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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights into Autophagy and Retinal Degeneration

edited by

Francesco Fornai

submission deadline 30 Jan 2026 | 1 articles | Viewed by 4492 | Submission Open

Keywords: autophagy; retinal degeneration; retinal inflammation; oxidative stress; retinal alterations; age-related macular degeneration; retinal damage; inflammatory processes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Crustacean Aquaculture

edited by Tom Levy and

Tomer Ventura

submission deadline 30 Jan 2026 | 3 articles | Viewed by 4434 | Submission Open

Keywords: androgenic gland; aquaculture; crustaceans; disease management; gene silencing; genetic modification; monosex; selective breeding; sex reversal; yield improvement

(This special issue belongs to the Section Molecular Biology)

Unraveling Sugar Signaling: Insights into Plant Stress Responses

edited by

Claudia Uhde-Stone

submission deadline 30 Jan 2026 | 2 articles | Viewed by 4369 | Submission Open

Keywords: sugar signaling; glucose signaling; sucrose signaling; signal transduction pathways; plant response to stress; biotic stress; abiotic stress; plant physiology

(This special issue belongs to the Section Molecular Plant Sciences)

The Transcendental World of Plant Toxic Compounds

edited by

Helena Fernández

submission deadline 30 Jan 2026 | 2 articles | Viewed by 4288 | Submission Open

Keywords: alcaloids; biotic stress; defence; phenols; phytotoxins; secondary metabolism; terpenes

(This special issue belongs to the Section Molecular Plant Sciences)

Design, Synthesis and Applications of the Task-Specific Molecules

edited by

Ye Yuan

and

Yang Yang

submission deadline 30 Jan 2026 | 3 articles | Viewed by 3894 | Submission Open

Keywords: task-specific molecules; molecular design and synthesis; physical/chemical absorption; catalysis (including electrocatalysis; photocatalysis; etc.); mechanism on the molecular level; molecular dynamic simulations; optical materials; optoelectronic devices; photoelectric detection; semiconductors

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Latest Molecular Advances in Autophagy

edited by

Gloria Riitano

submission deadline 30 Jan 2026 | 2 articles | Viewed by 3604 | Submission Open

Keywords: autophagy; lipid rafts; Beclin 1; autoimmune diseases; cancer; clock genes; CLOCK

(This special issue belongs to the Section Molecular Biology)

New Insights into Hyaluronan in Human Medicine

edited by

Monica Salamone

submission deadline 30 Jan 2026 | 3 articles | Viewed by 3201 | Submission Open

Keywords: hyaluronan; regenerative medicine; inflammation; cancer therapy; metabolomics ; hyaluronidases; cell– matrix interaction; glucose metabolism; pathological processes

(This special issue belongs to the Section Biochemistry)

Dietary Components in the Brain–Gut Axis: Exploring Nutrigenetic and Microbiome Interactions

edited by

Piotr Dobrowolski

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2762 | Submission Open

Keywords: dietary components; carbohydrates; proteins; fats; fatty acids; vitamins; minerals; brain– gut axis; nutrigenetics; microbiome interactions; neurodegenerative disorders; metabolic pathways

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Glutamine Metabolism in Cancer

edited by

Andrew R. Green

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2651 | Submission Open

Keywords: glutamine metabolism; cancer; oncometabolism; cancer metabolism; metabolic reprogramming; personalised medicine; therapeutic resistance; drug targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Innovations in Synthetic Organic Chemistry

edited by Anand H. Shinde

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2521 | Submission Open

Keywords: organic synthesis; catalysis; material applications; bioactive molecules; active pharmaceutical ingredients; green chemistry

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms and Therapeutic Strategies to Overcome Drug Resistance in Cancer

edited by

Inamul Haque

submission deadline 30 Jan 2026 | 2 articles | Viewed by 2357 | Submission Open

Keywords: drug resistance; cancer therapy; targeted therapy; nanotechnology; tumor microenvironment; signaling pathway; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

