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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Development of Dopaminergic Neurons, 4th Edition
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 2328 | Submission Open
Keywords: neuron; dopamine; mDA; signalling pathways; human stem cell
(This special issue belongs to the Section Molecular Neurobiology)
Mechanistic Insights, Therapeutic Potential, and Applications of Natural Bioactive Compounds
edited by and
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2326 | Submission Open
Keywords: oxidative stress; inflammation; chronic diseases; natural bioactive compounds; plant-derived molecules; redox homeostasis; anti-inflammatory mechanisms; antioxidant activity; drug discovery; synergistic effects; combination therapies
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Research on Rhizobia
edited by , María J. Delgado and
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2226 | Submission Open
Keywords: biodiversity; environmental factors; plant– rhizobia interaction; nitrogen fixation; regulation; signaling; symbiosis
(This special issue belongs to the Section Molecular Microbiology)
Oxidative Stress and Mitochondria in Human Diseases
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2105 | Submission Open
Keywords: mitochondrial dynamics; ROS; antioxidants; mitophagy; oxidative damage; lipid peroxidation; neurodegenerative diseases; cancer; obesity
(This special issue belongs to the Section Biochemistry)
Autophagic Related Proteins in Cancer
edited by Pietri Puustinen
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2009 | Submission Open
Keywords: cancer; autophagy; tumor suppressor; tumorigenesis; pro-survival mechanism; therapeutic strategies; cancer metabolism; signaling pathways; mTORC1; AMPK; CIP2A; PP2A; DNA damage response (DDR); DNA-PK; ATM/ATR; cellular growth
(This special issue belongs to the Section Molecular Oncology)
Molecular Research of Abiotic Stress in Plants
edited by Deguo Han
submission deadline 20 Dec 2025 | 2 articles | Viewed by 1993 | Submission Open
Keywords: abiotic stress; salt stress; drought stress; plant
(This special issue belongs to the Section Molecular Plant Sciences)
Hormone Receptor in Breast Cancer: 2nd Edition submission deadline 20 Dec 2025 | 2 articles | Viewed by 1967 | Submission Open
Keywords: estradiol; progesterone; calcitriol; androgen; resveratrol; phytoestrogens; therapeutic targets; fulvestrant; treatment response; SERM; estrogen receptor isoforms; selective ligands; hormonal carcinogenesis; breast cancer prevention; hormone signaling; endocrine disruptor compounds; ER-negative breast cancer; ER-positive breast cancer; aromatase inhibitors
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms and Signaling Pathways in Alzheimer’s Disease
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1923 | Submission Open
Keywords: Alzheimer’ s disease; aging; β -amyloid; biomarkers; cell signaling; tau; mitochondrial dysfunction; neuroinflammation; vascular alterations
(This special issue belongs to the Section Molecular Neurobiology)
MicroRNAs and mRNA in Human Health and Disease
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 1920 | Submission Open
Keywords: stem cells; mesenchymal stem cells; gene expression; microRNA; mRNA
(This special issue belongs to the Section Molecular Biology)
Antimicrobial Peptides in Reproductive Health and Disease
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1875 | Submission Open
Keywords: antimicrobial peptides; preterm birth; molecular mechanisms; microbiome; immune system
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Esophageal Inflammation, Injury, and Repair
edited by Anisa Shaker
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1842 | Submission Open
Keywords: GERD; eosinophilic esophagitis; achalasia; esophageal cancer; barrett’ s esophagus; microbiome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Treatment of Neurodegenerative Diseases with Natural Products
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1774 | Submission Open
Keywords: neurodegenerative diseases; natural product; misfolding protein aggregation; oxidative stress; neuroinflammation; autophagy; apoptosis; microbiota– gut– brain axis; therapeutic; prevention
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Plant Responses to Heavy Metals: From Deficiency to Excess, 2nd Edition submission deadline 20 Dec 2025 | 2 articles | Viewed by 1746 | Submission Open
