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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Pathophysiology of Lung Diseases—2nd Edition

edited by

Theodoros Karampitsakos

and Vassilios Tzilas

submission deadline 30 Aug 2026 | Viewed by 633 | Submission Open

Keywords: biomarkers; asthma; COPD; pulmonary fibrosis; post-COVID-19; interstitial lung disease; pathogenesis; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Safety, Toxicity, and Therapeutic Potential of Natural Products and Complex Mixtures

edited by

Fotios Tekos

and Demetrios Kouretas

submission deadline 30 Aug 2026 | 1 articles | Viewed by 574 | Submission Open

Keywords: natural products; complex mixtures; toxicity; safety assessment; antioxidant activity; bioactivity; redox biology; nutraceuticals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Neurotransmitter Dysregulation in Brain Disease: Focus on Epilepsy and Its Comorbidities

edited by

Giuseppe Di Giovanni

submission deadline 30 Aug 2026 | Viewed by 432 | Submission Open

Keywords: neurotransmitter dysregulation; epilepsy; addiction; serotonin; GABA; molecular neuroscience; neuropharmacology; brain networks

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Biology of Placental Function and Pregnancy Complications

edited by

Yoshinori Moriyama

submission deadline 30 Aug 2026 | Viewed by 402 | Submission Open

Keywords: placenta; placental dysfunction; pregnancy complications; preeclampsia; fetal growth restriction; placental immunology

(This special issue belongs to the Section Molecular Biology)

Iron Metabolism in Health and Disease

edited by

Dariusz Szukiewicz

submission deadline 30 Aug 2026 | Viewed by 379 | Submission Open

Keywords: iron metabolism; iron homeostasis; hepcidin; anemia; iron overload

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Evolutionary Genetics of Pathogens

edited by Leonardo Gabriel Panunzi

submission deadline 30 Aug 2026 | Viewed by 352 | Submission Open

Keywords: pathogenicity; genome evolution; horizontal gene transfer; virulence factors; comparative genomics; pangenome analysis mobile genetic elements; computational biology; machine learning; host–pathogen interactions

(This special issue belongs to the Section Molecular Genetics and Genomics)

MiRNA Regulation in the Early PME/TME: The Role of Non-Cancer Cells and the ECM in Solid Tumours

edited by

Kurt Sartorius

submission deadline 30 Aug 2026 | Viewed by 325 | Submission Open

Keywords: microRNAs; early tumor microenvironment (TME); stromal/ECM interaction; vascularization; ECM remodelling; signalling pathways

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms Fueling Glioblastoma Progression and Resistance: Emerging Therapeutic Opportunities

edited by

Anthony Lemarié

submission deadline 30 Aug 2026 | Viewed by 323 | Submission Open

Keywords: glioblastoma; cancer stem cells; radioresistance; chemoresistance; targeted therapies; tumor plasticity; tumor heterogeneity; invasion; immune escape

(This special issue belongs to the Section Molecular Neurobiology)

Cardioprotective Mechanisms in Myocardial Ischemia

edited by Virginia Pérez and Verónica D’annunzio

submission deadline 30 Aug 2026 | Viewed by 323 | Submission Open

Keywords: myocardial ischemia; ischemia–reperfusion injury; cardioprotection; molecular signaling; oxidative stress; inflammation; cardiac remodeling; therapeutic targets; translational cardiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pathways and Emerging Biomarkers in Inflammatory Diseases

edited by

René Huber

submission deadline 30 Aug 2026 | Viewed by 319 | Submission Open

Keywords: inflammation; resolution of inflammation; inflammatory diseases; cancer; biomarker; molecular pathways; mediators; signal transduction; transcription factors; gene regulation; modifications

(This special issue belongs to the Section Molecular Immunology)

