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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advanced Biomaterials for Tissue Regeneration submission deadline 30 Jun 2026 | Viewed by 44 | Submission Open
Keywords: biomaterials; tissue regeneration; molecular mechanisms; cell-instructive scaffolds; injectable hydrogels; ECM-mimetic materials; bioactive ceramics; bioactive surface coatings; mechanotransduction/mechanobiology; immunomodulation; angiogenesis and vascularization; biofabrication (3D/4D printing)
(This special issue belongs to the Section Materials Science)
Molecular and Translational Mechanisms of Cardiac Arrhythmias: From Oxidative Stress to Novel Therapeutic Strategies
edited by
submission deadline 30 Jun 2026 | Viewed by 44 | Submission Open
Keywords: cardiac arrhythmias; atrial fibrillation; oxidative stress; molecular mechanisms; translational research; antiarrhythmic therapy; cardiac remodeling
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Vitamin D Metabolism and Molecular Signaling in Human Diseases
edited by
submission deadline 30 Jun 2026 | Viewed by 43 | Submission Open
Keywords: vitamin D; vitamin D metabolism; molecular signaling; genomic and non-genomic pathways; epigenetics; immune regulation; inflammation; metabolic disorders; autoimmune diseases; cancer biology; gut microbiota; genetic polymorphisms; precision medicine
(This special issue belongs to the Section Molecular Biology)
Advances in Plant Breeding and Biotechnology: From Lab to Field
edited by
submission deadline 30 Jun 2026 | Viewed by 42 | Submission Open
Keywords: crop improvement; genetic transformation; omics approaches; plant metabolites; plant resistance; plant breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular and Omics Insights into Stress Responses and Adaptation in Fish
edited by
submission deadline 30 Jun 2026 | Viewed by 42 | Submission Open
Keywords: fish stress adaptation; environmental stressors; omics integration; molecular mechanisms; functional genomics; epigenetic regulation; systems biology; stress resilience
(This special issue belongs to the Section Molecular Biology)
Molecular Studies on Obesity and Related Diseases submission deadline 30 Jun 2026 | Viewed by 42 | Submission Open
Keywords: obesity; adipose tissue; immunometabolism; adipokines; metabolomics; gut microbiota; thermogenesis; NAFLD; inflammation; precision nutrition
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Next-Generation Disease Models for Neuropsychiatric Disorders: Organoids, iPSC-Derived Circuits, and Gene Editing
edited by Masaru Tanaka
submission deadline 30 Jun 2026 | Viewed by 41 | Submission Open
Keywords: brain organoids; induced pluripotent stem cells (iPSC); neural stem cells; CRISPER-CAS systems (CRISPR); neuropsychiatric disorders; neurodevelopmental disorders; synaptic transmission; neuroinflammation; drug discovery; animal disease models
(This special issue belongs to the Section Molecular Neurobiology)
Molecular and Bioactive Properties of Novel and Functional Food Ingredients
edited by
submission deadline 30 Jun 2026 | Viewed by 41 | Submission Open
Keywords: functional food; bioactive compounds; novel food; molecular properties; peptides; edible insects; metabolomics; health-promoting ingredients; oxidative stress
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Role of Gut Microbiome Regulation in Immunity and Inflammation
edited by Lei Deng
submission deadline 30 Jun 2026 | Viewed by 39 | Submission Open
Keywords: gut microbiome; adaptive immunity; IBD; inflammation; innate immunity; enteric infections; salmonella; intestine barrier; mucosal immunity
(This special issue belongs to the Section Molecular Microbiology)
Advances in Multi-Omics in Cancer: Second Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 39 | Submission Open
Keywords: cancer; multi-omics; genomics; transcriptomics; proteomics; metabolomics; lipidomics; epigenomics; artificial intelligence; machine learning; systems biology; biomarkers; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Characterization and Biological Function of Marine Biopolymers
edited by
submission deadline 30 Jun 2026 | Viewed by 39 | Submission Open
Keywords: marine-based biopolymers; sustainable extractions; polymer characterization; biological functions; marine resources
(This special issue belongs to the Section Materials Science)
Advances in the Bioactive Properties of Natural Products from Medicinal Plants: Antioxidant, Antibacterial, and Anticancer Activities
edited by Fhatuwani N. Mudau
submission deadline 30 Jun 2026 | Viewed by 39 | Submission Open
Keywords: antiproliferative properties; antimicrobial activity; medicinal plants; phytochemicals; metabolomics; natural products; cancer; therapeutic properties
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms of Adipose Tissue Dysfunction
