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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Treatment of Neurodegenerative Diseases with Natural Products

edited by

Eugene Huh

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1699 | Submission Open

Keywords: neurodegenerative diseases; natural product; misfolding protein aggregation; oxidative stress; neuroinflammation; autophagy; apoptosis; microbiota– gut– brain axis; therapeutic; prevention

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant Responses to Heavy Metals: From Deficiency to Excess, 2nd Edition

edited by

Anna D. Kozhevnikova

and

Ilya Vladimirovich Seregin

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1687 | Submission Open

Keywords: heavy metals; deficiency; metal toxicity; metal (hyper-)accumulation; mechanisms of metal tolerance; metal transport; metal uptake; metal sequestration; metal homeostasis

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights into Photosystem I (Second Edition)

edited by

Stefano Santabarbara

and

Gary Hastings

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1650 | Submission Open

Keywords: photosystem I; photochemisty; electron transfer; protein– cofactor interaction; reaction kinetics; reaction mechanism; redox tuning; light harvesting; low-energy (red) forms; bioenergetics; cyclic electron transfer

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Gastrointestinal Cancer, 3rd Edition

edited by

Aneta Koronowicz

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1636 | Submission Open

Keywords: gastrointestinal cancer; chemotherapeutic agents; innovative therapies; human nutrition; nutrigenomics; nutrition and immunity epigenetics; cytotoxicity; apoptosis

(This special issue belongs to the Section Molecular Oncology)

Recent Research in Probiotic Yeasts: Molecular Aspects

edited by

Maurizio Ciani

and

Francesca Comitini

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1573 | Submission Open

Keywords: probiotic yeasts; molecular mechanisms; mycocins active; compounds; functional compounds

(This special issue belongs to the Section Molecular Microbiology)

Sleep and Breathing: From Molecular Perspectives

edited by Alberto Alonso-Fernández

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1562 | Submission Open

Keywords: obstructive sleep apnea; cardiovascular risk; cardiovascular diseases/physiopathology; continuous positive airway pressure; hypertension; biomarkers; diabetes; pregnancy; gene expression profiling; genetic markers; inflammation mediators; oxidative stress; proteomics

(This special issue belongs to the Section Molecular Biology)

New Insights into Anticancer Strategies

edited by

Yong Teng

submission deadline 20 Dec 2025 | Viewed by 1560 | Submission Open

Keywords: novel targeted therapy; personalized medicine; nanotechnology; AI and machine learning; combination therapy

(This special issue belongs to the Section Molecular Oncology)

Metabolomics in Coronary Artery Disease: From Pathogenesis to Personalized Medicine

edited by

Tomasz Urbanowicz

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1518 | Submission Open

Keywords: coronary artery disease (CAD); atherosclerosis; epicardial disease; CAD pathogenesis; personalized approach; drug response; metabolomic

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nitric Oxide and Photosynthetic Machinery: Unveiling Molecular Mechanisms and Redox Balancing

edited by

Mun Bong-Gyu

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1484 | Submission Open

Keywords: nitric oxide; photosynthetic machinery; NO signaling pathways; plant physiology

(This special issue belongs to the Section Molecular Plant Sciences)

Biocomposite Hydrogels for Biomedical Applications

edited by

Leonard Ionut Atanase

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1453 | Submission Open

Keywords: hydrogels; biocomposite; micro/nanoparticles; electrospun fibers; inorganic particles; tissue engineering; drug delivery; 3D printing

(This special issue belongs to the Section Materials Science)

Epilepsy: From Molecular Basis to Therapy, 2nd Edition

edited by

Henry Hing Cheong Lee

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1449 | Submission Open

Keywords: genetic epilepsy; post-traumatic epilepsy; neurodevelopmental disorder; glutamate; GABA; ionic homeostasis; disease-modifying therapy; in vitro; in vivo; animal model; gene replacement therapy; gene editing; protein misfolding; small molecule; pharmacokinetics; pharmacodynamics; translational research; biomarker; clinical trial

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Structural Characterization and Pharmacological Activity of Natural Compounds

edited by

Ana Amić

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1438 | Submission Open

Keywords: natural compounds; bioactive molecules; molecular structure; characterisation; pharmacological activity; biochemical properties; pharmacokinetics; toxicity

(This special issue belongs to the Section Molecular Pharmacology)

Role of Ion Channels in Human Health and Diseases

edited by

Sheng-Nan Wu

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1407 | Submission Open

Keywords: sodium current; potassium current; ion channel kinetics; excitable cells; treatments; pathophysiology

(This special issue belongs to the Section Molecular Biology)

Insights into Functional Nanomaterials: Application-Related Structural Analysis

edited by Zoltán Dudás

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1403 | Submission Open

Keywords: functional porous nanomaterials; structure– activity relationship; molecular structure; characterization; nanoporous materials