From Genes to Medicine: Exploring the Genetic and Biological Bases of Medicinal Plants

edited by Wajid Zaman

submission deadline 30 Jan 2026 | 2 articles | Viewed by 2313 | Submission Open

Keywords: medicinal plants; genetic diversity; biosynthesis pathways; bioactive compounds; genomic technologies; plant breeding; biotechnology; CRISPR; phytochemistry; pharmacology; drug discovery; plant-based therapies

(This special issue belongs to the Section Molecular Biology)

Endothelial Function and Cardiovascular Disease: Molecular Advances and Challenges

edited by

Elena Grossini

submission deadline 30 Jan 2026 | 2 articles | Viewed by 2261 | Submission Open

Keywords: endothelium; heart; protection; therapeutic strategies; vascular system; vesicles

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Drug Development Breakthroughs: From Novel Antimicrobials to Targeted Cancer Drugs

edited by

Christos Papaneophytou

submission deadline 30 Jan 2026 | 2 articles | Viewed by 2241 | Submission Open

Keywords: drug development; molecular science; small-molecule inhibitors; biopharmaceuticals; peptides; cancer therapy

(This special issue belongs to the Section Molecular Pharmacology)

Metals and Metal Ions in Human Health, Diseases, and Environment

edited by

Agnieszka Scibior

and

Juan Llopis

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2014 | Submission Open

Keywords: metal toxicity; metal-based drugs; polyoxometalates; protein metalation; human health problems; diseases; in vitro/in vivo studies; human studies; environmental pollution

(This special issue belongs to the Section Molecular Biology)

Advanced Oxidation Processes for the Decontamination of Emerging Contaminants and Disinfection of Pathogenic Microorganisms

edited by

Chengdu Qi

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1947 | Submission Open

Keywords: advanced oxidation processes; emerging contaminants; pathogenic microorganisms; disinfection; hydroxyl radical; sulfate radical; organic radical

(This special issue belongs to the Section Molecular Microbiology)

Novel Biomarkers and Emerging Therapeutic Targets for Breast and Gynecologic Cancers

edited by

Hisham Bahmad

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1900 | Submission Open

Keywords: cancer; uterus; cervix; breast; ovary; endometrial cancer; ovarian cancer; cervical cancer; breast cancer; biomarkers; therapeutic target; personalized medicine; targeted therapy; molecular signatures; diagnosis; prognosis

(This special issue belongs to the Section Molecular Oncology)

Molecular Toxicity Research of Biological Venoms

edited by

Karla De Castro Figueiredo Bordon

and Suely Vilela Sampaio

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1819 | Submission Open

Keywords: neurotoxicity assays; insect models; electrophysiology; screening assays; ion channels; therapeutic molecules; animal venoms; antitumoral activity; enzyme activity; biotechnological application

(This special issue belongs to the Section Molecular Toxicology)

Neuroblastoma: Molecular Pathology, Diagnostics and Therapeutics

edited by

Simona Dedoni

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1811 | Submission Open

Keywords: neuroblastoma; solid cancer; immature nerve cells; molecular mechanism; biomarker; tumor heterogeneity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Dynamics Simulations of Nanobubble for Different Applications

edited by

Ebrahim Kadivar

submission deadline 30 Jan 2026 | 2 articles | Viewed by 1757 | Submission Open

Keywords: cavitation bubble; nanobubble dynamics; hydrodynamic cavitation; molecular dynamics simulations; laser-induced cavitation bubble; cavitation exploitation

(This special issue belongs to the Section Molecular Nanoscience)

Cancer Immunotherapy Biomarkers

edited by Ilias P. Nikas,

Ioannis Pateras

and

Apostolos Zaravinos

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1743 | Submission Open

Keywords: tumor microenvironment; tumor immunology; cancer biomarkers; immunotherapy; immunohistochemistry; pathology; personalized medicine; omics technologies; prognosis and therapy; bioinformatics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plasma-Based Technologies for Food Safety and Health Enhancement

edited by

Ihn Han

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1717 | Submission Open

Keywords: plasma-based technologies; food safety; microbial pathogens; oxidative stability; nutrient preservation

