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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms for Skin Protection and Aging
edited by Wonchul Lim and
submission deadline 20 Jan 2026 | 4 articles | Viewed by 18140 | Submission Open
Keywords: skin photo-aging; skin inflammation; molecular biology; inner beauty; natural product; skin microbiome; skin wrinkle formation; skin dehydration; skin pigmentation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
A Molecular Perspective on the Genetics of Kidney Diseases
edited by Joaquim Calado
submission deadline 20 Jan 2026 | 6 articles | Viewed by 16819 | Submission Open
Keywords: kidney; genetics; solute transport; genomics; inflammation; dysmetabolism
(This special issue belongs to the Section Molecular Genetics and Genomics)
New Mechanisms and Therapeutics in Neurological Diseases—4th Edition
edited by
submission deadline 20 Jan 2026 | 8 articles | Viewed by 16163 | Submission Open
Keywords: neurodegeneration; neuroinflammation; neurodegenerative diseases; neurodevelopmental disorders; tumor markers; specific proteins
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Research on Neurotransmitters
edited by , and Jing-Ning Zhu
submission deadline 20 Jan 2026 | 6 articles | Viewed by 15871 | Submission Open
Keywords: neurotransmitter; GABA; glutamate; monoamines; dopamine; serotonin; norepinephrine; neuropeptides; nitric oxide; neurosteroids; stress; neurotrophins; epigenetics; gut– brain axis
(This special issue belongs to the Section Molecular Neurobiology)
Flow Cytometry: Applications and Challenges
edited by
submission deadline 20 Jan 2026 | 7 articles | Viewed by 15572 | Submission Open
Keywords: flow cytometry; non-conventional flow cytometry; hematology; morphology; molecular tests; cell biology; immunology; target therapy; microbiology; antigens; functional mechanisms; new technologies
(This special issue belongs to the Section Molecular Biology)
Recent Advances of Novel Pharmaceutical Designs for Anti-Cancer Therapies, 3rd Edition
edited by
submission deadline 20 Jan 2026 | 7 articles | Viewed by 15306 | Submission Open
Keywords: cancer; anticancer drugs; drug design; targeted therapy; immunotherapy; molecular target; molecular mechanism; drug resistance
(This special issue belongs to the Section Molecular Pharmacology)
Genomic Research of Rare Diseases
edited by Shira Rockowitz and Piotr Sliz
submission deadline 20 Jan 2026 | 7 articles | Viewed by 15114 | Submission Open
Keywords: rare disease ontology; variants of uncertain significance; candidate genes; whole genome sequencing; long read whole genome sequencing; machine learning; multi-omics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Mechanisms Involved in Sperm Development, Maturation, and Fertilization (3rd Edition)
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 14904 | Submission Open
Keywords: sperm physiology; seminal plasma; extracellular vesicles; reproduction; spermatogenesis; capacitation; fertility
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Pathophysiology and Immunology Related to SARS-CoV-2 Infection
edited by
submission deadline 20 Jan 2026 | 9 articles | Viewed by 14486 | Submission Open
Keywords: SARS-CoV-2; COVID-19; immunology; pathophysiology; immunopathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Transporters in Health and Disease submission deadline 20 Jan 2026 | 7 articles | Viewed by 14446 | Submission Open
Keywords: transporters; disease; regulation; drugs; toxicity; signaling
(This special issue belongs to the Section Molecular Biology)
Growth Hormone Deficiency: Molecular Pathologies and Therapeutic Strategies
edited by
submission deadline 20 Jan 2026 | 8 articles | Viewed by 14277 | Submission Open
Keywords: growth hormone (GH); growth hormone deficiency (GHD); growth hormone therapy; long-acting growth hormone (LAGH); insulin-like growth factor-1 (IGF-1); growth hormone secretagogues; signaling pathways of the GH-IGF-1 axis; transition phase
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioactive Compounds in the Prevention of Chronic Diseases submission deadline 20 Jan 2026 | 6 articles | Viewed by 14248 | Submission Open
Keywords: bioactives; chronic disease; inflammation; oxidative stress; obesity; diabetes; cancer
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Diagnosis and Monitoring of Kidney Disease: From Biology to Biomarkers submission deadline 20 Jan 2026 | 6 articles | Viewed by 14069 | Submission Open
