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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in the Role of Retinoic Acid-Regulated Genes in Cancer Biology

edited by Fuming Tsai

submission deadline 20 Mar 2026 | Viewed by 242 | Submission Open

Keywords: retinoic acid; retinoic acid receptors; retinoic x receptors; tumorigenesis; metastasis; tumor microenvironment; molecular pathways

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advancing Forensic Genetics Through Massive Parallel Sequencing

edited by Daniel Kling

submission deadline 20 Mar 2026 | Viewed by 239 | Submission Open

Keywords: forensic genetics; molecular biology; genetics and aging; biochemistry; population genetics; fo-rensic statistics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Pathways and Mechanisms of Lung Injury: From Environmental Agents to Clinical Implications

edited by

Maria Lisa Garavaglia

and Cristina Porta

submission deadline 20 Mar 2026 | Viewed by 236 | Submission Open

Keywords: lung injury; lung cancer; pulmonary fibrosis; chronic obstructive pulmonary disease; acute respiratory distress syndrome; environmental pollutants and toxins; molecular and cellular mechanisms; biomarkers; therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Multifunctional Nano-Coatings for Biomedical Applications

edited by

Mikhail Kryuchkov

and Jana Valnohova

submission deadline 20 Mar 2026 | Viewed by 235 | Submission Open

Keywords: nanocoatings; nanomedicine; drug delivery; surface functionalization; diagnostics; therapeutics; prevention; stimuli-responsive materials; biomedical nanotechnology; targeted delivery systems; biocompatible coatings

(This special issue belongs to the Section Molecular Nanoscience)

From Diet to Health: Which Molecules or Chemicals Are at Work?

edited by Sara Baldelli

submission deadline 20 Mar 2026 | Viewed by 233 | Submission Open

Keywords: balanced diet; functional nutrition; nutraceuticals; disease prevention; bioactive biomolecules

(This special issue belongs to the Section Bioactives and Nutraceuticals)

CD8⁺ T Cells in the Cancer Immunity Cycle: Mechanisms, Barriers, and Therapeutic Opportunities

edited by Wael Traboulsi

submission deadline 20 Mar 2026 | Viewed by 227 | Submission Open

Keywords: CD8+ T cell; cancer immunotherapy; checkpoint inhibitor; CAR-T cell therapy; CD8 differentiation; epigenetic regulation; metabolism; exhaustion; dysfonctional CD8+ T cell

(This special issue belongs to the Section Molecular Immunology)

Regulation of Gene Expression in Cell Differentiation

edited by

Iole Robuffo

submission deadline 20 Mar 2026 | Viewed by 226 | Submission Open

Keywords: cell differentiation; gene expression regulation; signal transduction; autophagy; nutrigenomics; mechanobiology; longevity; aging mechanism; tumor progression; regenerative medicine; gene therapy; tissue remodeling

(This special issue belongs to the Section Molecular Genetics and Genomics)

Novel Immunotherapies for Reshaping the Tumor Immune Microenvironment

edited by

Alessandro Canella

submission deadline 20 Mar 2026 | Viewed by 220 | Submission Open

Keywords: TIME; TME; immunosuppression; inflammation; immune cells; immunotherapy; cancer immune evasion

(This special issue belongs to the Section Molecular Oncology)

Health Impacts of Environmental Pollution on the Urogenital and Reproductive Systems

edited by

Anna Perri

and

Silvestro Antonio Ruffolo

submission deadline 20 Mar 2026 | Viewed by 218 | Submission Open

Keywords: pollution; endocrine toxicity; endocrine disruptors; human biomonitoring; infertility; cancer; inflammation; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Molecular Research in Neuroimmunology

edited by Mireya Fernández-Fournier

submission deadline 20 Mar 2026 | Viewed by 218 | Submission Open

Keywords: neuroimmunology; antibodies; virus; multiple sclerosis; progression

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insight into Polymer Dynamics

edited by

Sirui Ge

submission deadline 20 Mar 2026 | Viewed by 212 | Submission Open

Keywords: polymer dynamics; glass transition; segmental relaxation; bulk relaxation; structure– property relationship; functional polymers; spectroscopy; instrumental characterization; simulations and modeling; polymer diffusion

