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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Ion Channels and Transporters: Regulation and Roles in Human Diseases

edited by

Susumu Ohya

submission deadline 31 Oct 2026 | 1 articles | Viewed by 492 | Submission Open

Keywords: Ca2+/K+/Na+/Cl- channels/transporters; organelle ion channels/transporters; Mg2+/ Zn2+/Mn2+ transporters; disease microenvironment; membrane trafficking; transcriptional regulation; post-translational regulation; epigenetic modification; protein degradation

(This special issue belongs to the Section Biochemistry)

New Advances in Synaptic Transmission

edited by

Frank Schmitz

submission deadline 31 Oct 2026 | Viewed by 469 | Submission Open

Keywords: synapses; synaptic transmission; synaptic activity; neurological disease

(This special issue belongs to the Section Molecular Neurobiology)

Intercellular Adhesion and Inflammatory Response in Cancer

edited by Anna Pryczynicz

submission deadline 31 Oct 2026 | Viewed by 468 | Submission Open

Keywords: adhesion; cancer; cancer therapy; inflammation; microenvironment

(This special issue belongs to the Section Molecular Biology)

Functional and Hybrid Imaging in Molecular Neuroscience

edited by Marija-Magdalena Petrinovic

submission deadline 31 Oct 2026 | Viewed by 464 | Submission Open

Keywords: molecular imaging; functional MRI; PET; multimodal brain imaging; neuroreceptor mapping; neuroinflammation; neurodegeneration; translational neuroscience

(This special issue belongs to the Section Molecular Neurobiology)

Allergy, Allergens and Therapeutics: Towards New Horizons

edited by

Luis Manuel Teran

and Gandhi Pavón-Romero

submission deadline 31 Oct 2026 | Viewed by 459 | Submission Open

Keywords: allergy; allergens; asthma; atopic dermatitis; urticaria; diagnostics; therapeutics; depemokimab; rimibrutinib; bazolvolimab

(This special issue belongs to the Section Molecular Immunology)

Phage Therapy: Breakthroughs and Challenges

edited by

Spyridon Megremis

and

Anisha Mahendra Thanki

submission deadline 31 Oct 2026 | Viewed by 455 | Submission Open

Keywords: phage therapy; phage production; phage engineering; phage genomics; phage evolution; phage structural biology

(This special issue belongs to the Section Molecular Microbiology)

From Molecular Mechanisms to Precision Medicine in Gastrointestinal Cancers: (Epi)genetics, Pharmacogenomics, and Emerging Biomarkers

edited by

Kostas A. Triantaphyllopoulos

submission deadline 31 Oct 2026 | Viewed by 442 | Submission Open

Keywords: gastrointestinal and colorectal cancer; genetic and epigenetic regulation; multi-omics and computational biology; molecular pathology and biomarker discovery; translational and precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Compounds from Microorganisms and Their Biotechnological Applications

edited by

Christian Anumudu

submission deadline 31 Oct 2026 | Viewed by 441 | Submission Open

Keywords: microbial bioactive compounds; secondary metabolites; natural products; antimicrobial agents; drug discovery; metabolomics; genomics; synthetic biology; fermentation biotechnology; bioprocessing; enzyme biotechnology; microbial peptides; polysaccharides; industrial biotechnology; biopharmaceuticals; anticancer compounds; anti-inflammatory agents; microbiome-derived compounds; sustainable production

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Effects of Dietary Factors and Nutrition on Chronic Disease

edited by

Zaidatul Akmal Othman

and

Zaida Zakaria

submission deadline 31 Oct 2026 | 1 articles | Viewed by 438 | Submission Open

Keywords: dietary patterns; chronic disease prevention; functional foods and bioactive compounds; nutritional epidemiology; gut microbiota; metabolic health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Melanoma Resistance to Targeted Therapy

edited by

Ignacija Vlasic

and

Anđela Horvat

submission deadline 31 Oct 2026 | Viewed by 428 | Submission Open

Keywords: melanoma; targeted therapy; mechanisms of therapy resistance; predictive biomarkers

