KRAS-Associated Cancer Signaling

Dear Colleagues,

Oncogenic KRAS orchestrates cancer signalling across colorectal, lung, and pancreatic malignancies through dynamic crosstalk with receptor tyrosine kinases, downstream MAPK/PI3K pathways, and the tumour microenvironment. Despite recent advances, including covalent KRASG12C inhibitors, adaptive rewiring, lineage context, and KRAS-independent survival circuits continue to limit durable responses. This Special Issue will gather mechanistic and translational studies that dissect KRAS-associated networks and therapeutic vulnerabilities, including RTK and membrane-proximal organizers (e.g., EGFR, c-MET, laminin receptor, prion protein), biomarker-driven patient stratification, and rational combinations with chemotherapy, targeted agents, or immunotherapy. We welcome original research, brief reports, and reviews using cellular and animal models, organoids, multi-omics, and computational approaches that inform clinically actionable strategies and early clinical translation.

Dr. Sang Hun Lee
Guest Editor

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