(This special issue belongs to the Section Materials Science)

The Future of Biomaterials in Dentistry: Innovations in Drug Delivery and Regenerative Medicine

edited by

Victor Martin

submission deadline 20 Mar 2026 | Viewed by 209 | Submission Open

Keywords: dentistry; regenerative medicine; drug delivery; tissue engineering; biomaterials; tooth; periodontal

(This special issue belongs to the Section Materials Science)

Flexible Sensors for Biomedical Application

edited by

Jimin Lee

submission deadline 20 Mar 2026 | Viewed by 207 | Submission Open

Keywords: biomedical applications; molecular diagnostics; molecular recognition mechanisms; biosensors; electrochemical sensing; nanomaterials for sensing; implantable sensors; soft bioelectronics

(This special issue belongs to the Section Biochemistry)

Light-On Molecular Probes for Biomedical Analysis

edited by Aleksey A. Vasilev

submission deadline 20 Mar 2026 | Viewed by 198 | Submission Open

Keywords: fluorogenic dyes; nucleic acid binders; nucleic acid labels; molecular probes; fluorogenic polymers and nanomaterials

(This special issue belongs to the Section Materials Science)

Activation of the Blood–Brain Barrier and Neurological Dysfunction: 2nd Edition

edited by

Monique F. Stins

submission deadline 20 Mar 2026 | Viewed by 197 | Submission Open

Keywords: blood– brain barrier; neuro-infectious diseases; microbes; traumatic brain injury; Alzheimer’ s disease; Parkinson’ s disease; schizophrenia; cerebral vasculature; vascular heterogeneity; white matter; gray matter; therapeutic delivery; opening the BBB; neuro vascular unit

(This special issue belongs to the Section Molecular Neurobiology)

Design, Synthesis and Application of Cellulose Materials

edited by

Jian Zhao

and

Yehan Tao

submission deadline 20 Mar 2026 | Viewed by 197 | Submission Open

Keywords: cellulose; polymer materials; biomass

(This special issue belongs to the Section Materials Science)

HPV Infection and Immune Escape Mechanisms

edited by

Vittorio Unfer

and Elisa Lepore

submission deadline 20 Mar 2026 | Viewed by 195 | Submission Open

Keywords: HPV; persistence; natural molecules; vaccination; genotypes; anal infection; oral infection; co-infection

(This special issue belongs to the Section Molecular Immunology)

Plant Senescence Under Environmental Stresses

edited by

Agnieszka Ostrowska

submission deadline 20 Mar 2026 | Viewed by 193 | Submission Open

Keywords: plant senescence; environmental stresses; phytohormones

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Aging and Alzheimer’s Disease Research: From Molecular Mechanisms to Therapeutics—2nd Edition

edited by Lilach Soreq

submission deadline 20 Mar 2026 | Viewed by 193 | Submission Open

Keywords: aging; Alzheimer’ s disease; bioinformatics; RNA-seq; Parkinson’ s disease

(This special issue belongs to the Section Molecular Neurobiology)

Omega-6 and Omega-3 Fatty Acid Imbalance: Roles in Human Health and Pathogenesis of Diseases

edited by

Jing X. Kang

submission deadline 20 Mar 2026 | Viewed by 179 | Submission Open

Keywords: omega-6/omega-3 ratio; omega-6 fatty acids; omega-3 fatty acids; omega-6/omega-3 imbalance; lipid metabolism; inflammation; chronic diseases; cardiovascular disease; cancer; metabolic syndrome; neurodegenerative diseases; autoimmune diseases; nutritional interventions; polyunsaturated fatty acids (PUFAs); molecular mechanisms; disease pathogenesis; disease management; health promotion

