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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Chlamydia trachomatis Pathogenicity and Disease (Third Edition)

edited by

Rosa Sessa

and

Marisa Di Pietro

submission deadline 20 Apr 2026 | Viewed by 296 | Submission Open

Keywords: Chlamydia trachomatis; virulence factors; host susceptibility or resistance; innate and adaptive immune responses; genetic studies; cervico-vaginal microbiota; clinical outcomes with molecular study

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Genomics and Genome Editing, 3rd Edition

edited by

Hikmet Budak

submission deadline 20 Apr 2026 | Viewed by 285 | Submission Open

Keywords: next-generation sequencing; structural and functional genomics; SNPs; miRNA; LncRNA; CRISPR/Cas9; TALEN; genome editing

(This special issue belongs to the Section Molecular Plant Sciences)

Unveiling Molecular Mysteries of Brain Barriers

edited by Ana Catarina Duarte

submission deadline 20 Apr 2026 | Viewed by 284 | Submission Open

Keywords: blood– brain barrier; blood– cerebrospinal fluid barrier; arachnoid barrier; transport mechanisms; drug delivery; drug metabolism; ATP-binding cassete (ABC) transporters

(This special issue belongs to the Section Molecular Neurobiology)

Selected Papers from the 1st RNA and RNase International Meeting and Related Research

edited by

Ester Boix

submission deadline 20 Apr 2026 | Viewed by 282 | Submission Open

Keywords: RNA; RNase; diagnosis markers; drug design; cell signalling; immunology; infection; cancer; structural biology; RNA binding proteins; RNA recognition patterns; RNA catalysis

(This special issue belongs to the Section Biochemistry)

Current Molecular Advances in Apoptosis

edited by

Mariarosaria Boccellino

and

Davide Viggiano

submission deadline 20 Apr 2026 | Viewed by 272 | Submission Open

Keywords: apoptosis; glomerulonephritis; aging; caspase; endonuclease; DNA; cytokeratin

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms Underlying Antimicrobial Resistance in Mycobacteria

edited by Maria Del Carmen Muñoz-Egea

submission deadline 20 Apr 2026 | Viewed by 271 | Submission Open

Keywords: mycobacteria; nontuberculous mycobacteria; Mycobacterium tuberculosis; antimicrobial resistance; drug resistance mechanisms; molecular mechanisms; antibiotic resistance

(This special issue belongs to the Section Molecular Microbiology)

Application of NMR Spectroscopy in Biomolecules: 2nd Edition

edited by

Luigi Russo

submission deadline 20 Apr 2026 | Viewed by 257 | Submission Open

Keywords: advanced solution and solid state biomolecular NMR techniques; structure and dynamics of biomolecules: proteins; peptides; and nucleic acids; paramagnetic NMR; in/on cell-NMR; protein– ligand; protein– DNA; protein– RNA interaction; protein folding and misfolding; structure-based drug screening; fragment-based drug screening; computational NMR methods; sample preparation and isotope labeling strategies; NMR metabolomics and foodomics; membrane proteins and lipids; natural-abundance NMR spectroscopy; pharmaceutical NMR applications; disordered proteins and peptides; drugs development; metal-binding biomolecules; hyperpolized NMR techniques; 19F NMR spectroscopy; NMR techniques for the analysis of complex mixtures; integrated NMR-based methodologies

(This special issue belongs to the Section Molecular Biophysics)

Immunopathogenesis and Novel Therapeutic Strategies for Systemic Lupus Erythematosus: Third Edition

edited by

Marzena Olesińska

and Hanna Przepiera-Bȩdzak

submission deadline 20 Apr 2026 | Viewed by 252 | Submission Open

Keywords: systemic lupus erythematosus; SLE pathogenesis; the epigenetic regulation of lupus; the genetic background of SLE; interferon; cytokine networks; innate immunity; adaptive immunity

(This special issue belongs to the Section Molecular Immunology)

