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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Protein–Protein Interactions in Human Cancer

edited by

Geng Wu

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2588 | Submission Open

Keywords: protein–protein interactions; protein–protein complexes; human cancer; signal transduction pathways; protein structure and function

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Lipids in Health and Diseases: 2nd Volume

edited by

Yutang Wang

submission deadline 30 Apr 2027 | 3 articles | Viewed by 2429 | Submission Open

Keywords: lipids; triglycerides; phospholipids; cholesterol; sphingolipids; steroids; fatty acids; lipid metabolism

(This special issue belongs to the Section Biochemistry)

DNA Methylation Dynamics Due to Environmental Factors and in Human Diseases

edited by

Naila Francis Paulo De Oliveira

and

José Maria Chagas Viana Filho

submission deadline 30 Apr 2027 | 3 articles | Viewed by 2382 | Submission Open

Keywords: inflammatory diseases; mental diseases; tumour diseases; epidrugs; exposure biomarkers; epigenetic drugs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Kidney Disease: Molecular Insights and Emerging Therapies

edited by

Yaochun Zhang

submission deadline 30 Apr 2027 | 3 articles | Viewed by 2368 | Submission Open

Keywords: kidney disease; molecular mechanism; precision medicine; translational nephrology; targeted molecular therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Therapeutic Strategies and Immunometabolic Pathways in Cancer

edited by Medhi Wangpaichitr

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2355 | Submission Open

Keywords: immunotherapy; targeted therapy; tumor metabolism pathway; tumor microenvironment; immune checkpoint blockade; immune evasion; glucose/amino acids/lipid metabolism

(This special issue belongs to the Section Molecular Immunology)

Insights in Multiple Sclerosis (MS) and Neuroimmunology: 3rd Edition

edited by

Michael C. Levin

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2302 | Submission Open

Keywords: neurodegeneration; neuroimmunology; macrophage; T-cell; B-cell; antibody; neurons; oligodendrocytes; axon; axonal damage; cell death; multiple sclerosis

(This special issue belongs to the Section Molecular Immunology)

Recent Advances in Non-Coding RNAs in Human Research

edited by

Jesús Adrián López

submission deadline 30 Apr 2027 | 4 articles | Viewed by 2268 | Submission Open

Keywords: microRNAs; lncRNAs; mRNA regulation; cell signaling pathways; RNA methylation; RNA phosphorylation; RNA deamidation; cell communication; chemoresistance; RNA inhibitors or activators

(This special issue belongs to the Section Molecular Genetics and Genomics)

Probiotics, Prebiotics, Synbiotics, and Gut Microbial Modulation in Intestinal Health and Disease

edited by Koji Yamamoto

submission deadline 30 Apr 2027 | 3 articles | Viewed by 2084 | Submission Open

Keywords: gut microbiota; probiotics; prebiotics; synbiotics; inter-organ network; intestinal barrier; microbial metabolites; immunoregulation; multi-omics; inflammatory bowel disease; microbiome-based therapy

(This special issue belongs to the Section Molecular Microbiology)

Mathematical Computation and Modeling in Biology

edited by

Shinuk Kim

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2025 | Submission Open

Keywords: mathematical model; computational methods; systemic molecular interaction; machine learning; integrating molecular materials

(This special issue belongs to the Section Molecular Informatics)

Advances in Diagnostics and Therapeutics of Neurodegenerative Disease

edited by

Romina Combi

submission deadline 30 Apr 2027 | 2 articles | Viewed by 1775 | Submission Open

Keywords: neurodegenerative disorders; biomarkers; diagnosis; therapy

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Skin Health and Disease

edited by

Federica Li Pomi

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1738 | Submission Open

Keywords: dermatology; molecular mechanisms; targeted therapy; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Alzheimer’s Disease: From Metabolic Dysregulation to Molecular Pathophysiology and Therapeutics

edited by Pedro Cisternas

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1647 | Submission Open

Keywords: Alzheimer’s disease; metabolic dysregulation; brain insulin resistance; neuroenergetics; mitochondrial dysfunction; adipokines; neuroinflammation; gut–brain axis; multi-omics biomarkers; therapeutics and precision medicine