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances in Food Allergenicity: From Molecular Mechanisms to Innovative Mitigation Strategies

edited by

Edyta Juszczuk-Kubiak

submission deadline 20 Mar 2026 | Viewed by 178 | Submission Open

Keywords: food allergenicity; food allergen detection; biosensors; mass spectrometry; immunoassays; allergen reduction; hypoallergenic food alternatives; personalized nutrition approaches

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Molecular Research on Candida Resistance

edited by

Angela Maione

submission deadline 20 Mar 2026 | Viewed by 177 | Submission Open

Keywords: Candida resistance; antifungal resistance; biofilm; drug repurposing; novel therapies; molecular mechanisms; antifungal agents; Candida albicans; Candida auris; host– pathogen interactions

(This special issue belongs to the Section Molecular Microbiology)

Skin Diseases: From Molecular Mechanisms to Pathology, 2nd Edition

edited by

Alessandro Terrinoni

submission deadline 20 Mar 2026 | Viewed by 167 | Submission Open

Keywords: skin diseases; immunology; genetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in the Molecular Biology of Lipids and Mitochondria

edited by

Alejandra Espinosa

submission deadline 20 Mar 2026 | Viewed by 166 | Submission Open

Keywords: lipids; lipid transport mechanisms; lipid peroxidation; mitochondrial integrity; bioenergetics; mitochondrial phospholipid

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Insights into Pediatric Cancer: Advances in Hematopoietic Stem Cell Research

edited by

Paola Muggeo

submission deadline 20 Mar 2026 | Viewed by 164 | Submission Open

Keywords: bone marrow; microenvironment; precursor; hematopoietic stem cells; pediatric hematological malignancies

(This special issue belongs to the Section Molecular Oncology)

Arthritis: From Molecular Basis to Therapy

edited by Cinzia Rotondo

submission deadline 20 Mar 2026 | Viewed by 159 | Submission Open

Keywords: comorbidities; biomarkers; inflammation; autoimmune disease; systemic disease; arthritis; autoimmune disease; psoriasis; axial involvement; biological drugs; target synthetic DMARDs; pathogenesis; rheumatoid arthritis; spondyloarthritis; psoriatic arthritis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research Advances in Common and Rare Pediatric Diseases

edited by

Lǎcrǎmioara Ionela Butnariu

submission deadline 20 Mar 2026 | Viewed by 147 | Submission Open

Keywords: pediatric diseases; diagnosis; therapeutic targets; molecular mechanisms; pediatric pathology; signaling pathways

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Musculoskeletal Development and Skeletal Pathophysiologies, 3rd Edition

edited by

Elizabeth W. Bradley

submission deadline 20 Mar 2026 | Viewed by 147 | Submission Open

Keywords: musculoskeletal development; growth plate; endochondral ossification; intramembranous ossification; osteoporosis; osteoarthritis; bone; cartilage; osteoblast; osteoclast; chondrocyte

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Application of Biomaterials in Human Diseases

edited by

Satoshi Komasa

submission deadline 20 Mar 2026 | Viewed by 145 | Submission Open

Keywords: implant; bone substitute material; titanium; zirconia; biomaterials; in vitro; in vivo

(This special issue belongs to the Section Materials Science)

Genetic Diversity, Founder Effects, and Migration in Neurodegeneration: Molecular and Population Perspectives

edited by

Dasiel Oscar Borroto-Escuela

submission deadline 20 Mar 2026 | Viewed by 144 | Submission Open

Keywords: neurodegeneration; population genetics; founder effects; genetic diversity; migration and disease risk; spinocerebellar ataxia; Alzheimer’ s disease; Parkinson’ s disease; genetic epidemiology; underrepresented populations

(This special issue belongs to the Section Molecular Neurobiology)