edited by
submission deadline 30 Jun 2026 | Viewed by 38 | Submission Open
Keywords: adipose tissue dysfunction; adipogenesis; immunometabolism and adipokines; mitochondrial dysfunction; extracellular vesicles; fibrosis and ECM remodeling; lipid metabolism; browning and beigeing; metabolic biomarkers and therapeutic targets; adipose-derived stem cells
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Plant and Lichen Metabolites: Characterization and Applications
edited by
submission deadline 30 Jun 2026 | Viewed by 38 | Submission Open
Keywords: phytochemicals; secondary metabolites; bioactive compounds; bioactivity evaluation; synthesis optimization; metabolite application; metabolite extraction; elicitors; stress physiology; plant biotechnology
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mediators at the Crossroads of Microbes, the Microbiome, and Cancer
edited by
submission deadline 30 Jun 2026 | Viewed by 38 | Submission Open
Keywords: molecular mediators; microbiome-cancer interface; proteomics; multi-omics; functional characterization
(This special issue belongs to the Section Molecular Microbiology)
Exosomes and Extracellular Vesicles in Health and Diseases: 4th Edition submission deadline 30 Jun 2026 | Viewed by 37 | Submission Open
Keywords: exosome; extracellular vesicles; network signals; biomarkers; pathological conditions
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
From Molecular Design to Functional Performance: Advanced Materials for Energy and Environmental Technologies submission deadline 30 Jun 2026 | Viewed by 36 | Submission Open
Keywords: molecular design; molecular engineering; functional materials; organic– inorganic hybrid materials; nanostructured materials; morphology engineering; surface and interface chemistry; defect and vacancy engineering; electrocatalysis; photocatalysis; photoelectrochemical systems; energy generation and conversion; energy harvesting; energy storage; supercapacitors; lithium-ion batteries (LIBs); sodium-ion batteries (SIBs); oxygen evolution reaction (OER); hydrogen evolution reaction (HER); overall water splitting; methanol oxidation reaction (MOR); urea oxidation reaction (UOR); advanced oxidation processes (AOPs); pollutant removal and degradation; hazardous material degradation; water purification; environmental remediation; charge transfer and reaction kinetics; structure– property– performance relationships; in situ and operando spectroscopy; electrochemical characterization; density functional theory (DFT); molecular modeling and simulation; reaction mechanisms; catalyst stability and reconstruction; sustainable and green materials
(This special issue belongs to the Section Materials Science)
The Role of Vitamin B6 in Metabolism and Genome Stability
edited by
submission deadline 30 Jun 2026 | Viewed by 36 | Submission Open
Keywords: vitamin B6; PLP; DNA damage; metabolism
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Hematopoietic Stem Cell Differentiation and Regeneration
edited by
submission deadline 30 Jun 2026 | Viewed by 36 | Submission Open
Keywords: hematopoiesis; leukemia; lymphoma; anemia; myelodysplastic syndromes; myeloproliferative neoplasm; myelofibrosis; erythropoiesis; hematopoietic stem cell
(This special issue belongs to the Section Molecular Immunology)
Latest Insight into Spin and Isomerism of Organic Molecules
edited by and
submission deadline 30 Jun 2026 | Viewed by 35 | Submission Open
Keywords: organic molecules; photoisomerization; spin states; isomerism; spin crossover; conformational dynamics; quantum chemistry; radical chemistry; singlet fission
(This special issue belongs to the Section Molecular Biophysics)
Emerging Molecular Research on Photocatalytic Functional Materials
edited by Yifan Chen
submission deadline 30 Jun 2026 | Viewed by 35 | Submission Open
Keywords: photocatalytic materials; molecular level; functional optimization; mechanism; synergistic effects
(This special issue belongs to the Section Materials Science)
Genetics- and Genomics-Based Wheat Improvement and Breeding
edited by Jian Ma
submission deadline 30 Jun 2026 | Viewed by 35 | Submission Open
Keywords: wheat crop; germplasm; genetics; genomics; breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Breast Cancer: From Pathophysiology to Novel Therapies, 2nd Edition
edited by Jennifer Sims-Mourtada
submission deadline 30 Jun 2026 | Viewed by 35 | Submission Open
Keywords: breast cancer; genetics; tumor microenvironment; model systems; organoids; immune cells; tumor stroma; therapeutic resistance; novel therapies
(This special issue belongs to the Section Molecular Oncology)
Advances in Amyloids: From Structure to Tailored Function
edited by
submission deadline 30 Jun 2026 | Viewed by 35 | Submission Open
