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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Emerging Targeted Therapies and Evolving Treatment Paradigms in Non-Small Cell Lung Cancer

edited by Luis E. Raez

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2355 | Submission Open

Keywords: non-small cell lung cancer (NSCLC); targeted therapies; human epidermal growth factor receptor 2 (HER2); mesenchymal-epithelial transition factor (MET); anaplastic lymphoma kinase (ALK); C-ROS oncogene 1 receptor tyrosine kinase (ROS1); rearranged during transfection (RET); neurotrophic tyrosine receptor kinase (NTRK); B-Raf proto-oncogene serine/threonine kinase V600 mutation (BRAFv600); Kirsten rat sarcoma viral oncogene homolog (KRAS); epidermal growth factor receptor (EGFR)

(This special issue belongs to the Section Molecular Oncology)

Male Reproductive and Sexual Health

edited by

Aris Kaltsas

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2347 | Submission Open

Keywords: male reproductive health; male sexual health; male infertility; erectile dysfunction (ED); prostate inflammation; Peyronie's disease; biomarkers; molecular mechanisms; androgen deprivation; nanotechnology

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Signaling Pathways Dysregulation in Cancer: Advances and New Therapeutics Hopes: 2nd Edition

edited by

Daniela Miricescu

submission deadline 31 Oct 2026 | 3 articles | Viewed by 2314 | Submission Open

Keywords: cancer; epithelial cells; oncogenic mutations; PI3K/AKT/mTOR; TGF-β; Ras/Raf/MEK/ERK; Wnt/β-catenin; angiogenesis; invasion; metastasis; inhibitors

(This special issue belongs to the Section Molecular Oncology)

Artificial Intelligence and Deep Learning in Biomedical and Molecular Research

edited by

Serhat Kılıçarslan

submission deadline 31 Oct 2026 | 3 articles | Viewed by 2252 | Submission Open

Keywords: machine learning; deep learning; image processing; bioinformatics; artificial intelligence

(This special issue belongs to the Section Molecular Informatics)

Extraction and Application of Natural Compound

edited by

Sakaewan Ounjaijean

submission deadline 31 Oct 2026 | 4 articles | Viewed by 2238 | Submission Open

Keywords: natural compounds; extraction; characterization

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mechanobiology of the Cell

edited by

Zbigniew Baster

submission deadline 31 Oct 2026 | 3 articles | Viewed by 2179 | Submission Open

Keywords: nuclear and chromatin mechanics; mechanobiology; mechanotransduction pathways

(This special issue belongs to the Section Molecular Biology)

Microbial Infections and Novel Biological Molecules for Treatment: 2nd Edition

edited by Matthew Cheesman

submission deadline 31 Oct 2026 | 5 articles | Viewed by 2101 | Submission Open

Keywords: microbial infections; infectious diseases; new antibiotics; antimicrobial resistance (AMR); antimicrobial drugs; active substance; bacterial; virus

(This special issue belongs to the Section Molecular Microbiology)

Biological Materials: Molecular Mechanisms, Tissue Responses, and Translational Perspectives

edited by

Andre Luiz Sena Guimaraes

submission deadline 31 Oct 2026 | 3 articles | Viewed by 2100 | Submission Open

Keywords: biological materials; biomaterials; molecular mechanisms; regenerative medicine; 4D biomaterials; living materials; extracellular vesicle-based systems; advanced delivery systems; scalable manufacturing; translational medicine

(This special issue belongs to the Section Materials Science)

Molecular Research on Proglucagon-Derived Peptides

edited by

Camilla Krizhanovskii

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2038 | Submission Open

Keywords: proglucagon; peptide hormones; post-translational processing; prohormone convertase; G-protein-coupled receptors; tissue specificity

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Applications of Polysaccharides in Biomedicine and Agriculture

edited by

Artur Valente

and

Edvani C. Muniz

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2021 | Submission Open

Keywords: polysaccharides; carbohydrates; oligosaccharides; biomedical applications; pharmaceutical applications; drugs

(This special issue belongs to the Section Macromolecules)

Unravelling Functional Biology in Retinal Dystrophies and Eye Disease

edited by

Luigi Donato

and

Simona Alibrandi

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1990 | Submission Open

Keywords: precision ophthalmology; inherited retinal diseases; functional genomics; multi-omics approaches; photoreceptor degeneration; retinal organoids and iPSC models; bioinformatics and systems biology; genotype–phenotype correlations; RNA therapeutics and gene editing; early and late biomarkers of retinal disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Research on Mesenchymal Stem Cells (2nd Edition)

edited by Marcel Costuleanu

submission deadline 31 Oct 2026 | 3 articles | Viewed by 1986 | Submission Open

Keywords: mesenchymal stem cell; MSC; niche; tissue homeostasis; exosomes; microvesicles; cancer; mitochondrial exchange; MSC secretome