(This special issue belongs to the Section Molecular Neurobiology)

State-of-the-Art Electrochemical Reaction Technologies

edited by

Cornelia Bandas

and

Carmen Lǎzǎu

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1581 | Submission Open

Keywords: energy storage; electrochemical sensors; electrocatalysis; supercapacitors; molecular electrochemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Lipid Metabolic and Signaling Dysregulations: From Molecular Mechanisms to Disease Pathogenesis

edited by Gergana M. Deevska

submission deadline 30 Apr 2027 | 3 articles | Viewed by 1518 | Submission Open

Keywords: lipid signaling; lipid metabolism; lipid homeostasis; metabolic dysregulation; signal transduction; disease pathogenesis

(This special issue belongs to the Section Molecular Biology)

Human Papillomavirus and Cellular Pathways

edited by

Marcus Vinícius de Aragão Batista

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1366 | Submission Open

Keywords: human papillomavirus; HPV oncogenesis; E6 and E7 oncoproteins; cellular signaling pathways; viral integration; epigenetics; molecular biomarkers; host susceptibility; cervical cancer; targeted therapy

(This special issue belongs to the Section Molecular Microbiology)

Advances in Alzheimer's Disease and Related Dementias: From Pathogenesis to Therapeutics

edited by

Amal Kaddoumi

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1317 | Submission Open

Keywords: Alzheimer's disease; cerebral amyloid angiopathy; blood–brain barrier; cerebrovascular dysfunction; neuroinflammation; therapeutic development; translational research

(This special issue belongs to the Section Molecular Neurobiology)

New Insights into Gastroesophageal Tumors

edited by

Michela Guardascione

and Luisa Foltran

submission deadline 30 Apr 2027 | 2 articles | Viewed by 1110 | Submission Open

Keywords: gastric cancer; esophageal cancer; biomarkers; target therapy; immunotherapy; NGS

(This special issue belongs to the Section Molecular Oncology)

New Research on Toxicology Research Models

edited by

Cláudia Maria Rosa Ribeiro

and

María Carolina Rocha-Pereira

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1080 | Submission Open

Keywords: contaminants of emerging concern; aquatic organisms; in vitro; in vivo; mammalian approaches; mechanisms of toxicity; environmental risk assessment; one health

(This special issue belongs to the Section Molecular Toxicology)

Advances in Plant Bioactive Compounds

edited by

Tarek Alshaal

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1077 | Submission Open

Keywords: plant bioactive compounds; phytochemicals; polyphenols; flavonoids; terpenoids; alkaloids; antioxidants; anti-inflammatory activity; molecular mechanisms; signaling pathways; gut microbiota; bioavailability; nutraceuticals; functional foods; phytochemistry; omics technologies; structure–activity relationship

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms, Biomarkers, and Therapeutic Targets in Heart Failure

edited by Celestino Sardu

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1052 | Submission Open

Keywords: heart failure; molecular mechanisms; ventricular remodeling; biomarkers; myocardial fibrosis; inflammation; oxidative stress; non-coding RNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Multi-Omics Research in Oncology

edited by

Wenchao Gu

submission deadline 30 Apr 2027 | 1 articles | Viewed by 980 | Submission Open

Keywords: multi-omics; cancer genomics; transcriptomics; single-cell sequencing; spatial omics; machine learning; artificial intelligence; biomarker discovery

(This special issue belongs to the Section Molecular Oncology)

