by 958 | Submission Open
Keywords: sirtuins; frailty; aging; age-related diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Pediatric Cancer: Advances in Hematopoietic Stem Cell Research
edited by
submission deadline 20 Nov 2026 | 1 articles | Viewed by 876 | Submission Open
Keywords: bone marrow; microenvironment; precursor; hematopoietic stem cells; pediatric hematological malignancies
(This special issue belongs to the Section Molecular Oncology)
Human Meningioma: Recent Developments
edited by Jason P. Sheehan, Yuki Shinya and Stylianos Pikis
submission deadline 20 Nov 2026 | Viewed by 754 | Submission Open
Keywords: meningioma; molecular pathogenesis; genomic alteration; radiogenomics; tumor microenvironment; biomarkers; neurosurgery; radiosurgery; translational neuroscience; artificial intelligence
(This special issue belongs to the Section Molecular Oncology)
Molecules and Mechanisms of Oxidative Stress Relevant in the Pathophysiology of Diseases: 2nd Edition
edited by
submission deadline 20 Nov 2026 | 1 articles | Viewed by 632 | Submission Open
Keywords: redox-active iron; reactive oxygen species; antioxidants; oxidative damage; biomarkers; degenerative disease
(This special issue belongs to the Section Molecular Biology)
The Involvement of the Ubiquitin Proteasome System in the Healthy and Diseased Heart
edited by
submission deadline 20 Nov 2026 | Viewed by 525 | Submission Open
Keywords: UPS; ubiquitin; proteasome; cardiac pathophysiology; coronary ischemia/reperfusion injury; heart failure; cardiomyopathies; E334K mutation; cMyBPC; electrophysiological dysfunction; hypertrophic cardiomyopathy; pharmacological targeting
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
ErbB Family of Receptor Tyrosine Kinases in Cancer and Drug Therapy
edited by Ilaria Marrocco and
submission deadline 20 Nov 2026 | Viewed by 512 | Submission Open
Keywords: ErbB; RTKs; EGFR; HER2; HER3; cancer; targeted therapies; drug resistance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research in Hepatic Amino Acid Catabolism
edited by Carolina Conter
submission deadline 20 Nov 2026 | Viewed by 458 | Submission Open
Keywords: amino acid catabolism; essential amino acids; non-essential amino acids; liver metabolism; urea cycle; gluconeogenesis; lipid metabolism; nutritional regulation; mTOR signaling; metabolic diseases
(This special issue belongs to the Section Biochemistry)
Bioactive Compounds in Foods: From Structural Profiling to Bioavailability and Health Benefits
edited by Cong Wang
submission deadline 20 Nov 2026 | Viewed by 454 | Submission Open
Keywords: food bioactives; profiling; bioactive compounds; characterization; bioavailability; bioaccessibility; functionality; health-promoting benefits; structure/constituents–bioactivity relationship
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Regulation of Gene Expression in Cell Differentiation
edited by
submission deadline 20 Nov 2026 | Viewed by 454 | Submission Open
Keywords: cell differentiation; gene expression regulation; signal transduction; autophagy; nutrigenomics; mechanobiology; longevity; aging mechanism; tumor progression; regenerative medicine; gene therapy; tissue remodeling
(This special issue belongs to the Section Molecular Genetics and Genomics)
Tau Pathology Mechanisms and Therapeutic Interventions
edited by
submission deadline 20 Nov 2026 | Viewed by 403 | Submission Open
Keywords: tau; misfolding; neurodegeneration; Alzheimer’s disease; oligomer; tauopathies; therapies; hyperphorphorylation; frontotemporal lobe dementia; synapses; spreading
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Stress Resilience: Unveiling Mechanisms and Mitigation Strategies
edited by
submission deadline 20 Nov 2026 | Viewed by 387 | Submission Open
Keywords: plant stress resilience; abiotic stress; biotic stress; stress signaling pathways; biostimulants; genetic and molecular mechanisms; crop improvement; GMO
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Insights into Cardiomyopathy
edited by
submission deadline 20 Nov 2026 | Viewed by 370 | Submission Open
Keywords: cardiomyopathy; inflammation; molecular mechanisms; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug Delivery for Human Diseases: From Basic Research to Clinical Applications