Keywords: heavy metals; deficiency; metal toxicity; metal (hyper-)accumulation; mechanisms of metal tolerance; metal transport; metal uptake; metal sequestration; metal homeostasis
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Advances in Gastrointestinal Cancer, 3rd Edition
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1743 | Submission Open
Keywords: gastrointestinal cancer; chemotherapeutic agents; innovative therapies; human nutrition; nutrigenomics; nutrition and immunity epigenetics; cytotoxicity; apoptosis
(This special issue belongs to the Section Molecular Oncology)
New Insights into Photosystem I (Second Edition) submission deadline 20 Dec 2025 | 1 articles | Viewed by 1667 | Submission Open
Keywords: photosystem I; photochemisty; electron transfer; protein– cofactor interaction; reaction kinetics; reaction mechanism; redox tuning; light harvesting; low-energy (red) forms; bioenergetics; cyclic electron transfer
(This special issue belongs to the Section Molecular Plant Sciences)
Sleep and Breathing: From Molecular Perspectives
edited by Alberto Alonso-Fernández
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1602 | Submission Open
Keywords: obstructive sleep apnea; cardiovascular risk; cardiovascular diseases/physiopathology; continuous positive airway pressure; hypertension; biomarkers; diabetes; pregnancy; gene expression profiling; genetic markers; inflammation mediators; oxidative stress; proteomics
(This special issue belongs to the Section Molecular Biology)
Recent Research in Probiotic Yeasts: Molecular Aspects submission deadline 20 Dec 2025 | 1 articles | Viewed by 1601 | Submission Open
Keywords: probiotic yeasts; molecular mechanisms; mycocins active; compounds; functional compounds
(This special issue belongs to the Section Molecular Microbiology)
New Insights into Anticancer Strategies
edited by
submission deadline 20 Dec 2025 | Viewed by 1562 | Submission Open
Keywords: novel targeted therapy; personalized medicine; nanotechnology; AI and machine learning; combination therapy
(This special issue belongs to the Section Molecular Oncology)
Metabolomics in Coronary Artery Disease: From Pathogenesis to Personalized Medicine
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1555 | Submission Open
Keywords: coronary artery disease (CAD); atherosclerosis; epicardial disease; CAD pathogenesis; personalized approach; drug response; metabolomic
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nitric Oxide and Photosynthetic Machinery: Unveiling Molecular Mechanisms and Redox Balancing
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1533 | Submission Open
Keywords: nitric oxide; photosynthetic machinery; NO signaling pathways; plant physiology
(This special issue belongs to the Section Molecular Plant Sciences)
Biocomposite Hydrogels for Biomedical Applications submission deadline 20 Dec 2025 | 1 articles | Viewed by 1489 | Submission Open
Keywords: hydrogels; biocomposite; micro/nanoparticles; electrospun fibers; inorganic particles; tissue engineering; drug delivery; 3D printing
(This special issue belongs to the Section Materials Science)
Epilepsy: From Molecular Basis to Therapy, 2nd Edition submission deadline 20 Dec 2025 | 1 articles | Viewed by 1473 | Submission Open
Keywords: genetic epilepsy; post-traumatic epilepsy; neurodevelopmental disorder; glutamate; GABA; ionic homeostasis; disease-modifying therapy; in vitro; in vivo; animal model; gene replacement therapy; gene editing; protein misfolding; small molecule; pharmacokinetics; pharmacodynamics; translational research; biomarker; clinical trial
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Structural Characterization and Pharmacological Activity of Natural Compounds
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1471 | Submission Open
Keywords: natural compounds; bioactive molecules; molecular structure; characterisation; pharmacological activity; biochemical properties; pharmacokinetics; toxicity
(This special issue belongs to the Section Molecular Pharmacology)
Neuroimaging Studies in Exploring the Molecular Mechanisms of Neurological Diseases
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1447 | Submission Open
Keywords: neuroimaging; neurological diseases; brain imaging; biomarkers; functional connectivity; AI in neuroimaging
(This special issue belongs to the Section Molecular Neurobiology)
Role of Ion Channels in Human Health and Diseases
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1433 | Submission Open