Liver Disease and Primary Liver Cancer: Translational Advances and Therapeutic Perspectives

edited by

Cristian Turato

submission deadline 20 Mar 2026 | Viewed by 126 | Submission Open

Keywords: liver disease; hepatocellular carcinoma; cholangiocarcinoma; molecular mechanisms; translational research; 3D models and organoids; biomarkers and therapeutic strategies; MASH/MASLD: pathogenesis; diagnosis; and management; primary liver cancer: pathogenesis; detection; and treatment; inflammation in liver disease; 3D liver models; microbiota and liver disease; mechanisms of damage and repair: ischemia-reperfusion injury; cellular pathology in acute and chronic liver damage of different origin; biomarkers in liver disease: emerging methods and potential applications; immunology in the liver— from homeostasis to disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Dry Eye Syndrome, Second Edition

edited by Maria Jesus Giráldez-Fernández

submission deadline 20 Mar 2026 | Viewed by 122 | Submission Open

Keywords: dry eye disease; tear film osmolarity; tear film; artificial tear substitutes; biological tear substitutes; tear fluid biomarkers; tear film lipid layer; meibomian gland dysfunction; evaporative dry eye; aqueous deficiency dry eye; ocular surface inflammation; cytokines; histological analysis; pharmacological treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cytokines in Inflammatory Signaling: 3rd Edition

edited by

Waipo Chong

and

Daniela Novick

submission deadline 20 Mar 2026 | Viewed by 118 | Submission Open

Keywords: cytokines; inflammation; autoimmune diseases; immune homeostasis; signaling pathway; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Drug Discovery and Preclinical Pharmacology for Cognitive and Neuropsychiatric Disorders in Aging

edited by

Malgorzata Zaremba

submission deadline 20 Mar 2026 | Viewed by 110 | Submission Open

Keywords: aging brain; neural aging; neurodegeneration; neuropsychiatric disorders; late-life psychiatric disorders; dementia syndromes

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Toxicology of Nano- and Microplastics: Mechanisms of Cellular Disruption and Biochemical Pathways

edited by Ioannis Alexandros Charitos

submission deadline 20 Mar 2026 | Viewed by 103 | Submission Open

Keywords: nanoplastics; microplastics (NMP); toxicology; toxicological impact; human health; human microbiota; metabolome

(This special issue belongs to the Section Molecular Toxicology)

The Role of Long Non-Coding RNAs in Cancer Metastasis and Drug Resistance

edited by

Tulasigeri M. Totiger

submission deadline 20 Mar 2026 | Viewed by 82 | Submission Open

Keywords: long non-coding RNAs (lncRNAs); cancer metastasis; drug resistance; epithelial– mesenchymal transition (EMT); tumor microenvironment; chemoresistance mechanisms; RNA-based therapeutics; gene regulation; functional genomics; biomarkers in cancer

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights into Genetic and Epigenetic Alterations in Age-Related Diseases

edited by

Valerio Caputo

and

Andrea Latini

submission deadline 25 Mar 2026 | Viewed by 631 | Submission Open

Keywords: genomics; epigenetic modifications; age-related pathologies; neurodegeneration; dysmetabolism; spatial omics; 3D genome; genetic variants; telomere length; mitochondrial DNA; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Glial Cells in Brain and Eye: Emerging Mechanisms and Functions in Health and Disease

edited by

Mario E. Guido

submission deadline 25 Mar 2026 | Viewed by 163 | Submission Open

Keywords: glial cells; brain & eye (retina); health & disease; neuronal regulation; therapeutic strategies; CNS; glia biology; cellular interactions

(This special issue belongs to the Section Molecular Biology)

