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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms of SARS-CoV-2 Infection and Pathogenesis

edited by

Virginia Lotti

and

Erica Diani

submission deadline 28 Feb 2026 | Viewed by 99 | Submission Open

Keywords: SARS-CoV-2; molecular virology; host– pathogen interactions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Stress Resilience: Unveiling Mechanisms and Mitigation Strategies

edited by

Giuseppe Mannino

submission deadline 28 Feb 2026 | Viewed by 99 | Submission Open

Keywords: plant stress resilience; abiotic stress; biotic stress; stress signaling pathways; biostimulants; genetic and molecular mechanisms; crop improvement; GMO

(This special issue belongs to the Section Molecular Plant Sciences)

Epigenetic Elicitation of Dormant Microorganisms for Anti-Cancer Therapy

edited by

Komal Anjum

submission deadline 28 Feb 2026 | Viewed by 99 | Submission Open

Keywords: dormant microbes; epigenetic; bioactive molecules; anti-cancer therapy; biosynthetic pathways; bioactive secondary metabolites

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Basis of Proteinopathies in Neurodegenerative Diseases

edited by

Kyoung Joo Cho

submission deadline 28 Feb 2026 | Viewed by 97 | Submission Open

Keywords: protein misfolding; neurodegenerative diseases; protein aggregation; proteostasis; post-translational modifications; ubiquitin– proteasome system; autophagy; targeted protein degradation; therapeutic strategies

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Signatures for Risk Stratification and Therapeutic Decision-Making in Primary and Recurrent Prostate Cancer

edited by

Chengfei Liu

submission deadline 28 Feb 2026 | Viewed by 95 | Submission Open

Keywords: molecular mechanisms; biomolecular research; mechanistic insights; molecular pathways; translational biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Future Perspective and Challenge of Nanomaterials

edited by

Antreas Afantitis

submission deadline 28 Feb 2026 | Viewed by 94 | Submission Open

Keywords: nanomaterial; nanoinformatics; materials informatics; functional material; molecular dynamics

(This special issue belongs to the Section Molecular Nanoscience)

Identification and Analysis of Interspecies Interactions in Microbial Biofilms

edited by

Terence L. Marsh

submission deadline 28 Feb 2026 | Viewed by 94 | Submission Open

Keywords: biofilm; interspecies communication; biofilm demographics; competition; commensalism; parasitism; mutualism; methodologies

(This special issue belongs to the Section Molecular Microbiology)

Molecular Motor Mechanochemistry: Structure, Dynamics, and Function

edited by

Takeshi Sakamoto

submission deadline 28 Feb 2026 | Viewed by 91 | Submission Open

Keywords: molecular motors; kinesin; dynein; myosin; DNA helicase; cell motility; non-muscle myosin II; vesicle trafficking/transportation; single molecule imaging; force measurement; structure of cytoskeleton; ATP synthesis

(This special issue belongs to the Section Biochemistry)

Design and Application of Biocatalysts: Emerging Advances and Innovations in Enzyme Immobilization and Technologies

edited by

María Luján Ferreira

submission deadline 28 Feb 2026 | Viewed by 90 | Submission Open

Keywords: low-cost immobilization of enzymes; treatments post-immobilization; enzymatic synthesis of derivatives; polyesters depolymerization; hydroxy-acids polymerization; bioimprinting; post-immobilization treatments; composites

(This special issue belongs to the Section Biochemistry)

Biological Polyphenols in Cognitive Impairment-Related Diseases: Effects, Dosage and Molecular Mechanisms

edited by

Chunmei Li

submission deadline 28 Feb 2026 | Viewed by 89 | Submission Open

Keywords: natural polyphenols; cognitive impairment-related diseases; Alzheimer's disease; Parkinson's disease; depression; anxiety; lowest effective dose; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Machine Learning in RNA and Chromatin Dynamics

edited by Haopeng Yu

submission deadline 28 Feb 2026 | Viewed by 89 | Submission Open

Keywords: machine learning; chromatin architecture; RNA dynamics; genomic foundation models; computational biology

