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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Decoding the Bone Microenvironment: Molecular Control of Regeneration and Repair

edited by

Xinyuan Yuan

and

Teliang Lu

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1086 | Submission Open

Keywords: bone regeneration; biomaterials; heterotopic ossification; calcium phosphates; bone tissue engineering

(This special issue belongs to the Section Molecular Biology)

Design, Synthesis, and Applications of Advanced Functional Materials

edited by

Angelika Kmita

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1042 | Submission Open

Keywords: advanced functional materials; materials synthesis; nanomaterials; hybrid materials

(This special issue belongs to the Section Materials Science)

KRAS-Associated Cancer Signaling

edited by Sang Hun Lee

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1033 | Submission Open

Keywords: KRAS signaling; receptor tyrosine kinases; EGFR; c-MET; PI3K–MAPK pathways; tumor microenvironment; drug resistance and adaptive rewiring; combination therapy; biomarker stratification; prion protein (PrPC)

(This special issue belongs to the Section Molecular Oncology)

Molecular Biomarkers and Mechanisms of Environmental Exposure

edited by

Supakit Khacha-Ananda

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1013 | Submission Open

Keywords: multi-omics technologies; molecular toxicology; environmental toxicants; toxicants; mechanism of toxicity; biomarkers; in vitro; in vivo; human model; health

(This special issue belongs to the Section Molecular Toxicology)

Biopolymers and Their Application

edited by

Diego Acevedo

and

Edith Inés Yslas

submission deadline 31 Oct 2026 | 1 articles | Viewed by 985 | Submission Open

Keywords: biopolymers; biodegradable polymers; bio-based materials; biopolymer composites; sustainable materials; green chemistry; functional biopolymers; advanced polymer applications

(This special issue belongs to the Section Materials Science)

Molecular Docking and Structure-Based Modeling

edited by Serap Yalçın Azarkan

submission deadline 31 Oct 2026 | 1 articles | Viewed by 973 | Submission Open

Keywords: molecular docking; structure-based drug design; challenging diseases; cancer; neurological disorders; infectious diseases; computational technique; binding affinity estimation; computer-based methods; personalized treatments

(This special issue belongs to the Section Molecular Biology)

Skin Immune-Related Diseases: New Molecular Insights in Pathogenesis and Treatment

edited by

Bogusław Nedoszytko

Radoslaw Spiewak

Agnieszka Owczarczyk-Saczonek

and

Dorota Purzycka-Bohdan

submission deadline 31 Oct 2026 | 1 articles | Viewed by 968 | Submission Open

Keywords: skin immune system (SIS); immune-mediated skin diseases; allergens; haptens; allergy to nickiel; inflammatory; allergic and autoimmunologic skin diseases; immunological retuning of the skin in systemic reactions to xenobiotics and foreign bodies; atopic dermatitis; psoriasis; allergic contact dermatitis; skin cancer: BCC, SCC, melanoma; T-cells lymphomas; mastocytosis; genomic studies: GWAS, NGS, SNPs; transcriptomic, proteomic studies in skin disorders; regulations of genes expression by epigenetic mechanisms: noncoding RNAs (ln, pi mi RNAs); promoter methylations; histone modifications; transcriptions factors: NFkB; oncogenes; cytokine and chemokine networks; growth factors; molecular markers of skin diseases; artificial intelligence (AI) in patients’ data analysis; AI applications in molecular biology and medicine; biological therapy of skin diseases; JAK/STAT inhibitors in skin diseases; BRAF inhibitors in skin diseases; gene therapies

(This special issue belongs to the Section Molecular Immunology)

Pathophysiology and Treatments of Spinal Cord Injury

edited by Roxana Rodríguez-Barrera and Elisa García-Vences

submission deadline 31 Oct 2026 | 1 articles | Viewed by 965 | Submission Open

Keywords: spinal cord injury; treatments; therapy cell; neuromodulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Protein Biomarkers in Cancer and Neurodegeneration

edited by

Barbara Mroczko

submission deadline 31 Oct 2026 | 2 articles | Viewed by 930 | Submission Open

Keywords: neurological diseases; potential biomarkers; tumour markers

(This special issue belongs to the Section Biochemistry)