(This special issue belongs to the Section Molecular Biology)

Molecular Advances on Gut Microbiota in Human Health

edited by

Sanda Cretoiu

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1804 | Submission Open

Keywords: gut microbiota; dysbiosis; metabolomics; host–microbe interaction; molecular pathways; inflammation; personalized medicine

(This special issue belongs to the Section Molecular Microbiology)

Antibody-Based Therapeutics for Autoimmune Diseases

edited by

Naim Mahroum

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1794 | Submission Open

Keywords: autoimmune diseases; antibody-based therapeutics; autoantibodies; immunotherapy; precision medicine

(This special issue belongs to the Section Molecular Immunology)

Molecular Biology of Foodborne Pathogens: Genomics, Resistance, and New Perspectives

edited by

Joanna Gajewska

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1773 | Submission Open

Keywords: foodborne pathogens; antibiotic resistance; virulence factor; virulence genes; gene expression; bioinformatics; whole geomic sequencing

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Cellular Biology of Germ Cells

edited by

Anna Tabęcka-Łonczyńska

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1680 | Submission Open

Keywords: germ cell development; meiosis; epigenetic regulation; autophagy; mitochondrial dynamics; infertility; reproductive medicine; germ cell tumors; steroidogenesis; endocrine disrupting chemicals; reproductive toxicity

(This special issue belongs to the Section Molecular Biology)

Progress in Photobiomodulation Therapy

edited by

Amílcar Sabino Damazo

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1652 | Submission Open

Keywords: photobiomodulation (PBM); low-level light therapy (LLLT); light-emitting diodes (LEDs); mitochondrial photostimulation; anti-inflammatory effects; tissue regeneration; neuromodulation; biostimulation; clinical applications; pain management

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

T Regulatory and NKT Cells as Prognostic Biomarkers in Inflammatory Disorders and Cancers

edited by

Elena Matei

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1650 | Submission Open

Keywords: immune response; Tregs; NKT; regulation pathways; prognostic biomarkers

(This special issue belongs to the Section Molecular Immunology)

Cotton Breeding and Genetics: Advances and Perspectives

edited by Xuwu Sun

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1645 | Submission Open

Keywords: molecular design breeding; smart breeding; CRISPR-Cas; artificial intelligence; cotton genomics; multi-omics; high-throughput phenotyping; trait prediction; genome editing; crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Transcriptional Regulation in Plant Development: 3rd Edition

edited by

Konstantinos E. Vlachonasios

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1640 | Submission Open

Keywords: environmental stresses; plant development; vegetative development; plant physiology and biochemistry; transcriptional regulation; plant–environment interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Andrology

edited by Elikanah Olusayo Adegoke

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1633 | Submission Open

Keywords: fertilty; assisted reproduction technology; endocrine disrupting chemicals; hormones; male reproductive aging; semen analysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Interactions with Bacteria and Fungi: Mechanisms, Ecology, and Applications

edited by

Amjad Ali

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1563 | Submission Open

Keywords: plant–microbe interactions; plant pathology; host–pathogen interactions; microbiome; molecular diagnostics; omics; disease epidemiology; biocontrol; RNAi; sustainable agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Dementia with Lewy Bodies (DLB) and Alzheimer’s Disease (AD)

edited by Yuan-Han Yang

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1524 | Submission Open

Keywords: dementia with Lewy bodies; Alzheimer's disease; amyloid; tau; alpha-synuclein

(This special issue belongs to the Section Molecular Neurobiology)

Application of NMR Spectroscopy in Biomolecules: 2nd Edition

edited by

Luigi Russo

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1470 | Submission Open

Keywords: advanced solution and solid state biomolecular NMR techniques; structure and dynamics of biomolecules: proteins, peptides, and nucleic acids; paramagnetic NMR; in/on cell-NMR; protein–ligand, protein–DNA, protein–RNA interaction; protein folding and misfolding; structure-based drug screening, fragment-based drug screening; computational NMR methods; sample preparation and isotope labeling strategies; NMR metabolomics and foodomics; membrane proteins and lipids; natural-abundance NMR spectroscopy; pharmaceutical NMR applications; disordered proteins and peptides; drugs development; metal-binding biomolecules; hyperpolized NMR techniques; 19F NMR spectroscopy; NMR techniques for the analysis of complex mixtures; integrated NMR-based methodologies