(This special issue belongs to the Section Molecular Nanoscience)

Neuroimaging Studies in Exploring the Molecular Mechanisms of Neurological Diseases

edited by

Ming-Chang Chiang

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1395 | Submission Open

Keywords: neuroimaging; neurological diseases; brain imaging; biomarkers; functional connectivity; AI in neuroimaging

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Virus-Host Immune Interactions

edited by

Claudia Vanetti

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1311 | Submission Open

Keywords: viral diseases; virus– host interactions; vaccination; interferon signalling; antibody responses; viral proteins; SARS-CoV-2

(This special issue belongs to the Section Molecular Immunology)

Molecular Advances in Plant Reproductive Development

edited by Zsolt Pónya and

Iman Mirmazloum

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1304 | Submission Open

Keywords: plant reproduction; sexual reproduction; gamete recognition; zygote formation; embryogenesis; endosperm development; seed maturation; plant developmental biology; epigenetic regulation; gene expression; cellular signalling pathways; protein interactions; hormonal controls

(This special issue belongs to the Section Molecular Plant Sciences)

Ongoing Anticancer Agents

edited by

Mauro Coluccia

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1219 | Submission Open

Keywords: tumorigenesis; anticancer drugs; therapeutic innovation; platinum-based drugs; anticancer therapies

(This special issue belongs to the Section Molecular Oncology)

The Role of Non-Coding RNAs in Female Reproduction

edited by

Angela Caponnetto

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1211 | Submission Open

Keywords: microRNAs; long non-coding RNAs; circular RNAs; female reproduction; reproductive aging; molecular biomarkers; ceRNA network

(This special issue belongs to the Section Molecular Genetics and Genomics)

Immune-Liver Axis—from Disease Pathogenesis to Therapeutic Target

edited by

Beata Kasztelan-Szczerbińska

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1193 | Submission Open

Keywords: immune response; inflammation; liver disease; liver injury; liver cirrhosis; immune-related liver disease; alcohol-related liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); Wilson’ s disease; hemochromatosis; liver cancer

(This special issue belongs to the Section Molecular Immunology)

Neural Stem Cells: Latest Applications and Future Perspectives

edited by

Evangelos Delivopoulos

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1185 | Submission Open

Keywords: neural differentiation; embryonic stem cells; neural stem cells; neural progenitor cells; neuropathology; neurological disease

(This special issue belongs to the Section Molecular Biology)

Regulatory Mechanisms Underlying Tumorigenesis

edited by

Kazuhiko Kuwahara

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1155 | Submission Open

Keywords: tumor suppressor genes; tumor microenviroment; cell-cycle checkpoint; novel fusion genes; novel molecular targets; small-molecule drugs; animal models

(This special issue belongs to the Section Molecular Oncology)

Pharmacokinetics of Psychoactive Substances: Molecular and Forensic Aspects

edited by

Angelo Montana

and

Fabrizio Lo Faro

submission deadline 20 Dec 2025 | Viewed by 1127 | Submission Open

Keywords: psychoactive substances; pharmacokinetics; forensic Toxicology; forensic pathology; toxicological biomarkers; cerebral damage; in vitro; in vivo; and in silico models; new Psychoactive Substances (NPS); new synthetic opioids; liquid chromatography-high resolution mass spectrometry (LC-HRMS/MS); liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography; tandem mass spectrometry (GC-MS/MS)

(This special issue belongs to the Section Molecular Pharmacology)

Latest Molecular Research on Polymer Coatings

edited by

Joanna Karasiewicz

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1088 | Submission Open

Keywords: synthesis of specialty compounds; specialty compounds in industrial treatment; amphiphilic compounds; wettability (including solids and biomaterials); antimicrobial activity; surface activity; superwetting; high hydrophobic/hydrophilic/olrophobic/olephilic properties; special applications: self-cleaning; anti-icing; self-healing; biocidal; etc.

(This special issue belongs to the Section Materials Science)

Intestinal Diseases and Gut Microbiota

edited by

Anna Duda-Madej

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1029 | Submission Open

Keywords: gut microbiota; dysbiosis; natural compounds; colorectal cancer; neurological diseases; autoimmune diseases; probiotics; gut-brain axis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Cancer Stem Cells

edited by

Sabrina Battista

submission deadline 20 Dec 2025 | 1 articles | Viewed by 943 | Submission Open

Keywords: self-renewal; microenvironment; plasticity; epigenetics; epithelial-mesenchymal transition; heterogeneity; targeting; dormancy

(This special issue belongs to the Section Biochemistry)

Molecular Insight into Natural Nutraceuticals for Cancer Chemoprevention

edited by

Jia-Feng Chang

and

Chih-Hsin Tang

submission deadline 20 Dec 2025 | 1 articles | Viewed by 939 | Submission Open

Keywords: natural nutraceuticals; cancer; cancer chemoprevention; natural compounds