Advances in Molecular Research of Supramolecular Polymers

edited by

Attila Bende

submission deadline 30 Aug 2026 | Viewed by 311 | Submission Open

Keywords: supramolecular polymers; supramolecular aggregates; molecular self-assemblies; photochemistry and photophysics of molecular materials

(This special issue belongs to the Section Materials Science)

Biomarkers and Early Detection Strategies of Ovarian Tumors: 2nd Edition

edited by Lukasz Szafron

submission deadline 30 Aug 2026 | Viewed by 304 | Submission Open

Keywords: biomarker; ovarian cancer; borderline ovarian tumor; genetic variant; epigenetics; transciptomics; proteomics; metabolomics; ovarian tumor prevention; ovarian tumor treatment

(This special issue belongs to the Section Molecular Oncology)

Effects and Applications of Nanoparticles in Plant Physiology

edited by

Fan Zhang

submission deadline 30 Aug 2026 | Viewed by 280 | Submission Open

Keywords: nano-enabled agriculture; nanotoxicology; molecular mechanisms; nanosafety; micro/nanoparticle stresses; combined risk

(This special issue belongs to the Section Molecular Plant Sciences)

New Advances in Graphene Nanocomposites

edited by Enrique Mejía-Ospino

submission deadline 30 Aug 2026 | Viewed by 262 | Submission Open

Keywords: graphene derivatives; interface chemistry; dispersion; molecular mechanisms

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Nutrition and Functional Foods: Mechanisms of Metabolic Health Regulation

edited by

Eugene Chang

submission deadline 30 Aug 2026 | Viewed by 231 | Submission Open

Keywords: nutrients; bioactive food components; functional food; signaling pathways; metabolism; metabolic regulation; nutrigenomics; gut microbiota; inflammation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Traditional Tree Breeding for Growth, Adaptation, and Genetic Improvement

edited by Huiyu Li

submission deadline 30 Aug 2026 | Viewed by 212 | Submission Open

Keywords: tree breeding; genetic improvement; progeny testing; seed orchard; parental selection; growth adaptation; polyploid breeding; interspecific hybridization; forest genetics; climate resilience

(This special issue belongs to the Section Molecular Plant Sciences)

Protein Regulation and Targeted Therapeutics in Neurodegenerative Disorders

edited by

Niti Sharma

submission deadline 30 Aug 2026 | Viewed by 197 | Submission Open

Keywords: neurodegeneration; protein regulation; protein aggregation; small molecules; therapeutic approaches

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms Regulating Stress Tolerance in Ornamental Plants

edited by

Haizhen Zhang

submission deadline 30 Aug 2026 | Viewed by 167 | Submission Open

Keywords: ornamental plants; biotic stresses; abiotic stresses; signal transduction pathways; transcription factors; functional proteins; transcription; translation; post-translational modification

(This special issue belongs to the Section Molecular Plant Sciences)

Hormone Replacement Therapy

edited by

Marco Antonio Botelho

and

Raouf A. Khalil

submission deadline 31 Aug 2026 | 3 articles | Viewed by 37890 | Submission Open

Keywords: hormone replacement therapy; molecular insights; endocrine signaling; precision medicine; gene expression; epigenetics; non-coding RNAs; personalized regimens

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Dopamine, Histamine, Serotonin—Receptors, Ligands and Their Biological Role in Central Nervous System Diseases, 2nd Edition

edited by

Dorota Łażewska

and

Anna Stasiak

submission deadline 31 Aug 2026 | 6 articles | Viewed by 21377 | Submission Open

Keywords: biogenic amines (histamine, dopamine, serotonin); receptors; ligands; antagonist/inverse agonist; affinity; intrinsic activity; multitarget ligands; molecular modeling; CNS diseases; neurodegeneration; psychiatric disorders; pain; in vitro studies; in silico studies; in vivo studies

(This special issue belongs to the Section Molecular Neurobiology)

