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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biomarkers in Cardiovascular Diseases: Diagnosis, Pathology and Treatment submission deadline 20 Jan 2026 | 3 articles | Viewed by 5158 | Submission Open
Keywords: heart failure; myocardial remodeling; ischemic heart disease; myocarditis; cardiomyopathies; prevention; diagnosis; therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Immunologic Perspectives on Mycobacterium tuberculosis Infection submission deadline 20 Jan 2026 | 1 articles | Viewed by 5018 | Submission Open
Keywords: M. tb infection; molecular immunology; HIV; AIDS; pathogenesis; host immune responses; adjunctive therapy; immune-enhancing agents; antimycobacterial compounds; host-directed therapies; pathogenesis; modulation of host immune responses
(This special issue belongs to the Section Molecular Immunology)
Neurological Diseases: From Molecular Basis to Therapy
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 5012 | Submission Open
Keywords: neurological diseases; pathogenesis; therapy; personalized medicine; early diagnosis; genetics; neurology; pharmacology
(This special issue belongs to the Section Molecular Neurobiology)
Plant Molecular Regulatory Networks and Stress Responses
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 4748 | Submission Open
Keywords: plant stress response; stress response gene; regulatory mechanism; gene regulatory network; transcriptional regulation; post-transcriptional regulation; multi-omics integration; single-cell RNA-seq; spatial genomics; bioinformatics
(This special issue belongs to the Section Molecular Plant Sciences)
Tissue Regeneration and Repair in Airway Diseases
edited by Rolf Ziesche
submission deadline 20 Jan 2026 | 2 articles | Viewed by 4737 | Submission Open
Keywords: chronic inflammation; structural integrity; regenerative repair; structural disintegration; impact of aging on inflammation and repair
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights into Satellite DNAs submission deadline 20 Jan 2026 | 2 articles | Viewed by 4726 | Submission Open
Keywords: satellite DNA; satellitome; satellite DNA organization; satellite DNA evolution; satellite DNA origin; satellite DNA transcription; satellite DNA function; satellite DNA regulation; satellite RNA; heterochromatin; centromere; telomere; gene regulation; cancer; biomarkers; epigenetics; next-generation sequencing (NGS); nanopore sequencing; PacBio sequencing
(This special issue belongs to the Section Molecular Biology)
Chronic Kidney Disease: From Molecular Mechanisms to Therapeutic Approaches
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 4660 | Submission Open
Keywords: genetics; epigenetics; inflammation; metabolomics; oxiative stress
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Antimicrobial Activity submission deadline 20 Jan 2026 | 2 articles | Viewed by 4569 | Submission Open
Keywords: antimicrobial activity; antimicrobial agents; antimicrobial peptides; phytochemicals with antimicrobial properties; antimicrobial synergy; pathogen-specific targeting; antimicrobial resistance; biomedical science; nanotechnology in antimicrobials; genomic
(This special issue belongs to the Section Molecular Microbiology)
New Perspectives in Steroidomics
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 4506 | Submission Open
Keywords: steroidomics; steroids; pathophysiology; physiology; diagnostics; treatment; prediction; prognosis; LC-MS/MS; GC-MS/MS
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Diabetic Bone Disease: New Insights into Molecular Mechanisms and Therapeutic Approaches
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 4505 | Submission Open
Keywords: diabetic bone disease; molecular mechanisms; therapeutic approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and the Link Between Obesity, Diabetes and Inflammation submission deadline 20 Jan 2026 | 4 articles | Viewed by 4494 | Submission Open
Keywords: adipose tissue; biomarkers; diabetes; inflammation; obesity; cytokine; insulin resistance; signaling pathways; metabolic diseases
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
New Insights into Male Infertility and Sperm Biology
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 4251 | Submission Open
Keywords: male infertility; sperm DNA fragmentation; sperm oxidative stress; sperm nuclear condensation; assisted reproductive technologies; genomics; epigenomics; transcriptomics; proteomics; metabolomics
(This special issue belongs to the Section Molecular Biology)
Oral Squamous Cell Carcinoma: Insights into Molecular Pathways and Emerging Therapeutic Approaches
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 4221 | Submission Open
Keywords: oral squamous cell carcinoma; epigenetics; molecular genetics; gene expression targeted therapy; molecular biomarkers
(This special issue belongs to the Section Molecular Oncology)
Cell and Molecular Perspectives in Breast Cancer
edited by Seungbaek Lee
submission deadline 20 Jan 2026 | 1 articles | Viewed by 4213 | Submission Open