Bioactives from Natural Products

edited by

Antía González Pereira

submission deadline 20 Apr 2026 | Viewed by 252 | Submission Open

Keywords: natural products; bioactive compounds; therapeutic potential; secondary metabolites; omics technologies; biotechnology; phytochemistry; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Sex Determination and Differentiation

edited by

Martin A. Estermann

submission deadline 20 Apr 2026 | Viewed by 244 | Submission Open

Keywords: sex determination; sex differentiation; ovary; testis; epigenetics; gene regulatory networks; DSDs; transcriptomics; evolution

(This special issue belongs to the Section Molecular Biology)

The Anti-Inflammatory and Antioxidant Potential of Phytochemicals

edited by

Woo-Sik Jeong

submission deadline 20 Apr 2026 | Viewed by 244 | Submission Open

Keywords: phytochemicals; dietary bioactives; inflammation; natural compounds; functional foods; oxidative stress; cytokine modulation; NF-κ B signaling; chronic diseases; plant-derived metabolites

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Magnetic Materials: Synthesis, and Applications

edited by Artur Chrobak

submission deadline 20 Apr 2026 | Viewed by 242 | Submission Open

Keywords: magnetic materials; properties; synthesis; applications

(This special issue belongs to the Section Materials Science)

Protection of Natural Products in Liver Injury

edited by

Jeon-Ok Moon

submission deadline 20 Apr 2026 | Viewed by 241 | Submission Open

Keywords: liver injury; natural product; antioxidant activity; modulation of inflammatory pathway; mitigation of fibrosis; pharmacology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Liver Disease: Pathogenesis, Progression, and Therapeutic Strategies

edited by

Andrea Dalbeni

submission deadline 20 Apr 2026 | Viewed by 241 | Submission Open

Keywords: liver disease; molecular pathogenesis; therapeutic strategies; liver fibrosis; hepatocellular carcinoma; MASLD and MetALD; molecular biomarkers; tailored medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Translational Neuroscience of Emotion, Cognition, and Behavior: From Mechanisms to Mental Health

edited by

Masaru Tanaka

submission deadline 20 Apr 2026 | Viewed by 241 | Submission Open

Keywords: translational neuroscience; emotion and cognition; neurobehavioral mechanisms; mental health biomarkers; Neuroimmunology; brain– gut axis; optogenetics and behavior; single-cell transcriptomics; psychiatric disorders; neuromodulation therapies

(This special issue belongs to the Section Molecular Neurobiology)

Investigating Gut Axes: Pathophysiological Functions and Therapeutic Strategies

edited by

Alessio Ardizzone

and

Sarah Adriana Scuderi

submission deadline 20 Apr 2026 | Viewed by 240 | Submission Open

Keywords: gut– brain axis; gut– heart axis; gut– liver axis; neurological diseases; cancer; novel and alternative therapies; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Antioxidant Molecules: From Discovery to Therapeutic Applications

edited by

Davide Moi

submission deadline 20 Apr 2026 | Viewed by 239 | Submission Open

Keywords: antioxidants; natural products; small molecules; polyphenols; reactive oxygen species; drug discovery; oxidative stress; apoptosis; target validation

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms of Reproduction and Reproductive Diseases

edited by

Sung Tae Kim

submission deadline 20 Apr 2026 | Viewed by 231 | Submission Open

Keywords: reproduction; implantation; fertilization; gametogenesis; preimplantation genetic testing; in vitro fertilization; infertility; miscarriage; reproductive aging; endometriosis; premature ovarian failure; menopause; preeclampsia; preterm birth; placenta; testis; azoospermia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Medicinal Plants in the Treatment of Neurodegenerative Diseases: Advances, Challenges, and Future Perspectives

edited by

Katarzyna E. Stȩpnik

submission deadline 20 Apr 2026 | Viewed by 229 | Submission Open

Keywords: medicinal plants; neuroprotection; neurodegeneration; plant secondary metabolites; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The New Developments in Third-Generation Sequencing Methods in Human Rare Diseases