edited by
submission deadline 20 Nov 2026 | Viewed by 201 | Submission Open
Keywords: drug delivery systems; nanomedicine; targeted therapy; traditional medicine; translational pharmaceutical research
(This special issue belongs to the Section Molecular Pharmacology)
The Impact of the Exposome on Gut Health: Deciphering Molecular Mechanisms and Pathophysiological Pathways
edited by
submission deadline 20 Nov 2026 | Viewed by 191 | Submission Open
Keywords: exposome (internal & external); molecular gastroenterology; intestinal barrier function; gut-microbiota-host crosstalk; environmental toxicology; signal transduction pathways; nutritional epigenomics; metabolic dysregulation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapies of Colorectal Cancer: 5th Edition submission deadline 20 Nov 2026 | Viewed by 173 | Submission Open
Keywords: pancreatic cancer; metabolism; cellular plasticity; tumor microenvironment; target therapy
(This special issue belongs to the Section Molecular Oncology)
Latest Molecular Discoveries of Arthropod-Borne Viruses
edited by Henry Puerta-Guardo
submission deadline 20 Nov 2026 | Viewed by 159 | Submission Open
Keywords: arbovirus; whole genome sequencing; pathogenesis; transcriptomics; CRISPR-Cas9; in silico; antivirals; vaccines; diagnostics
(This special issue belongs to the Section Molecular Microbiology)
Advances in Olfactory Neurobiology, Adult Neurogenesis and Dopaminergic Neuron Research
edited by
submission deadline 20 Nov 2026 | Viewed by 135 | Submission Open
Keywords: olfaction; olfactory bulb; dopaminergic neurons; Parkinson’s disease; Alzheimer’s disease; adult neurogenesis; early biomarker; neurodegenerative disease; smell impairment; smell test
(This special issue belongs to the Section Molecular Neurobiology)
Role of MicroRNAs in Human Diseases: 2nd Edition
edited by
submission deadline 25 Nov 2026 | 10 articles | Viewed by 20287 | Submission Open
Keywords: microRNAs, miRNAs, miRs; preclinical models; target interaction; regulatory networks; oncology; cancer biology; cardiovascular disease; neurodegenerative conditions; diagnostic applications; therapeutic development and clinical trials
(This special issue belongs to the Section Molecular Genetics and Genomics)
Nutrition and Cardiovascular Development, from Fetal Origins to Adulthood
edited by
submission deadline 25 Nov 2026 | Viewed by 325 | Submission Open
Keywords: fetal programming; developmental origins of health and disease; maternal nutrition; placental function; offspring; cardiovascular function; cardiometabolic risk; cardio renal development; essential fatty acids; linoleic acid
(This special issue belongs to the Section Molecular Biology)
Novel Antiviral Agents: Challenges and Opportunities from Molecular Targeting to Validation submission deadline 25 Nov 2026 | Viewed by 212 | Submission Open
Keywords: antiviral agents; molecular targeting; virus–host interactions; drug repurposing; host-directed antivirals; combination therapy; antiviral resistance; translational virology
(This special issue belongs to the Section Molecular Pharmacology)
Advanced 3D-Bioprinting for Next-Generation In Vitro Models: Molecular and Technological Perspectives submission deadline 25 Nov 2026 | Viewed by 196 | Submission Open
Keywords: 3D bioprinting; in vitro models; biofabrication; bioinks; hydrogels; disease modeling; toxicology; drug screening; biomaterials; organ-on-a-chip
(This special issue belongs to the Section Macromolecules)
Nanomaterial: Synthesis and Application
edited by
submission deadline 25 Nov 2026 | Viewed by 180 | Submission Open
Keywords: nanomaterials; green synthesis; surface functionalization; nanoparticle engineering; drug delivery systems; energy storage; catalysis; environmental remediation; biocompatibility; molecular nanotechnology
(This special issue belongs to the Section Molecular Nanoscience)
Mitochondrial Functions and Dynamics
edited by
submission deadline 27 Nov 2026 | 4 articles | Viewed by 16688 | Submission Open
Keywords: bioenergetics; mitochondrial biogenesis; mitochondrial morphology; apoptosis; mitophagy; reactive oxygen species; calcium homeostasis; cardiovascular diseases; neurodegenerative diseases; in vitro, cellular, and animal models; myopathies; mitochondria and immune system