Omics Approaches to Decipher Inborn Errors of Immunity and Secondary Immunodeficiencies

edited by

Francesco Saettini

submission deadline 31 Oct 2026 | 1 articles | Viewed by 918 | Submission Open

Keywords: inborn errors of immunity; primary immunodeficiency; secondary immunodeficiency; omics; genomics; proteomics; metabolomics; transcriptomics; lipidomics; single-cell; spatial transcriptomics; immune dysregulation

(This special issue belongs to the Section Molecular Immunology)

Recent Research on Natural Compounds: Biosynthesis, Analysis, and Application

edited by

Aleksandar Shkondrov

submission deadline 31 Oct 2026 | 1 articles | Viewed by 840 | Submission Open

Keywords: phytochemicals; natural compounds; chromatography; MS; NMR; analysis; identification; extraction; standardisation; quantitation; activity; moleabular mechanism; biosynthesis

(This special issue belongs to the Section Biochemistry)

Advances in Legume Crop Breeding, Genetics, and Genomic Approaches

edited by

Duygu Sari

submission deadline 31 Oct 2026 | 1 articles | Viewed by 819 | Submission Open

Keywords: legume breeding; plant genetics; crop improvement; molecular breeding; genomic approaches; genetic diversity; abiotic stress tolerance; root system architecture; interspecific hybridization; sustainable agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms Underlying Natural Products for Metabolic Disease Treatment

edited by

Saioa Gómez-Zorita

submission deadline 31 Oct 2026 | Viewed by 812 | Submission Open

Keywords: metabolic diseases; natural products; MAFLD

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mechanistic Studies of Neuroplasticity

edited by Jorge Bergado

submission deadline 31 Oct 2026 | 1 articles | Viewed by 786 | Submission Open

Keywords: neural plasticity; influence of trophic factors on plasticity; molecular cascades of plasticity; restorative neurology

(This special issue belongs to the Section Molecular Neurobiology)

The Microbiome: Bridging Human Health and Natural Ecosystems

edited by

Nitin Saksena

submission deadline 31 Oct 2026 | 1 articles | Viewed by 778 | Submission Open

Keywords: microbiome; human health; natural ecosystems; gut microbiome; environmental microbiomes; gut–brain axis; soil microbiome; 16S sequencing; aquatic microbiome; climate change; One Health; probiotics; metagenomics; microbial diversity; therapeutic interventions

(This special issue belongs to the Section Molecular Microbiology)

Antioxidant, Anti-Inflammatory and Anticancer Activities of Natural Products

edited by

Daeho Kwon

submission deadline 31 Oct 2026 | 1 articles | Viewed by 751 | Submission Open

Keywords: antioxidant; immunology; cancer; natural products; molecular biology; cell biology; secondary metabolites

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Environmental Stressors and Aquatic Life: A Molecular Perspective

edited by Xin Zhang

submission deadline 31 Oct 2026 | 1 articles | Viewed by 748 | Submission Open

Keywords: aquaculture; aquatic organisms; environmental stress; aquaculture ecology; pathology; physiology and toxicology; molecular biology and multi-omics

(This special issue belongs to the Section Molecular Biology)

T Cells in Cancer: From Effectors to Regulators and Therapeutic Targeting

edited by

Sabrina Bossio

submission deadline 31 Oct 2026 | 1 articles | Viewed by 744 | Submission Open

Keywords: T-cell in cancer; tumor microenvironment (TME); T cell exhaustion; oncogenic signaling pathways; cancer immunotherapy; immunometabolism

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanism and Therapeutic Strategy in Viral Infection

edited by Luisa Fernanda Duarte, Aracelly Gaete-Argel and Aldo Barrera

submission deadline 31 Oct 2026 | 1 articles | Viewed by 687 | Submission Open

Keywords: viral infections; immune evasion; inflammation; antiviral responses; vaccine; drug delivery systems; single-cell analysis; multi-omics approaches

