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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Computational Studies of Natural Products

edited by

Leonid B. Krivdin

submission deadline 31 Oct 2026 | 4 articles | Viewed by 4081 | Submission Open

Keywords: computational chemistry; natural products; structural elucidation; Nuclear Magnetic Resonance (NMR); Density Functional Theory (DFT)

(This special issue belongs to the Section Molecular Informatics)

Advances in Laboratory Animal Research for Precision Medicine in Cardiovascular Diseases

edited by Conrado Calvo

submission deadline 31 Oct 2026 | 1 articles | Viewed by 3522 | Submission Open

Keywords: cardiovascular disease; experimental models and research; arrhythmias and cardiac electrophysiology; molecular science and imaging techniques; myocardial ischemia and heart failure; cardiac fibrillation and sudden cardiac death; circulation and blood vessels; diabetes and metabolic disorders; experimental datasets for precision medicine; data-driven in silico approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Peripheral Nerve Regeneration—2nd Edition

edited by

Cinzia Fabrizi

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3446 | Submission Open

Keywords: peripheral nerve regeneration; schwann cells; axonal regrowth; nerve regrowth

(This special issue belongs to the Section Molecular Neurobiology)

Hormonal and Metabolic Markers in Health and Disease

edited by

Rafał Podgórski

and

Kornelia Łach

submission deadline 31 Oct 2026 | 3 articles | Viewed by 3410 | Submission Open

Keywords: hormonal biomarkers; molecular mechanism of endocrine disorders; steroidogenesis; hormonal dysregulation; endocrine disruptors; metabolomics; metabolic regulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Role of the Gut-Islet Axis in and Beyond Metabolic Diseases

edited by Simona Georgiana Popa

submission deadline 31 Oct 2026 | 1 articles | Viewed by 3234 | Submission Open

Keywords: entero-insular axis; adipocytokines; precision therapy; insulin resistance; type 2 diabetes; neuroprotection; aging

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Evolutionary Genomics in Plants: From Single Gene to Genome

edited by

Bei Gao

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3127 | Submission Open

Keywords: evolutionary genomics; plant adaptation; genome evolution; crop improvement; bioinformatics; polyploidy

(This special issue belongs to the Section Molecular Plant Sciences)

Novel Mechanisms of Receptor Activation

edited by

Zong Jie Cui

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2965 | Submission Open

Keywords: G protein-coupled receptors; nuclear (steroid) hormone receptors; catalytic receptors; receptor structural motifs important for activation; receptor pharmacophores; structure–function correlates; cellular functions; integrated physiology; compartmentalized GPCRs; receptor pharmacology; aryl hydrocarbon receptor (AHR); “orphan” GPCRs

(This special issue belongs to the Section Biochemistry)

Molecular Insights into Liver Disease: Pathogenesis, Progression, and Therapeutic Strategies

edited by

Andrea Dalbeni

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2908 | Submission Open

Keywords: liver disease; molecular pathogenesis; therapeutic strategies; liver fibrosis; hepatocellular carcinoma; MASLD and MetALD; molecular biomarkers; tailored medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Adipose Tissue as a Central Driver of Obesity-Related Complications

edited by

Anca Pantea Stoian

and

Teodor Salmen

submission deadline 31 Oct 2026 | 3 articles | Viewed by 2856 | Submission Open

Keywords: obesity; adipose tissue; adipokine; cardiometabolic disease; metabolic complications

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Emerging Viral Epidemics

edited by Nikolaos Siafakas

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2837 | Submission Open

Keywords: emerging viruses; diagnostic virology; viral epidemiology; viral evolution; zoonotic infections; public health; surveillance

(This special issue belongs to the Section Molecular Microbiology)

Enzymes and Enzyme Inhibitors—Applications in Medicine and Diagnosis, 3rd Edition

edited by

Athina Geronikaki

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2701 | Submission Open

Keywords: enzyme; enzyme inhibitor; drug target; enzyme deficiency; enzyme overexpression; biomarker; drugs; diagnosis; therapy

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Genetic Research in Skin Diseases

edited by

Yiannis Vasilopoulos

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2542 | Submission Open

Keywords: inflammatory skin diseases; genome-wide association studies (GWAS); epigenetic modifications; multi-omic integration; precision dermatology

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular and Cellular Research on Taste Receptors

edited by

Ana R. Costa

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2539 | Submission Open

Keywords: taste receptors; taste signaling; gustatory system; molecular signaling; cellular mechanisms; health and disease; functional roles; neurobiology of taste; cancer biology and metastasis; translational research

(This special issue belongs to the Section Molecular Biology)