Keywords: breast cancer; molecular biology; cell biology; biomarker; novel therapeutics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Compounds: Structural Diversity, Modifications, and Biological Activities
edited by Tomasz Pospieszny
submission deadline 20 Jan 2026 | 3 articles | Viewed by 4180 | Submission Open
Keywords: bile acids; molecular research; biological activity; natural products; steroids
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Novel Insights into Molecular Mechanisms of Pulmonary Pathology
edited by Qiaozhen Liu
submission deadline 20 Jan 2026 | 2 articles | Viewed by 4151 | Submission Open
Keywords: fibrosis; infection; COPD; asthma; IPF; pneumonia; lung cancer; molecular mechanism
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research and Innovations in Green Monomers and Macromolecular Materials submission deadline 20 Jan 2026 | 2 articles | Viewed by 4117 | Submission Open
Keywords: green monomers and macromolecular material for a sustainable future; current barriers and future needs of green macromolecular materials; latest breakthroughs and approaches in molecular sciences; bio-based and/or biodegradable polymers based on natural; renewable; and synthetic polymers; synthesis; design; characterization; and development of innovative; technologically advanced; adaptable; and multifunctional green polymers in chemistry; biology; and medicine; relationships between structure; properties; functions; and performance of green polymers; sustainability; recycling; and environmental issues of green macromolecular materials; commercial applications: concepts; methodologies; and tools; 3D printing for personalized consumer products
(This special issue belongs to the Section Materials Science)
Applications of Machine Learning in Bioinformatics and Biomedicine
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 4083 | Submission Open
Keywords: bioinformatics; computational biology; machine learning; deep learning; AI for biology
(This special issue belongs to the Section Molecular Informatics)
Advances and Emerging Trends in Marine Natural Products
edited by Rafael Alexandre Faria da Costa Félix and
submission deadline 20 Jan 2026 | 3 articles | Viewed by 4007 | Submission Open
Keywords: marine natural products; bioprospecting; circular bioeconomy; bioactive compounds; antioxidant; antimicrobial; anti-inflammatory; polymers; peptides; genome mining; enzyme inhibitors; plant priming; green extraction methodologies
(This special issue belongs to the Section Molecular Pharmacology)
The Role of Artificial Intelligence in Cancer Treatment: Molecular Perspective
edited by Andra Valentina Krauze
submission deadline 20 Jan 2026 | 2 articles | Viewed by 3939 | Submission Open
Keywords: cancer treatment; artificial intelligence; machine learning; precision medicine; molecular insights
(This special issue belongs to the Section Molecular Informatics)
Molecular Insights into Lipodystrophy submission deadline 20 Jan 2026 | 2 articles | Viewed by 3898 | Submission Open
Keywords: lipodystrophy; adipogenesis; animal models; lipid metabolism; therapeutic targets; insulin signaling pathways; adipose tissue
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring the Complex Interplay Between Metabolic Diseases, MASLD, and Liver Cancer submission deadline 20 Jan 2026 | 3 articles | Viewed by 3835 | Submission Open
Keywords: hepatocellular carcinoma; MASLD; MASH; obesity; insulin resistance; dyslipidemia; liver cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Hormone Metabolism and Signaling in Human Health and Disease
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 3744 | Submission Open
Keywords: hormone metabolism; signaling pathways; pathophysiology; molecular and cellular biology; diseases originating from hormone disorders; hormonal therapy
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Pathophysiology and Treatment of Congenital Neuromuscular Disorders
edited by Johan Lindqvist
submission deadline 20 Jan 2026 | 2 articles | Viewed by 3670 | Submission Open
Keywords: nemaline myopathy; hereditary neuromuscular disorder; genetic mutations; pathogenesis; pathophysiology; therapy; myofilament dysfunction; congenital neuromuscular disorders; congenital muscular dystrophy; spinal muscular atrophy; Duchenne muscular dystrophy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Hemophilia: From Pathophysiology to Novel Therapies
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 3519 | Submission Open
Keywords: hemophilia; novel therapy in hemophilia; ultra-long half life clotting factor; clotting factor mimics; coagulation rebalancing agent; gene therapy; pathogenesis of hemophilia; molecular biology of hemophilia
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Role of HLA (Human Leucocyte Antigen) in Human Diseases submission deadline 20 Jan 2026 | 2 articles | Viewed by 3422 | Submission Open
