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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cutting-Edge Insights into Bacterial Infection and Host Immune Response

edited by

Pablo C. Baldi

submission deadline 31 Dec 2025 | 4 articles | Viewed by 3690 | Submission Open

Keywords: bacteria– host interaction; virulence factors; cellular and molecular immune response; immune evasion mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Functional Food Ingredients in Immunity Improvement

edited by

Prodromos Skenderidis

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3466 | Submission Open

Keywords: functional food ingredients; bioactive compounds; health potentials; food processing and immunomodulation; green extraction techniques; molecular mechanisms; nutritional immunology; dietary intervention

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Biomarkers for Targeted Therapies

edited by Vija Lavinia

submission deadline 31 Dec 2025 | 4 articles | Viewed by 3369 | Submission Open

Keywords: biomarkers; molecular targeted radiotherapies; prognostic biomarkers; predictive biomarkers; single or composite biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Ion and Molecule Transport in Membrane Systems, 6th Edition

edited by

Victor V. Nikonenko

and

Dmitrii Butylskii

submission deadline 31 Dec 2025 | 4 articles | Viewed by 3233 | Submission Open

Keywords: ion and molecular transport; physical chemistry; chemical physics; transport mechanisms; living systems; biological and artificial membranes; biomimetic structure; structure– property relationships; thermodynamics; irreversible thermodynamics; equilibriums; kinetics

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Urologic Cancers: Molecular Basis for Novel Therapeutic Approaches

edited by

Whi-An Kwon

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3094 | Submission Open

Keywords: urologic cancers; prostate cancer; urothelial cancer; renal cell cancer; genomics; proteomics; biomarkers; molecular pathways

(This special issue belongs to the Section Molecular Oncology)

The Biological Activities of Curcumin and Its Analogues

edited by Francis Johnson

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2936 | Submission Open

Keywords: curcumin; analogues; natural compounds; inflammation; tissue reconstruction

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanism Involved in Cancer Metastasis

edited by

Mohamed Jemaà

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2744 | Submission Open

Keywords: cell motility; cell migration; spheroid; metastasis; extracellular matrix; cell architecture; lamellipodia; epithelial-mesenchymal transition EMT; videomicroscopy; confocal microscopy; animal model

(This special issue belongs to the Section Molecular Oncology)

25th Anniversary of IJMS: Advances in Physical Chemistry and Chemical Physics

edited by

Mihai V. Putz

Hyotcherl Ihee

and

Carlos Miguel Costa

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2673 | Submission Open

Keywords: molecular dynamics; quantum chemistry; spectroscopic techniques; supramolecular interactions; computational modeling; AI in chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Selected Papers from the 5th International Symposium on Frontiers in Molecular Science (ISFMS)

edited by

Yoshinori Marunaka

Masayuki Takahashi

Yusaku Iwasaki

, Atsushi Shiozaki and Akiyuki Taruno

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2548 | Submission Open

Keywords: protein structure and function; multidomain proteins; drug design and drug resistance; enzymes; molecular biology of galectins; glycobiophysics; NMR spectroscopy; specific sensory systems; brain and systemic function

(This special issue belongs to the Section Biochemistry)

25th Anniversary of IJMS: Updates and Advances in "Materials Science" Section

edited by

Miklós Fried

and

Filippo Rossi

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2049 | Submission Open

Keywords: nanomaterials; functional polymers; bio-inspired systems; complex intelligent; responsive materials

(This special issue belongs to the Section Materials Science)

25th Anniversary of IJMS: Updates and Advances in Molecular Informatics

edited by

M. Natália D.S. Cordeiro

and

Giulio Vistoli

submission deadline 31 Dec 2025 | 3 articles | Viewed by 1953 | Submission Open

Keywords: AI-guided drug repurposing; virtual screening in personalized medicine; machine learning for toxicity prediction; network-based biomarkers in complex diseases; in silico pharmacokinetics and ADMET profiling; data-driven materials design; deep learning for molecular property prediction; AI-assisted nanomaterial synthesis; systems biology models for metabolic engineering

(This special issue belongs to the Section Molecular Informatics)

Physicochemical Properties and Applications of Nanomaterials in Biology and Medicine

edited by

Gangho Lee

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1908 | Submission Open

Keywords: nanoparticle; nanomaterial; biomedicine; synthesis; physicochemical properties; imaging; therapy; contrast agent; therapeutic agent