Tumor Markers and Tumor Microenvironment

edited by Tamás Micsik

submission deadline 31 Oct 2026 | 3 articles | Viewed by 2526 | Submission Open

Keywords: tumor markers; tumor environment; molecular and genetics; omics; artificial intelligence; digital pathology; computational pathology; individualized therapy; prognostication

(This special issue belongs to the Section Molecular Oncology)

Interplay Between Blood Cells and Cytokines

edited by

Mats B. Eriksson

and

Anders O. Larsson

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2488 | Submission Open

Keywords: blood cells; communication; cytokine; erythrocyte; immunology; inflammation; interplay; leucocyte; platelet; network

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Next-Generation Antimicrobials and Anticancer Agents: From Natural to Synthetic Compounds

edited by

Manuela E. Crisan

and Roxana Popescu

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2471 | Submission Open

Keywords: bioactive molecules; natural products; synthetic compounds; molecular design; antimicrobial agents; anticancer agents; drug-resistant infections; drug discovery

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms and Therapeutic Targets in Inflammation and Cancer Immunity

edited by

Hyuk Soon Kim

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2457 | Submission Open

Keywords: immune regulation; inflammation; cancer immunity; immunotherapy; cytokine signaling; therapeutic targets; immune evasion; antibody-based therapy; histamine; drug repositioning

(This special issue belongs to the Section Molecular Immunology)

Genome Editing in Autologous Stem Cells: From Bench to Bedside

edited by

Edina Poletto

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2399 | Submission Open

Keywords: genome editing; gene therapy; autologous transplant; preclinical studies; process development; scalability; quality control; manufacturing; regulatory compliance; IND-enabling studies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms and Pathophysiology of Sepsis (2nd Edition)

edited by

Vlad Pădureanu

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2378 | Submission Open

Keywords: animal models; therapeutic concepts; biomarkers; sepsis; immune suppression; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Targeted Therapies and Evolving Treatment Paradigms in Non-Small Cell Lung Cancer

edited by Luis E. Raez

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2355 | Submission Open

Keywords: non-small cell lung cancer (NSCLC); targeted therapies; human epidermal growth factor receptor 2 (HER2); mesenchymal-epithelial transition factor (MET); anaplastic lymphoma kinase (ALK); C-ROS oncogene 1 receptor tyrosine kinase (ROS1); rearranged during transfection (RET); neurotrophic tyrosine receptor kinase (NTRK); B-Raf proto-oncogene serine/threonine kinase V600 mutation (BRAFv600); Kirsten rat sarcoma viral oncogene homolog (KRAS); epidermal growth factor receptor (EGFR)

(This special issue belongs to the Section Molecular Oncology)

Male Reproductive and Sexual Health

edited by

Aris Kaltsas

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2343 | Submission Open

Keywords: male reproductive health; male sexual health; male infertility; erectile dysfunction (ED); prostate inflammation; Peyronie's disease; biomarkers; molecular mechanisms; androgen deprivation; nanotechnology

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Signaling Pathways Dysregulation in Cancer: Advances and New Therapeutics Hopes: 2nd Edition

edited by

Daniela Miricescu

submission deadline 31 Oct 2026 | 3 articles | Viewed by 2311 | Submission Open

Keywords: cancer; epithelial cells; oncogenic mutations; PI3K/AKT/mTOR; TGF-β; Ras/Raf/MEK/ERK; Wnt/β-catenin; angiogenesis; invasion; metastasis; inhibitors

(This special issue belongs to the Section Molecular Oncology)

Artificial Intelligence and Deep Learning in Biomedical and Molecular Research

edited by

Serhat Kılıçarslan

submission deadline 31 Oct 2026 | 3 articles | Viewed by 2252 | Submission Open

Keywords: machine learning; deep learning; image processing; bioinformatics; artificial intelligence

(This special issue belongs to the Section Molecular Informatics)

Extraction and Application of Natural Compound

edited by

Sakaewan Ounjaijean

submission deadline 31 Oct 2026 | 4 articles | Viewed by 2237 | Submission Open

Keywords: natural compounds; extraction; characterization

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mechanobiology of the Cell

edited by

Zbigniew Baster

submission deadline 31 Oct 2026 | 3 articles | Viewed by 2179 | Submission Open

Keywords: nuclear and chromatin mechanics; mechanobiology; mechanotransduction pathways

(This special issue belongs to the Section Molecular Biology)