Keywords: HLA (human leukocyte antigen); molecular immunology; autoimmune diseases; HLA genetics; antigen presentation; HLA and cancer; immunotherapy and HLA; immune responses; immunity and HLA; infectious diseases and HLA; innate and adaptive immunity; organ transplantation and HLA; HLA and immune responses; HLA genotypes and susceptibility; autoimmunity and HLA; HLA and infectious diseases; HLA and personalized therapies; molecular mechanisms of HLA; HLA mutations; experimental models of HLA; HLA and inflammation; HLA biomarkers; HLA and immunosuppression; immune tolerance and HLA; immune evasion by HLA
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Biology and Targeted Therapies in Leukemias
edited by Fabio Stagno and
submission deadline 20 Jan 2026 | 2 articles | Viewed by 3347 | Submission Open
Keywords: molecular biology; target therapy; leukemia; TKI; BCL-2; FLT3; CAR-T cells; CML
(This special issue belongs to the Section Molecular Oncology)
Lipid Peroxidation and Protein Carbonylation in Human Diseases
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 3333 | Submission Open
Keywords: free radicals; lipid peroxidation; protein carbonylation; apoptosis; autophagy; ferroptosis; antioxidant enzymes
(This special issue belongs to the Section Biochemistry)
Current Research for Heart Disease Biology and Therapeutics (Third Edition)
edited by Claudia Kusmic
submission deadline 20 Jan 2026 | 3 articles | Viewed by 3253 | Submission Open
Keywords: myocardial hypertrophy; cardiac remodeling; heart failure; drug therapy; molecular therapeutic targets; myocardial gene therapy; heart disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Targets in Gastrointestinal Diseases
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 3238 | Submission Open
Keywords: molecular pathways; gastrointestinal cancers; inflammatory bowel disease; targeted therapies; microbiota; gene editing
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Clostridial and Related Neurotoxins, 3rd Edition
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 3230 | Submission Open
Keywords: botulinum neurotoxin; BoNT; toxicity; molecular mechanisms; recombinant; derivative; clostridium botulinum
(This special issue belongs to the Section Molecular Toxicology)
Molecular Advances in Understanding Plant-Microbe Interactions submission deadline 20 Jan 2026 | 2 articles | Viewed by 3197 | Submission Open
Keywords: phytomicrobiome; symbiosis; pathogen resistance; microbial signalling
(This special issue belongs to the Section Molecular Plant Sciences)
Oxidative Stress Responses in Cardiovascular Diseases
edited by Vladimir Jakovljevic
submission deadline 20 Jan 2026 | 1 articles | Viewed by 3173 | Submission Open
Keywords: antioxidant capacity; cardiovascular disease; cell death; endothelial dysfunction; ischemia/reperfusion injury; oxidative stress
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Hematologic Diseases: Molecular Insights and Novel Methods
edited by and Samantha Bruno
submission deadline 20 Jan 2026 | 1 articles | Viewed by 3160 | Submission Open
Keywords: hematologic malignancies; high-throughput technologies; omics data; biomarkers; drug resistance; minimal residual disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genomics of Human Disease
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 3107 | Submission Open
Keywords: genome-wide association study (GWAS); next-generation sequencing (NGS); multi-omics analysis; epidemiology data analysis; precision medicine approaches; disease prediction analysis
(This special issue belongs to the Section Molecular Genetics and Genomics)
New Insights into Plant Stress submission deadline 20 Jan 2026 | 3 articles | Viewed by 3105 | Submission Open
Keywords: abiotic stress; biotic stress; bioinformatics; artificial intelligence; biotechnology; breeding; crop plants; horticultural plants; GWAS; CRISPR-Cas; multi-omics; genomics; epigenomics; transcriptomics; proteomics; genetic diversity; gene expression
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Dynamics Simulations of Protein Structures
edited by Alfonso Trezza
submission deadline 20 Jan 2026 | 3 articles | Viewed by 3084 | Submission Open
Keywords: molecular dynamics simulations; protein structure analysis; computational methods in structural biology; bioinformatics and drug discovery; protein– ligand interactions
(This special issue belongs to the Section Molecular Biophysics)
Advances in Molecular Research of Cartilage: 2nd Edition
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2949 | Submission Open
Keywords: articular cartilage; cartilage lesions; tissue engineering; cell therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms: New Insights into the Pathogenesis of Neonatal Disorders
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2900 | Submission Open
Keywords: neonate; neonatal infections; molecular and cellular mechanisms; necrotizing enterocolitis; immature immune system; neonatal inflammation; epigenetic modification; regulatory RNAs; bronchopulmonary dysplasia; neonatal hypoxic– ischemic injury
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancing Precision Medicine in Urological Cancers: Integrating Multi-Omics and Optimizing Therapeutic Approaches
edited by Magaly Martinez-Ferrer
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2773 | Submission Open