(This special issue belongs to the Section Molecular Biology)

New Advances in Cardio-Oncology: Mechanisms, Biomarkers, and Therapeutic Strategies

edited by Valentina Citi

submission deadline 28 Feb 2026 | Viewed by 89 | Submission Open

Keywords: cardio-oncology; cardiotoxicity; cancer therapies; cardiovascular complications; risk stratification; biomarkers; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Exploring Glia: New Insights into Neurobiology and Therapeutic Potential

edited by María de los Ángeles García-Robles

submission deadline 28 Feb 2026 | Viewed by 88 | Submission Open

Keywords: glial metabolism; astrocytes; microglia; oligodendrocytes; tanycytes; obesity; diabetes; metabolic disorders; neurogenesis; cognitive decline

(This special issue belongs to the Section Molecular Neurobiology)

Amino Acid and Sugar Metabolism in Disease

edited by V. Tkach

submission deadline 28 Feb 2026 | Viewed by 83 | Submission Open

Keywords: metabolic diseases; metabolic disturbances; carbohydrate metabolism; aminoacid metabolism; artificial sweeteners; metabolic path alterations

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Pivotal Role of Endothelial Cells in Vascular Homeostasis and Immune Regulation

edited by

Ilenia Calcaterra

submission deadline 28 Feb 2026 | Viewed by 82 | Submission Open

Keywords: endothelial cells; vascular homeostasis; immune regulation; leukocyte trafficking; endothelial barrier function; mechanotransduction; glycocalyx; endothelial dysfunction; atherosclerosis; thrombosis

(This special issue belongs to the Section Molecular Immunology)

Pancreatic Ductal Adenocarcinoma: Unveiling Pathogenic Mechanisms and Pioneering Novel Therapeutic Strategies

edited by

Elena Astanina

submission deadline 28 Feb 2026 | Viewed by 81 | Submission Open

Keywords: pancreatic ductal adenocarcinoma; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Stem Cell Research in Urological, Hepatological, and Ophthalmological Disorders

edited by Yuanyuan Zhang

submission deadline 28 Feb 2026 | Viewed by 80 | Submission Open

Keywords: stem cells; induced pluripotent stem cells (iPSCs); exosomes; tissue regeneration; urinary incontinence; kidney dysfunction; ocular disorders; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

Application of Metabolomics in Health and Human Diseases: Diagnostic, Therapeutic, Nutritional and Nutraceutical Perspectives

edited by

Barbara Tomasello

and Francesco Bellia

submission deadline 28 Feb 2026 | Viewed by 80 | Submission Open

Keywords: metabolomics; metabolomic profile biomarkers; preclinical studies; clinical studies; drug and nutraeuticals biological activities; precision medicine; personalized medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Diagnostics and Therapeutics of Neurodegenerative Disease

edited by

Romina Combi

submission deadline 28 Feb 2026 | Viewed by 78 | Submission Open

Keywords: neurodegenerative disorders; biomarkers; diagnosis; therapy

(This special issue belongs to the Section Molecular Neurobiology)

Viral and Host Targets to Fight RNA Viruses: 2nd Edition

edited by

Tommaso Felicetti

submission deadline 28 Feb 2026 | Viewed by 77 | Submission Open

Keywords: RNA viruses; antiviral agents; medicinal chemistry; direct-acting antivirals; host-targeting agents; drug design

(This special issue belongs to the Section Molecular Microbiology)

Next-Generation Drug Development: Novel Modalities, AI Modeling, and Biomarkers

edited by

Chun-Yi Wu

submission deadline 28 Feb 2026 | Viewed by 76 | Submission Open

Keywords: pharmacokinetics; PK/PD modeling; biologics; antibody– drug conjugates (ADCs); biomarkers; artificial intelligence; novel therapeutic modalities; precision medicine