Novel Biomarkers and Emerging Therapeutic Targets for Breast and Gynecologic Cancers

edited by

Hisham Bahmad

submission deadline 31 Aug 2026 | 11 articles | Viewed by 16724 | Submission Open

Keywords: cancer; uterus; cervix; breast; ovary; endometrial cancer; ovarian cancer; cervical cancer; breast cancer; biomarkers; therapeutic target; personalized medicine; targeted therapy; molecular signatures; diagnosis; prognosis

(This special issue belongs to the Section Molecular Oncology)

Skin Microbiome and Skin Health: Molecular Interactions

edited by

Terenzio Cosio

submission deadline 31 Aug 2026 | 4 articles | Viewed by 14224 | Submission Open

Keywords: skin microbiota; human disease; human health; omics; microbiota–host interactions; microbiota manipulation; microbiota; virota; inflammatory diseases; dysbiosis

(This special issue belongs to the Section Molecular Immunology)

Neuroinflammation and Cellular Senescence in Brain Aging and Neurodegeneration: From Molecular Mechanisms to Therapeutic Applications

edited by Jordi Olloquequi and M. Emília Juan

submission deadline 31 Aug 2026 | 3 articles | Viewed by 10202 | Submission Open

Keywords: SASP; glial activation; age-related disorders; neurotherapeutics; molecular signaling

(This special issue belongs to the Section Molecular Neurobiology)

Exploring the Genetics in Rare Diseases: A Genomic Odyssey

edited by

Klaus Brusgaard

submission deadline 31 Aug 2026 | 2 articles | Viewed by 5329 | Submission Open

Keywords: novel discoveries in rare disorders; polygenic risk scores; mosaicism; protein interaction; tools utilized to engineer DNA; somatic variants; patient advocacy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Anti-Inflammatory Strategies and Cell Models for Alzheimer’s Disease

edited by Sophia Lavrentiadou

submission deadline 31 Aug 2026 | 1 articles | Viewed by 4204 | Submission Open

Keywords: Alzheimer’s disease; neuroinflammation; anti-inflammatory strategies; cell models

(This special issue belongs to the Section Molecular Neurobiology)

Developmental Biology: Computational and Experimental Approaches, 3rd Edition

edited by

Mikhail P. Ponomarenko

submission deadline 31 Aug 2026 | 6 articles | Viewed by 4164 | Submission Open

Keywords: animal; plant; fungus; biological organization hierarchy; evolutionary limitations; fertilization; zygote; cell cycle; stem cell; meristem; cell layer; tissue; embryo; multicellular organism; ontogenesis; morphogenesis; life cycle; molecular mechanism; signal transduction; gene regulation; gene networks; cellular process; differentiation; migration; segmentation; high-resolution 3D-map; real-time in silico simulator; developmental hourglass; transcriptome ontogenetic switch; developmental abnormality; premature aging; neurodegeneration; tumorigenesis; atherogenesis; autoimmunity; induced pluripotent cell; wound healing; regeneration; assisted reproductive technologies; epigenetic reprogramming; predictive preventive personalized participatory (4P) medicine

(This special issue belongs to the Section Molecular Biology)

Algae-Derived Bioactives: Key Molecular Interactions Govern High-Value Applications

edited by Evan Stephens and Kirsten Heimann

submission deadline 31 Aug 2026 | 4 articles | Viewed by 4033 | Submission Open

Keywords: microalgae; macroalgae; cyanobacteria; bioactive compounds; health and nutrition; algal food products; market analysis

(This special issue belongs to the Section Molecular Microbiology)