Keywords: sodium current; potassium current; ion channel kinetics; excitable cells; treatments; pathophysiology
(This special issue belongs to the Section Molecular Biology)
Insights into Functional Nanomaterials: Application-Related Structural Analysis
edited by Zoltán Dudás
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1425 | Submission Open
Keywords: functional porous nanomaterials; structure– activity relationship; molecular structure; characterization; nanoporous materials
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Insights into Virus-Host Immune Interactions
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1343 | Submission Open
Keywords: viral diseases; virus– host interactions; vaccination; interferon signalling; antibody responses; viral proteins; SARS-CoV-2
(This special issue belongs to the Section Molecular Immunology)
Ongoing Anticancer Agents
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 1342 | Submission Open
Keywords: tumorigenesis; anticancer drugs; therapeutic innovation; platinum-based drugs; anticancer therapies
(This special issue belongs to the Section Molecular Oncology)
Molecular Advances in Plant Reproductive Development
edited by Zsolt Pónya and
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1322 | Submission Open
Keywords: plant reproduction; sexual reproduction; gamete recognition; zygote formation; embryogenesis; endosperm development; seed maturation; plant developmental biology; epigenetic regulation; gene expression; cellular signalling pathways; protein interactions; hormonal controls
(This special issue belongs to the Section Molecular Plant Sciences)
The Role of Non-Coding RNAs in Female Reproduction
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1244 | Submission Open
Keywords: microRNAs; long non-coding RNAs; circular RNAs; female reproduction; reproductive aging; molecular biomarkers; ceRNA network
(This special issue belongs to the Section Molecular Genetics and Genomics)
Neural Stem Cells: Latest Applications and Future Perspectives submission deadline 20 Dec 2025 | 1 articles | Viewed by 1236 | Submission Open
Keywords: neural differentiation; embryonic stem cells; neural stem cells; neural progenitor cells; neuropathology; neurological disease
(This special issue belongs to the Section Molecular Biology)
Immune-Liver Axis—from Disease Pathogenesis to Therapeutic Target submission deadline 20 Dec 2025 | 1 articles | Viewed by 1236 | Submission Open
Keywords: immune response; inflammation; liver disease; liver injury; liver cirrhosis; immune-related liver disease; alcohol-related liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); Wilson’ s disease; hemochromatosis; liver cancer
(This special issue belongs to the Section Molecular Immunology)
Intestinal Diseases and Gut Microbiota
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 1212 | Submission Open
Keywords: gut microbiota; dysbiosis; natural compounds; colorectal cancer; neurological diseases; autoimmune diseases; probiotics; gut-brain axis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Regulatory Mechanisms Underlying Tumorigenesis
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1181 | Submission Open
Keywords: tumor suppressor genes; tumor microenviroment; cell-cycle checkpoint; novel fusion genes; novel molecular targets; small-molecule drugs; animal models
(This special issue belongs to the Section Molecular Oncology)
Pharmacokinetics of Psychoactive Substances: Molecular and Forensic Aspects submission deadline 20 Dec 2025 | Viewed by 1131 | Submission Open
Keywords: psychoactive substances; pharmacokinetics; forensic Toxicology; forensic pathology; toxicological biomarkers; cerebral damage; in vitro; in vivo; and in silico models; new Psychoactive Substances (NPS); new synthetic opioids; liquid chromatography-high resolution mass spectrometry (LC-HRMS/MS); liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography; tandem mass spectrometry (GC-MS/MS)
(This special issue belongs to the Section Molecular Pharmacology)
Latest Molecular Research on Polymer Coatings
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1109 | Submission Open
Keywords: synthesis of specialty compounds; specialty compounds in industrial treatment; amphiphilic compounds; wettability (including solids and biomaterials); antimicrobial activity; surface activity; superwetting; high hydrophobic/hydrophilic/olrophobic/olephilic properties; special applications: self-cleaning; anti-icing; self-healing; biocidal; etc.