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Disease-Modifying Strategies in Type 1 Diabetes

edited by

Tarun Pant

submission deadline 31 Oct 2026 | Viewed by 425 | Submission Open

Keywords: type 1 diabetes; molecular mechanisms; disease-modifying strategies; immunometabolism; cytokine signaling; precision immunotherapy

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Bioactive Lipid Metabolites in Age-Related Comorbidities: From Mechanisms to Therapeutics

edited by

Sadanand Fulzele

submission deadline 31 Oct 2026 | Viewed by 424 | Submission Open

Keywords: lipid metabolites; aging; sarcopenia; osteoporosis; osteoarthritis

(This special issue belongs to the Section Biochemistry)

Ophthalmology: New Molecular Insights and Therapeutic Strategies

edited by

Meritxell López-Gallardo

and

José A. Fernández-Albarral

submission deadline 31 Oct 2026 | Viewed by 420 | Submission Open

Keywords: ophthalmology; molecular mechanisms; neuroinflammation; oxidative stress; retinal degeneration; neuroprotection; gene therapy; regenerative medicine; ocular biomarkers; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Estrogen Therapy for CNS Diseases

edited by

Istvan Merchenthaler

submission deadline 31 Oct 2026 | Viewed by 418 | Submission Open

Keywords: estrogen; central nervous system (CNS) diseases; neurodegenerative disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Polysaccharides: Properties, Structure and Biological Activity

edited by

Thanapon Charoenwongpaiboon

submission deadline 31 Oct 2026 | Viewed by 417 | Submission Open

Keywords: polysaccharides; oligosaccharides; carbohydrate engineering; glycosidic linkage; polysaccharide modification; bioactive carbohydrates; prebiotic activity; immunomodulatory effects; antioxidant activity; functional biomaterials

(This special issue belongs to the Section Macromolecules)

Molecular Mechanisms of Environment-Induced Human Diseases

edited by

Halim İşsever

submission deadline 31 Oct 2026 | 1 articles | Viewed by 415 | Submission Open

Keywords: environmental exposures; heavy metal toxicity; environment-induced human diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Gene Variants and Phenotypic Diversity: Insights into CFTR, SLC Transporters and Disease

edited by Veronique Ladeveze

submission deadline 31 Oct 2026 | 1 articles | Viewed by 411 | Submission Open

Keywords: mutations; polymorphisms; alternative splicing; exon skipping; intron retention; CFTR (ABCC7); cystic fibrosis; SLC16a3; Alzheimer’s disease; pulmonary and brain cancer

(This special issue belongs to the Section Molecular Genetics and Genomics)

Research Progress on Food Packaging Materials

edited by Ayca Aydogdu Emir

submission deadline 31 Oct 2026 | Viewed by 408 | Submission Open

Keywords: bio-based polymers; biodegradable packaging; active packaging; intelligent systems; antimicrobial films; nanotechnology; agri-food by-products; shelf-life extension; molecular interactions; sustainable materials

(This special issue belongs to the Section Materials Science)

Advances in Computational Research in Molecular Oncology: Tumor Initiation, Progression, and Treatment

edited by

Lip Yee Por

submission deadline 31 Oct 2026 | Viewed by 399 | Submission Open

Keywords: artificial intelligence; molecular oncology; multi-omics; digital twin; systems biology

(This special issue belongs to the Section Molecular Oncology)

Advanced Drug Delivery Systems: From Nanocarrier Design to Translation Application

edited by Santu Sarkar

submission deadline 31 Oct 2026 | 1 articles | Viewed by 396 | Submission Open

Keywords: nanocarriers; clinical translation; targeted delivery; immunogenicity; formulation strategies

(This special issue belongs to the Section Molecular Nanoscience)