Keywords: chronic kidney disease (CKD); end-stage renal disease; CKD biomarkers; CKD progression; metabolomics; molecular pathways; biomolecules; CKD anemia; cardiovascular disease risk; CKD-related disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Insight into Epigenomic Studies of Human Disease
edited by and Takashi Ito
submission deadline 20 Jan 2026 | 6 articles | Viewed by 13875 | Submission Open
Keywords: epigenetic regulation; DNA methylation; protein methylation; protein acetylation; histone modification; noncoding RNAs (ncRNAs); post-translational modifications (PTMs); chromatin; human disease
(This special issue belongs to the Section Molecular Genetics and Genomics)
Cytotoxicity, Antioxidant and Anticancer Activity of Natural Products, 2nd Edition
edited by
submission deadline 20 Jan 2026 | 7 articles | Viewed by 13363 | Submission Open
Keywords: natural products; anticancer activity; apoptosis; immunomodulation; free radicals; proliferation; phytomolecules; nanoparticles; drug delivery
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Focus on Hippocampus Biology: From Neurophysiology to Dysfunctions (2nd Edition)
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 13332 | Submission Open
Keywords: hippocampus; dentate gyrus; cornu ammonis (CA); spatial memory; episodic memory; learning; spatial navigation; synaptic plasticity; neuroplasticity; neurogenesis; ischemia; neuroinflammation; chronic stress; aging; neurodegenerative diseases; Alzheimer’ s disease; epilepsy; depression; anxiety
(This special issue belongs to the Section Molecular Neurobiology)
The Structures and Biologic Activity of Marine Natural Products submission deadline 20 Jan 2026 | 4 articles | Viewed by 12562 | Submission Open
Keywords: marine natural products; secondary metabolites; structure elucidation; biologic activity; structure-activity relationships; taxonomic distribution; biosynthesis; functions
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Insights into the Treatment of Metabolic Syndrome and Diabetes
edited by
submission deadline 20 Jan 2026 | 5 articles | Viewed by 12155 | Submission Open
Keywords: metabolic dysfunction; metabolic disorder; diabetes
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Zoology
edited by
submission deadline 20 Jan 2026 | 9 articles | Viewed by 12000 | Submission Open
Keywords: zoology; genomics; transcriptomics; phylogeny; molecular evolution; mtDNA; eDNA; RNA; molecular zoolog
(This special issue belongs to the Section Molecular Biology)
Editorial Board Members’ Collection Series: Cardiovascular Diseases submission deadline 20 Jan 2026 | 5 articles | Viewed by 11941 | Submission Open
Keywords: cardiovascular disease; metabolism; cardiometabolic risk; coronary artery disease; CVD
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Research Advances in the Bioinformatics of Genome Editing and Gene Function Analysis
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 11819 | Submission Open
Keywords: genome editing; functional genomics; genome analysis; transcriptome analysis; metagenome analysis; meta-analysis; bioinformatics; large language model (LLM); public databases
(This special issue belongs to the Section Molecular Informatics)
Molecular Progression of Genetics in Breeding of Farm Animals
edited by
submission deadline 20 Jan 2026 | 6 articles | Viewed by 11167 | Submission Open
Keywords: farm animal; livestock; genome sequencing
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Aspects of Bacterial Infection submission deadline 20 Jan 2026 | 5 articles | Viewed by 10689 | Submission Open
Keywords: bacterial pathogenesis; antimicrobial resistance; molecular mechanism of host-pathogen interaction; biofilm; infectious diseases
(This special issue belongs to the Section Molecular Microbiology)
Inflammation in Chronic Disease: Molecular Mechanisms and Signaling Pathways
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 10616 | Submission Open
Keywords: inflammation; neuroinflammation; immune response; inflammation-associated disease; inflammation mediators (proteins; enzymes; ecc); cytokines; macrophages; mast cells; monocytes; dendritic cells; oxidative stress; signaling pathways
(This special issue belongs to the Section Molecular Immunology)
Renin-Angiotensin System in Health and Diseases
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 10489 | Submission Open
Keywords: coronavirus disease 2019 (COVID-19); SARS-CoV-2; RAAS; spike protein; angiotensin; ACE2; clinical study; basic experiments
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanism Underlying Plant Drought and Salinity Stress Tolerance submission deadline 20 Jan 2026 | 4 articles | Viewed by 10479 | Submission Open
Keywords: drought; salinity; oxidative stress; antioxidant mechanism; photosynthesis; aquaporins; gene expression analysis