Keywords: amyloid; aggregation; self-assembly; seeding; protein structure
(This special issue belongs to the Section Macromolecules)
Updates on Synthetic and Natural Antioxidants (2nd Edition) submission deadline 30 Jun 2026 | Viewed by 34 | Submission Open
Keywords: antioxidants; synthetic; natural compounds
(This special issue belongs to the Section Biochemistry)
Thyroid Disease: From Molecular Mechanisms to Diagnosis and Therapeutic Advances
edited by and Juan Nicola
submission deadline 30 Jun 2026 | Viewed by 34 | Submission Open
Keywords: thyroid disease; hypothyroidism; hyperthyroidism; autoimmune thyroid disease; thyroid nodules; thyroid cancer
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Insights into Diabetic Nephropathy submission deadline 30 Jun 2026 | Viewed by 34 | Submission Open
Keywords: diabetic nephropathy; hyperglycemia; insulin resistance; oxidative stress; mitochondrial dysfunction; chronic kidney disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
KCTD Proteins in Cellular Processes Regulation: Advances and Challenges
edited by
submission deadline 30 Jun 2026 | Viewed by 33 | Submission Open
Keywords: KCTD proteins; cancer biology; cell signaling pathway; ubiquitination; genetic disorder; protein– protein interaction; developmental biology; protein stability; gene expression; new therapeutic target
(This special issue belongs to the Section Molecular Biology)
Phenolic Compounds as Adjunct Therapy in Cardiometabolic Disorders submission deadline 30 Jun 2026 | Viewed by 33 | Submission Open
Keywords: phenolic compounds; cardiovascular diseases; metabolism; diabetes; obesity; hypertension; mitochondria; oxidative stress; gut microbiota; inflammation
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Cellular Immunotherapy in Cancer: Current Trends and Future Directions
edited by
submission deadline 30 Jun 2026 | Viewed by 33 | Submission Open
Keywords: cellular immunotherapy; CAR-T cells; CAR-NK cells; CAR-macrophages; tumor-infiltrating lymphocytes (TILs); immune receptor signaling; tumor microenvironment; CRISPR/Cas9 genome editing; precision cancer immunotherapy; translational immuno-oncology
(This special issue belongs to the Section Molecular Immunology)
New Molecular Perspectives on Diabetic Retinopathy
edited by Martina Tomić and
submission deadline 30 Jun 2026 | Viewed by 32 | Submission Open
Keywords: diabetic retinopathy; diabetes; complications; vascular endothelial growth factor; retina; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Psychedelics and Mental Disorders: From Molecular Mechanisms to Therapies Potential submission deadline 30 Jun 2026 | Viewed by 32 | Submission Open
Keywords: psychedelics; drug-induced neurotoxicity; therapeutic potential; mental disorders; neuroprotective mechanisms; adult neurogenesis
(This special issue belongs to the Section Molecular Neurobiology)
Biomedical Applications of Mesenchymal Stem Cells, 2nd Edition submission deadline 30 Jun 2026 | Viewed by 31 | Submission Open
Keywords: mesenchymal stem cells; cell differentiation; cell therapy; regenerative medicine; tissue homeostasis; disease; cartilage
(This special issue belongs to the Section Molecular Biology)
Molecular and Omics Approaches in Toxicology and Precision Pharmacology
edited by
submission deadline 30 Jun 2026 | Viewed by 31 | Submission Open
Keywords: toxicology; precision pharmacology; omics technologies; proteomics; mode of action (MoA); mechanism of activity; biomarkers; prediction and modeling
(This special issue belongs to the Section Molecular Toxicology)
Liposome-Related Nanotechnology and Lipid-Based Nanocarriers
edited by
submission deadline 30 Jun 2026 | Viewed by 31 | Submission Open
Keywords: liposomes; lipid nanoparticles; solid lipid nanoparticles; nanostructured lipid carriers; nanocarriers; drug delivery; controlled release
(This special issue belongs to the Section Molecular Nanoscience)
Effects of Bioactive Compounds in Cardiovascular and Neurological Diseases submission deadline 30 Jun 2026 | Viewed by 30 | Submission Open
Keywords: inflammation; oxidative stress; bioactive compounds; cardiovascular diseases; neurological diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Electrochemical Detection Research: A Molecular Insight
edited by
submission deadline 30 Jun 2026 | Viewed by 29 | Submission Open
Keywords: electrochemical sensors; phenolic compounds; theoretical study; experimental study; nanostructured electrodes
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Biochemistry and Biophysics Tools for Peptide and Protein Research
edited by
submission deadline 30 Jun 2026 | Viewed by 29 | Submission Open
Keywords: protein– protein interactions; peptide therapeutics development; biosensor and labeling technologies; high-throughput screening; mass spectrometry proteomics; protein dynamics and folding; single-molecule biophysics; analytical ultra-centrifugation; computational protein design; structural biology techniques