edited by

Rick Kamps

submission deadline 20 Apr 2026 | Viewed by 228 | Submission Open

Keywords: short-read sequencing; long-read sequencing; single-cell rna sequencing; spatial-transcriptomic sequencing; single-nucleotide sequencing; structural-variant sequencing; protein-omics sequencing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanosensitive Ion Channels in the Nervous System

edited by

Rashid Giniatullin

submission deadline 20 Apr 2026 | Viewed by 220 | Submission Open

Keywords: mechanosensitive ion channels; Piezo1; Piezo2; mechanosensitive K2P channels; mechanical pain; pulsating blood flow; tissue stiffness; mechanobiology of glymphatic system; chemical agonists of mechanosensitive channels; mechanosensitive TRP channels; neuron; glial cells

(This special issue belongs to the Section Molecular Neurobiology)

Serum Amyloid A: Established Roles and Emerging Questions in Health and Disease

edited by Preetha Shridas

submission deadline 20 Apr 2026 | Viewed by 215 | Submission Open

Keywords: Serum Amyloid A; high-density lipoprotein; acute inflammation; chronic inflammatory

(This special issue belongs to the Section Biochemistry)

Hyaluronan and Proteoglycans in Cancer and Inflammatory Diseases: Molecular Mechanisms and Therapeutic Implications

edited by Angela D’Ascola and

Michele Scuruchi

submission deadline 20 Apr 2026 | Viewed by 212 | Submission Open

Keywords: hyaluronan; proteoglycans; inflammation; cancer; tumor microenvironment; therapy

(This special issue belongs to the Section Molecular Oncology)

Immunological Regulation as Determinant of Outcomes in Critically Sick Patients

edited by

Krzysztof Laudanski

submission deadline 20 Apr 2026 | Viewed by 212 | Submission Open

Keywords: critical illness; outcome; immune system; inflammation; homeostasis; epigenetic; microbiome; central nervous system; dysregulation; recovery

(This special issue belongs to the Section Molecular Immunology)

Recent Molecular Research in Colitis

edited by

Pablo García-Miranda

and

María Vázquez-Carretero

submission deadline 20 Apr 2026 | Viewed by 207 | Submission Open

Keywords: colitis; inflammatory bowel disease (IBD); gut-brain axis; intestinal barrier; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Alzheimer’s Disease: Molecular Mechanisms and Novel Therapies

edited by Noah R. Johnson and

Chih Hung Lo

submission deadline 20 Apr 2026 | Viewed by 207 | Submission Open

Keywords: intrinsically disordered proteins; apolipoproteins; neuroinflammation and neuroimmune; autolysosomal and mitochondrial functions; lipid metabolism; blood-brain barrier; biosensors; nanomedicine; high-throughput screening; therapeutic discovery

(This special issue belongs to the Section Molecular Neurobiology)

3D Printing in Pharmaceutical Drug Delivery

edited by

Sagar Narala

and

Dinesh Nyavanandi

submission deadline 20 Apr 2026 | Viewed by 207 | Submission Open

Keywords: personalized medication; 3-dimensional printing; solubility and bioavailability enhancement; polymers for 3D printing; bio-inks; 3D-printed implants; additive manufacturing

(This special issue belongs to the Section Molecular Pharmacology)

Drug-Induced Toxicity and Its Role in Disease Progression and Therapeutic Outcomes

edited by

Eugenia Gallardo

and

Tiago Rosado

submission deadline 20 Apr 2026 | Viewed by 206 | Submission Open

Keywords: drug-induced toxicity; drug-drug interactions; drug delivery systems; toxicity; disease

(This special issue belongs to the Section Molecular Toxicology)

Molecular and Cellular Research on Cardiac Repair and Regeneration

edited by

Francesca Pagano

and

Vittorio Picchio

submission deadline 20 Apr 2026 | Viewed by 204 | Submission Open

Keywords: cardiac repair; cardiomyocyte differentiation; cardiac fibroblast activation; cardiac fibrosis; cardiac tissue microenvironment; cardiac remodeling

(This special issue belongs to the Section Molecular Biology)