(This special issue belongs to the Section Biochemistry)

Molecular Biological Determination of Physical Injury

edited by

Sorin Hostiuc

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1626 | Submission Open

Keywords: molecular markers; physical injury; micro-RNA; dating of traumatic injuries

(This special issue belongs to the Section Molecular Biology)

Unravelling Functional Biology in Retinal Dystrophies and Eye Disease

edited by

Luigi Donato

and

Simona Alibrandi

submission deadline 30 Jan 2026 | 1 articles | Viewed by 995 | Submission Open

Keywords: precision ophthalmology; inherited retinal diseases; functional genomics; multi-omics approaches; photoreceptor degeneration; retinal organoids and iPSC models; bioinformatics and systems biology; genotype– phenotype correlations; RNA therapeutics and gene editing; early and late biomarkers of retinal disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Biogenesis, Structure, Function and Division of Plastids

edited by

Xiaomin Liu

and Li'na Yin

submission deadline 30 Jan 2026 | Viewed by 913 | Submission Open

Keywords: plastid; chloroplast; chlorophyll; endosymbiotic cyanobacteria; photosynthesis; genetic engineering

(This special issue belongs to the Section Biochemistry)

Significance and Challenges of Plant-Derived Natural Compounds in Cancers

edited by Ba Vinh Le

submission deadline 30 Jan 2026 | 1 articles | Viewed by 893 | Submission Open

Keywords: metabolomic; bioactive compound; pharmacognosy; oriental medicine; drug discovery; pharmacology; anti-cancer; pharmacological effects

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Exosomes and Non-Coding RNA Research in Health and Disease—2nd Edition

edited by Stergios Boussios

submission deadline 30 Jan 2026 | 1 articles | Viewed by 839 | Submission Open

Keywords: exosomes; non-coding RNA; health; disease; intercellular communication; cancer; neurodegenerative disorders; cardiovascular diseases; immune regulation; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

KRAS-Mutant Cancers: From Basic Biology to Clinical Translation

edited by

Mirela Sedic

Sérgia Velho

and Luka Bočkor

submission deadline 30 Jan 2026 | Viewed by 803 | Submission Open

Keywords: KRAS mutations; KRAS signalling; cancer; KRAS inhibitors; drug resistance; tumour microenvironment; cellular metabolism

(This special issue belongs to the Section Molecular Oncology)

Latest Advances in Aquatic Genetic Improvement

edited by Jun Qiang,

Yifan Tao

and Wenjing Tao

submission deadline 30 Jan 2026 | 1 articles | Viewed by 675 | Submission Open

Keywords: aquaculture genetic breeding; genomic selection; gene editing; disease-resistant breeding; multi-omics analysis; stress resistance enhancement; smart aquaculture; artificial intelligence

(This special issue belongs to the Section Molecular Genetics and Genomics)

Spectral Control of Stress Response in Plants

edited by

Gábor Kocsy

and Zsolt Gulyás

submission deadline 30 Jan 2026 | Viewed by 607 | Submission Open

Keywords: spectral control; stress response; light spectrum; photoreceptor; reactive oxygen; plant hormone; antioxidant; plant growth and development

(This special issue belongs to the Section Molecular Plant Sciences)

Mechanistic and Small Molecule Discoveries for Therapeutic Advances in Hypertrophic and Dilated Cardiomyopathies

edited by Osha Roopnarine

submission deadline 30 Jan 2026 | Viewed by 598 | Submission Open

Keywords: hypertrophic cardiomyopathy; dilated cardiomyopathies; cardiomyopathies

(This special issue belongs to the Section Molecular Pharmacology)