(This special issue belongs to the Section Molecular Pharmacology)

Advancements in Prognostic and Predictive Biomarkers for Advanced Prostate Cancer

edited by

Daniel Khalaf

submission deadline 28 Feb 2026 | Viewed by 75 | Submission Open

Keywords: biomarkers; predictive biomarkers; prognostic biomarkers; genomic biomarkers; biomarker directed therapy; advanced prostate cancer; metastatic prostate cancer; circulating tumour DNA; precision oncology; systemic therapy

(This special issue belongs to the Section Molecular Oncology)

Unveiling the Multifaceted Potential of Mesenchymal Stem/Stromal Cells and Their Extracellular Vesicles

edited by

Bruno Solano de Freitas Souza

submission deadline 28 Feb 2026 | Viewed by 75 | Submission Open

Keywords: mesenchymal stem/stromal cells; extracellular vesicles; molecular mechanisms; preclinical and clinical studies; GMP manufacturing and scale-up

(This special issue belongs to the Section Molecular Biology)

Molecular Handshakes: Engineering Protein–Ligand Interfaces for Precision Drug Design

edited by Tarun Jairaj Narwani

submission deadline 28 Feb 2026 | Viewed by 74 | Submission Open

Keywords: structure-based drug design (SBDD); AI-driven drug discovery; protein– ligand dynamics; molecular interface engineering; structural biology; chemical biology; allosteric modulation; undruggable targets and drug resistance

(This special issue belongs to the Section Biochemistry)

Interactions Between Nanoparticles and Biomolecules

edited by

Zhengwei Huang

submission deadline 28 Feb 2026 | Viewed by 74 | Submission Open

Keywords: nanoparticle– biomolecule interaction; nanomedicine; bio-corona; targeting; in vivo fate

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Xenobiotic Toxicity: From Transcriptional Regulation to Reproductive and Behavioural Impacts

edited by Sylwia Swigonska

submission deadline 28 Feb 2026 | Viewed by 72 | Submission Open

Keywords: xenobiotic interactions; molecular mechanisms of toxicity; reproductive toxicology; early biomarkers; emerging contaminants; neurobehavioral toxicity; microbiota– xenobiotic interactions; biomolecular responses; environmental health; molecular toxicology

(This special issue belongs to the Section Molecular Toxicology)

Molecular Developments in the Diagnosis and Treatment of Cerebral Gliomas

edited by

Alejandro N. Santos

submission deadline 28 Feb 2026 | Viewed by 72 | Submission Open

Keywords: glioma; molecular profiling; liquid biopsy; radiogenomics; tumor microenvironment; immuno-therapy; targeted therapy; blood– brain barrier; biomarkers; precision oncology

(This special issue belongs to the Section Molecular Nanoscience)

T Cell Immunity in Coronavirus Infection: Mechanisms, Dysregulation, and Therapeutic Targets

edited by Jian Zheng

submission deadline 28 Feb 2026 | Viewed by 70 | Submission Open

Keywords: T cell; coronavirus; immune memory; immunopathogenesis; aging

(This special issue belongs to the Section Molecular Immunology)

The Role of Diet and Nutrition in Metabolic Diseases

edited by

Junjie Luo

submission deadline 28 Feb 2026 | Viewed by 69 | Submission Open

Keywords: diet; nutrition; metabolic diseases; molecular mechanisms; nutrigenomics; metabolomics; epigenetics; mitochondrial function; oxidative stress; biomarkers

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Structure–Property Correlations in Electrocatalysis: Role of Chemistry, Phases, and Morphology

edited by

Dawid Kutyła

submission deadline 28 Feb 2026 | Viewed by 65 | Submission Open

Keywords: electrocatalysis; structure– property correlations; chemical composition; phases; morphology; porous electrodes; high-entropy alloys; molten salts; semiconductors; nanostructures; operando methods; hydrogen/oxygen evolution; CO2 reduction; fuel cells