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Molecular Forensic Pathology and Toxicology: An Update
edited by
submission deadline 20 Jan 2026 | 5 articles | Viewed by 10345 | Submission Open
Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro; in vivo; and in silico models; hypoxic– ischemic brain injury; pregnancy biomarkers; vitality
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Neurologic and Neurodegenerative Disorders submission deadline 20 Jan 2026 | 4 articles | Viewed by 10211 | Submission Open
Keywords: traumatic brain injury; chronic traumatic encephalopathy; Alzheimer’ s disease; motor neuron disease; amyotrophic lateral sclerosis; neurosignalling; neurodegeneration; brain– gut axis impairment; oxidative stress; chronic inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Trends in Experimental Models for Cancer Research submission deadline 20 Jan 2026 | 4 articles | Viewed by 9711 | Submission Open
Keywords: experimental models; cancer research; cell culture; animal models; organoids; computational models
(This special issue belongs to the Section Molecular Oncology)
Molecular Studies of Natural Compounds and Plant Extracts—3rd Edition
edited by
submission deadline 20 Jan 2026 | 5 articles | Viewed by 9688 | Submission Open
Keywords: bioactive substances; plant chemistry; polysaccharides; flavonoids; alkaloids; saponins; terpenes; phenolic acids; volatile oils; antioxidant/anti-inflammatory/anti-cancer; blood pressure lowering; blood sugar lowering; antibacterial; antiviral; antiallergic
(This special issue belongs to the Section Biochemistry)
Molecular Perspective of Precision Medicine Revolutionizing Kidney Disease submission deadline 20 Jan 2026 | 1 articles | Viewed by 9443 | Submission Open
Keywords: personalized medicine; kidney diseases; genomics; biomarkers; therapeutics; proteomics; metabolomics; machine learning
(This special issue belongs to the Section Molecular Informatics)
Natural Compounds in Human Health and Disease
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 9415 | Submission Open
Keywords: nutrition; human health; obesity; polyphenol; tea; pathology; animal model
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Advances in the Treatment and Diagnosis of Neuromuscular Diseases
edited by Silvia Consalvi
submission deadline 20 Jan 2026 | 2 articles | Viewed by 9332 | Submission Open
Keywords: neuromuscular diseases; gene therapies; stem cell therapy; treatment and diagnosis
(This special issue belongs to the Section Molecular Neurobiology)
Developmental Biology: Computational and Experimental Approaches, 2nd Edition submission deadline 20 Jan 2026 | 5 articles | Viewed by 9293 | Submission Open
Keywords: animal; plant; fungus; biological organization hierarchy; evolutionary limitations
(This special issue belongs to the Section Molecular Biology)
Respiratory Virus Infection
edited by Nikolaos Siafakas
submission deadline 20 Jan 2026 | 6 articles | Viewed by 8774 | Submission Open
Keywords: respiratory virus; diagnosis; surveillance; epidemiology; therapy; vaccination; influenza virus; coronavirus; respiratory syncytial virus; rhinovirus/enterovirus
(This special issue belongs to the Section Molecular Microbiology)
Multiple Sclerosis: From Molecular Pathology to Novel Therapeutic Approaches submission deadline 20 Jan 2026 | 5 articles | Viewed by 8474 | Submission Open
Keywords: progression-independent relapses (PIRAs); smouldering-associated worsening (SAW); lack of new relapses and of new magnetic resonance imaging activity (NEIDA); slowly expanding lesions (SEL); no evidence of smouldering disease activity (NESDA); neurofilament (NfL); glial fibrillary acidic protein (GFAP); patient-reported outcome (PRO); paramagnetic rim lesions (PRLs); relapse-associated worsening (RAW)
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Biomarkers in Cancers: Advances and Challenges, 2nd Edition submission deadline 20 Jan 2026 | 5 articles | Viewed by 8247 | Submission Open
Keywords: cancer; cancer staging; diagnostic tools; novel biomarkers; proteomics; molecular markers; metabolic profiling; prognostic value
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biochemical and Molecular Aspects of Bioremediation of Soils with Organic Pollutants by Microorganisms
edited by
submission deadline 20 Jan 2026 | 5 articles | Viewed by 8232 | Submission Open
Keywords: bioremediation; soil pollution; organic pollutants; microorganisms; microbial communities; gene expression; enzyme degradation; molecular tools; indigenous soil microorganisms; contaminated soils