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms and Therapeutics in Chronic Kidney Diseases

edited by

Haiyong Chen

submission deadline 31 Oct 2026 | 1 articles | Viewed by 679 | Submission Open

Keywords: chronic kidney disease; molecular pathway; cellular interaction; post-translational modification; genetics; renal injury susceptibility; molecular-based intervention; therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Deciphering the Molecular Symphony of Microbiome-Driven Immune Modulation

edited by Edda Russo and

Sara Salvetti

submission deadline 31 Oct 2026 | Viewed by 664 | Submission Open

Keywords: microbiome; immune; microbial-host interactions

(This special issue belongs to the Section Molecular Immunology)

The Latest Molecular and Psycho-Physiological Insights on “Brain Fatigue”

edited by

Takehiko Fujino

and

Masanori Honsho

submission deadline 31 Oct 2026 | 1 articles | Viewed by 635 | Submission Open

Keywords: epigenetics; neurotransmitter including dopamine; mitochondria dysfunction; neuroinflammation; lipidomics including plasmalogen; proteomics including neuropeptide; neural network; cognition abilities; decline in attention; judgement capacity; depressive state

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Targets for HPV-Related Head and Neck Cancer

edited by

Joshua D. Smith

submission deadline 31 Oct 2026 | Viewed by 634 | Submission Open

Keywords: human papillomavirus; HPV; head and neck; squamous cell carcinoma; recurrent; p16; immune; targeted; vaccine; antibody

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Plant–Pathogen Interactions: The Role of Effectors and Host Targets

edited by

Muhammad Asif

submission deadline 31 Oct 2026 | Viewed by 629 | Submission Open

Keywords: plant immunity; effector proteins; pattern-triggered immunity (PTI); effector-triggered immunity (ETI); NLR receptors; plant-microbe interactions; susceptibility; secreted virulence factors; signal transduction; host manipulation

(This special issue belongs to the Section Molecular Plant Sciences)

Ion Channels and Transporters: Regulation and Roles in Human Diseases

edited by

Susumu Ohya

submission deadline 31 Oct 2026 | 2 articles | Viewed by 626 | Submission Open

Keywords: Ca2+/K+/Na+/Cl- channels/transporters; organelle ion channels/transporters; Mg2+/ Zn2+/Mn2+ transporters; disease microenvironment; membrane trafficking; transcriptional regulation; post-translational regulation; epigenetic modification; protein degradation

(This special issue belongs to the Section Biochemistry)

Agro-Food Waste: From Bioactive Molecules to Materials

edited by

Natale Badalamenti

and

Antonella Maria Maggio

submission deadline 31 Oct 2026 | Viewed by 603 | Submission Open

Keywords: agro-food waste; phytochemistry; novel bio-products; physical–chemical characterization; innovative and sustainable extraction methodologies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Extracellular Vesicles: From Molecular Mechanisms to Therapeutic Applications: 2nd Edition

edited by Jung-Hyun Lee

submission deadline 31 Oct 2026 | 1 articles | Viewed by 585 | Submission Open

Keywords: extracellular vesicles; intercellular communications; biomarkers; drug delivery systems

(This special issue belongs to the Section Biochemistry)

Repurposed Anti-Cancer Drugs

edited by Jacek Kubiak and Malgorzata Kloc

submission deadline 31 Oct 2026 | 1 articles | Viewed by 584 | Submission Open

Keywords: repurposed drugs; cancer; cell cycle; computational approaches; apoptosis; molecular pathways; metformin; sertraline; thalidomide; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Structure-Based Design of Drugs and Other Bioactive Molecules

edited by

Antonio Carrieri

submission deadline 31 Oct 2026 | 1 articles | Viewed by 573 | Submission Open

Keywords: three-dimensional structure; molecular descriptor; molecular similarity; database searching; drug repositioning; target fishing; novel algorithm; data prediction

(This special issue belongs to the Section Molecular Informatics)

Microbial Fermentation Optimization and Product Bioactivity

edited by

Wai Prathumpai

submission deadline 31 Oct 2026 | 1 articles | Viewed by 554 | Submission Open

Keywords: microbial processes; bioprocess engineering; bioreactor process optimization; engineering design; synthetic biology; metabolic engineering; metabolic regulation

(This special issue belongs to the Section Molecular Microbiology)