(This special issue belongs to the Section Molecular Nanoscience)

Biomolecular Structure, Function and Interactions: 2nd Edition

edited by

Ivo Crnolatac

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1901 | Submission Open

Keywords: biophysical chemistry; protein– protein interactions; protein– DNA interactions; protein– ligand interactions; receptor– ligand interactions; biomolecular structure and function; protein folding and stability

(This special issue belongs to the Section Biochemistry)

Research Progress in Cellular Senescence in Health and Disease

edited by

Gabriella Teti

and Mirella Falconi

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1827 | Submission Open

Keywords: senotherapy; cellular senescence; physiological relations; pathological relations; cell biology in aging; age-related diseases; senescence in mesenchymal stroma cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Technologies and Molecular Approaches in Brain Disease Diagnosis and Therapy

edited by

Furong Tian

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1812 | Submission Open

Keywords: neurodegenerative diseases; brain cancer; nanotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Research and Advances in Ocular Disease

edited by Da-Wen Lu

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1772 | Submission Open

Keywords: ophthalmology; AI; ocular; eye diseases; retina; cornea; glaucoma; neuro-ophthalmology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Genome Evolution and Environmental Adaptation

edited by

Zhonghu Li

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1752 | Submission Open

Keywords: plant phylogeny; genome evolution; molecular evolution of cytoplasmic genomes; species divergence

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into RNA Diseases

edited by

Naoyuki Kataoka

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1702 | Submission Open

Keywords: RNA splicing; RNA modification; RNA processing; translation; RNA transport

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Ovarian Cancer Metastasis and Chemotherapy Resistance

edited by

Carmela Ricciardelli

and

Noor A. Lokman

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1579 | Submission Open

Keywords: ovarian cancer; metastasis; biomarkers; chemotherapy resistance; tumor microenvironment; peritoneal– cancer cell interactions; proteomics; novel therapeutic targets

(This special issue belongs to the Section Molecular Oncology)

Advances in Conventional Tree Breeding: Integrating Phenotypic Selection, Genetic Gain, and Sustainable Forest Management

edited by

Jingli Yang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1510 | Submission Open

Keywords: forest trees; genetic breeding; conventional tree breeding; forest management; forest tree varieties; modern molecular technology; genetic engineering

(This special issue belongs to the Section Molecular Plant Sciences)

Melanoma: From Molecular Pathology to Therapeutic Approaches, 2nd Edition

edited by

Michael Eccles

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1423 | Submission Open

Keywords: melanoma; pathology; therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Focus on Plant Biotechnology and Molecular Breeding

edited by

Magdalena Wróbel-Kwiatkowska

submission deadline 31 Dec 2025 | 3 articles | Viewed by 1395 | Submission Open

Keywords: genetic engineering; plant transformation; applied biotechnology; functional genomics; crop plants; crop improvement; plant tissue cultures; secondary metabolites

(This special issue belongs to the Section Molecular Plant Sciences)

Highlights in Pathophysiology and Treatment of Osteoarthritis

edited by

Antonella Fioravanti

and

Serena Guiducci

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1388 | Submission Open

Keywords: osteoarthritis; pathophysiology (cytokines; adipokines; chemokines; epigenetics; microbiome); cartilage; synovial membrane; subchondral bone; treatment; disease-modifying osteoarthritis drugs; non-pharmacological treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanobiomaterials and Beyond: Innovations in Drug Delivery, Diagnostics, and Therapeutics

edited by

Alexandru Mihai Grumezescu

and

Adelina-Gabriela Niculescu

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1380 | Submission Open

Keywords: nanobiomaterials; drug delivery systems; targeted drug delivery; controlled drug release; stimulus-responsive nanomaterials; biocompatibility; biodegradability; functionalized nanocarriers; theranostics; nanocarriers for cancer therapy; tumor-targeted drug delivery; organ-specific delivery systems; pH-responsive materials; temperature-sensitive nanobiomaterials; light-activated drug delivery; enzyme-responsive systems; multimodal nanomaterials; translational nanomedicine; computational modeling in nanobiomaterials; preclinical studies of nanomaterials

(This special issue belongs to the Section Materials Science)

Advanced Research of Plant-Pathogen Interaction

edited by

Hyong Woo Choi

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1346 | Submission Open

Keywords: molecular plant-pathogen interactions; pathogen detection; secondary metabolism; multi-omics approaches; antibiotic resistance