(This special issue belongs to the Section Molecular Biophysics)

Natural Compounds in Cancer Drugs Treatment and Prevention

edited by

Saad Bakrim

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1426 | Submission Open

Keywords: natural compounds; cancer prevention; cancer treatment; drug resistance; secondary metabolites; anticancer agents; molecular mechanisms; clinical trials; drug delivery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Basis of Plant Traits Associated with Responses to Biotic and Abiotic Stress

edited by Nobuhiro Suzuki

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1416 | Submission Open

Keywords: molecular mechanisms ; biotic and abiotic stress ; plant trait ; signaling

(This special issue belongs to the Section Molecular Plant Sciences)

Deciphering the Molecular Landscape of Thyroid Biology and Pathogenesis

edited by Cesar Seigi Fuziwara

submission deadline 31 Oct 2026 | 3 articles | Viewed by 1341 | Submission Open

Keywords: thyroid cancer; thyroid diseases; gene regulation; signalling pathways; miRNA; lncRNAs; epigenetics; endocrine disruptors; thyroid development; animal models

(This special issue belongs to the Section Molecular Biology)

Cytomegalovirus: An Unresolved Puzzle in Transplantation

edited by

Eleonora Forte

, Zheng Zhang and Lorenzo Gallon

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1329 | Submission Open

Keywords: cytomegalovirus; latency; reactivation; transplantation; virus-host interaction; immune evasion; host immune response; omics approaches; high-throughput technologies

(This special issue belongs to the Section Molecular Microbiology)

Microbial Biofilms in Health and Disease: Molecular Perspectives

edited by

Paweł Krzyżek

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1321 | Submission Open

Keywords: biofilm; antibiofilm; biofilm matrix; matrixome; antibiotic resistance; antibiotic tolerance

(This special issue belongs to the Section Molecular Microbiology)

Cardiovascular Diseases: From Molecular Mechanisms to Therapeutics

edited by

Paul Quax

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1309 | Submission Open

Keywords: yocardial infarction and cardiac regeneration; microvasculature in cardiovascular health and disease; gender specific aspects of cardiovascular disease; heart failure; aneurysm formation and dissection; vascular remodeling (restenosis, atherosclerosis, angioegenesis); valve failure, replacement or regeneration; atherosclerosis; imaging; new therapeutic options including non-coding RNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Aquaculture: Genomics, Genetics and Breeding

edited by Chunde Wang and Shaoxuan Wu

submission deadline 31 Oct 2026 | 4 articles | Viewed by 1293 | Submission Open

Keywords: aquaculture; genetics; molecular breeding

(This special issue belongs to the Section Molecular Genetics and Genomics)

Plant-Origin Bioactive Substances

edited by

Simon Bernard Iloki Assanga

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1288 | Submission Open

Keywords: plant-derived bioactive compounds; phytochemicals; oxidative stress; antioxidant activity; nutraceuticals; polyphenols; flavonoids; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Drug Toxicity and Its Impact on Disease Therapies

edited by Metoda Lipnik-Štangelj

submission deadline 31 Oct 2026 | 3 articles | Viewed by 1281 | Submission Open

Keywords: computational methods; toxicity prediction; pharmacogenomics; molecular mechanisms; drug-induced toxicity; adverse drug effects; organ toxicity; polypharmacy

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research on Ischemia-Reperfusion Injury

edited by

Mustafa Arslan

and

Ayşegül Küçük

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1259 | Submission Open

Keywords: ischemia reperfusion models; experimental models; pre-post conditioning; cell death pathways; inflammation; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic and Molecular Diversity Underlying Metal Tolerance and Homeostasis in Plants

edited by

Yu Pan

Vivek Yadav

and

Bilal Ahmad

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1189 | Submission Open

Keywords: genetic regulation; expression; genomics; metal; oxidative stress; natural diversity; homeostasis; hormone signaling networks

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Dynamics Simulations in Enzyme Structure–Function Relationships and Substrate Specificity

edited by

Weiwei Han

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1178 | Submission Open

Keywords: molecular dynamics; enzyme mechanism; structure–function relationship; substrate specificity; enzyme engineering; free energy calculation; computational enzymology; protein dynamics; molecular modeling

(This special issue belongs to the Section Molecular Informatics)

Application of Biomaterials in Human Diseases

edited by

Satoshi Komasa

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1159 | Submission Open

Keywords: implant; bone substitute material; titanium; zirconia; biomaterials; in vitro; in vivo

(This special issue belongs to the Section Materials Science)

