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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Cellular Immunotherapies
edited by Maria Elena Candela
submission deadline 28 Feb 2027 | Viewed by 24 | Submission Open
Keywords: cellular immunotherapy; adoptive cell therapy; engineered immune cells; CAR-T cells; natural killer cells; macrophage therapy; immune regulation; gene editing; regenerative medicine; clinical translation
(This special issue belongs to the Section Molecular Immunology)
Next-Generation and Third-Generation Sequencing in Life Sciences: Methods and Applications submission deadline 28 Feb 2027 | Viewed by 24 | Submission Open
Keywords: next-generation sequencing; third-generation sequencing; NGS; long-read sequencing; short-read sequencing; whole-genome sequencing; transcriptomics; RNA sequencing; metagenomics; metatranscriptomics; microbiome; genome assembly; bioinformatics; sequencing technologies; multi-omics; genomic analysis; molecular biology; life sciences
(This special issue belongs to the Section Molecular Informatics)
Drug Delivery Systems of Curcumin and Its Therapeutic Applications
edited by and
submission deadline 28 Feb 2027 | Viewed by 22 | Submission Open
Keywords: bioavailability; curcumin; drug delivery; nanocarriers; nanomedicine; nanoparticles; pharmacokinetics
(This special issue belongs to the Section Molecular Pharmacology)
Recent Advances in Nanoelectronics and Associated Applications submission deadline 28 Feb 2027 | Viewed by 22 | Submission Open
Keywords: nanoelectronics; low-dimensional materials; semiconductor devices; neuromorphic; quantum; nanosensors; nanophotonics; energy-efficient circuits; healthcare; environmental monitoring; energy systems; next-generation computing
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Advanced Functional Luminescent Materials
edited by Arkadiusz Matwijczuk
submission deadline 28 Feb 2027 | Viewed by 20 | Submission Open
Keywords: room-temperature phosphorescence (RTP); ultralong RTP and afterglow; delayed fluorescence and long-lived luminescence; triplet-state photophysics; intersystem crossing (ISC) and reverse intersystem crossing (RISC); polymer matrices and polymer-based luminescent materials; sustainable and bio-derived luminescent materials; molecular rigidification and restriction of intramolecular motion (RIM); aggregation-induced emission (AIE) and aggregation-enhanced emission (AEE); molecular aggregation and self-assembly; excited-state proton transfer (ESIPT/ESPT); charge-transfer processes (ICT, TICT); excited-state dynamics; molecular packing and intermolecular interactions; crystalline, amorphous, supramolecular, and hybrid luminescent materials; fluorescence and phosphorescence spectroscopy; time-resolved and time-gated spectroscopy; DFT and TD-DFT calculations; optical sensing and time-gated bioimaging; anti-counterfeiting and information encryption; functional photonic and optoelectronic materials
(This special issue belongs to the Section Materials Science)
Editorial Board Members’ Collection Series in "Biomolecular Structure and Interactions"
edited by
submission deadline 28 Feb 2027 | Viewed by 18 | Submission Open
Keywords: protein–protein interactions; molecular dynamics simulations; cryo-electron microscopy; binding free energy; intrinsically disordered proteins
(This special issue belongs to the Section Molecular Biophysics)
Neuroinflammation: Molecular Mechanisms and Therapeutic Targets
edited by Rajkumar Vutukuri and
submission deadline 28 Feb 2027 | Viewed by 17 | Submission Open
Keywords: neuroinflammation; neurodegenerative diseases; glial activation; therapeutic targets; blood–brain barrier; neuroimmune signaling
(This special issue belongs to the Section Molecular Neurobiology)
Current Research on Polyphenol and Neurodegenerative Diseases
edited by
submission deadline 28 Feb 2027 | Viewed by 17 | Submission Open
Keywords: polyphenols; neurodegenerative disorders; Alzheimer's disease; Parkinson's disease; neuroprotection; oxidative stress; neuroinflammation; natural products; mitochondrial dysfunction; functional foods
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Novel Biomaterials and Formulations in Tissue Regeneration