Chemoinformatics and Bioinformatics Tools in Structure-Activity Modelling in Molecular Sciences: 3rd Edition

edited by

Bono Lučić

submission deadline 30 Jan 2026 | Viewed by 580 | Submission Open

Keywords: chemoinformatics tools and models; bioinformatics tools and models; structure– activity modeling; structure– property modeling; QSAR; QSPR; drug/structure identification in bioprospecting research; molecular docking; molecular interactions; protein– protein interactions; development of algorithms; databases and web servers; data mining in chemoinformatics and bioinformatics; structure representation and optimization; molecular descriptors; modeling of health and environmentally relevant endpoints (activities; properties); toxicity modeling and prediction; carcinogenicity modeling and prediction; computational methods in molecular sciences; model validation approaches; multivariate modeling; predictive modeling; descriptive modeling; continuous data modeling; classification data modeling; machine learning in molecular sciences; deep learning in molecular sciences; structure visualization tools

(This special issue belongs to the Section Molecular Informatics)

Protease and Carbonic Anhydrase Inhibitors: 3rd Edition

edited by

Alessio Nocentini

submission deadline 30 Jan 2026 | Viewed by 546 | Submission Open

Keywords: carbonic anhydrase; protease; inhibitor; antiviral drug; antitumor drug; drug design; serine protease; metalloprotease; aspartic protease

(This special issue belongs to the Section Biochemistry)

Experimental Models and Applications in Muscle Regeneration

edited by

Daiva Bironaite

submission deadline 30 Jan 2026 | Viewed by 544 | Submission Open

Keywords: stem cells; internal and external stimuli; scaffolds; signaling systems; muscle regeneration mechanisms

(This special issue belongs to the Section Molecular Biology)

Hepatocellular Carcinoma: From Pathophysiology to Innovative Therapeutic Approaches

edited by Andrea Martini

submission deadline 30 Jan 2026 | Viewed by 526 | Submission Open

Keywords: liver carcinogenesis; tumor microenvironment; immune surveillance; fibrogenesis; inflammation

(This special issue belongs to the Section Molecular Oncology)

Epigenetics of Metabolic Diseases

edited by

Makrina Karaglani

submission deadline 30 Jan 2026 | 1 articles | Viewed by 525 | Submission Open

Keywords: epigenetics; metabolic diseases; DNA methylation; histone modifications; non-coding RNAs; obesity; diabetes; metabolic syndrome

(This special issue belongs to the Section Molecular Genetics and Genomics)

Recent Advances in Molecular and Cellular Approaches to Tuberculosis Pathogenesis, Treatment and Prevention

edited by

Selvakumar Subbian

submission deadline 30 Jan 2026 | 1 articles | Viewed by 516 | Submission Open

Keywords: tuberculosis (TB); animal models of mycobacterium infections; molecular pathogenesis; host-directed therapy (HDT); nanoparticle drug delivery; vaccine development; cellular immunology; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Insights into Neurological and Psychiatric Diseases from Invertebrate Models

edited by

Efthimios M. C. Skoulakis

submission deadline 30 Jan 2026 | Viewed by 478 | Submission Open

Keywords: disease model development; disease model validation; GWAS validation; ameliorative approaches; pharmacogenetics; pharmacoproteomics; disease mechanisms; suppressor/enhancer genetic screens; synthetic lethality screens; biomarker screens and validation

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Dialogues in the Tumor Microenvironment: Mechanisms, Methods and Therapeutic Implications

edited by

José M. Muñoz-Félix

submission deadline 30 Jan 2026 | 1 articles | Viewed by 473 | Submission Open

Keywords: tumor microenvironment; blood vessels; immune cells; spatial transcriptomics; histology

(This special issue belongs to the Section Molecular Oncology)