Microenviromental Signalling in Tumorigenesis and Anti-Cancer Drugs Resistance

edited by

Pierluigi Scalia

submission deadline 31 Oct 2026 | Viewed by 549 | Submission Open

Keywords: tumor microenvironment; cancer cell signaling; paracrine and autocrine mechanisms; cancer drug resistance; oncogenic pathways; immune checkpoints; cancer immune evasion; cancer-associated fibroblasts; tumor-infiltrating lymphocytes; onco-immunology; CAR-T

(This special issue belongs to the Section Molecular Oncology)

Toward an Integrated Understanding of Circadian and Neuroendocrine Interactions in Health and Disease

edited by

Estela Maris Muñoz

and

Agata Rita Carpentieri

submission deadline 31 Oct 2026 | 1 articles | Viewed by 547 | Submission Open

Keywords: chronobiology; circadian system; neuroendocrine system; multidirectional crosstalk; neurons; endocrine cells; endocrine regulation; zeitgebers; hormones; neurotransmitters; homeostasis; diseases

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Calcium Channel Signaling: From Molecular Structure to Physiological Function

edited by

Dongki Yang

submission deadline 31 Oct 2026 | 1 articles | Viewed by 520 | Submission Open

Keywords: calcium signaling; ion channels; cell signaling; intracellular signaling; membrane proteins; electrophysiology; structural biology; cryo-electron microscopy; protein structure–function; signal transduction; calcium homeostasis; cellular physiology; molecular mechanisms; imaging techniques; live-cell imaging; systems biology; computational biology; pharmacology; drug discovery; therapeutic targets; translational research; disease mechanisms; cardiovascular diseases; neurological disorders; neurodegeneration; cancer biology; metabolism; inflammation; stem cells

(This special issue belongs to the Section Molecular Biology)

RNA Processing in Diseases

edited by

Naoyuki Kataoka

submission deadline 31 Oct 2026 | Viewed by 518 | Submission Open

Keywords: RNA splicing; alternative splicing; aberrant splicing; mis-splicing; RNA modification; RNA export; RNA processing; translation; mRNA stability

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Targeted Therapy and Epigenetic Advances in Cancer

edited by Qing Sheng Mi and

Li Zhou

submission deadline 31 Oct 2026 | Viewed by 508 | Submission Open

Keywords: cancer; epigenetic; therapeutic targets; chromatin; DNA methylation; histone modification; noncoding RNA; histone variants

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Mineral Nutrition and Tolerance to Salt and Drought in Plants

edited by

Bruno Filipe Pereira de Sousa

submission deadline 31 Oct 2026 | Viewed by 503 | Submission Open

Keywords: ionic stress; water stress; salinity; mineral nutrition; uptake and transport; signalling and metabolism; plant-microbe interactions; tolerance mechanisms; plant physiology; climate change

(This special issue belongs to the Section Molecular Plant Sciences)

The Effects of Dietary Factors and Nutrition on Chronic Disease

edited by

Zaidatul Akmal Othman

and

Zaida Zakaria

submission deadline 31 Oct 2026 | 1 articles | Viewed by 492 | Submission Open

Keywords: dietary patterns; chronic disease prevention; functional foods and bioactive compounds; nutritional epidemiology; gut microbiota; metabolic health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Environment-Induced Human Diseases

edited by

Halim İşsever

submission deadline 31 Oct 2026 | 1 articles | Viewed by 489 | Submission Open

Keywords: environmental exposures; heavy metal toxicity; environment-induced human diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Synaptic Transmission

edited by

Frank Schmitz

submission deadline 31 Oct 2026 | Viewed by 474 | Submission Open

Keywords: synapses; synaptic transmission; synaptic activity; neurological disease

(This special issue belongs to the Section Molecular Neurobiology)

Collagen and Lipid-Based Nanoagents/Nanoparticles: Chemical Investigation and Delivery

edited by

Riyanto Teguh Widodo

submission deadline 31 Oct 2026 | 1 articles | Viewed by 473 | Submission Open

Keywords: collagen nanoparticles; lipid nanoparticles; drug delivery system; nanocarriers; liposomes; niosomes; nanostructured lipid carriers; biocompatibility; surface functionalisation; nanoagents; molecular characterisation; controlled release