Phytohormones in Plant Responses to Abiotic Stress

edited by

Marzena Kurowska

submission deadline 30 Apr 2027 | 1 articles | Viewed by 952 | Submission Open

Keywords: phytohormones; hormone signaling; abiotic stress responses; signaling crosstalk; transcriptional regulation; gene expression; molecular mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Antibacterial Drug Discovery and Molecular Mechanisms of Antimicrobial Resistance

edited by

Eduardo Martins De Sousa

submission deadline 30 Apr 2027 | 2 articles | Viewed by 938 | Submission Open

Keywords: antibacterial drug discovery; molecular mechanisms of resistance; molecular microbiology; antibiotic targets; structure–function relationships; bacterial efflux pumps; drug-inactivating enzymes; bacterial biofilms

(This special issue belongs to the Section Molecular Microbiology)

Gut Microbiota and Host Immune Interactions in Inflammatory Diseases

edited by

Tomomi Kuwahara

submission deadline 30 Apr 2027 | 1 articles | Viewed by 841 | Submission Open

Keywords: gut microbiota; host–microbe interactions; innate and adaptive immunity; microbial metabolites; short-chain fatty acids; intestinal dysbiosis; inflammatory bowel disease (IBD); metabolic syndrome; autoimmune diseases; gut–organ axis; microbiome-targeted therapies

(This special issue belongs to the Section Molecular Microbiology)

Trends in Allergy and Autoimmunity: Pathogenesis, Biomarkers, and Treatment (Second Edition)

edited by

Ilaria Mormile

submission deadline 30 Apr 2027 | 2 articles | Viewed by 818 | Submission Open

Keywords: allergy; autoimmunity; autoimmune diseases; asthma; allergic rhinitis; urticaria; inflammation in allergic and autoimmune diseases; molecular pathway involved in allergic and autoimmune diseases; biomarkers of allergic and autoimmune diseases; target therapy

(This special issue belongs to the Section Molecular Immunology)

Natural Products and Synthetic Molecules: Development of Novel Anticancer Drugs

edited by Vinícius D’Ávila Bitencourt Pascoal

submission deadline 30 Apr 2027 | Viewed by 792 | Submission Open

Keywords: anticancer drugs; natural products; synthetic molecules; bioactive compounds; molecular biology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Nutrition and Food Science

edited by

Sze Ying Leong

and

Indrawati Oey

submission deadline 30 Apr 2027 | 1 articles | Viewed by 753 | Submission Open

Keywords: molecular nutrition; functional foods; bioactives; food matrix; nutrient bioavailability; digestion kinetics; gut microbiota; nutritional functionality; food structure–function relationships; food reformulation; food science

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms and Advanced Diagnostic Technologies in Hair Disorders

edited by Maria Fernanda Reis Gavazzoni-Dias

submission deadline 30 Apr 2027 | 1 articles | Viewed by 670 | Submission Open

Keywords: inflammatory hair disorders; scarring and non-scarring alopecias; trichoscopy and scalp pathology; immunologic mechanisms in hair loss

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research in Nutritional Physiology and Gut Microbiome

edited by

Haiqiang Yao

submission deadline 30 Apr 2027 | 1 articles | Viewed by 640 | Submission Open

Keywords: nutritional physiology; gut microbiome; microbial metabolites; nutrient sensing; metabolic homeostasis; gut–brain axis; prebiotics; probiotics; molecular nutrition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Stem Cell and Epigenetic Regulation in Regenerative Medicine

edited by

Giuseppe Garroni

submission deadline 30 Apr 2027 | Viewed by 615 | Submission Open

Keywords: mesenchymal stem cells; regenerative medicine; stemness genes; stem cell differentiation; molecular regulation; gene expression; cell–environment interactions; conditioned medium; secreted factors; epigenetic modification

(This special issue belongs to the Section Molecular Biology)