Mechanistic Insights into the Ubiquitin System’s Role in Cellular Signal Transduction and Homeostasis

edited by Michael Massiah

submission deadline 31 Oct 2026 | Viewed by 396 | Submission Open

Keywords: ubiquitination; protein homeostasis; deubiquitinases; E3-associated diseases; autophagy; ubiquitin dysregulation; proteasome-targeting; protac

(This special issue belongs to the Section Molecular Biology)

Mesenchymal Stromal/Stem Cells (MSCs) in Regenerative Medicine

edited by

Miomir Knezevic

submission deadline 31 Oct 2026 | Viewed by 396 | Submission Open

Keywords: mesenchymal stromal cells; mesenchymal stem cells; regenerative medicine; cell therapy; immunomodulation; molecular mechanisms; extracellular vesicles; translational research; clinical applications; tissue regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neuroendocrine Tumors (NETs): New Molecular Insights

edited by Juan Pablo Petiti

submission deadline 31 Oct 2026 | Viewed by 396 | Submission Open

Keywords: neuroendocrine neoplasms; cell signaling; biomarkers; molecular targets; tumor progression; invasion

(This special issue belongs to the Section Molecular Oncology)

Molecular-Scale Design, Synthesis, and Applications of (Photo)Electrochemical Materials for Sustainable Energy and Environmental Solutions

edited by

Shiwei Lin

and

Zhaohui Xiao

submission deadline 31 Oct 2026 | Viewed by 395 | Submission Open

Keywords: molecular-scale material engineering; photoelectrocatalysis/electrocatalysis; sustainable energy conversion; atomic-precision synthesis; environmental remediation technologies

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Mechanisms and Therapeutics in Chronic Kidney Diseases

edited by

Haiyong Chen

submission deadline 31 Oct 2026 | Viewed by 390 | Submission Open

Keywords: chronic kidney disease; molecular pathway; cellular interaction; post-translational modification; genetics; renal injury susceptibility; molecular-based intervention; therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Plant Abiotic Stress: Recent Advances and Challenges

edited by

Quaid Hussain

submission deadline 31 Oct 2026 | Viewed by 389 | Submission Open

Keywords: abiotic stress; plant stress tolerance; molecular mechanisms; gene expression; transcription factors; stress signaling pathways; functional genomics; plant hormones; omics technologies; gene family

(This special issue belongs to the Section Molecular Plant Sciences)

Collagen and Lipid-Based Nanoagents/Nanoparticles: Chemical Investigation and Delivery

edited by

Riyanto Teguh Widodo

submission deadline 31 Oct 2026 | 1 articles | Viewed by 387 | Submission Open

Keywords: collagen nanoparticles; lipid nanoparticles; drug delivery system; nanocarriers; liposomes; niosomes; nanostructured lipid carriers; biocompatibility; surface functionalisation; nanoagents; molecular characterisation; controlled release

(This special issue belongs to the Section Molecular Pharmacology)

Natural Antioxidants from Plant Sources: Functional Roles and Health Implications

edited by

Socorro Vanesca Frota Gaban

submission deadline 31 Oct 2026 | Viewed by 384 | Submission Open

Keywords: plant-derived antioxidants; polyphenols; oxidative stress; functional foods; preventive nutrition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Eco-Conscious Therapeutics: Molecular Foundations and Future Directions in Green Medicine

edited by

Adi Lahat

and

Kassem Sharif

submission deadline 31 Oct 2026 | Viewed by 368 | Submission Open

Keywords: green medicine; molecular therapeutics; sustainable healthcare; biomarker profiling; predictive toxicology; eco-friendly drug design; environmental impact; biodegradable materials

(This special issue belongs to the Section Molecular Toxicology)