edited by Giulio Ghersi and Francesco Carfì Pavia
submission deadline 28 Feb 2027 | Viewed by 16 | Submission Open
Keywords: extracellular matrix; fibroblast; microvascular fragments; collagen; growth factors; scaffolds; hydrogels; composite materials; additive manufacturing; green molecules
(This special issue belongs to the Section Materials Science)
Stem Cells for Neurological Disorders: Disease Modeling and Therapy
edited by Leonardo Romorini
submission deadline 28 Feb 2027 | Viewed by 6 | Submission Open
Keywords: stem cells; neurological disorders; regenerative medicine; disease modeling; induced pluripotent stem cells; neural stem cells; brain organoids; cell therapy; neurodegeneration; precision medicine
(This special issue belongs to the Section Molecular Neurobiology)
Advances and Perspectives in Mass Spectrometry for Biomaterial Analysis
edited by
submission deadline 1 Mar 2027 | Viewed by 373 | Submission Open
Keywords: mass spectrometry; biopolymers; biomaterials; compositional and structural analysis; surface and interface analysis; biofunctionalization; industrial and clinical applications
(This special issue belongs to the Section Materials Science)
Molecular Breeding for Abiotic Stress Tolerance in Crops (Second Edition)
edited by
submission deadline 20 Mar 2027 | 9 articles | Viewed by 16140 | Submission Open
Keywords: plant breeding; advance molecular approach; molecular characterization; environmental stresses plant tolerance; resistant genes; QTLs; drought; salinity; climatic changes
(This special issue belongs to the Section Molecular Plant Sciences)
Intestinal Diseases and Gut Microbiota
edited by
submission deadline 20 Mar 2027 | 2 articles | Viewed by 5523 | Submission Open
Keywords: gut microbiota; dysbiosis; natural compounds; colorectal cancer; neurological diseases; autoimmune diseases; probiotics; gut-brain axis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Conventional Tree Breeding: Integrating Phenotypic Selection, Genetic Gain, and Sustainable Forest Management
edited by
submission deadline 20 Mar 2027 | 1 articles | Viewed by 3907 | Submission Open
Keywords: forest trees; genetic breeding; conventional tree breeding; forest management; forest tree varieties; modern molecular technology; genetic engineering
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Plant Protein and Enzyme Inhibitors
edited by Yan Zhang
submission deadline 20 Mar 2027 | Viewed by 645 | Submission Open
Keywords: plant proteins; active substances; bioactive compounds; enzyme inhibitors
(This special issue belongs to the Section Molecular Plant Sciences)
Application of Molecular Technology to Dental Treatment
edited by
submission deadline 20 Mar 2027 | Viewed by 350 | Submission Open
Keywords: biotechnology; implant material; titanium; zirconia; PEEK; in vitro; in vivo
(This special issue belongs to the Section Materials Science)
Hepatopancreatic and Intestine Diseases: From Molecular Basis to Therapy—Mitochondrial Insights submission deadline 20 Mar 2027 | Viewed by 237 | Submission Open
Keywords: hepatopancreatic diseases; intestine diseases; molecular basis therapy; pathogenesis; molecular pathways; pharmacological interventions; surgical techniques; immunotherapies; regenerative medicine approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Marine Toxins: Molecular and Biochemical Mechanisms of Marine and Freshwater Algal Toxins
edited by and Allisson Astuya-Villalón
submission deadline 20 Mar 2027 | Viewed by 90 | Submission Open
Keywords: harmful algal blooms (HABs); molecular toxicology; marine and freshwater toxins; cytotoxicity mechanisms; toxin–cell interactions; biochemical and structural biology; mechanistic omics; ichthyotoxicity; signal transduction; structure–activity relationships
(This special issue belongs to the Section Molecular Toxicology)
Mechanisms, Diagnosis, and Treatment of Kidney Disease
edited by Zesergio Melo
submission deadline 25 Mar 2027 | Viewed by 166 | Submission Open
Keywords: kidney disease; biomarkers; diagnosis; pathophysiology; therapeutics; chronic kidney disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cancer Metabolism as a Therapeutic Target: From Mechanisms to Therapies