(This special issue belongs to the Section Molecular Oncology)

Proteases and Their Inhibitors: From Biochemistry to Applications

edited by

Gonzalo Izaguirre

submission deadline 20 Dec 2025 | 1 articles | Viewed by 927 | Submission Open

Keywords: proteases; peptidases; proteinases; proteolysis; hydrolysis; enzymes; inhibitors; biotechnology; drug discovery; therapeutics

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Biomolecular Recognition: 3rd Edition

edited by

Ray Luo

submission deadline 20 Dec 2025 | 1 articles | Viewed by 882 | Submission Open

Keywords: proteins; nucleic acids; membrane; ligand; binding

(This special issue belongs to the Section Molecular Biophysics)

Natural Products for Cancer Therapy: Mechanisms, Synergies, and Clinical Applications

edited by

Qibiao Wu

and Hiu Yee Kwan

submission deadline 20 Dec 2025 | 1 articles | Viewed by 863 | Submission Open

Keywords: natural products; cancer therapy; traditional Chinese medicine (TCM); integrative medicine; cancer drug resistance; antitumor mechanisms; molecular targeting; drug synergy; clinical application

(This special issue belongs to the Section Molecular Oncology)

25th Anniversary of IJMS: Updates and Advances in Molecular Biophysics

edited by

Vladimir N. Uversky

submission deadline 20 Dec 2025 | 1 articles | Viewed by 840 | Submission Open

Keywords: biomolecular interactions; biomolecular NMR; biophysics; chaperones; computational modeling; computer simulations; crystal thermodynamics; DNA structure and dynamics; drug– receptor interactions; enzymology; fluorescence imaging; genome structure; inter-molecular interactions; intrinsically disordered proteins; ion channels; macromolecular crystallography; macromolecular structure and dynamics; membrane dynamics; microcalorimetry; molecular dynamics; molecular imprinting; molecular mechanics; molecular modeling; molecular simulations; molecular modeling; molecular structure; molecular recognition; nucleic acid– protein interactions; post-translational modifications; protein design; protein– DNA interactions; protein engineering; protein– ligand binding; protein– membrane interactions; protein structure and folding; RNA structure; single-molecule techniques; spectroscopic techniques; statistical mechanics; structure– function relationships; structure prediction; thermodynamics; transient kinetic techniques; transmembrane proteins; x-ray crystallography

(This special issue belongs to the Section Molecular Biophysics)

Recent Advances in Protein Folding and Misfolding

edited by

Ho-Jin Lee

submission deadline 20 Dec 2025 | Viewed by 836 | Submission Open

Keywords: protein folding; protein misfolding; 3D protein structure; CRISPR/Cas 9

(This special issue belongs to the Section Molecular Biophysics)

Electron Transport Mechanism in Optoelectronic Materials

edited by Paolo Umari

submission deadline 20 Dec 2025 | Viewed by 791 | Submission Open

Keywords: photovoltaics; density functional theory; quantum chemistry; optoelectronic devices; semiconductors; polymers; charge transport

(This special issue belongs to the Section Materials Science)

Molecular Studies of Skin Diseases: From Mechanisms to Therapy

edited by

Soon Hyo Kwon

submission deadline 20 Dec 2025 | 1 articles | Viewed by 681 | Submission Open

Keywords: multiomics; genomics; transcriptomics; proteomics; metabolomics; skin diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Age-Related Cognitive Decline

edited by

Cristovam Wanderley Picanço Diniz

submission deadline 20 Dec 2025 | Viewed by 680 | Submission Open

Keywords: cognitive decline; molecular mechanisms; aging individuals; therapeutic targets; neuroinflammation; oxidative stress; protein aggregation; vascular changes

(This special issue belongs to the Section Molecular Neurobiology)

Signaling in GPCR Research

edited by

Zvi Naor

submission deadline 20 Dec 2025 | Viewed by 659 | Submission Open

Keywords: GPCR; G protein; signaling; drug design; cell surface receptors

(This special issue belongs to the Section Biochemistry)

Rethinking Fat: A Deeper Dive into the Diversity and Dynamic Roles of Adipose Tissue

edited by

Ahmed Bettaieb

submission deadline 20 Dec 2025 | Viewed by 657 | Submission Open

Keywords: adipose tissue biology; stem cell commitment and differentiation; thermogenic adipocytes; genetic regulation; metabolic homeostasis; selective targeting

(This special issue belongs to the Section Molecular Biology)

Biomolecular Condensates and Their Role in Cellular Organization and Disease

edited by Anna Bratek-Skicki

submission deadline 20 Dec 2025 | Viewed by 595 | Submission Open

Keywords: biocondensates; membrane-less organelles; liquid-liquid phase separation; protein aggregation; neurogenerative diseases