Molecular Progress of Cardiovascular and Metabolic Disease

edited by

Ilenia Calcaterra

submission deadline 31 Oct 2026 | Viewed by 367 | Submission Open

Keywords: cardiometabolic continuum; endothelial dysfunction; heart failure; metabolic complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Expanding Genetic Landscape of Parkinson's Disease

edited by

Christos Koros

and

Vasilios C. Constantinides

submission deadline 31 Oct 2026 | Viewed by 365 | Submission Open

Keywords: Parkinson’s disease; monogenic; polygenic risk score; alpha-synuclein

(This special issue belongs to the Section Molecular Neurobiology)

Integrating Molecular Genetic and Geospatial Approaches for Advanced Monitoring of Plant Biodiversity

edited by

Luigi De Masi

and

Marina Maura Calandrelli

submission deadline 31 Oct 2026 | Viewed by 358 | Submission Open

Keywords: plant biodiversity; biodiversity monitoring; genetic diversity; gene flow; population structure; landscape genetics; adaptive variation; spatiotemporal modelling; genetic erosion; conservation biology; geospatial analysis; remote sensing

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Multicomponent Reactions (MCR) in Organic Synthesis

edited by

Diana Camelia Nuta

, Camelia Elena Stecoza and Carmen Limban

submission deadline 31 Oct 2026 | Viewed by 347 | Submission Open

Keywords: multicomponent reactions; one-pot synthesis; green chemistry; drug discovery; bignelli reaction; mannich reaction; hantzsch reaction; sustainable synthesis; nanoparticle catalysts; supramolecular chemistry; mechanochemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Research on Beneficial Mechanisms of Plant Growth Promoting Bacteria

edited by

Laith K.T. Al-Ani

submission deadline 31 Oct 2026 | Viewed by 331 | Submission Open

Keywords: biological control; plant resistance; induce systemic resistance (ISR); antifungal compounds; secondary compounds; siderophores; next-generation sequencing; soil biodiversity; microbiome; PGPF; trichoderma; mushroom; DSE; mycorrhiza

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Reprogramming of Mitochondrial Signalling and Metabolism in Cancers

edited by

Yunfeng Zhao

submission deadline 31 Oct 2026 | Viewed by 314 | Submission Open

Keywords: mitochondria; metabolic reprogramming; cancer metabolism; redox signaling

(This special issue belongs to the Section Molecular Oncology)

Quorum Quenching in Medicine–Molecular Interactions

edited by

Emil Paluch

submission deadline 31 Oct 2026 | Viewed by 312 | Submission Open

Keywords: quorum sensing; quorum quenching; biofilm; virulence; host; pathogenicity

(This special issue belongs to the Section Molecular Microbiology)

Cold Atmospheric Plasma Effect on Cancer Cells

edited by

Pradeep Lamichhane

and

Tirtha Raj Acharya

submission deadline 31 Oct 2026 | Viewed by 307 | Submission Open

Keywords: cold atmospheric plasma; plasma medicine; cancer cells; reactive oxygen species; molecular mechanisms; apoptosis; redox biology; immunogenic cell death; plasma oncology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Organ Axis: Insights from Molecular Metabolism

edited by

Peiwen Wang

submission deadline 31 Oct 2026 | Viewed by 298 | Submission Open

Keywords: organ axis; molecular metabolism; interorgan crosstalk; metabolic regulation; metabolic diseases; biomarkers; molecular pathways; metabolites

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Exploring Plant Growth and Development: From Molecular Mechanisms to Environmental Adaptations

edited by Lénia Rodrigues,

Hélia Cardoso

and

Catarina Campos

submission deadline 31 Oct 2026 | Viewed by 294 | Submission Open

Keywords: plant growth and development; molecular pathways; phytohormones; genome editing; high-throughput; omics; crop resilience; plant stress responses and adaptations

(This special issue belongs to the Section Molecular Plant Sciences)

Plant Bioactives: Sustainable Extraction, Characterization, and Antimicrobial Potential

edited by

Muhammad Saleem Kalhoro

submission deadline 31 Oct 2026 | Viewed by 290 | Submission Open

Keywords: plant extracts; bioactive compounds; phytochemistry; natural compounds; green based extraction; therapeutic potential