Genetic and Epigenetic Regulation of Ageing

edited by Hidekazu Yamada

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3493 | Submission Open

Keywords: epigenetic clocks; biological resilience; DNA methylation; chromatin architecture; multi-omics integration; geroscience; cellular reprogramming; longevity interventions; immunosenescence; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Ruminant Physiology: Digestion, Metabolism, and Endocrine System

edited by Rui Hu

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3303 | Submission Open

Keywords: ruminant physiology; digestive health; metabolic regulation; endocrine signaling; rumen microbiome; nutrient partitioning; methane mitigation; epigenetic modulation; nutritional stress adaptation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Role of Neuropeptides and Their GPCRs in the Neuroendocrine System

edited by

Hirotaka Sakamoto

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3158 | Submission Open

Keywords: neuropeptides; G-protein-coupled receptors (GPCRs); neuroendocrine system; signal transduction; hypothalamus

(This special issue belongs to the Section Molecular Neurobiology)

Cardiovascular Diseases: From Molecular Diagnosis to Treatment

edited by

Li Wang

submission deadline 31 Aug 2026 | 2 articles | Viewed by 3076 | Submission Open

Keywords: cardiovascular diseases; molecular diagnosis; multi-omics approaches; liquid biopsies; molecular imaging; gene and cell therapies; nanomedicine; pharmacogenomics; targeted molecular therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Zoology: 2nd Edition

edited by

Valeria Maselli

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2846 | Submission Open

Keywords: zoology; genomics; transcriptomics; phylogeny; molecular evolution; mtDNA; eDNA; RNA; molecular zoology

(This special issue belongs to the Section Molecular Biology)

Exploring Melatonin and Related Indolic Agents

edited by

Burkhard Poeggeler

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2555 | Submission Open

Keywords: aging; antioxidant; bioenergetic agent; biological clock; immunomodulation; indole-3-propionic acid; indole-3-propionamide; melatonin; senescence; tryptophan

(This special issue belongs to the Section Molecular Pharmacology)

Bioactivity and Mechanistic Insights of Plant-Derived Chemical Compounds

edited by

Mohammed Dalli

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2340 | Submission Open

Keywords: plant-derived compounds; bioactivity; mechanism of action; phytochemicals; pharmacology; natural products; molecular targets; ethnopharmacology; drug discovery; translational research

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Role of Integrins in Cytokine Signaling

edited by

Yoshikazu Takada

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2230 | Submission Open

Keywords: integrins; cytokines; FGF1; CX3CL1; ternary-complex; antagonist; inside-out signaling; integrin-binding motif; cytokine-integrin crosstalk; ligand-induced activation

(This special issue belongs to the Section Molecular Biology)

MicroRNA and Non-Coding RNA: From Basic Research to Potential Clinical Application—2nd Edition

edited by

Erika Cione

and

Diana Abrego-Guandique

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2214 | Submission Open

Keywords: microRNA; non-coding RNA; gene regulation; biomarkers; RNA therapeutics; extracellular vesicles; microarray; NGS

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in the Molecular Diagnosis and Treatment of Neurodegenerative Diseases

edited by

Bruno Manadas

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2163 | Submission Open

Keywords: neurodegenerative disorders; biomarkers; treatment; omics; systems biology

(This special issue belongs to the Section Molecular Neurobiology)

The Toxicity of Bisphenol A and Its Analogs

edited by

Krystyna Makowska

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2118 | Submission Open

Keywords: bisphenols; endocrine disruptors; bisphenol A and analogs; toxicology

(This special issue belongs to the Section Molecular Toxicology)

Techniques and Applications of Forensic Molecular Biology: From Pathology to Clinical Practice

edited by

Angelo Montana

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2075 | Submission Open

Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro, in vivo, and in silico models; hypoxic–ischemic brain injury; pregnancy biomarkers; vitality

(This special issue belongs to the Section Molecular Biology)

Advanced In Vitro Systems for Mechanistic Toxicology

edited by

João Pedro Silva

and

Félix Carvalho

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2008 | Submission Open

Keywords: mechanistic toxicology; organ-on-chip; microphysiological systems; human iPSC models; organoids; AI/ML modeling; multi-omics; high-content screening; 3D cell cultures

(This special issue belongs to the Section Molecular Toxicology)