Molecular, Cellular and Systems Research on Neuroanatomy, Brain Function and Its Impact on Human Behavior

edited by

Frank Schmitz

submission deadline 20 Apr 2026 | Viewed by 202 | Submission Open

Keywords: central nervous system; neuroanatomy; human behavior; nuclei; neuronal circuits; connectivity channels

(This special issue belongs to the Section Molecular Neurobiology)

MDSCs in Health and Disease

edited by

Víctor Sánchez-Margalet

submission deadline 20 Apr 2026 | Viewed by 202 | Submission Open

Keywords: MDSCs; inflammation; immune regulation; cancer; autoimmune diseases; pregnancy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Probiotics and Prebiotics in Gut Health and Disease

edited by

Hikmate Abriouel

submission deadline 20 Apr 2026 | Viewed by 201 | Submission Open

Keywords: probiotics; prebiotics; gut microbiota; intestinal health; dysbiosis; host– microbe interactions; omics; gut– brain axis

(This special issue belongs to the Section Molecular Microbiology)

Bone Microenvironment and Bone Metastasis

edited by

Cristina Sanchez de Diego

submission deadline 20 Apr 2026 | Viewed by 200 | Submission Open

Keywords: bone metastasis; tumor– bone interaction; bone microenvironment; osteoclastogenesis; osteoblast signaling; bone remodeling; dormancy; immune evasion; extracellular matrix

(This special issue belongs to the Section Molecular Oncology)

Molecular Research of Cardiovascular Disease

edited by

John A. St. Cyr

submission deadline 20 Apr 2026 | Viewed by 197 | Submission Open

Keywords: myocardium; metabolism; ischemia; function; integrity; cardiovascular; disease; infarction; failure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbial Metabolism: From Pathway Analysis to Metabolic Engineering and Synthetic Biology

edited by

Elias R. Olivera

submission deadline 20 Apr 2026 | Viewed by 195 | Submission Open

Keywords: bacteria; fungi; archeobacteria; metabolic pathways; biodegradation; biosynthesis; biotransformation; omic sciences; metabolic engineering; synthetic regulatory circuits

(This special issue belongs to the Section Molecular Microbiology)

Antibacterial and Antioxidant Effects of Plant-Sourced Compounds: 2nd Edition

edited by Johana Rondevaldova

submission deadline 20 Apr 2026 | Viewed by 194 | Submission Open

Keywords: antibacterial effect; antioxidants; medicinal plants; anti-infective agents; phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Applications of Polymers in Organic Functional Materials

edited by

Paola Manini

submission deadline 20 Apr 2026 | Viewed by 193 | Submission Open

Keywords: functional polymers; polymer synthesis; stimuli-responsive polymers; self-healing polymers; nanostructured polymers; polymer composites; smart materials; polymeric catalysts; polymers in (bio)electronics; polymers for sustainable processes

(This special issue belongs to the Section Macromolecules)

Molecular Application of Biomaterial in Skin Diseases

edited by

Danuta Nowicka

submission deadline 20 Apr 2026 | Viewed by 190 | Submission Open

Keywords: chronic dermatoses; autologus material; PRP; stem cells; growth factors

(This special issue belongs to the Section Materials Science)

Heavy Metal and Fluoride Stress: Toxicity and Tolerance Mechanisms in Plants

edited by

Hatem Rouached

submission deadline 20 Apr 2026 | Viewed by 188 | Submission Open

Keywords: heavy metal toxicity; fluoride stress; stress tolerance mechanisms; phytoremediation; oxidative stress response

(This special issue belongs to the Section Molecular Plant Sciences)

Autosomal Dominant Polycystic Kidney Disease (ADPKD): Molecular Mechanism, Management and Therapy

edited by

Maria Teresa Sciarrone Alibrandi

submission deadline 20 Apr 2026 | Viewed by 188 | Submission Open

Keywords: autosomal dominant polycystic kidney disease; ADPKD progression; cystic kidney disease; cardiovascular complications in ADPKD; biomarkers of ADPKD; genetics of polycystic kidney disease; renal imaging; targeted therapies in ADPKD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