Advances in Therapeutic Antibody Engineering

edited by

Chatchai Tayapiwatana

submission deadline 30 Apr 2027 | 1 articles | Viewed by 593 | Submission Open

Keywords: therapeutic antibodies; bispecific antibodies; antibody-drug conjugates (ADCs); nanobodies; AI-driven drug design; Fc engineering; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Neurotransmitter Dysregulation in Brain Disease: Focus on Epilepsy and Its Comorbidities

edited by

Giuseppe Di Giovanni

submission deadline 30 Apr 2027 | Viewed by 456 | Submission Open

Keywords: neurotransmitter dysregulation; epilepsy; addiction; serotonin; GABA; molecular neuroscience; neuropharmacology; brain networks

(This special issue belongs to the Section Molecular Neurobiology)

Epigenetic Regulation in Cell Development, Differentiation and Cell Fate

edited by Gang Ren

submission deadline 30 Apr 2027 | Viewed by 439 | Submission Open

Keywords: 3D genome; myogenesis; transgenerational inheritance; enhancer–promoter interaction; histone modification; epigenetic variation; complex traits

(This special issue belongs to the Section Molecular Genetics and Genomics)

Endocrine Tumors: Genetics, Genomics, and Molecular Pathogenesis

edited by Vito Guarnieri,

Alberto Falchetti

and Antonio Stefano Salcuni

submission deadline 30 Apr 2027 | Viewed by 357 | Submission Open

Keywords: parathyroid; adrenal; pancreas; thyroid; pituitary

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cardioprotective Mechanisms in Myocardial Ischemia

edited by Virginia Pérez and Verónica D’annunzio

submission deadline 30 Apr 2027 | Viewed by 354 | Submission Open

Keywords: myocardial ischemia; ischemia–reperfusion injury; cardioprotection; molecular signaling; oxidative stress; inflammation; cardiac remodeling; therapeutic targets; translational cardiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms in Cardiovascular and Metabolic Diseases: Effective and Potential Treatments

edited by

Alex Cleber Improta-Caria

submission deadline 30 Apr 2027 | Viewed by 334 | Submission Open

Keywords: molecular mechanisms; cardiovascular diseases; metabolic diseases; microRNAs; circRNAs; long non-coding RNAs; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Products for Cancer: Cutting-Edge Trends and Future Directions

edited by

Mounir Tilaoui

and Abdelmajid Zyad

submission deadline 30 Apr 2027 | Viewed by 333 | Submission Open

Keywords: natural products; cancer therapy; drug discovery; molecular mechanisms; multi-drug resistance; tumor heterogeneity; structure–activity relationships (SARs); biosynthetic pathway engineering; AI-driven drug discovery; multi-omics approaches

(This special issue belongs to the Section Molecular Pharmacology)

Biomarkers and Early Detection Strategies of Ovarian Tumors: 2nd Edition

edited by Lukasz Szafron

submission deadline 30 Apr 2027 | Viewed by 329 | Submission Open

Keywords: biomarker; ovarian cancer; borderline ovarian tumor; genetic variant; epigenetics; transciptomics; proteomics; metabolomics; ovarian tumor prevention; ovarian tumor treatment

(This special issue belongs to the Section Molecular Oncology)

DNA Damage and Repair Mechanisms in Cancer Development

edited by

Mengfan Tang

submission deadline 30 Apr 2027 | Viewed by 328 | Submission Open

Keywords: DNA damage response and repair; DNA replication; genome instability; drug resistance; targeted therapy; cellular senescence; innate immunity; nucleic acid homeostasis

(This special issue belongs to the Section Molecular Oncology)

Molecular and Cellular Mechanisms of Tissue Regeneration: Experimental Models and Emerging Approaches

edited by

Daiva Bironaite

submission deadline 30 Apr 2027 | Viewed by 289 | Submission Open

Keywords: regenerative medicine; stem cells; inflammation; degenerative disease models; extracellular matrix remodeling and intracellular signaling; tissue engineering; biomaterials and bioactive scaffolds; organoids; translational and cell-based therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Plant Transporters and Tolerance Proteins

edited by Kun Qiao

submission deadline 30 Apr 2027 | Viewed by 283 | Submission Open

Keywords: heavy metal; transporter; antioxidant; ornamental plants and horticulture; ion transport; phytoremediation; biofortification