(This special issue belongs to the Section Molecular Biology)
Molecular Insight into Catalysis of Nanomaterials
edited by Dandan Liu
submission deadline 27 Nov 2026 | 3 articles | Viewed by 5136 | Submission Open
Keywords: nanomaterial catalyst; thermal catalysis; photocatalysis; electrocatalysis; DFT calculation
(This special issue belongs to the Section Molecular Nanoscience)
Mechanisms and Effects of Endocrine Disruptors and Environmental Contaminants on Human Health submission deadline 27 Nov 2026 | 3 articles | Viewed by 4926 | Submission Open
Keywords: environmental exposure; emerging compounds; human health; risk assessment; adverse outcome pathway; new approach methodologies; one health
(This special issue belongs to the Section Molecular Toxicology)
Recent Approaches for Wound Treatment: 3rd Edition submission deadline 27 Nov 2026 | 1 articles | Viewed by 3433 | Submission Open
Keywords: wound healing; inflammation; angiogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Insights into Buckwheat Reproductive Biology
edited by
submission deadline 27 Nov 2026 | 1 articles | Viewed by 2007 | Submission Open
Keywords: antioxidant properties; biotechnological methods; embryology; seed chemical composition; yield
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of Various Diseases and Drugs Involved in Vascular Tone Regulation in Cardiovascular Disease
edited by
submission deadline 27 Nov 2026 | 1 articles | Viewed by 1914 | Submission Open
Keywords: vasoconstriction; vasodilation; calcium; protein kinase C; Rho-kinase; hypertension; nitric oxide
(This special issue belongs to the Section Molecular Biology)
Solid Tumours in Focus: Tissue Biomarkers and Spatial Technologies in Cancer Pathology
edited by Kathryn Pennel
submission deadline 27 Nov 2026 | 2 articles | Viewed by 1606 | Submission Open
Keywords: biomarkers; cancer pathology; spatial biology; molecular mechanisms; tumour microenvironment; cell signalling and communication
(This special issue belongs to the Section Molecular Oncology)
Tissue Engineering and Advanced Biomaterials for Regenerative Medicine submission deadline 27 Nov 2026 | 1 articles | Viewed by 1336 | Submission Open
Keywords: tissue engineering; regenerative medicine; drug delivery; bioengineering; angiogenesis
(This special issue belongs to the Section Molecular Biology)
Harnessing Natural Compounds to Combat Cancer and Metastasis
edited by
submission deadline 27 Nov 2026 | Viewed by 954 | Submission Open
Keywords: natural compounds; bioactive molecules; natural extracts; chemotherapy; immunomodulatory compounds; anti-metastatic compounds; anti-angiogenic compounds
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Targeting Receptor Tyrosine Kinases and Related Signalling Pathways in Cancer: Mechanisms, Resistance, and Therapeutic Advances submission deadline 27 Nov 2026 | 1 articles | Viewed by 940 | Submission Open
Keywords: tyrosine kinase receptors (TKRs); tyrosine kinase inhibitors (TKIs); cancer; therapeutic resistance/cancer drug resistance/chemotherapy resistance; signaling pathways; metastasis; combination therapy; targeted therapy; next-generation inhibitors; allosteric inhibitors; personalized medicine; tumor microenvironment; immune evasion; immunotherapy; crosstalk in cancer signaling; miRNAs; lncRNAs; cancer therapeutics; biomarkers
(This special issue belongs to the Section Molecular Oncology)
Cellular Plasticity in Cancer: Mechanisms, Measurement and Therapeutic Opportunities
edited by Costa Frangou and
submission deadline 27 Nov 2026 | 1 articles | Viewed by 929 | Submission Open
Keywords: cellular plasticity; cancer progression; EMT/MET; lineage infidelity; therapy-induced reprogramming; stem-like states; single-cell analysis; spatial transcriptomics; lineage tracing; computational modeling; biomarkers; therapeutic re-sistance; metastasis; solid tumors
(This special issue belongs to the Section Molecular Oncology)
New Advances in DNA Nanotechnology
edited by Zhaoqi Yang
submission deadline 27 Nov 2026 | Viewed by 648 | Submission Open
Keywords: DNA nanotechnology; DNA-based drug delivery; DNA cages and DNA polyhedra; DNA origami; DNA-based electronic circuits; DNA-based sensors; DNA-based catalysis; DNA-based data storage
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Targeting and Pharmacology of Neuroinflammation