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Nano-Enabled Molecular Strategies Against Oxidative Stress in Human Physiology

edited by

Ali Amer

submission deadline 28 Feb 2026 | Viewed by 61 | Submission Open

Keywords: nanoparticles; oxidative stress; reproductive toxicology; redox signalling pathways; mitochondrial regulation; controlled drug release; antioxidant defence mechanisms; pharmaceutical nanotechnology

(This special issue belongs to the Section Molecular Immunology)

Synthesis and Activity of Natural Products and Analogues

edited by

Jin-pyo An

submission deadline 28 Feb 2026 | Viewed by 60 | Submission Open

Keywords: natural products; functional food; synthesis; high-resolution mass spectrometry; bioactive compound

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Innate Immune Response in Infectious Diseases

edited by

Julia Fischer

submission deadline 28 Feb 2026 | Viewed by 56 | Submission Open

Keywords: innate immunity; metabolism; bacteria; virus; inflammation; mechanism; immune defense

(This special issue belongs to the Section Molecular Immunology)

Innovative Delivery Systems of Natural and Synthetic Active Compounds

edited by

Aleksandra Gostyńska-Stawna

submission deadline 28 Feb 2026 | Viewed by 55 | Submission Open

Keywords: delivery systems; nanocarriers; natural and synthetic compounds; oral and parenteral administration; molecular mechanisms of action

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Dietary Fibre, Nutrition in Gastrointestinal Diseases

edited by

Sara Jarmakiewicz-Czaja

submission deadline 1 Mar 2026 | Viewed by 134 | Submission Open

Keywords: dietary fibre; gut microbiome; gastrointestinal disease; inflammatory bowel disease; nutrients; nutrition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Advance on Skin Irritation and Inflammation

edited by Nazgol-Sadat Haddadi

submission deadline 12 Mar 2026 | Viewed by 86 | Submission Open

Keywords: photoimmunology; keratinocyte stress; type I interferon; cutaneous lupus erythematosus; der-matomyositis; monocyte-derived dendritic cells; fibroblast heterogeneity; cytokine– chemokine networks; single-cell and spatial omics; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Natural Products in Health and Diseases

edited by

Katarína Bauerová

submission deadline 15 Mar 2026 | 4 articles | Viewed by 14855 | Submission Open

Keywords: natural products; health; chronic diseases; biomolecular research; functional food; oncology; rheumatology; infections; inflammation; autoimmunity

(This special issue belongs to the Section Molecular Pharmacology)

Translating Molecular Psychiatry: From Biomarkers to Personalized Therapies

edited by

Masaru Tanaka

submission deadline 20 Mar 2026 | 11 articles | Viewed by 44277 | Submission Open

Keywords: molecular psychiatry; biomarkers; pharmacogenomics; precision medicine; gene-environment Interaction; neuroinflammation; immune modulation; neuroimaging; molecular imaging; psychiatric disorders

(This special issue belongs to the Section Molecular Neurobiology)

Kynurenic Acid: Emerging Research Advances and Therapeutic Implications

edited by

Piotr Paluszkiewicz

and Monika Turska-Kozłowska

submission deadline 20 Mar 2026 | 8 articles | Viewed by 39988 | Submission Open

Keywords: kynurenic acid; kynurenine pathway; kynurenine; therapeutic use; supply and distribution

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Signaling Pathways Dysregulation in Cancer: Advances and New Therapeutics Hopes

edited by

Daniela Miricescu

submission deadline 20 Mar 2026 | 11 articles | Viewed by 34266 | Submission Open

Keywords: cancer; epithelial cells; oncogenic mutations; PI3K/AKT/mTOR; TGF-β ; Ras/Raf/MEK/ERK; Wnt/β -catenin; angiogenesis; invasion; metastasis; inhibitors

