Organ Axis: Insights from Molecular Metabolism
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 31 October 2026
Special Issue Editor
Special Issue Information
Dear Colleagues,
Organ-to-organ crosstalk, orchestrated by the "organ axis," represents a fundamental regulatory network that maintains systemic homeostasis. Molecular metabolism—encompassing the synthesis, breakdown, and interconversion of biomolecules—serves as the core driver and functional readout of this interorgan communication. In recent years, accumulating evidence has revealed that dysregulation of molecular metabolism within key organ axes (e.g., gut–brain, liver–adipose, gut–liver axes) is intricately linked to the pathogenesis of major human diseases, including metabolic syndrome, diabetes, neurodegenerative disorders, and cancer. Deciphering the molecular metabolic mechanisms underlying organ axis function not only deepens our understanding of basic biological processes but also provides novel targets for clinical diagnosis, prognosis, and therapeutic intervention. Despite significant progress, critical gaps remain in elucidating how metabolic signals are transmitted across organs, how organ-specific metabolic rewiring modulates interorgan crosstalk, and how these interactions can be translated into clinical applications.
This Special Issue aims to gather high-quality original research articles that highlight cutting-edge insights into the interplay between organ axes and molecular metabolism. It seeks to bridge basic and translational research, fostering dialogue among investigators focusing on interorgan communication, metabolic regulation, and disease mechanisms. The scope of this Special Issue is closely aligned with the journal’s focus on fundamental and translational research in biological regulation, metabolic pathways, and disease-related interorgan interactions.
In this Special Issue, original research articles and comprehensive reviews are welcome. Research areas may include (but are not limited to) the following:
- Molecular metabolic regulation of classic organ axes;
- Metabolites as signaling molecules in interorgan crosstalk;
- Dysregulated organ axis metabolism in metabolic diseases and age-related disorders;
- Molecular pathways mediating organ axis–metabolism interactions;
- Biomarkers of organ axis dysfunction derived from metabolic profiling;
- Therapeutic targeting of organ axis metabolic crosstalk for disease treatment;
- Multi-omics analyses of organ axis metabolism;
- Organoid and animal models for studying organ axis-metabolism interplay.
We look forward to receiving your contributions.
Dr. Peiwen Wang
Guest Editor
Manuscript Submission Information
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Keywords
- organ axis
- molecular metabolism
- interorgan crosstalk
- metabolic regulation
- metabolic diseases
- biomarkers
- molecular pathways
- metabolites
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