(This special issue belongs to the Section Biochemistry)
Cancer Drugs That Target Epigenetic Processes
edited by Eileen Brantley
submission deadline 30 Jun 2026 | Viewed by 29 | Submission Open
Keywords: histone modifications; non-coding RNA; DNA methylation; cancer agents
(This special issue belongs to the Section Molecular Oncology)
Thyroid Hormone Signaling: Mechanisms and Pathophysiological Implications
edited by and Horacio Eduardo Romeo
submission deadline 30 Jun 2026 | Viewed by 29 | Submission Open
Keywords: thyroid hormones; mitochondrial function; oxidative stress; redox signaling; metabolic disorders; immune modulation; cardiovascular pathology; neurodevelopment and aging; cancer progression
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Insights into Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD)
edited by Shirin Pourteymour
submission deadline 30 Jun 2026 | Viewed by 29 | Submission Open
Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); hepatic lipid metabolism; immunometabolism; inflammation and innate immunity; mitochondrial dysfunction in MASLD; genetic and epigenetic regulation; inter-organ communication; fibrosis and disease progression; translational liver biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Inflammasome Signaling
edited by
submission deadline 30 Jun 2026 | Viewed by 28 | Submission Open
Keywords: PANoptosis; NLRP6; NLRP12; CARD8; non-immune cells; viral proteins; gasdermin family; inflammasome-independent signaling; inflammaging; MxA inflammasome
(This special issue belongs to the Section Biochemistry)
Advances in Cardiovascular and Vascular Biology
edited by
submission deadline 30 Jun 2026 | Viewed by 28 | Submission Open
Keywords: cardiovascular diseases; vascular biology; molecular mechanisms; biomarkers; endothelial dysfunction; translational medicine
(This special issue belongs to the Section Molecular Biology)
Research on Trace Elements in Nutrition and Health
edited by
submission deadline 30 Jun 2026 | Viewed by 28 | Submission Open
Keywords: trace elements; molecular mechanisms; micronutrients; supplementation; speciation analysis; biomarkers; health risk assessment
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Exploring Molecular Mechanisms Involved in Head and Neck Cancer
edited by Jae Won Chang
submission deadline 30 Jun 2026 | Viewed by 28 | Submission Open
Keywords: head and neck squamous cell carcinoma (HNSCC); molecular targeted therapy; tumor microenvironment (TME); therapeutic resistance; cancer stem cells (CSCs); immunotherapy; ferroptosis and cuproptosis; non-coding RNAs; microbiome and exosomes; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Molecular Advances in Cancer and Cell Metabolism—3rd Edition submission deadline 30 Jun 2026 | Viewed by 28 | Submission Open
Keywords: cell metabolism; cancer metabolism; cancer cell; oxidative stress; gene expression; signaling pathways; metabolic regulation; tumor growth; energy metabolism; metabolic phenotype; metabolic substrates
(This special issue belongs to the Section Molecular Oncology)
New Developments in Fluorescent Biosensors
edited by
submission deadline 30 Jun 2026 | Viewed by 27 | Submission Open
Keywords: carbon-based luminescent materials; green fluorescent sensors; C-dots; environmental sensing; biomedical applications; green synthesis strategies; fluorescence quenching; heavy metal detection
(This special issue belongs to the Section Molecular Biophysics)
Animal‐Derived Bioactive Peptides as Next‐Generation Therapeutics submission deadline 30 Jun 2026 | Viewed by 26 | Submission Open
Keywords: venom-derived peptides; animal toxins; antimicrobial peptides; immunomodulation; wound healing; antiparasitic agents; peptide‐based therapeutics; skin secretions
(This special issue belongs to the Section Molecular Toxicology)
Advances in Research on Cotton Breeding and Genetics
edited by
submission deadline 30 Jun 2026 | Viewed by 26 | Submission Open
Keywords: cotton genomics; molecular breeding; gene regulation; abiotic stress tolerance; fiber quality improvement; disease resistance; genetic engineering; marker-assisted selection; transcriptomics; genome editing
(This special issue belongs to the Section Molecular Plant Sciences)
Applications and Advances of Organic Synthesis in the Design of Antiparasitic, Antiviral, and Anticancer Drugs
edited by and Juan B. Rodriguez
submission deadline 30 Jun 2026 | Viewed by 26 | Submission Open
Keywords: antiparasitic agents; antiviral agents; chagas disease; toxoplasmosis; medicinal chemistry
(This special issue belongs to the Section Molecular Pharmacology)
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