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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Impact of Exercise on Molecular and Cellular Processes in the CNS

edited by

Philippe De Deurwaerdere

and Hélène Gréa

submission deadline 30 Apr 2026 | Viewed by 61 | Submission Open

Keywords: physical exercise; plasticity; neurotransmission; metabolism; neuroinflammation; glia; epigenetic; CNS disease; animal models; humans

(This special issue belongs to the Section Molecular Biology)

Bone Health: From Molecular Mechanisms to Therapeutics

edited by

Farasat Zaman

submission deadline 30 Apr 2026 | Viewed by 61 | Submission Open

Keywords: bone growth; chondrocytes; osteoporosis; fractures; inflammation; cancer; nutrition; stress; biomechanics; biotechnology; bioengineering

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Redox Homeostasis and Oxidative Stress in Human Metabolism and Disease: 3rd Edition

edited by

Jarosław Nuszkiewicz

and

Alina Woźniak

submission deadline 30 Apr 2026 | Viewed by 61 | Submission Open

Keywords: oxidative stress; redox homeostasis; reactive oxygen species (ROS); redox signaling; antioxidants and defense mechanisms; metabolic regulation; inflammation and redox imbalance; mitochondrial dysfunction; biomarkers of oxidative stress; therapeutic redox modulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Mechanisms of Genotoxicity Induced by Environmental Mutagens—Focus on Nanoparticles and Micro/Nanoplastics

edited by

Ricard Marcos

and Susana Pastor

submission deadline 30 Apr 2026 | Viewed by 59 | Submission Open

Keywords: genotoxicity; DNA damage; chromosome damage; DNA repair; comet assay; micronucleus assay; mechanisms; environmental pollutants; micro/nanoplastics; nanoparticles

(This special issue belongs to the Section Molecular Toxicology)

The Zebrafish Model in Animal and Human Health Research, 3rd Edition

edited by

Marta Anna Szychlinska

and Federica Scalia

submission deadline 30 Apr 2026 | Viewed by 58 | Submission Open

Keywords: zebrafish; environmental toxicology; predictive toxicology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microplastics, Gut Microbiome and Human Health

edited by

Ying Zhang

submission deadline 30 Apr 2026 | Viewed by 56 | Submission Open

Keywords: microplastics; gut microbiome; dysbiosis; intestinal barrier; immunotoxicity; metabolic inflammation; na-noplastics; molecular mechanisms

Endometrial Cancer: From Molecular Mechanisms to Treatment

edited by Ursula Catena

submission deadline 30 Apr 2026 | Viewed by 54 | Submission Open

Keywords: endometrial cancer; molecular mechanisms; biomarkers; targeted therapy; immunotherapy; genomics; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Molecular Crosstalk Between Metabolic Dysregulation and Neuropsychiatric Disorders: Novel Therapeutic Perspectives

edited by Aleksandra Szopa and Anna D. Serefko

submission deadline 30 Apr 2026 | Viewed by 54 | Submission Open

Keywords: metabolic dysregulation; neuropsychiatric disorders; molecular crosstalk; neuroinflammation; mitochondrial dysfunction; neuroendocrine signaling; gut– brain axis; innovative therapeutic strategies; natural compounds; drug repurposing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Fibroblasts in the Regulation of Tissue Inflammation and Repair

edited by Rebeca Illescas Montes

submission deadline 30 Apr 2026 | Viewed by 54 | Submission Open

Keywords: fibroblast; wound healing; inflammation; tissue repair; immune– stromal crosstalk; extracellular matrix remodeling; myofibroblast; regenerative medicine; exosomes; biomaterials

(This special issue belongs to the Section Molecular Immunology)

3D Printing and Biomaterials for Hearing and Balance Restoration

edited by

Chenkai Dai

submission deadline 30 Apr 2026 | Viewed by 53 | Submission Open

Keywords: hearing; balancing; 3D printing; biomaterial

(This special issue belongs to the Section Materials Science)