Breaking Antimicrobial Resistance: Unraveling Mechanisms and Pioneering Control Strategies

edited by

Yiyun Liu

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1121 | Submission Open

Keywords: antimicrobial resistance; novel mechanisms; combination therapies; rapid diagnostics; antimicrobial stewardship; biofilm resistance; phage therapy; novel antimicrobials; adjuvant development; one health; resistance surveillance

(This special issue belongs to the Section Molecular Pharmacology)

Aptamers: Insights into Functional and Structural Research

edited by

Serap Evran

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1091 | Submission Open

Keywords: nucleic acid aptamers; aptamer selection; SELEX; post-SELEX; aptamer engineering; aptasensors, diagnostic aptamers; therapeutic aptamers; aptamer–target interaction; aptamer structure

(This special issue belongs to the Section Molecular Biology)

Novel Molecular Targets and Prognostic Markers Focused on Improving Quality in Healthcare, 2nd Edition

edited by

Ion Cristóbal

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1083 | Submission Open

Keywords: prognostic markers; molecular targets; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Functional Foods in Human Disease and Health

edited by

Ochuko Lucky Erukainure

and Chika Ifeanyi Chukwuma

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1077 | Submission Open

Keywords: functional foods; oxidative stress; immune responses; metabolic balance

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Unraveling Neurodevelopmental Disorders: A Molecular Perspective

edited by Marija-Magdalena Petrinovic

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1065 | Submission Open

Keywords: neurodevelopmental disorders; molecular neuroscience; genetics; epigenetics; functional MRI (fMRI); magnetic resonance spectroscopy (MRS); PET imaging; imaging biomarkers; translational neuroscience; precision medicine

(This special issue belongs to the Section Molecular Neurobiology)

Decoding the Bone Microenvironment: Molecular Control of Regeneration and Repair

edited by

Xinyuan Yuan

and

Teliang Lu

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1050 | Submission Open

Keywords: bone regeneration; biomaterials; heterotopic ossification; calcium phosphates; bone tissue engineering

(This special issue belongs to the Section Molecular Biology)

Glycobiology in Human Health and Disease, 2nd Edition

edited by Katrin Mani

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1047 | Submission Open

Keywords: glycans and glycoconjugates; glycoproteins; proteoglycans; glycolipids; glycosylation including glycosyltransferases and glycosidases; carbohydrate and glycan metabolism; glycan structure; disease biomarkers; glycan signaling; glycoimmunology; glycomics

(This special issue belongs to the Section Biochemistry)

KRAS-Associated Cancer Signaling

edited by Sang Hun Lee

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1007 | Submission Open

Keywords: KRAS signaling; receptor tyrosine kinases; EGFR; c-MET; PI3K–MAPK pathways; tumor microenvironment; drug resistance and adaptive rewiring; combination therapy; biomarker stratification; prion protein (PrPC)

(This special issue belongs to the Section Molecular Oncology)

Design, Synthesis, and Applications of Advanced Functional Materials

edited by

Angelika Kmita

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1002 | Submission Open

Keywords: advanced functional materials; materials synthesis; nanomaterials; hybrid materials

(This special issue belongs to the Section Materials Science)

Molecular Biomarkers and Mechanisms of Environmental Exposure

edited by

Supakit Khacha-Ananda

submission deadline 31 Oct 2026 | 1 articles | Viewed by 967 | Submission Open

Keywords: multi-omics technologies; molecular toxicology; environmental toxicants; toxicants; mechanism of toxicity; biomarkers; in vitro; in vivo; human model; health

(This special issue belongs to the Section Molecular Toxicology)

Biopolymers and Their Application

edited by

Diego Acevedo

and

Edith Inés Yslas

submission deadline 31 Oct 2026 | 1 articles | Viewed by 962 | Submission Open

Keywords: biopolymers; biodegradable polymers; bio-based materials; biopolymer composites; sustainable materials; green chemistry; functional biopolymers; advanced polymer applications

(This special issue belongs to the Section Materials Science)

Molecular Docking and Structure-Based Modeling

edited by Serap Yalçın Azarkan

submission deadline 31 Oct 2026 | 1 articles | Viewed by 923 | Submission Open

Keywords: molecular docking; structure-based drug design; challenging diseases; cancer; neurological disorders; infectious diseases; computational technique; binding affinity estimation; computer-based methods; personalized treatments

(This special issue belongs to the Section Molecular Biology)

Pathophysiology and Treatments of Spinal Cord Injury

edited by Roxana Rodríguez-Barrera and Elisa García-Vences

submission deadline 31 Oct 2026 | 1 articles | Viewed by 923 | Submission Open

Keywords: spinal cord injury; treatments; therapy cell; neuromodulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 901-950 on page 19 of 62.

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