RNA in Human Diseases: Challenges and Opportunities: 2nd Edition

edited by

Nicoletta Potenza

submission deadline 20 Apr 2026 | Viewed by 187 | Submission Open

Keywords: microRNA; piRNA; lncRNA; circRNA; RNA therapeutics; ceRNET; RNA disease; RNA processing; RNA modification

(This special issue belongs to the Section Molecular Biology)

The Impact of Circulating Biomarkers and Metabolites on Cardiometabolic Disease and Cancer: New Insights and Therapeutic Opportunities

edited by Melania Gaggini and

Cristina Vassalle

submission deadline 20 Apr 2026 | Viewed by 183 | Submission Open

Keywords: lipidomic; metabolomic; lipotoxicity; oxidative stress; amino acids; metabolic disease; cardiovascular risk; tumorigenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Intercellular Adhesion and Inflammatory Response in Cancer

edited by Anna Pryczynicz

submission deadline 20 Apr 2026 | Viewed by 182 | Submission Open

Keywords: adhesion; cancer; cancer therapy; inflammation; microenvironment

(This special issue belongs to the Section Molecular Biology)

Targeting Receptor Tyrosine Kinases and Related Signalling Pathways in Cancer: Mechanisms, Resistance, and Therapeutic Advances

edited by

Athina-Myrto Chioni

and

Richard Grose

submission deadline 20 Apr 2026 | Viewed by 181 | Submission Open

Keywords: tyrosine kinase receptors (TKRs); tyrosine kinase inhibitors (TKIs); cancer; therapeutic resistance/cancer drug resistance/chemotherapy resistance; signaling pathways; metastasis; combination therapy; targeted therapy; next-generation inhibitors; allosteric inhibitors; personalized medicine; tumor microenvironment; immune evasion; immunotherapy; crosstalk in cancer signaling; miRNAs; lncRNAs; cancer therapeutics; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Viral Biology: Infection and Pathology, Diagnosis and Treatment

edited by

Gergana Zahmanova

submission deadline 20 Apr 2026 | Viewed by 179 | Submission Open

Keywords: viral infection; viral pathogenesis; diagnostics; antiviral therapy; host– virus interactions; emerging viruses; zoonotic viruses; one health; vaccine development; CRISPR antivirals

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Proglucagon-Derived Peptides

edited by

Camilla Krizhanovskii

submission deadline 20 Apr 2026 | Viewed by 177 | Submission Open

Keywords: proglucagon; peptide hormones; post-translational processing; prohormone convertase; G-protein-coupled receptors; tissue specificity

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanism and Pharmacological Target of Neuroprotection

edited by

Pietro Cacialli

submission deadline 20 Apr 2026 | Viewed by 176 | Submission Open

Keywords: neurodegeneration; animal model; brain regeneration; pharmacological drug; molecular analysis

(This special issue belongs to the Section Molecular Neurobiology)

The Influence of Genetics on Lymphatic System Diseases

edited by

Tomomi Watanabe-Asaka

submission deadline 20 Apr 2026 | Viewed by 176 | Submission Open

Keywords: lymphatic system; gene expression; disease model; medical application; lymphatic development; lymphatic function

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Positive Impact of DNA-Derived Substances on Inflammation, Aging and Associated Symptoms

edited by

Mi Young Lee

submission deadline 20 Apr 2026 | Viewed by 175 | Submission Open

Keywords: PDRN; PN; DNA-derived substances; nucleic acid-based therapeutics; inflammation; aging

(This special issue belongs to the Section Molecular Biology)

Metabolic Dependencies of the Influence of Intestinal Microbiota During Pregnancy, Childbirth and Infancy

edited by Małgorzata Szczuko and Maciej Ziętek

submission deadline 20 Apr 2026 | Viewed by 174 | Submission Open

Keywords: microbiota; dysbiosis; intestinal microbiome; LPS; zonulin; calprotectin; occludin; SCFA; citrulline; glucagon-like peptide (GLP)-2; LPS binding protein (LBP); amyloid A; intestinal leakage

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Displaying special issue 2901-2950 on page 59 of 69.

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