(This special issue belongs to the Section Molecular Microbiology)
Protein and Protein Interactions
edited by Wu Xu
submission deadline 20 Jan 2026 | 3 articles | Viewed by 8011 | Submission Open
Keywords: protein and protein interactions; ligand and protein interactions; computational method; geometry-based; energy-based; conformational changes; binding site prediction; structural biology; computational biology and bioinformatics
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Electrochemical-Related Materials
edited by Celia García-Hernandez
submission deadline 20 Jan 2026 | 5 articles | Viewed by 7672 | Submission Open
Keywords: novel electrochemical devices; advanced micro- and nanomaterials for electrochemical applications; batteries; fuel and photoelectrochemical cells; electrochemical sensors and biosensors; new advances in supercapacitors; electrochemical electrolyzers; advanced electrochemical materials for environmental applications
(This special issue belongs to the Section Materials Science)
Abiotic Stresses in Plants: From Molecules to Environment—2nd Edition
edited by
submission deadline 20 Jan 2026 | 5 articles | Viewed by 7607 | Submission Open
Keywords: stress signaling; abiotic stress; oxidative stress; genotoxic stress
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research in Bone and Soft Tissue Tumors
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 7455 | Submission Open
Keywords: sarcoma; therapeutic target; metastasis; anticancer agent; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
New Insights into the Immunopathology of Infectious Diseases
edited by Marta Camici
submission deadline 20 Jan 2026 | 4 articles | Viewed by 7263 | Submission Open
Keywords: infection immunology; immune dysregulation in infectious diseases; interactions between infective agents and immune responses; modeling of the immune system; new pathways of pathogenesis
(This special issue belongs to the Section Molecular Immunology)
Latest Research on Plant Genomics and Genome Editing, 2nd Edition
edited by
submission deadline 20 Jan 2026 | 5 articles | Viewed by 7059 | Submission Open
Keywords: next-generation sequencing; structural and functional genomics; SNPs; miRNA; LncRNA; CRISPR/Cas9; TALEN; genome editing
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms and Therapies for Melanoma
edited by Anna Piotrowska
submission deadline 20 Jan 2026 | 3 articles | Viewed by 7052 | Submission Open
Keywords: melanoma; targeted therapy; BRAF/MEK inhibitors; immunotherapy; anti-PD-1 and anti-CTLA-4 immunotherapy; melanoma microenvironment; cancer-associated fibroblasts (CAFs)/melanoma-associated fibroblasts (MAFs); MAPK (mitogen-activated protein kinase) signaling pathway
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomaterials for Drug Delivery and Advanced Therapies
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 7033 | Submission Open
Keywords: polymers; biomaterials; drug delivery; scaffold; ATMPs; tissue regeneration
(This special issue belongs to the Section Materials Science)
Advanced Electrode and Electrolyte Materials: Molecular Scale Design, Synthesis, Mechanisms and Applications
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 6956 | Submission Open
Keywords: cathode; anode; electrolyte; synthesis; electrochemistry; rechargeable batteries; lithium-ion batteries; all-solid-state lithium metal batteries
(This special issue belongs to the Section Materials Science)
Mesenchymal Stem Cell-Based Therapy: Cell Therapy vs. EV Therapy
edited by Masahito Nakazaki
submission deadline 20 Jan 2026 | 1 articles | Viewed by 6866 | Submission Open
Keywords: mesenchymal stromal/stem cells; small extracellular vesicles; large extracellular vesicles; clinical trials; spinal cord injury; cerebrovascular disease
(This special issue belongs to the Section Biochemistry)
Oxidative Stress in Human Diseases
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 6766 | Submission Open
Keywords: inflammation; oxidative stress; free radicals; proteins; lipids; DNA damage; biomarkers
(This special issue belongs to the Section Biochemistry)
Investigating Host-Parasite Interactions for the Discovery of Novel Therapies and Vaccine Targets submission deadline 20 Jan 2026 | 3 articles | Viewed by 6706 | Submission Open
Keywords: parasites; host-pathogen interactions; helminths; worms; protozoans; leishmania; malaria; schistosomiasis; trypanosomiasis; ascariasis; anisakiasis; vectors; mosquitoes; ticks; neglected tropical diseases
(This special issue belongs to the Section Molecular Immunology)
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