New Insights in Antibiotic Resistance/Tolerance

edited by

Mara Di Giulio

submission deadline 30 Apr 2026 | Viewed by 53 | Submission Open

Keywords: antibiotic resistance; biofilm; innovative antimicrobial strategies and compounds; synergistic actions; One Health; bacterial tolerant phenotypes; resistant pathogenic microorganisms; mechanisms of antimicrobial resistance

(This special issue belongs to the Section Molecular Microbiology)

Novel Advances in Ataxia-Telangiectasia

edited by David Coman

submission deadline 30 Apr 2026 | Viewed by 51 | Submission Open

Keywords: ataxia-telangiectasia; ATM; metabolism; mitochondrial dysfunction; DNA repair; natural history; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Research on Autophagy in Aging and Age Related Diseases

edited by

Tímea Sigmond

submission deadline 30 Apr 2026 | Viewed by 51 | Submission Open

Keywords: autophagy; aging; molecular mechanisms; age related diseases; mitochondria

(This special issue belongs to the Section Biochemistry)

Molecular Insights into Heredity and Metabolism of Osteosarcoma

edited by

Hiroki Kuniyasu

and

Kanya Honoki

submission deadline 30 Apr 2026 | Viewed by 51 | Submission Open

Keywords: osteosarcoma; clinical imaging; genetics; epigenetics; metabolism; signal transduction; stemness; pathology; metastasis; novel druggable target

(This special issue belongs to the Section Molecular Oncology)

New Insights into the Structure and Function of Nuclear Receptors

edited by

Elza Fonseca

submission deadline 30 Apr 2026 | Viewed by 50 | Submission Open

Keywords: transcription factors; endocrine disorders; ligands; xenobiotics; pharmacology; modelling; drug design; evolution; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Breast Cancer and Hormone Receptors: Molecular Insights

edited by

Alkistis Papatheodoridi

and

Antonella Muscella

submission deadline 30 Apr 2026 | Viewed by 49 | Submission Open

Keywords: hormone receptor-positive breast cancer; estrogen receptor (ER); progesterone receptor (PR); endocrine therapy resistance; breast cancer genomics; molecular biomarkers; transcriptomic profiling; targeted therapies

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Plant-Pathogen Interactions: The Role of Effectors and Host Targets

edited by

Muhammad Asif

submission deadline 30 Apr 2026 | Viewed by 48 | Submission Open

Keywords: plant immunity; effector proteins; pattern-triggered immunity (PTI); effector-triggered immunity (ETI); NLR receptors; plant-microbe interactions; susceptibility; secreted virulence factors; signal transduction; host manipulation

(This special issue belongs to the Section Molecular Plant Sciences)

Novel Diagnostic and Theragnostic Strategies in Brain Tumors

edited by Andrea Cimini and Laura Travascio

submission deadline 30 Apr 2026 | Viewed by 48 | Submission Open

Keywords: brain tumor; novel diagnostic and theragnostic approaches; neuro-oncology; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Emerging Metabolomics Techniques and Applications

edited by Jun Han

submission deadline 30 Apr 2026 | Viewed by 46 | Submission Open

Keywords: metabolomics; lipidomics; bioinformatics; micro-extraction; chemical derivatization; liquid chromatography-mass spectrometry (LC-MS); matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS); gas chromatography-mass spectrometry (GC-MS); metabolic profiling; biomarker assay

(This special issue belongs to the Section Molecular Informatics)

Application of Germplasm Innovation Technology in Aquactic Genetic Breeding

edited by

Hui Qiao

submission deadline 30 Apr 2026 | Viewed by 46 | Submission Open

Keywords: aquaculture; biotechnology; germplasm improvement; genetic breeding; gene function; genomics; gene editing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Multi-Target and Synergistic Therapeutic Strategies in Modern Drug Discovery

edited by

Vincenzo Piccolo

submission deadline 30 Apr 2026 | Viewed by 45 | Submission Open

Keywords: multi-target and synergistic therapeutic strategies; drug design; combination therapy; polypharmacology; drug re-purposing