DNA Methylation Dynamics Due to Environmental Factors and in Human Diseases

edited by

Naila Francis Paulo De Oliveira

and

José Maria Chagas Viana Filho

submission deadline 31 Aug 2026 | 3 articles | Viewed by 1980 | Submission Open

Keywords: inflammatory diseases; mental diseases; tumour diseases; epidrugs; exposure biomarkers; epigenetic drugs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Nutrition, Inflammation and Chronic Kidney Diseases

edited by

Rodolfo A. Valtuille

submission deadline 31 Aug 2026 | 3 articles | Viewed by 1976 | Submission Open

Keywords: chronic kidney disease; nutrition; inflammation; bioimpedance; gut-kidney axis; uremic toxins; oxidative stress; protein-energy wasting; precision nutrition; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Sjogren's Disease: Multidimensional Perspectives on Pathogenesis, Clinical Manifestations, and Therapeutic Advancements (2nd Edition)

edited by

Xiang Lin

submission deadline 31 Aug 2026 | 3 articles | Viewed by 1905 | Submission Open

Keywords: Sjögren's disease; diagnosis; therapeutics; bioinformatics; pre-clinical; cytokine; lymphocytes; autoantibodies; exocrine glands

(This special issue belongs to the Section Molecular Immunology)

Hydrogen Medicine: From Molecular Insights to Disease Intervention

edited by

Fei Xie

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1747 | Submission Open

Keywords: hydrogen medicine; molecular hydrogen; oxidative stress; inflammation; mitochondrial function; gasotransmitters; ischemia–reperfusion injury; clinical trials; signal transduction; bioinformatics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Degradable Polymers: Synthesis, Applications, and Environmental Impact

edited by Ce Sun and

Haiyang Gao

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1742 | Submission Open

Keywords: degradable polymer; synthesis; degradation mechanisms; sustainability

(This special issue belongs to the Section Macromolecules)

Molecular Targets and Toxic Interactomes of Pathogenic Proteins in Neurodegeneration

edited by

Kohji Fukunaga

and Ichiro Kawahata

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1723 | Submission Open

Keywords: neurodegenerative diseases; tau protein; TDP-43; α-synuclein; endoplasmic reticulum stress; mitochondrial toxicity; liquid–liquid phase separation; toxic Interactomes

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Cellular Mechanisms of Vaccine-Induced Immune Responses

edited by In Ohk Ouh

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1721 | Submission Open

Keywords: vaccine platforms; molecular mechanisms; innate immune sensing; adaptive immune responses; adjuvants and signaling pathways; antigen processing and presentation; immunological memory; systems immunology

(This special issue belongs to the Section Molecular Immunology)

New Pharmacological Insights on Natural Macromolecules and Natural Small Molecules: 2nd Edition

edited by

Dong-Sung Lee

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1716 | Submission Open

Keywords: bioactive natural molecules; natural macromolecules; natural small molecules; drug delivery; inflammatoty diseases; neurodegenerative diseases; skin diseases; cancer; metabolic diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mathematical Computation and Modeling in Biology

edited by

Shinuk Kim

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1684 | Submission Open

Keywords: mathematical model; computational methods; systemic molecular interaction; machine learning; integrating molecular materials

(This special issue belongs to the Section Molecular Informatics)

Feature Papers in ‘Physical Chemistry and Chemical Physics’: Fifth Edition

edited by

Dongho Kim

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1554 | Submission Open

Keywords: heterogeneous structures; alignment and surface phenomena; quantum theory; mathematical physics; statistical and classical mechanics; molecular structure; chemical kinetics; laser physics; dynamics; kinetics; photochemistry; spectroscopy; exciton dynamics; statistical mechanics; thermodynamics; electrochemistry; catalysis; surface science; quantum mechanics; theoretical developments; fundamental aspects of catalysis; solar energy conversion; polymer dynamics

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Displaying special issue 251-300 on page 6 of 62.

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