Advances in Nasopharyngeal Carcinoma Immunology, Epigenetics, and Therapy

edited by

Wei Dai

submission deadline 25 Mar 2026 | Viewed by 156 | Submission Open

Keywords: nasopharyngeal carcinoma (NPC); epstein– barr virus (EBV); cancer epigenomics; virus– host interaction; tumor microenvironment (TME); immunotherapy; targeted therapy; biomarker; metastasis; radiotherapy resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Central Nervous System Inflammatory Demyelinating Diseases

edited by Yong Guo

submission deadline 25 Mar 2026 | Viewed by 153 | Submission Open

Keywords: central nervous system; autoimmune; demyelination; inflammation; multiple sclerosis; pathology

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Engineering of Antimicrobial Agents: From Structure-Function Insights to Combinatorial Therapies

edited by Mingrui Liao

submission deadline 25 Mar 2026 | Viewed by 146 | Submission Open

Keywords: antimicrobial amphiphiles; antimicrobial resistance; structure– activity relationship; synergistic antimicrobial therapy; drug delivery systems

(This special issue belongs to the Section Molecular Biology)

The Expanding Genetic Landscape of Parkinson's Disease

edited by Christos Koros and

Vasilios C. Constantinides

submission deadline 25 Mar 2026 | Viewed by 112 | Submission Open

Keywords: Parkinson’ s disease; monogenic; polygenic risk score; alpha-synuclein

(This special issue belongs to the Section Molecular Neurobiology)

Prostate Cancer: Molecular Mechanisms and Targeting

edited by

Guoliang Li

submission deadline 25 Mar 2026 | Viewed by 98 | Submission Open

Keywords: prostate cancer; androgen receptor; therapy resistance; epigenetics; tumor microenvironment; molecular signaling; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Pulmonary Fibrosis: Molecular Mechanisms and Therapeutic Strategies

edited by

Barbara Ruaro

submission deadline 28 Mar 2026 | 2 articles | Viewed by 817 | Submission Open

Keywords: machine learning; pulmonary fibrosis; interstitial lung diseases; molecular mechanisms; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular-Level Insights into Retinal Vascular Disorders

edited by

Nikhlesh Singh

submission deadline 28 Mar 2026 | Viewed by 128 | Submission Open

Keywords: retina; retinal neovascularization; diabetic retinopathy; retinopathy of prematurity; VEGF; blood– retinal barrier

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Diagnostic, Prognostic and Predictive Biomarkers in Prostate Cancer

edited by Radka S. Stoyanova

submission deadline 28 Mar 2026 | Viewed by 107 | Submission Open

Keywords: prostate cancer; molecular biomarkers; imaging; non-invasive biomarkers; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Advances in Enzyme Inhibitors: Mechanisms, Applications, and Future Perspectives

edited by

Clemente Capasso

and

Valeria Pittalà

submission deadline 30 Mar 2026 | 5 articles | Viewed by 13511 | Submission Open

Keywords: enzyme inhibitors; drug design; drug discovery; drug therapy; resistance mechanisms; cancer; drug delivery systems; biocatalysts; enzymes in industrial applications

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms and Therapies of Brain Tumors

edited by Oana Alexandru

submission deadline 30 Mar 2026 | 4 articles | Viewed by 12751 | Submission Open

Keywords: brain tumors; molecular mechanisms; signal transduction; cell proliferation; apoptosis; targeted therapies; chemotherapy; radiotherapy

(This special issue belongs to the Section Molecular Oncology)

Neuroprotective Effects of Food Ingredients

edited by

Elena Ibáñez

and

Alejandro Cifuentes

submission deadline 30 Mar 2026 | 4 articles | Viewed by 8157 | Submission Open

Keywords: neuroprotection; Parkinson; Alzheimer; bioactive compounds; agri-food by-products; chemical characterization; foodomics; metabolomics; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Diagnostics and Genomics of Tumors, 2nd Edition

edited by

Petra Korać

submission deadline 30 Mar 2026 | 4 articles | Viewed by 3524 | Submission Open

Keywords: tumor biology; cancer genomics; molecular diagnostics; biomarkers; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 1001-1050 on page 21 of 64.

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