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insights in Women’s Health: Advances in Gynecological Disease Mechanisms and Therapeutics

edited by Tsung-Hsuan Lai

submission deadline 30 Apr 2026 | Viewed by 45 | Submission Open

Keywords: ART and IVF; prenatal diagnosis; infertility; minimally invasive surgery; robotic surgery; PCOS; endometriosis; menopause; AI

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Tumor Organoids in Translational Cancer Research: Mechanisms and Applications

edited by Yong-Jun Kwon

submission deadline 30 Apr 2026 | Viewed by 45 | Submission Open

Keywords: tumor organoids; tumor heterogeneity; multi-omics profiling; drug resistance; tumor microenvironment; patient-derived models; organoid biobank; high-throughput drug screening; personalized therapy; translational research

(This special issue belongs to the Section Molecular Oncology)

Mitochondria: Not Just Powerhouse of the Cell

edited by

Kailash Chandra Mangalhara

submission deadline 30 Apr 2026 | Viewed by 44 | Submission Open

Keywords: mitochondrial nucleic acid; mitonuclear communication; mito-ER communication; mito-lysosome communication; mitochondria in cancer; mitochondrial metabolic disorders; mitochondria in inflammation

(This special issue belongs to the Section Molecular Biology)

Multi-Omic Data Integration in Oncology

edited by Hung-Yu Lin and

Hsing-Ju Wu

submission deadline 30 Apr 2026 | Viewed by 44 | Submission Open

Keywords: bioinformatics; multi-omics at bulk level; single-cell omics; spatial multi-omics; metabolomics; proteomics; pharmacogenomics; tumor microenvironment; tumor molecular profiling; therapy resistance

(This special issue belongs to the Section Molecular Informatics)

Machine Learning Applications in Bioinformatics and Biomedicine: 4th Edition

edited by Hao Lv

submission deadline 30 Apr 2026 | Viewed by 44 | Submission Open

Keywords: genome; transcriptome; proteome; metabolome; drug target; machine learning; prediction of drug side effects; epigenetic marker discovery for diseases; molecular network marker; early screening of diseases

(This special issue belongs to the Section Molecular Informatics)

Advanced Composite Materials: Innovative Molecular Design, Cross-Scale Materials Characterization and Integrated Engineering Applications

edited by

Zhengzhi Mu

submission deadline 30 Apr 2026 | Viewed by 44 | Submission Open

Keywords: composite materials; molecular design; cross-scale characterization; advanced synthesis; integrated applications

(This special issue belongs to the Section Materials Science)

Intermittent Hypoxia: Physiological and Biomedical Perspectives

edited by

Teresa Carbonell Camós

Olga Tura-Ceide

and Norma Alva

submission deadline 30 Apr 2026 | Viewed by 43 | Submission Open

Keywords: altitude training; cardiovascular adaptation; endothelial dysfunction; EPO; intermittent hypoxia conditioning programs; HIF-1; neuroplasticity; obstructive sleep apnea; oxidative stress; pulmonary hypertension

(This special issue belongs to the Section Molecular Biology)

Exploring the Chemistry of 2D Transition Metal Carbides and Nitrides (MXenes): Synthesis Methods and Surface Chemistry

edited by

Hyunho Kim

submission deadline 30 Apr 2026 | Viewed by 43 | Submission Open

Keywords: synthesis optimization of non-Al MAX phase; wet chemical etching of non-Al MAX phase; molten salt etching of non-Al MAX phase; surface modification of MXenes; colloidal stability of MXenes; solution process of MXenes

(This special issue belongs to the Section Materials Science)

The Role of Dopamine Neurotransmission in Schizophrenia

edited by

Mirian Akemi Furuie Hayashi

submission deadline 30 Apr 2026 | Viewed by 43 | Submission Open

Keywords: schizophrenia; dopamine; dopaminergic system; neurotransmission; psychosis; pathophysiology; molecular psychiatry

(This special issue belongs to the Section Molecular Neurobiology)