Microbial Infections and Novel Biological Molecules for Treatment: 2nd Edition

edited by Matthew Cheesman

submission deadline 31 Oct 2026 | 5 articles | Viewed by 2099 | Submission Open

Keywords: microbial infections; infectious diseases; new antibiotics; antimicrobial resistance (AMR); antimicrobial drugs; active substance; bacterial; virus

(This special issue belongs to the Section Molecular Microbiology)

Biological Materials: Molecular Mechanisms, Tissue Responses, and Translational Perspectives

edited by

Andre Luiz Sena Guimaraes

submission deadline 31 Oct 2026 | 3 articles | Viewed by 2097 | Submission Open

Keywords: biological materials; biomaterials; molecular mechanisms; regenerative medicine; 4D biomaterials; living materials; extracellular vesicle-based systems; advanced delivery systems; scalable manufacturing; translational medicine

(This special issue belongs to the Section Materials Science)

Molecular Research on Proglucagon-Derived Peptides

edited by

Camilla Krizhanovskii

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2037 | Submission Open

Keywords: proglucagon; peptide hormones; post-translational processing; prohormone convertase; G-protein-coupled receptors; tissue specificity

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Applications of Polysaccharides in Biomedicine and Agriculture

edited by

Artur Valente

and

Edvani C. Muniz

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2021 | Submission Open

Keywords: polysaccharides; carbohydrates; oligosaccharides; biomedical applications; pharmaceutical applications; drugs

(This special issue belongs to the Section Macromolecules)

Unravelling Functional Biology in Retinal Dystrophies and Eye Disease

edited by

Luigi Donato

and

Simona Alibrandi

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1988 | Submission Open

Keywords: precision ophthalmology; inherited retinal diseases; functional genomics; multi-omics approaches; photoreceptor degeneration; retinal organoids and iPSC models; bioinformatics and systems biology; genotype–phenotype correlations; RNA therapeutics and gene editing; early and late biomarkers of retinal disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Research on Mesenchymal Stem Cells (2nd Edition)

edited by Marcel Costuleanu

submission deadline 31 Oct 2026 | 3 articles | Viewed by 1985 | Submission Open

Keywords: mesenchymal stem cell; MSC; niche; tissue homeostasis; exosomes; microvesicles; cancer; mitochondrial exchange; MSC secretome

(This special issue belongs to the Section Molecular Biology)

Molecular Advances on Gut Microbiota in Human Health

edited by

Sanda Cretoiu

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1802 | Submission Open

Keywords: gut microbiota; dysbiosis; metabolomics; host–microbe interaction; molecular pathways; inflammation; personalized medicine

(This special issue belongs to the Section Molecular Microbiology)

Antibody-Based Therapeutics for Autoimmune Diseases

edited by

Naim Mahroum

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1792 | Submission Open

Keywords: autoimmune diseases; antibody-based therapeutics; autoantibodies; immunotherapy; precision medicine

(This special issue belongs to the Section Molecular Immunology)

Molecular Biology of Foodborne Pathogens: Genomics, Resistance, and New Perspectives

edited by

Joanna Gajewska

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1773 | Submission Open

Keywords: foodborne pathogens; antibiotic resistance; virulence factor; virulence genes; gene expression; bioinformatics; whole geomic sequencing

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Cellular Biology of Germ Cells

edited by

Anna Tabęcka-Łonczyńska

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1679 | Submission Open

Keywords: germ cell development; meiosis; epigenetic regulation; autophagy; mitochondrial dynamics; infertility; reproductive medicine; germ cell tumors; steroidogenesis; endocrine disrupting chemicals; reproductive toxicity

(This special issue belongs to the Section Molecular Biology)

T Regulatory and NKT Cells as Prognostic Biomarkers in Inflammatory Disorders and Cancers

edited by

Elena Matei

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1648 | Submission Open

Keywords: immune response; Tregs; NKT; regulation pathways; prognostic biomarkers

(This special issue belongs to the Section Molecular Immunology)

Progress in Photobiomodulation Therapy

edited by

Amílcar Sabino Damazo

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1648 | Submission Open

Keywords: photobiomodulation (PBM); low-level light therapy (LLLT); light-emitting diodes (LEDs); mitochondrial photostimulation; anti-inflammatory effects; tissue regeneration; neuromodulation; biostimulation; clinical applications; pain management