edited by
submission deadline 25 Mar 2027 | Viewed by 60 | Submission Open
Keywords: metabolism; tumor microenvironment; tracing; molecular imaging; therapy; omics; drug response; cancer; immune populations
(This special issue belongs to the Section Molecular Oncology)
Biophysical Characterization and Molecular Engineering of Multidomain Proteins (4th Edition) submission deadline 26 Mar 2027 | 3 articles | Viewed by 3508 | Submission Open
Keywords: multidomain proteins; protein dynamics; domain interactions; allosteric regulation; protein engineering; SAXS; Cryo-EM; protein NMR; computational modeling; protein design
(This special issue belongs to the Section Molecular Biophysics)
Sustainable Material Development: From Molecular Insights to Functional Applications
edited by
submission deadline 26 Mar 2027 | Viewed by 449 | Submission Open
Keywords: sustainable materials; biodegradable polymers; green chemistry; functional materials; structure–property relationships; chemical modification; recycling and upcycling; circular economy; composites; analytical techniques
(This special issue belongs to the Section Materials Science)
Insights in Metabolomics: Chromatography and Mass Spectrometry Applications in Cancer Research submission deadline 30 Mar 2027 | 2 articles | Viewed by 3160 | Submission Open
Keywords: metabolomics; chromatography; mass spectrometry; molecular oncology; cancer pathways; precision medicine
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Novel Insights into Cardiac Diseases
edited by Kuo-Tzu Sung
submission deadline 30 Mar 2027 | 3 articles | Viewed by 2532 | Submission Open
Keywords: cardiovascular genetics; inherited cardiomyopathies; lysosomal storage disorders; precision medicine; translational cardiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Plant–Microbe Interactions in Biological Disease Control
edited by
submission deadline 30 Mar 2027 | Viewed by 402 | Submission Open
Keywords: plant–microbe interactions; microbial biocontrol; plant immunity; induced systemic resistance; microbial antagonism; secondary metabolites; functional genomics; multi-omics; rhizosphere microbiome; synthetic microbial communities
(This special issue belongs to the Section Molecular Plant Sciences)
Natural Products in Metabolic Diseases: From Molecular Target Discovery to Clinical Translation
edited by
submission deadline 30 Mar 2027 | 1 articles | Viewed by 284 | Submission Open
Keywords: metabolic diseases; natural products; molecular targets; network pharmacology; multi-omics and artificial intelligence; clinical translation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Regulatory Networks in Plant Development and Environmental Stress Response submission deadline 30 Mar 2027 | Viewed by 99 | Submission Open
Keywords: plant development; environmental stress; gene regulatory networks; transcriptional regulation; post-transcriptional regulation; transcription factors; signal transduction; hormone signaling; epigenetic regulation; genome-wide analysis
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of Cytokinin Biosynthesis, Metabolism, Signaling, and Action
edited by Martin Raspor
submission deadline 30 Mar 2027 | Viewed by 93 | Submission Open
Keywords: natural and synthetic cytokinins; isoprenoid cytokinins; aromatic cytokinins; diphenylurea-type cytokinins; cytokinin biosynthesis; cytokinin metabolism; histidine kinases; phosphotransfer; two-component signaling
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Vaccines: From Precision Molecular Platforms to Immune Remodeling
edited by Hong Jia
submission deadline 30 Mar 2027 | Viewed by 78 | Submission Open
Keywords: next-generation vaccines; mRNA; saRNA; circRNA; nanoparticle vaccines; structural vaccinology; emerging infectious diseases; cancer vaccines; neoantigens; tumor microenvironment; multi-omics; AI immunology
(This special issue belongs to the Section Molecular Immunology)
Functional Genetics and Signaling Networks in Neurodevelopmental and Neuromuscular Disorders
edited by , Francesco Chemello and
submission deadline 30 Mar 2027 | Viewed by 29 | Submission Open