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Forensic Molecular Biology and Genetics

edited by

Anna Barbaro

submission deadline 31 Dec 2025 | Viewed by 1149 | Submission Open

Keywords: nuclear and mt-DNA; rapid DNA analysis; next-generation sequencing; mRNA analysis; microbiome analysis; barcode DNA; time since deposition; fluid identification; DNA phenotyping; DNA ancestry

(This special issue belongs to the Section Molecular Biology)

Molecular Biology of Human Reproduction

edited by

Houda Amor

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1149 | Submission Open

Keywords: human reproduction; genomics; transcriptomics; proteomics; imaging technologies

(This special issue belongs to the Section Molecular Biology)

Nature-Inspired and Synthetic Compounds: New Frontiers in Bioactivity and Drug Discovery

edited by

Alina Bora

and

Luminita Crisan

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1127 | Submission Open

Keywords: natural and synthetic products; drug discovery and development; drug repurposing; artificial intelligence and machine learning; biological evaluation; healthcare; green and sustainable chemistry; natural and synthetic drug applications

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Food Allergy: Molecular Mechanisms, Clinical Challenges, and Future Directions

edited by

Sylwia Smolińska

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1095 | Submission Open

Keywords: food allergy; allergen; environmental exposures; gut microbiome; non-IgE-mediated pathways

(This special issue belongs to the Section Molecular Immunology)

25th Anniversary of IJMS: Updates and Advances in Molecular Pharmacology

edited by

Roberto Scatena

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1049 | Submission Open

Keywords: precision medicine; pharmacogenomics; targeted protein degradation (TPD); molecular pharmacology; RNA Therapeutics; novel drug modalities; proteomics; transcriptomics; personalized drug therapy

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Inflammasomes

edited by

Roberto Negro

submission deadline 31 Dec 2025 | Viewed by 1045 | Submission Open

Keywords: inflammasome; pyroptosis; innate immunity; cancer; neurodegenerative diseases; microbiota; gasdermin; ninjurin; drug screening; personalized treatments; multi-omics analysis

(This special issue belongs to the Section Molecular Immunology)

Upcycling Food Industry By-Products: Bioactive Ingredients for Nutrition and Health

edited by

Giusy Rita Caponio

and

Graziana Difonzo

submission deadline 31 Dec 2025 | 1 articles | Viewed by 934 | Submission Open

Keywords: bioactive compounds; food by-products; functional foods; molecular mechanisms; polyphenols; oxidative stress; inflammation; nutrigenomics; microbiome; prebiotics; postbiotics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Trends in Alzheimer’s Disease Research: From Molecular Mechanisms to Therapeutics: 3rd Edition

edited by

Ramón Cacabelos

submission deadline 31 Dec 2025 | 1 articles | Viewed by 894 | Submission Open

Keywords: Alzheimer’ s disease; pathogenic mechanisms; genomics; epigenetics; biomarkers; prevention; treatment; pharmacogenetics

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Breeding for Important Economic Traits in Livestock

edited by

Dawei Wei

and

Syed Haidar Abbas Raza

submission deadline 31 Dec 2025 | Viewed by 877 | Submission Open

Keywords: molecular breeding; livestock genetics; economic traits; genomic selection; adipogenesis; feed efficiency; disease resistance; non-coding RNAs; multi-omics; genetic improvement

(This special issue belongs to the Section Molecular Biology)

Atherosclerosis and Comorbidities: From Molecular Pathogenesis to Diagnosis and Therapeutic Targets

edited by

Alexandr Ceasovschih

Victoriţa Şorodoc

and

Yusuf Ziya Şener

submission deadline 31 Dec 2025 | Viewed by 826 | Submission Open

Keywords: atherosclerosis; comorbidities; lipidology; inflammation; obesity; arterial stiffness; vascular remodeling; cardiovascular risk; cardiovascular diseases; targeted therapies; lifestyle

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Trends in Enzymology

edited by

Francesco Malatesta

submission deadline 31 Dec 2025 | Viewed by 805 | Submission Open

(This special issue belongs to the Section Biochemistry)

Enzymes and Enzyme Inhibitors—Applications in Medicine and Diagnosis, 3rd Edition

edited by

Athina Geronikaki

submission deadline 31 Dec 2025 | 1 articles | Viewed by 764 | Submission Open

Keywords: enzyme; enzyme inhibitor; drug target; enzyme deficiency; enzyme overexpression; biomarker; drugs; diagnosis; therapy