(This special issue belongs to the Section Molecular Plant Sciences)

Mapping Lipid Metabolism in Cancer: Cellular, Metabolic, and Molecular Approaches

edited by

Iorio Egidio

submission deadline 30 Apr 2027 | Viewed by 282 | Submission Open

Keywords: lipid metabolism; cancer; metabolomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Epigenetic and Molecular Control of Plant Hormones in Development and Abiotic Adaptation

edited by

Leonardo Bruno

and

Emanuela Talarico

submission deadline 30 Apr 2027 | Viewed by 266 | Submission Open

Keywords: plant hormones; phytohormone signaling; epigenetic regulation; chromatin remodeling; abiotic stress; plant development; hormone crosstalk; stress adaptation; epigenetic memory

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into Plant–Soil–Microbe Interactions Under Abiotic Stress

edited by

Youcai Xiong

and

Muhammad Abrar

submission deadline 30 Apr 2027 | Viewed by 266 | Submission Open

Keywords: abiotic stress; microbial metabolites; molecular signaling; plant–microbe interactions; plant stress tolerance; rhizosphere microbiome; stress-responsive genes

(This special issue belongs to the Section Molecular Plant Sciences)

RNA Structure and Regulation in Biological Processes

edited by Changrui Lu

submission deadline 30 Apr 2027 | Viewed by 258 | Submission Open

Keywords: RNA structure; RNA three-dimensional conformation; RNA dynamics; RNA chemical modifications; structural biology; RNA–protein interactions; RNA structures in plant disease resistance; viral RNA structure and function; computational structure prediction; host–pathogen interactions

(This special issue belongs to the Section Biochemistry)

Forward in Vasculitis: Genetics and Beyond, 2nd Edition

edited by

Marija Jelusic

submission deadline 30 Apr 2027 | Viewed by 242 | Submission Open

Keywords: systemic vasculitides; ethiopathogenesis; risk factors; genetics; genomics; proteomics; transcriptomics; epigenetics; molecular pathways; novel therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Design, Synthesis and Evaluation of Anticancer Agents

edited by

Gourav Kumar

submission deadline 30 Apr 2027 | Viewed by 238 | Submission Open

Keywords: anticancer drug design; structure–activity relationship (SAR); molecular targets in cancer; synthetic antitumor agents; in vitro and ex vivo cancer models; molecular pharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Recent Progress on Optical Molecular Sensors

edited by

Nicola Y. Edwards

submission deadline 30 Apr 2027 | Viewed by 197 | Submission Open

Keywords: molecular sensors; chemosensors; luminescence; fluorescence; absorbance; chemometrics; computational studies; sensor arrays; receptors; assays

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Biochemical Mechanisms of the Gut–Brain Axis: Microbial Metabolites, Barrier Integrity, and Neuroimmune Signaling

edited by

Sidharth Prasad Mishra

submission deadline 30 Apr 2027 | Viewed by 144 | Submission Open

Keywords: gut–brain axis; gut microbiota; microbial metabolites; intestinal barrier integrity; neuroimmune signaling; host-microbiome interactions; microbiome-brain communication; neuroinflammation; multi-omics; microbiome-based therapeutics

(This special issue belongs to the Section Molecular Biology)

Targeting Membrane Proteins: Structure, Function, and Dynamic Relationships

edited by Ki-Young Lee

submission deadline 30 Apr 2027 | Viewed by 124 | Submission Open

Keywords: membrane proteins; conformational dynamics; allosteric regulation; signal transduction; drug discovery; cryo-electron microscopy; nuclear magnetic resonance spectroscopy; artificial intelligence; membrane mimetics

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 3001-3050 on page 61 of 63.

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