New Insight Into Pathogen Stress Effects on Plant Structure and Metabolism

edited by

Edmund Kozieł

and

Katarzyna Otulak-Kozieł

submission deadline 30 Apr 2026 | Viewed by 42 | Submission Open

Keywords: plant– pathogen interaction; innate immunity; ultrastructure; plant defense systems; plant physiology; signal transduction; resistance genes

(This special issue belongs to the Section Molecular Plant Sciences)

The Tumor Microenvironment in Hepatocellular Carcinoma: Mechanistic Insights and Future Therapeutic Approaches

edited by

Agnes Chan

submission deadline 30 Apr 2026 | Viewed by 42 | Submission Open

Keywords: advance or metastatic hepatocellular carcinoma; liver disease; radiotherapy; transarterial chemoembolization (TACE) or SBRT; immune checkpoint inhibitors; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Precision Nutrition and Cancer: Molecular Insights Into Cancer Prevention and Development

edited by

Da Pan

submission deadline 30 Apr 2026 | Viewed by 41 | Submission Open

Keywords: precision nutrition; cancer prevention; cancer development; nutrigenomics; personalized diets; tumor metabolism; dietary interventions

(This special issue belongs to the Section Molecular Oncology)

Current Insights into the Role of Exosomes in Intercellular Communication, 2nd Edition

edited by

Orit Uziel

submission deadline 30 Apr 2026 | Viewed by 41 | Submission Open

Keywords: exosomes; extracellular vesicles; intracellular communication; intercellular communication

(This special issue belongs to the Section Molecular Biology)

The Structure, Function, and Application of Zinc Finger Proteins

edited by

Sabrina Esposito

submission deadline 30 Apr 2026 | Viewed by 41 | Submission Open

Keywords: zinc finger proteins: structure; function and properties; applications; protein folding and dynamics; environmental contaminants and metal ions exposure; uptake; toxicity; molecular recognition and signal transduction; mechanisms of action and effects of abnormal zinc finger proteins on human health; zinc finger proteins as drug targets

(This special issue belongs to the Section Molecular Biology)

Micro- and Nanoplastics: Molecular Insights from the One Health Perspective

edited by

Magdalena Zemelka-Wiacek

submission deadline 30 Apr 2026 | Viewed by 41 | Submission Open

Keywords: microplastics; nanoplastics; One Health; molecular toxicology; oxidative stress; inflammation; microbiome; bioaccumulation; environmental exposure

(This special issue belongs to the Section Molecular Toxicology)

Molecular Mechanisms, Epigenetics and Therapeutics in Liver Cirrhosis

edited by Ana Soledad Sandoval-Rodríguez

submission deadline 30 Apr 2026 | Viewed by 40 | Submission Open

Keywords: liver cirrhosis; molecular pathogenesis; fibrosis and inflammation; epigenetics; hepatocellular carcinoma (HCC); viral hepatitis; molecular mechanism; hepatic nutrition; therapeutic targets; translational hepatology; MASLD; ALD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Involvement of Connexin-, Pannexin-, and Innexin-Based Hemichannels in Physiological Functions of Diverse Tissues

edited by

Juan Carlos Saéz

submission deadline 30 Apr 2026 | Viewed by 40 | Submission Open

Keywords: connexin; pannexin; innexin; hemichannel; permeant ions

(This special issue belongs to the Section Molecular Biology)

Preservation of Testicular Function: From Andrological Pathologies to Testis Cancer

edited by

Elisa Dalla Pozza

and

Ilaria Dando

submission deadline 30 Apr 2026 | Viewed by 38 | Submission Open

Keywords: testicular function; male infertility; fertility preservation; spermatogenesis; oxidative stress; cell death; testicular cancer; testosterone

(This special issue belongs to the Section Molecular Pharmacology)

Phage Therapy: Breakthroughs and Challenges

edited by

Spyridon Megremis

and

Anisha Mahendra Thanki

submission deadline 30 Apr 2026 | Viewed by 37 | Submission Open

Keywords: phage therapy; phage production; phage engineering; phage genomics; phage evolution; phage structural biology