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Heart Failure: From Pathophysiology to Therapeutic Targets

edited by

Michele Correale

submission deadline 31 Oct 2026 | Viewed by 286 | Submission Open

Keywords: heart failure; pathophysiology; pharmacological targets; congestion; edema; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Dysfunctional Neural Circuits in Brain Disorders

edited by

Yun Li

submission deadline 31 Oct 2026 | Viewed by 283 | Submission Open

Keywords: dynamic wiring; brain network; brain connectivity; neuropathology; neuromodulation; neuroplasticity; circuit mapping

(This special issue belongs to the Section Molecular Neurobiology)

Metal Complexes: From Synthesis to Pharmacological Studies and Application

edited by Joksimović Nenad and

Snežana Stojanović

submission deadline 31 Oct 2026 | Viewed by 281 | Submission Open

Keywords: metal complexes; medicinal inorganic chemistry; bioactive ligands; pharmacological activity; molecular docking; biomolecular interactions; anticancer agents; antimicrobial activity; coordination chemistry; structure–activity relationship

(This special issue belongs to the Section Molecular Pharmacology)

Latest Research Progress in Sport Genomics

edited by

Korkut Ulucan

submission deadline 31 Oct 2026 | Viewed by 277 | Submission Open

Keywords: sport genetics; genomics; athlete; performance; microbiota; epigenetics; injury; psychogenomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Microplastics and Nanoplastics: Cellular Toxicity and Health Implications

edited by Gaetana Gambino

submission deadline 31 Oct 2026 | Viewed by 277 | Submission Open

Keywords: microplastics (MPs); nanoplastics (NPs); cellular toxicity; human health; oxidative stress; inflammation; genotoxicity; mitochondrial; dysfunction; bioaccumulation; mechanistic toxicology

(This special issue belongs to the Section Molecular Toxicology)

Molecular Mechanisms of Resistance to Targeted Cancer Therapies

edited by

Patrick Ming-Kuen Tang

and

Dongmei Zhang

submission deadline 31 Oct 2026 | Viewed by 269 | Submission Open

Keywords: cancer therapy; drug resistance; molecular mechanism; artificial intelligence; singel-cell bioinformatics; spatial analysis

(This special issue belongs to the Section Molecular Oncology)

Toward an Integrated Understanding of Circadian and Neuroendocrine Interactions in Health and Disease

edited by

Estela Maris Muñoz

and

Agata Rita Carpentieri

submission deadline 31 Oct 2026 | Viewed by 267 | Submission Open

Keywords: chronobiology; circadian system; neuroendocrine system; multidirectional crosstalk; neurons; endocrine cells; endocrine regulation; zeitgebers; hormones; neurotransmitters; homeostasis; diseases

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Heart Diseases: Molecular Research and Novel Therapies

edited by Monika M. Gladka

submission deadline 31 Oct 2026 | Viewed by 266 | Submission Open

Keywords: cardiovascular diseases; molecular mechanisms; cardiac remodeling; heart failure; gene regulation; epigenetics; non-coding RNA; inflammation; regenerative medicine; novel therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Approaches in Glaucoma and Retinal Neurodegeneration

edited by Yukihiro Shiga

submission deadline 31 Oct 2026 | Viewed by 261 | Submission Open

Keywords: glaucoma; retinal neurodegeneration; retinal ganglion cells; mitochondrial dysfunction; neuroinflammation; neuro-glial interactions; multi-omics; biomarkers; disease-modifying therapies; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immune Crosstalk Between Host and Pathogens

edited by

Ulrike Kemmerling

and

Christian Castillo

submission deadline 31 Oct 2026 | Viewed by 261 | Submission Open

Keywords: host-pathogen interactions; virus; bacteria; parasites; innate immunity; adaptive immunity, signal transduction; immune evasion; cytokines; inflammation

(This special issue belongs to the Section Molecular Immunology)

Displaying special issue 851-900 on page 18 of 62.

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