Keywords: zebrafish; neurodevelopment; neuromuscular disorders; functional genetics; gene editing; organoids; mammalian animal models; OMICs approaches; transgenesis; cell signaling
(This special issue belongs to the Section Molecular Neurobiology)
25th Anniversary of IJMS: Updates and Advances in Molecular Genetics and Genomics submission deadline 31 Mar 2027 | 32 articles | Viewed by 36077 | Submission Open
Keywords: molecular genetics; genomics; precision medicine; genetic diagnostics; gene therapy; next-generation sequencing (NGS); pharmacogenomics; epigenetics; forensic genomics; translational genomics; genome replication; gene expression; cell stress; cell cycle; cell signaling; macromolecular surveillance and turnover; molecular evolution
(This special issue belongs to the Section Molecular Genetics and Genomics)
25th Anniversary of IJMS: Updates and Advances in Molecular Informatics submission deadline 31 Mar 2027 | 14 articles | Viewed by 17215 | Submission Open
Keywords: AI-guided drug repurposing; virtual screening in personalized medicine; machine learning for toxicity prediction; network-based biomarkers in complex diseases; in silico pharmacokinetics and ADMET profiling; data-driven materials design; deep learning for molecular property prediction; AI-assisted nanomaterial synthesis; systems biology models for metabolic engineering
(This special issue belongs to the Section Molecular Informatics)
Plant Stress Biology
edited by
submission deadline 31 Mar 2027 | 11 articles | Viewed by 11416 | Submission Open
Keywords: abiotic stress; biotic stress; stress response mechanisms; oxidative stress; phytohormones signaling; stress tolerance
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Advances in Brain Cancers: Second Edition submission deadline 31 Mar 2027 | 1 articles | Viewed by 11379 | Submission Open
Keywords: brain tumors; malignant brain tumor; advanced cancer biology
(This special issue belongs to the Section Molecular Oncology)
Multifaceted Roles of Extracellular Vesicles in Cancer and Other Diseases submission deadline 31 Mar 2027 | 3 articles | Viewed by 9000 | Submission Open
Keywords: extracellular vesicles; exosomes; cancer diagnostics; non-invasive tests; liquid biopsy; cancer therapy; biomarker discovery; nanotechnology; EV engineering; drug delivery; neurodegenerative diseases; cardiovascular diseases; infectious diseases; autoimmune diseases; precision diagnostics
(This special issue belongs to the Section Molecular Oncology)
Colorectal Cancer: Molecular and Cellular Basis
edited by Martina Lepore Signorile
submission deadline 31 Mar 2027 | 5 articles | Viewed by 8047 | Submission Open
Keywords: colorectal cancer; molecular and cellular biology; tumor initiation; tumor progression; metastasis
(This special issue belongs to the Section Molecular Oncology)
New Insights into the Mechanisms of Neurodegeneration and Regeneration: From Bench to Bedside
edited by Irina Ivanova Stoyanova
submission deadline 31 Mar 2027 | 4 articles | Viewed by 7858 | Submission Open
Keywords: neurodegeneration; neuroregeneration; molecular neurobiology; brain development; developmental brain disorders; synaptogenesis; synaptic plasticity; cognitive neuroscience; neurotrauma
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Genetics and Genomics of Neurodevelopmental Disorders submission deadline 31 Mar 2027 | 6 articles | Viewed by 7121 | Submission Open
Keywords: neurodevelopmental disorders; genetics; molecular biology; biomarkers; epigenetics; precision medicine; rare variants; common variants; artificial intelligence; machine learning
(This special issue belongs to the Section Molecular Genetics and Genomics)
Bioactive Natural Products: From Molecular Mechanisms to Biological Function submission deadline 31 Mar 2027 | 7 articles | Viewed by 6861 | Submission Open
Keywords: natural products; molecular mechanism; biological activities; drug discovery
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Advances on Solubility and Diffusivity in Water-Based Systems and in Biological Media submission deadline 31 Mar 2027 | 1 articles | Viewed by 6495 | Submission Open
