Neural Circuit Mechanisms of Brain Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 April 2026
Special Issue Editor
Interests: functions and dysfunctions of the prefrontal cortex; prefrontal microcircuit; the miniscope in vivo calcium imaging technique; aberrant neural activity and dysfunctional prefrontal network in mouse models of dementia, depression, and autism
Special Issue Information
Dear Colleagues,
Normal cognition and behavior rely on the proper functioning of neural circuits. Advanced microscopic techniques—such as two-photon laser scanning microscopy, miniature fluorescent microscopy, and photometry—combined with sophisticated viral tracing tools, optogenetics, chemogenetics, and behavioral assays in animal models, have greatly enhanced our understanding of the complex alterations in neural circuits during the progression of neurological and psychiatric disorders. Unraveling the molecular and cellular mechanisms underlying such selective vulnerability and fine changes in neural circuitry that occurred during early disease stages is crucial for the development of potential neuromodulatory interventions.
In this Special Issue, we will discuss how the selective loss of connectivity and impairment of neural circuits, and how molecular and cellular pathways contribute to such changes, lead to various brain disorders.
Dr. Yun Li
Guest Editor
Manuscript Submission Information
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Keywords
- dynamic wiring
- brain network
- brain connectivity
- neuropathology
- neuromodulation
- neuroplasticity
- circuit mapping
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