Keywords: prostate cancer; proteomics; metabolomics; precision medicine; biomarker
(This special issue belongs to the Section Molecular Oncology)
Psoriasis: Molecular Pathologies, Lipid Disturbances, Diagnosis and Therapeutic Strategies
edited by Hanna Mysliwiec
submission deadline 20 Jan 2026 | 3 articles | Viewed by 2717 | Submission Open
Keywords: psoriasis; pathogenesis; lipid metabolism disturbances; metabolic syndrome; systemic comorbidities; epigenetics; therapeutic strategies; biologic treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Dysregulation of Bone Health–a Matter of Several Culprits
edited by Ana Gomes
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2691 | Submission Open
Keywords: bone metabolism; osteoporosis; osteopenia; low-impact fractures; osteoimmunology; leptin; lung disorders; cancer; renal disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Chronic Lymphocytic Leukemia: Molecular Pathologies and Therapeutic Strategies
edited by Tang Her Jaing
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2634 | Submission Open
Keywords: chronic lymphocytic leukemia; genomic landscapes; precision medicine; clinical trials; biomarker
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Microbial Resistance Mechanisms in Biotechnology: From Extremes to Applications
edited by Giovanni Gallo and
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2633 | Submission Open
Keywords: microorganism resistance systems; extreme environments; molecular adaptation; genetic pathways; biotechnological applications; industrial biotechnology; environmental remediation; extremophiles; stress tolerance; evolutionary adaptations
(This special issue belongs to the Section Molecular Microbiology)
The Multiple Faces of Non-Small Cell Lung Cancer: Targeted Therapies and Recent Developments
edited by Angelo Delmonte and Alberto Verlicchi
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2626 | Submission Open
Keywords: non-small cell lung cancer; tyrosine-kinase inhibitors; next generation sequencing; immunoconjugates; targeted therapies 
(This special issue belongs to the Section Molecular Oncology)
Exploring New Field in Hydrocolloids Research and Applications
edited by , Cristina Elena Dinu-Pirvu and
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2619 | Submission Open
Keywords: drug delivery systems; controlled-release; targeted delivery; wound healing; tissue engineering; bioadhesive agents; transdermal patches; mucoadhesive hydrogels; ophthalmic preparations; oral disintegrating films; gastroretentive systems; rheology modifiers; textural characteristics; stabilizing agents; encapsulation for protection and stability (drugs; probiotics and bioactive compounds); 3D bioprinting; nutraceutical delivery
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Cell Envelope Biogenesis and, Molecular Strategies to Maintain Cellular Homeostasis in Bacteria submission deadline 20 Jan 2026 | 3 articles | Viewed by 2619 | Submission Open
Keywords: LpxC and the regulation of LPS; periplasmic protein folding; disulfide bond formation; BAM proteins and assembly of outer membrane proteins; periplasmic protease DegP (HtrA); lipopolysaccharide assembly; LPS modifications and diversity; LPS and phospholipid trafficking; bacterial virulence factors; antibiotic resistance; extracytoplasmic function sigma factors; regulatory RNAs; two-component systems; lipid A and its modification
(This special issue belongs to the Section Molecular Microbiology)
Autophagy and Kidney Diseases
edited by Francesco Reggiani
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2566 | Submission Open
Keywords: autophagy; kidney diseases; cellular homeostasis; molecular signaling; autophagy biomarkers; renal homeostasis; autophagy modulators
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Innovative Strategies in the Design and Development of Anticancer Agents
edited by Sanjay Kumar
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2555 | Submission Open
Keywords: chemotherapy; biomimetic; natural product analogs; prodrugs; nanodrugs; drug release
(This special issue belongs to the Section Molecular Pharmacology)
Structure, Function and Dynamics in Proteins: 3rd Edition
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2506 | Submission Open
Keywords: protein structure and dynamics; protein– protein and protein– DNA interactions; protein folding and misfolding; protein aggregation processes; intermediate/misfolded states; conformational equilibria; DNA and ligand recognition mechanisms; membrane receptors; enzyme dynamics; metal-binding proteins; intrinsically disordered proteins; cell signaling; phase separation mechanims; solution- and solid-state NMR; molecular dynamics simulations; time-resolved X-ray; NMR relaxation; in-/on-cell NMR; cryo-EM; fluorescence polarization; surface plasmon resonance; static and dynamic light scattering; isothermal titration calorimetry; microscale thermophoresis; protein– fragment complementation assay; cross-linking; protein microarray
(This special issue belongs to the Section Molecular Biology)
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