edited by
submission deadline 27 Nov 2026 | Viewed by 613 | Submission Open
Keywords: glia-targeted therapeutics; neuroinflammation; CNS drug development; astrocyte; microglia; neurodegeneration; translational neuroscience; biomarkers; human genetics; cytokine signaling
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research on Endocrine and Metabolic Diseases
edited by
submission deadline 27 Nov 2026 | Viewed by 343 | Submission Open
Keywords: systems biology; metabolomics; fluxomics; organoid models; epigenetic regulation; precision medicine; endocrine–metabolic crosstalk
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Nanocomplexes and Drug Delivery Systems for Cancer Therapy
edited by
submission deadline 27 Nov 2026 | Viewed by 333 | Submission Open
Keywords: nanocomplexes; drug delivery systems; cancer therapy; nanocarriers; stimuli-responsive systems; theranostics; biomolecules delivery; tumor microenvironment; personalized medicine; multidrug resistance
(This special issue belongs to the Section Molecular Nanoscience)
Current Research for Heart Disease Biology and Therapeutics: Fourth Edition
edited by Claudia Kusmic
submission deadline 29 Nov 2026 | 3 articles | Viewed by 2182 | Submission Open
Keywords: myocardial hypertrophy; cardiac remodeling; heart failure; drug therapy; molecular therapeutic targets; myocardial gene therapy; heart disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Ethylene Signaling in Plants: Molecular Mechanisms from Growth Regulation to Postharvest Biology submission deadline 29 Nov 2026 | Viewed by 320 | Submission Open
Keywords: ethylene signaling networks; ethylene in plant development and senescence; ethylene-responsive gene expression; ethylene control of senescence and ripening; ethylene in postharvest biology
(This special issue belongs to the Section Molecular Plant Sciences)
Viruses as Therapeutic Tools: Medical and Biotechnological Applications
edited by
submission deadline 30 Nov 2026 | 8 articles | Viewed by 28310 | Submission Open
Keywords: molecular virology; virus–host interactions; immunology; gene therapy vectors; vaccines; antivirals
(This special issue belongs to the Section Molecular Microbiology)
Antimicrobial and Antiviral Peptides: 2nd Edition
edited by
submission deadline 30 Nov 2026 | 5 articles | Viewed by 21787 | Submission Open
Keywords: antimicrobial peptides; antiviral peptides; peptide mining; molecular mechanism of biological activity; structure–activity relationship; molecular targets; in silico design; in vivo models; peptide delivery strategies; biomedical applications
(This special issue belongs to the Section Biochemistry)
Molecular Advances on Cannabinoid and Endocannabinoid Research, 3rd Edition submission deadline 30 Nov 2026 | 5 articles | Viewed by 17887 | Submission Open
Keywords: cannabinoid; endocannabinoid; cannabinoid receptor; endogenous cannabinoid; pharmacological research
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Epigenetics of Mental Disorders
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 17839 | Submission Open
Keywords: mental disorders; epigenetic; epigenomic; gene–environment interactions
(This special issue belongs to the Section Molecular Neurobiology)
Lifestyle Interventions in MASLD: Molecular and Clinical Perspectives
edited by Muhammad Y. Sheikh
submission deadline 30 Nov 2026 | 1 articles | Viewed by 17796 | Submission Open
Keywords: NAFLD (nonalcoholic fatty liver disease); MASLD (metabolic syndrome-associated steatotic liver disease); metabolic syndrome; dyslipidemia; diabetes mellitus 2; hypertension; natural bioactive
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Studies in Aging, 2nd Edition
edited by
submission deadline 30 Nov 2026 | 8 articles | Viewed by 17082 | Submission Open
Keywords: senescence; active aging; sarcopenia; osteoporosis; oxidative stress; brain aging; cardiovascular aging
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms Linked to Exercise
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 15615 | Submission Open
Keywords: molecular mechanisms; exercise adaptations; translational health
(This special issue belongs to the Section Molecular Biology)
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