(This special issue belongs to the Section Molecular Pharmacology)

Advances in the Synthesis and Study of Novel Bioactive Molecules

edited by

Adriana Georgieva Bakalova

and

Emiliya Demireva Cherneva

submission deadline 31 Dec 2025 | 1 articles | Viewed by 682 | Submission Open

Keywords: organic compounds; metal complexes; bioactive molecules

(This special issue belongs to the Section Biochemistry)

Molecular Insights into Plasma in Seed and Plant Treatment

edited by

Ricardo Molina

and

Karina Balestrasse

submission deadline 31 Dec 2025 | Viewed by 670 | Submission Open

Keywords: seed; plant; plasma; germination; dormancy; sterilization; reactive oxygen species; reactive nitrogen species; molecular mechanism; growth promotion; essential oils; plant stem cells; seed coating and pelleting

(This special issue belongs to the Section Molecular Plant Sciences)

Microbial Fermentation: Advances in Synthetic Biology, Metabolic Engineering, and Biomanufacturing

edited by

Yaokang Wu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 656 | Submission Open

Keywords: microbial fermentation; synthetic biology; metabolic engineering; biomanufacturing; industrial biotechnology

(This special issue belongs to the Section Molecular Microbiology)

Recent Advances in Molecular Research and Therapeutic Strategies for Endometrial Cancer

edited by

Yung-Taek Ouh

submission deadline 31 Dec 2025 | 1 articles | Viewed by 646 | Submission Open

Keywords: endometrial cancer; molecular classification; biomarkers; precision medicine; targeted therapy; immunotherapy; early detection; non-invasive diagnostics; genomic profiling; translational research

(This special issue belongs to the Section Molecular Oncology)

Chelating Ligands in Therapeutics: Recent Advances and Future Directions

edited by

Matteo Mori

and

Fiorella Meneghetti

submission deadline 31 Dec 2025 | Viewed by 634 | Submission Open

Keywords: metal complexes; chelation therapy; chelating agents; diagnostic imaging; metal detoxification; chelation pharmacokinetics

(This special issue belongs to the Section Biochemistry)

Red Blood Cells: Dynamic Regulators, Disease Indicators and Therapeutic Targets

edited by Leonid Livshits

submission deadline 31 Dec 2025 | 1 articles | Viewed by 629 | Submission Open

Keywords: red blood cell (RBC); RBC biochemical; hemodynamic; biophysical properties

(This special issue belongs to the Section Molecular Biology)

Advancing Research on Alexander Disease

edited by

Ming-Der Perng

submission deadline 31 Dec 2025 | Viewed by 610 | Submission Open

Keywords: Alexander disease; astrocyte dysfunction; intermediate filaments; GFAP; astrogliosis; neurodegeneration; leukodystrophy; rare disease; rosenthal fibers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Plant RNA Biology: Non Coding RNAs in Plant Development, Defense, and Adaptation

edited by

Andrew Eamens

submission deadline 31 Dec 2025 | 1 articles | Viewed by 596 | Submission Open

Keywords: plant RNA biology; regulatory RNA; non-coding RNA; small RNA (including miRNAs and siRNAs); RNA interacting proteins; plant development; plant pathogen defense; plant environmental stress adaptation

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Therapeutic Strategies for Pregnancy Complications

edited by

Joško Osredkar

submission deadline 31 Dec 2025 | 1 articles | Viewed by 591 | Submission Open

Keywords: pregnancy complications; placenta diseases; molecular mechanisms; therapeutics; biomarkers; preeclampsia; gestational diabetes; intrauterine growth restriction; maternal-fetal exchange; inflammation mediators

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Carbon Fiber, Carbon Nanofiber for Composites: Synthesis, Processing, Molecular Structure, Characterization, and Application

edited by Tridung Ngo

submission deadline 31 Dec 2025 | Viewed by 585 | Submission Open

Keywords: carbon fiber; carbon nanofiber; nanotube; carbon fiber composites; synthesis; advanced manufacturing; characterization; recent advancements; applications

(This special issue belongs to the Section Materials Science)

T-Cell Lymphoma: From Basic Science to Novel Therapeutics

edited by

Daniele Caracciolo

and