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cotton Breeding and Genetics: Advances and Perspectives

edited by Xuwu Sun

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1643 | Submission Open

Keywords: molecular design breeding; smart breeding; CRISPR-Cas; artificial intelligence; cotton genomics; multi-omics; high-throughput phenotyping; trait prediction; genome editing; crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Transcriptional Regulation in Plant Development: 3rd Edition

edited by

Konstantinos E. Vlachonasios

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1639 | Submission Open

Keywords: environmental stresses; plant development; vegetative development; plant physiology and biochemistry; transcriptional regulation; plant–environment interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Andrology

edited by Elikanah Olusayo Adegoke

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1633 | Submission Open

Keywords: fertilty; assisted reproduction technology; endocrine disrupting chemicals; hormones; male reproductive aging; semen analysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Interactions with Bacteria and Fungi: Mechanisms, Ecology, and Applications

edited by

Amjad Ali

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1561 | Submission Open

Keywords: plant–microbe interactions; plant pathology; host–pathogen interactions; microbiome; molecular diagnostics; omics; disease epidemiology; biocontrol; RNAi; sustainable agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Dementia with Lewy Bodies (DLB) and Alzheimer’s Disease (AD)

edited by Yuan-Han Yang

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1522 | Submission Open

Keywords: dementia with Lewy bodies; Alzheimer's disease; amyloid; tau; alpha-synuclein

(This special issue belongs to the Section Molecular Neurobiology)

Application of NMR Spectroscopy in Biomolecules: 2nd Edition

edited by

Luigi Russo

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1469 | Submission Open

Keywords: advanced solution and solid state biomolecular NMR techniques; structure and dynamics of biomolecules: proteins, peptides, and nucleic acids; paramagnetic NMR; in/on cell-NMR; protein–ligand, protein–DNA, protein–RNA interaction; protein folding and misfolding; structure-based drug screening, fragment-based drug screening; computational NMR methods; sample preparation and isotope labeling strategies; NMR metabolomics and foodomics; membrane proteins and lipids; natural-abundance NMR spectroscopy; pharmaceutical NMR applications; disordered proteins and peptides; drugs development; metal-binding biomolecules; hyperpolized NMR techniques; 19F NMR spectroscopy; NMR techniques for the analysis of complex mixtures; integrated NMR-based methodologies

(This special issue belongs to the Section Molecular Biophysics)

Natural Compounds in Cancer Drugs Treatment and Prevention

edited by

Saad Bakrim

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1425 | Submission Open

Keywords: natural compounds; cancer prevention; cancer treatment; drug resistance; secondary metabolites; anticancer agents; molecular mechanisms; clinical trials; drug delivery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Basis of Plant Traits Associated with Responses to Biotic and Abiotic Stress

edited by Nobuhiro Suzuki

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1416 | Submission Open

Keywords: molecular mechanisms ; biotic and abiotic stress ; plant trait ; signaling

(This special issue belongs to the Section Molecular Plant Sciences)

Deciphering the Molecular Landscape of Thyroid Biology and Pathogenesis

edited by Cesar Seigi Fuziwara

submission deadline 31 Oct 2026 | 3 articles | Viewed by 1335 | Submission Open

Keywords: thyroid cancer; thyroid diseases; gene regulation; signalling pathways; miRNA; lncRNAs; epigenetics; endocrine disruptors; thyroid development; animal models

(This special issue belongs to the Section Molecular Biology)

Cytomegalovirus: An Unresolved Puzzle in Transplantation

edited by

Eleonora Forte

, Zheng Zhang and Lorenzo Gallon

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1329 | Submission Open

Keywords: cytomegalovirus; latency; reactivation; transplantation; virus-host interaction; immune evasion; host immune response; omics approaches; high-throughput technologies

(This special issue belongs to the Section Molecular Microbiology)

Microbial Biofilms in Health and Disease: Molecular Perspectives

edited by

Paweł Krzyżek

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1320 | Submission Open

Keywords: biofilm; antibiofilm; biofilm matrix; matrixome; antibiotic resistance; antibiotic tolerance

(This special issue belongs to the Section Molecular Microbiology)

Cardiovascular Diseases: From Molecular Mechanisms to Therapeutics

edited by

Paul Quax

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1308 | Submission Open

Keywords: yocardial infarction and cardiac regeneration; microvasculature in cardiovascular health and disease; gender specific aspects of cardiovascular disease; heart failure; aneurysm formation and dissection; vascular remodeling (restenosis, atherosclerosis, angioegenesis); valve failure, replacement or regeneration; atherosclerosis; imaging; new therapeutic options including non-coding RNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Aquaculture: Genomics, Genetics and Breeding

edited by Chunde Wang and Shaoxuan Wu

submission deadline 31 Oct 2026 | 4 articles | Viewed by 1291 | Submission Open

Keywords: aquaculture; genetics; molecular breeding

(This special issue belongs to the Section Molecular Genetics and Genomics)

Displaying special issue 901-950 on page 19 of 63.

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