Keywords: water solubility ; water-solute interactions ; solvation, hydrophobic and hydrophilic effects ; improving water solubility and prediction ; solution of chemicals in biological media ; diffusivity ; drug transport and bioavailability; chemicals diffusivity across biological barriers
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Natural Products in Cancer Prevention and Treatment—Second Edition submission deadline 31 Mar 2027 | 3 articles | Viewed by 5637 | Submission Open
Keywords: natural products; cancer; therapeutic strategies; novel molecular pathways
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Application of an Electron Microscope in the Study of Cell Structure
edited by
submission deadline 31 Mar 2027 | 5 articles | Viewed by 5445 | Submission Open
Keywords: intracellular structure; organelles; cell surface structure; immuno-labeling
(This special issue belongs to the Section Molecular Biophysics)
SGLT2 Inhibitors and GLP/GIP/Glucagon Agonists: From Fundamental Mechanisms to Clinical Translation
edited by
submission deadline 31 Mar 2027 | 3 articles | Viewed by 5318 | Submission Open
Keywords: SGLT2 inhibitors; GLP-1 receptor agonists; GIP; glucagon; multi-agonists; cardiometabolic disease; renal protection; obesity; translational research
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Zebrafish as a Novel Model for Toxicological Research
edited by Leobardo Manuel Gómez-Oliván
submission deadline 31 Mar 2027 | 3 articles | Viewed by 5130 | Submission Open
Keywords: zebrafish; toxicological assessment; organic and inorganic contaminants; oxidative stress; developmental toxicity; neurotoxicity; reproductive toxicity; genotoxicity; alternative testing models; One Health
(This special issue belongs to the Section Molecular Toxicology)
Molecular Mechanisms and Therapeutic Strategies for Pregnancy Complications
edited by
submission deadline 31 Mar 2027 | 4 articles | Viewed by 4758 | Submission Open
Keywords: pregnancy complications; placenta diseases; molecular mechanisms; therapeutics; biomarkers; preeclampsia; gestational diabetes; intrauterine growth restriction; maternal-fetal exchange; inflammation mediators
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cell Proliferation and Differentiation in Cancer submission deadline 31 Mar 2027 | 2 articles | Viewed by 4260 | Submission Open
Keywords: cell signaling; cell transduction; transcriptional and post-transcriptional pathways; growth factors; second messengers; cell proliferation; cell differentiation; cell metabolism; cell death; cell invasion
(This special issue belongs to the Section Molecular Oncology)
Recent Advances in Molecular Imaging and Therapy
edited by
submission deadline 31 Mar 2027 | 2 articles | Viewed by 4033 | Submission Open
Keywords: molecular imaging; therapy; clinical translation; precision medicine; radiotheranostics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Breeding Strategies: Employment of Plant Adaptation Mechanisms to Biotic and Abiotic Stresses
edited by
submission deadline 31 Mar 2027 | 3 articles | Viewed by 3944 | Submission Open
Keywords: marker-assisted selection; molecular breeding; whole-transcriptome analysis; RNA sequencing; DNA sequencing; plant stress response
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Genetic and Epigenetic Research in Skin Diseases
edited by
submission deadline 31 Mar 2027 | 3 articles | Viewed by 3911 | Submission Open
Keywords: skin diseases; genodermatoses; psoriasis; atopic dermatitis; hidradenitis; suppurativa; epigenetic regulation; genome-wide association studies (GWAS); next-generation sequencing; translational dermatogenomics; Mendelian randomization; rare disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Forensic Science: Integrating Innovation and Investigation
edited by
submission deadline 31 Mar 2027 | 1 articles | Viewed by 3885 | Submission Open
Keywords: DNA profiling; artificial intelligence; trace evidence analysis; immunohistochemical markers; molecular biology techniques; super-resolution microscopy; integrated forensic approach; new bioinformatics techniques; digital pathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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