(This special issue belongs to the Section Molecular Biology)

Red Blood Cells in Health and Disease

edited by Annamaria Russo and Ester Tellone

submission deadline 20 Dec 2025 | Viewed by 591 | Submission Open

Keywords: oxidative stress; metabolism; hemoglobin; erythrocytes

(This special issue belongs to the Section Biochemistry)

Exploring Natural Products for Antimicrobial Innovation: New Paths and Promising Leads

edited by

Shagufta Perveen

submission deadline 20 Dec 2025 | Viewed by 565 | Submission Open

Keywords: antimicrobial agents; drug resistance; plant-derived compounds; bioactive molecules; phytochemicals; marine natural products; fungal metabolites; novel drug discovery; microbial pathogens; natural product isolation; drug development; biotechnology in antimicrobial research

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Fibrinolytic Factors in Disease

edited by

Yosuke Kanno

submission deadline 20 Dec 2025 | Viewed by 525 | Submission Open

Keywords: fibrinolysis; plasminogen; plasmin; α 2-antiplasmin; uPA; uPAR; tPA; PAI-1

(This special issue belongs to the Section Molecular Biology)

Design, Synthesis and Biological Activity of Heterocyclic Compounds

edited by

Monika Kadela-Tomanek

submission deadline 20 Dec 2025 | Viewed by 484 | Submission Open

Keywords: synthesis of new bioactive compounds; biological activity of heterocyclic compounds; structural analysis; pharmacokinetic analysis of potential drugs; molecular docking study of new heterocyclic compounds

(This special issue belongs to the Section Biochemistry)

Collagen-Based Biomaterials in Tissue Engineering and Regenerative Medicine

edited by Martin Braun,

Selestina Gorgieva

and

Eva Filova

submission deadline 20 Dec 2025 | Viewed by 473 | Submission Open

Keywords: collagen; tissue engineering; advanced biomaterials; biodegradable composites; scaffolds; protein structure; biochemical analysis; material characterization; medical application; gelatine

(This special issue belongs to the Section Macromolecules)

Histological and Molecular Perspectives on Immune Mechanisms of the Nasal and Bronchial Mucosa Diseases

edited by

Emanuela Chiarella

submission deadline 20 Dec 2025 | Viewed by 469 | Submission Open

Keywords: nasal and bronchial mucosa; nasal polyposis; bronchial inflammation; immunotherapy; mucosal immunity; inflammatory biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of EGFR in Colorectal Cancer

edited by

Verónica Moreno-Viedma

submission deadline 20 Dec 2025 | Viewed by 464 | Submission Open

Keywords: EGFR; RAS; biomarkers/prognosis; resistance mechanisms; tumor microenvironment; EGFR signaling pathways; EGFR inhibitors; onco-immunology

(This special issue belongs to the Section Biochemistry)

Metabolomics of Medicinal Plants

edited by

L. Gerardo Zepeda Vallejo

and

Elvia Becerra-Martínez

submission deadline 20 Dec 2025 | 2 articles | Viewed by 455 | Submission Open

Keywords: metabolomics; medicinal plants; nuclear magnetic resonance; mass spectrometry; bioinformatic; phenotyping; metabolic pathways; bioactive metabolites

(This special issue belongs to the Section Molecular Plant Sciences)

Physiopathology and Therapeutics of HIV Infection

edited by

Inês Bártolo

submission deadline 20 Dec 2025 | Viewed by 446 | Submission Open

Keywords: HIV; physiopathology; ART; HAART; NRTIs; NNRTIs; PIs; INSTIs; fusion inhibitors; CCR5 antagonists; post-attachment inhibitors; capsid inhibitors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanotransduction and Tissue Regeneration in Skeletal Muscle

edited by

Mahtab Nourbakhsh

submission deadline 20 Dec 2025 | Viewed by 435 | Submission Open

Keywords: skeletal muscle tissue regeneration; mechanotransduction; skeletal muscle spindles; tissue-resident macrophages

(This special issue belongs to the Section Molecular Biology)

Adipose Tissue and Adipose Tissue-Derived Stem Cells in Multidisciplinary Research

edited by Oliver Felthaus

submission deadline 20 Dec 2025 | Viewed by 430 | Submission Open

Keywords: adipose tissue; adipose-derived stem cells; regenerative medicine; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Molecular and Immunological Biomarkers in Cervical Cancer

edited by Janaina Cristiana de Oliveira Crispim and

Ricardo Ney Oliveira Cobucci

submission deadline 20 Dec 2025 | Viewed by 415 | Submission Open

Keywords: cervical cancer; molecular biomarkers; immunological biomarkers; human papillomavirus (HPV); tumor microenvironment; immune responses; immunotherapy; diagnostic biomarkers; prognostic biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Displaying special issue 651-700 on page 14 of 70.

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