(This special issue belongs to the Section Molecular Microbiology)

Toxicology of Cyanobacterial Toxins

edited by

Carlos García

submission deadline 30 Apr 2026 | Viewed by 36 | Submission Open

Keywords: toxicology; cyanotoxins; cyanobacteria; harmful effects; health risk

(This special issue belongs to the Section Molecular Toxicology)

Nanoparticles in Nanobiotechnology and Nanomedicine: 3rd Edition

edited by

Costica Caizer

submission deadline 30 Apr 2026 | Viewed by 35 | Submission Open

Keywords: nanoparticles; properties of nanoparticles; methods of obtaining nanoparticles; characterization techniques; theoretical models; computational simulation; applications in nanomedicine; applications in nanobiotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Decoding the Pediatric Brain Tumor Microenvironment: A Molecular Perspective

edited by

Samuele Tardito

submission deadline 30 Apr 2026 | Viewed by 35 | Submission Open

Keywords: pediatric brain tumor; precision immunotherapy; pediatric neuro-oncology; tumor microenvironment (TME); single-cell RNA sequencing; whole transcriptomics; mass spectrometry-based proteomics; mass cytometry; cellular and molecular architecture; organoid

(This special issue belongs to the Section Molecular Oncology)

Effects of Natural Bioactive Compounds on Cellular Responses

edited by

Amélia M. Silva

submission deadline 30 Apr 2026 | Viewed by 34 | Submission Open

Keywords: cellular targets; cell proliferation; cell death mechanisms; cell signalling; cytokines; vitamins; phytochemicals; venoms; peptides; pharmacological effect

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mechanobiology of the Cell

edited by

Zbigniew Baster

submission deadline 30 Apr 2026 | Viewed by 32 | Submission Open

Keywords: nuclear and chromatin mechanics; mechanobiology; mechanotransduction pathways

(This special issue belongs to the Section Molecular Biology)

KRAS-Associated Cancer Signaling

edited by Sang Hun Lee

submission deadline 30 Apr 2026 | Viewed by 30 | Submission Open

Keywords: KRAS signaling; receptor tyrosine kinases; EGFR; c-MET; PI3K– MAPK pathways; tumor microenvironment; drug resistance and adaptive rewiring; combination therapy; biomarker stratification; prion protein (PrPC)

(This special issue belongs to the Section Molecular Oncology)

Modern Synthetic Pathways for Anticancer Drug Discovery

edited by

Łukasz Struk

submission deadline 30 Apr 2026 | Viewed by 30 | Submission Open

Keywords: new anticancer agents; bioactive molecules; drug design; drug synthesis; cancer therapy; medicinal chemistry

(This special issue belongs to the Section Molecular Oncology)

Natural Compounds: Impact on Health and Diseases

edited by

Charles Benneh

submission deadline 30 Apr 2026 | Viewed by 29 | Submission Open

Keywords: natural compounds; bioactive compounds; efficacy; toxicity; mechanism; compound isolation; chemical characterisation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Pathology, Diagnosis and Therapeutic Strategies of Thrombotic Diseases

edited by Emanuele Valeriani

submission deadline 30 Apr 2026 | Viewed by 29 | Submission Open

Keywords: anticoagulants; cardiovascular diseases; diagnosis; platelet aggregation inhibitors; venous thromboembolism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Silica-Based Materials: From Molecular Design to Sustainable Applications

edited by Marius Rǎdulescu

submission deadline 30 Apr 2026 | Viewed by 29 | Submission Open

Keywords: silica-based materials; molecular design; hybrid nanomaterials; surface chemistry; structure– property relationships; functionalized silica; sol– gel processes; molecular interactions; green synthesis; sustainable applications; nanostructured systems; catalysis and adsorption; biomedical interfaces; energy and environmental materials; molecular modeling

(This special issue belongs to the Section Molecular Nanoscience)

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