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Therapies of Chronic Obstructive Pulmonary Disease

edited by

Marija Stankovic

submission deadline 20 Mar 2026 | 8 articles | Viewed by 32608 | Submission Open

Keywords: COPD; molecular mechanism; inflammation; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research and Insights into COVID-19: Third Edition

edited by

Manuela Rizzi

and

Pier Paolo Sainaghi

submission deadline 20 Mar 2026 | 4 articles | Viewed by 28887 | Submission Open

Keywords: SARS-CoV-2; COVID-19; prognostic and diagnostic biomarkers; molecular mechanism of infection; molecular pathophysiology; immune response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant-Sourced Functional and Bioactive Compounds—Nature’s Blueprint for Improving Human Well-Being

edited by

Dasha Mihaylova

and

Aneta Popova

submission deadline 20 Mar 2026 | 8 articles | Viewed by 26587 | Submission Open

Keywords: plants; antioxidants; phytochemicals; phyto-nutrition; natural products; health enhancing

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Serum Amyloid A (SAA) Family: (Patho)Physiological Functions in (Non)Mammalian Systems

edited by

Ernst Malle

and

János G. Filep

submission deadline 20 Mar 2026 | 7 articles | Viewed by 24998 | Submission Open

Keywords: Serum Amyloid A in (Non)Mammalian systems; phylogenetic overview of different SAA isoforms; expression of SAA1-4 on mRNA and protein level; comparison of SAA with other acute-phase reactants; role of SAA during normal development and inflammation; role of SAA in cancer and other malignancies; potential role of SAA as a suitable biomarker during disease progression

(This special issue belongs to the Section Biochemistry)

Advances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2nd Edition

edited by

Vincent C. Lombardi

submission deadline 20 Mar 2026 | 4 articles | Viewed by 24863 | Submission Open

Keywords: ME/CFS; PASC; long COVID-19; inflammation; innate immunity; adaptive immunity; mast cell activation; post-infection syndrome; metabolism; autoantibodies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Therapeutics for Diabetes and Related Complications, 2nd Edition

edited by

Kota V. Ramana

submission deadline 20 Mar 2026 | 8 articles | Viewed by 24485 | Submission Open

Keywords: diabetes; diabetes complications; molecular therapeutics; drug development; hyperglycemia; insulin resistance; cell signaling and oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Therapeutic Strategies for Neurodegenerative Disease

edited by

Vasileios Papaliagkas

submission deadline 20 Mar 2026 | 4 articles | Viewed by 23784 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; therapy

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Cell Metabolism in Endocrine Diseases

edited by

Antonella Muscella

submission deadline 20 Mar 2026 | 7 articles | Viewed by 23408 | Submission Open

Keywords: cellular metabolism; homeostasis; endocrine disorders; hormonal signals; dynamic system

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Recent Advances in Human Papillomavirus (HPV) Research

edited by

Jane Shen-Gunther

submission deadline 20 Mar 2026 | 3 articles | Viewed by 22866 | Submission Open

Keywords: human papillomavirus (HPV)/genetics; HPV-associated cancers; HPV cell-free DNA (cfDNA); HPV circulating tumor DNA (ctDNA); HPV circulating tumor cells (CTCs); carcinogenesis/genetics; CRISPR-cas systems/genetics; digital PCR; molecular diagnostics/methods; point-of-care diagnostics/methods; next-generation sequencing/methods; single-cell sequencing/methods; genomics; epigenomics; proteomics; metagenomics; phylogenomics; virus evolution; virus– host interactions; virus integration/genetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Lung Cancers: An Update on Molecular Diagnostics and Therapy

edited by

Mariusz Chabowski

submission deadline 20 Mar 2026 | 6 articles | Viewed by 22567 | Submission Open

Keywords: lung cancer; cancer cachexia; prognosis; anti-lung cancer agents

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 1151-1200 on page 24 of 65.

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