Autoimmune and Inflammatory Diseases: Latest Advances and Prospects

edited by

Paola Galozzi

submission deadline 30 Jan 2026 | Viewed by 472 | Submission Open

Keywords: autoimmunity; autoimmune disease; inflammation; inflammatory disease; cellular pathways; molecular mechanisms; pathogenesis; therapy

(This special issue belongs to the Section Molecular Immunology)

Molecular Research and Insights into Anti-Cancer Vaccines

edited by

Alfredo Martínez

submission deadline 30 Jan 2026 | 1 articles | Viewed by 469 | Submission Open

Keywords: anti-cancer vaccines; tumor antigens; molecular mechanisms; immunotherapy; molecular oncology

(This special issue belongs to the Section Molecular Oncology)

Inflammation and Metabolic Response in Mitochondrial Diseases

edited by

Guido Primiano

submission deadline 30 Jan 2026 | Viewed by 417 | Submission Open

Keywords: mitochondrial diseases; mitochondria; mtDNA; metabolic remodeling; inflammation; immunity; cell death; neurodegenration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Artificial Intelligence in Human Disease: Current and Future Perspectives in Digital Medicine

edited by

Dumache Raluca-Oana

submission deadline 30 Jan 2026 | Viewed by 398 | Submission Open

Keywords: molecular genetics; artificial intelligence; pharmacogenomics; internet of things; molecular pathology; genomic medicine

(This special issue belongs to the Section Molecular Informatics)

New Insights in Nanomaterials and Electroactive Molecules—in Memory of Prof. Royce W. Murray

edited by

Zeev Porat

submission deadline 30 Jan 2026 | Viewed by 373 | Submission Open

Keywords: nanomaterials; organic electrochemistry; macromolecules and polymers; analytical chemistry

(This special issue belongs to the Section Molecular Nanoscience)

Tumor Specific Immunotherapeutic Targets

edited by

Roberto Perris

submission deadline 30 Jan 2026 | Viewed by 362 | Submission Open

Keywords: immunotherapy; immunotherapeutics; tumour-specific antigens; immunotherapeutic targets; multi-omics approaches

(This special issue belongs to the Section Molecular Immunology)

New Research Perspectives in Protein Glycosylation

edited by

Hirokazu Yagi

submission deadline 30 Jan 2026 | Viewed by 331 | Submission Open

Keywords: glycan function; glycan structural analysis; glycoproteomics; glycoengineering; systems glycobiology

(This special issue belongs to the Section Biochemistry)

Plant Cell/Organ Structure and Function Research

edited by

Bartosz Płachno

submission deadline 30 Jan 2026 | Viewed by 303 | Submission Open

Keywords: leaf development; root development; plant cell ultrastructure; plant morphogenesis; plant organs and bacteria; fungi and animal interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Nutritional Modulators of Healthy Longevity: Mechanisms and Interventions

edited by

Shaokang Wang

submission deadline 30 Jan 2026 | Viewed by 290 | Submission Open

Keywords: aging; healthspan; nutrient signaling; oxidative stress; inflammation; autophagy; sarcopenia; bioactive compounds; molecular nutrition; protein metabolism

(This special issue belongs to the Section Molecular Biology)

Developing Methods and Molecular Basis in Plant Biotechnology: 2nd Edition

edited by

Wojciech Makowski

submission deadline 30 Jan 2026 | Viewed by 254 | Submission Open

Keywords: plant biotechnology; plant genetics; plant proteomics; plant metabolomics; stress

(This special issue belongs to the Section Molecular Plant Sciences)

Photosensitizers for Photodynamic Therapy: From Molecular Design to Application

edited by

Carlos Monteiro

M. Amparo F. Faustino

and

Leandro M. O. Lourenço

submission deadline 30 Jan 2026 | Viewed by 215 | Submission Open

Keywords: photodynamic therapy (PDT); photosensitizers (PS); reactive oxygen species (ROS); molecular design; nanocarriers; porphyrins and analogs; targeted drug delivery; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 1101-1150 on page 23 of 65.

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