(This special issue belongs to the Section Materials Science)
Molecular Research on Cancer Stem Cells
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 993 | Submission Open
Keywords: self-renewal; microenvironment; plasticity; epigenetics; epithelial-mesenchymal transition; heterogeneity; targeting; dormancy
(This special issue belongs to the Section Biochemistry)
Molecular Insight into Natural Nutraceuticals for Cancer Chemoprevention submission deadline 20 Dec 2025 | 1 articles | Viewed by 964 | Submission Open
Keywords: natural nutraceuticals; cancer; cancer chemoprevention; natural compounds
(This special issue belongs to the Section Molecular Oncology)
Proteases and Their Inhibitors: From Biochemistry to Applications
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 956 | Submission Open
Keywords: proteases; peptidases; proteinases; proteolysis; hydrolysis; enzymes; inhibitors; biotechnology; drug discovery; therapeutics
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Biomolecular Recognition: 3rd Edition
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 906 | Submission Open
Keywords: proteins; nucleic acids; membrane; ligand; binding
(This special issue belongs to the Section Molecular Biophysics)
Natural Products for Cancer Therapy: Mechanisms, Synergies, and Clinical Applications
edited by and Hiu Yee Kwan
submission deadline 20 Dec 2025 | 1 articles | Viewed by 904 | Submission Open
Keywords: natural products; cancer therapy; traditional Chinese medicine (TCM); integrative medicine; cancer drug resistance; antitumor mechanisms; molecular targeting; drug synergy; clinical application
(This special issue belongs to the Section Molecular Oncology)
25th Anniversary of IJMS: Updates and Advances in Molecular Biophysics submission deadline 20 Dec 2025 | 1 articles | Viewed by 869 | Submission Open
Keywords: biomolecular interactions; biomolecular NMR; biophysics; chaperones; computational modeling; computer simulations; crystal thermodynamics; DNA structure and dynamics; drug– receptor interactions; enzymology; fluorescence imaging; genome structure; inter-molecular interactions; intrinsically disordered proteins; ion channels; macromolecular crystallography; macromolecular structure and dynamics; membrane dynamics; microcalorimetry; molecular dynamics; molecular imprinting; molecular mechanics; molecular modeling; molecular simulations; molecular modeling; molecular structure; molecular recognition; nucleic acid– protein interactions; post-translational modifications; protein design; protein– DNA interactions; protein engineering; protein– ligand binding; protein– membrane interactions; protein structure and folding; RNA structure; single-molecule techniques; spectroscopic techniques; statistical mechanics; structure– function relationships; structure prediction; thermodynamics; transient kinetic techniques; transmembrane proteins; x-ray crystallography
(This special issue belongs to the Section Molecular Biophysics)
Recent Advances in Protein Folding and Misfolding
edited by
submission deadline 20 Dec 2025 | Viewed by 839 | Submission Open
Keywords: protein folding; protein misfolding; 3D protein structure; CRISPR/Cas 9
(This special issue belongs to the Section Molecular Biophysics)
Electron Transport Mechanism in Optoelectronic Materials
edited by Paolo Umari
submission deadline 20 Dec 2025 | Viewed by 791 | Submission Open
Keywords: photovoltaics; density functional theory; quantum chemistry; optoelectronic devices; semiconductors; polymers; charge transport
(This special issue belongs to the Section Materials Science)
Metabolomics of Medicinal Plants submission deadline 20 Dec 2025 | 2 articles | Viewed by 715 | Submission Open
Keywords: metabolomics; medicinal plants; nuclear magnetic resonance; mass spectrometry; bioinformatic; phenotyping; metabolic pathways; bioactive metabolites
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Studies of Skin Diseases: From Mechanisms to Therapy
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 709 | Submission Open
Keywords: multiomics; genomics; transcriptomics; proteomics; metabolomics; skin diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Age-Related Cognitive Decline submission deadline 20 Dec 2025 | Viewed by 683 | Submission Open
Keywords: cognitive decline; molecular mechanisms; aging individuals; therapeutic targets; neuroinflammation; oxidative stress; protein aggregation; vascular changes
(This special issue belongs to the Section Molecular Neurobiology)
Rethinking Fat: A Deeper Dive into the Diversity and Dynamic Roles of Adipose Tissue
edited by
submission deadline 20 Dec 2025 | Viewed by 662 | Submission Open
Keywords: adipose tissue biology; stem cell commitment and differentiation; thermogenic adipocytes; genetic regulation; metabolic homeostasis; selective targeting
(This special issue belongs to the Section Molecular Biology)
Signaling in GPCR Research
edited by
submission deadline 20 Dec 2025 | Viewed by 661 | Submission Open
Keywords: GPCR; G protein; signaling; drug design; cell surface receptors
(This special issue belongs to the Section Biochemistry)
Biomolecular Condensates and Their Role in Cellular Organization and Disease
edited by Anna Bratek-Skicki
submission deadline 20 Dec 2025 | Viewed by 600 | Submission Open
Keywords: biocondensates; membrane-less organelles; liquid-liquid phase separation; protein aggregation; neurogenerative diseases
(This special issue belongs to the Section Molecular Biology)
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