(This special issue belongs to the Section Molecular Pharmacology)

Intercellular Adhesion and Inflammatory Response in Cancer

edited by Anna Pryczynicz

submission deadline 31 Oct 2026 | Viewed by 470 | Submission Open

Keywords: adhesion; cancer; cancer therapy; inflammation; microenvironment

(This special issue belongs to the Section Molecular Biology)

Functional and Hybrid Imaging in Molecular Neuroscience

edited by Marija-Magdalena Petrinovic

submission deadline 31 Oct 2026 | Viewed by 468 | Submission Open

Keywords: molecular imaging; functional MRI; PET; multimodal brain imaging; neuroreceptor mapping; neuroinflammation; neurodegeneration; translational neuroscience

(This special issue belongs to the Section Molecular Neurobiology)

Phage Therapy: Breakthroughs and Challenges

edited by

Spyridon Megremis

and

Anisha Mahendra Thanki

submission deadline 31 Oct 2026 | Viewed by 463 | Submission Open

Keywords: phage therapy; phage production; phage engineering; phage genomics; phage evolution; phage structural biology

(This special issue belongs to the Section Molecular Microbiology)

Allergy, Allergens and Therapeutics: Towards New Horizons

edited by

Luis Manuel Teran

and Gandhi Pavón-Romero

submission deadline 31 Oct 2026 | Viewed by 461 | Submission Open

Keywords: allergy; allergens; asthma; atopic dermatitis; urticaria; diagnostics; therapeutics; depemokimab; rimibrutinib; bazolvolimab

(This special issue belongs to the Section Molecular Immunology)

Gene Variants and Phenotypic Diversity: Insights into CFTR, SLC Transporters and Disease

edited by Veronique Ladeveze

submission deadline 31 Oct 2026 | 1 articles | Viewed by 458 | Submission Open

Keywords: mutations; polymorphisms; alternative splicing; exon skipping; intron retention; CFTR (ABCC7); cystic fibrosis; SLC16a3; Alzheimer’s disease; pulmonary and brain cancer

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advanced Drug Delivery Systems: From Nanocarrier Design to Translation Application

edited by Santu Sarkar

submission deadline 31 Oct 2026 | 1 articles | Viewed by 455 | Submission Open

Keywords: nanocarriers; clinical translation; targeted delivery; immunogenicity; formulation strategies

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Mechanisms of Melanoma Resistance to Targeted Therapy

edited by

Ignacija Vlasic

and

Anđela Horvat

submission deadline 31 Oct 2026 | 1 articles | Viewed by 448 | Submission Open

Keywords: melanoma; targeted therapy; mechanisms of therapy resistance; predictive biomarkers

(This special issue belongs to the Section Molecular Oncology)

Bioactive Compounds from Microorganisms and Their Biotechnological Applications

edited by

Christian Anumudu

submission deadline 31 Oct 2026 | Viewed by 446 | Submission Open

Keywords: microbial bioactive compounds; secondary metabolites; natural products; antimicrobial agents; drug discovery; metabolomics; genomics; synthetic biology; fermentation biotechnology; bioprocessing; enzyme biotechnology; microbial peptides; polysaccharides; industrial biotechnology; biopharmaceuticals; anticancer compounds; anti-inflammatory agents; microbiome-derived compounds; sustainable production

(This special issue belongs to the Section Bioactives and Nutraceuticals)

From Molecular Mechanisms to Precision Medicine in Gastrointestinal Cancers: (Epi)genetics, Pharmacogenomics, and Emerging Biomarkers

edited by

Kostas A. Triantaphyllopoulos

submission deadline 31 Oct 2026 | Viewed by 445 | Submission Open

Keywords: gastrointestinal and colorectal cancer; genetic and epigenetic regulation; multi-omics and computational biology; molecular pathology and biomarker discovery; translational and precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Disease-Modifying Strategies in Type 1 Diabetes

edited by

Tarun Pant

submission deadline 31 Oct 2026 | Viewed by 434 | Submission Open

Keywords: type 1 diabetes; molecular mechanisms; disease-modifying strategies; immunometabolism; cytokine signaling; precision immunotherapy

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Displaying special issue 801-850 on page 17 of 63.

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