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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Ovarian Insufficiency: From Molecular Pathology to Novel Therapeutic Approach

edited by Aleksandar Ljubić

submission deadline 30 Jun 2026 | Viewed by 56 | Submission Open

Keywords: ovarian insufficiency; premature ovarian insufficiency; molecular pathology; regenerative medicine; stem cell therapy; platelet-rich plasma; epigenetics; intraovarian treatment; ovarian stem cells; mitochondrial dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Reproductive Endocrinology Research: 2nd Edition

edited by

Tsung-Hsien Lee

submission deadline 30 Jun 2026 | Viewed by 52 | Submission Open

Keywords: molecular endocrinology; reproductive genetics; hormonal signaling pathways; fertility and infertility; epigenetics in reproduction; environmental impact on reproduction

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Insights and Therapeutic Advances in Atherosclerosis

edited by

Zhu Bo

submission deadline 30 Jun 2026 | Viewed by 47 | Submission Open

Keywords: atherosclerosis; molecular mechanisms; lipid metabolism; inflammation; endothelial dysfunction; RNA therapeutics; nanomedicine; cardiovascular disease; biomarkers; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Trends in Metal–Organic and Covalent Organic Frameworks

edited by

Muhammad Asad

submission deadline 30 Jun 2026 | Viewed by 47 | Submission Open

Keywords: metal– organic frameworks; covalent organic frameworks; porous materials; electrocatalysis; sustainable energy systems; adsorption; supercapacitors

(This special issue belongs to the Section Materials Science)

Advances in Polymeric Nanomaterials in Medicine

edited by Prabhanjan Giram

submission deadline 30 Jun 2026 | Viewed by 47 | Submission Open

Keywords: nanomaterials; nanocomposites; biomolecules; nano pharmaceuticals; nanoparticles; applications of nanomaterials; nanoformulation design; characterization; nanodrug delivery system; targeted and controlled release therapies

(This special issue belongs to the Section Molecular Nanoscience)

Exploring the Crossroads of Autoimmunity, Inflammatory Diseases, and Cancer

edited by Xuming Mao

submission deadline 30 Jun 2026 | Viewed by 46 | Submission Open

Keywords: autoimmune disorders; tumor microenvironment; chronic inflammation; immune checkpoint inhibitors; machine learning; epidemiology

(This special issue belongs to the Section Molecular Immunology)

Leukemia in the Omics Era: From Mechanisms to Therapies

edited by Marco Rossi

submission deadline 30 Jun 2026 | Viewed by 45 | Submission Open

Keywords: FLT3 inhibitors; JAK inhibitors; BTK inhibitors; BCL 2 inhibitors; BTK degraders; menin inhibitors; IDH inibitors

(This special issue belongs to the Section Molecular Oncology)

From Drug Design to Mechanistic Understanding and Resistance

edited by

Yuan Ma

submission deadline 30 Jun 2026 | Viewed by 44 | Submission Open

Keywords: drug resistance; drug discovery; targeted protein degradation; systems pharmacology; structural biology

(This special issue belongs to the Section Molecular Pharmacology)

Viral Infections and Host Antiviral Responses: Molecular Mechanisms and Molecular Regulation

edited by Hong Jia

submission deadline 30 Jun 2026 | Viewed by 44 | Submission Open

Keywords: antiviral immunity; viral entry; host– virus interaction; innate immunity; interferon signaling; viral immune evasion; non-coding RNAs; post-translational modifications; molecular therapeutics; viral pathogenesis

(This special issue belongs to the Section Molecular Microbiology)

The Roles of Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists in Health and Disease

edited by

Katarzyna Kaczyńska

submission deadline 30 Jun 2026 | Viewed by 31 | Submission Open

Keywords: GLP-1; GLP-1 receptor; GLP-1 signaling pathway; mechanism of action; GLP-1 agonists; human diseases; adverse effects

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Next-Generation Disease Models for Neuropsychiatric Disorders: Organoids, iPSC-Derived Circuits, and Gene Editing

edited by Masaru Tanaka

submission deadline 30 Jun 2026 | Viewed by 28 | Submission Open

Keywords: brain organoids; induced pluripotent stem cells (iPSC); neural stem cells; CRISPER-CAS systems (CRISPR); neuropsychiatric disorders; neurodevelopmental disorders; synaptic transmission; neuroinflammation; drug discovery; animal disease models

(This special issue belongs to the Section Molecular Neurobiology)

Liposome-Related Nanotechnology and Lipid-Based Nanocarriers

edited by

Carla Matos

submission deadline 30 Jun 2026 | Viewed by 26 | Submission Open

Keywords: liposomes; lipid nanoparticles; solid lipid nanoparticles; nanostructured lipid carriers; nanocarriers; drug delivery; controlled release

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Insights into Hematopoietic Stem Cell Differentiation and Regeneration

edited by

Baobing Zhao

submission deadline 30 Jun 2026 | Viewed by 20 | Submission Open

Keywords: hematopoiesis; leukemia; lymphoma; anemia; myelodysplastic syndromes; myeloproliferative neoplasm; myelofibrosis; erythropoiesis; hematopoietic stem cell

(This special issue belongs to the Section Molecular Immunology)

Plant Secondary Metabolites and Their Regulatory Mechanisms

edited by

Daniela Trono

submission deadline 30 Jun 2026 | Viewed by 20 | Submission Open

Keywords: secondary metabolites; plant growth and development; response to biotic and abiotic stresses; biosynthesis and degradation; gene and enzyme regulation; metabolic engineering; omics approaches

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Studies on Obesity and Related Diseases

edited by

Juliana Soares Severo

Francisco L. Torres-Leal

and

Moisés Tolentino B. Da Silva

submission deadline 30 Jun 2026 | Viewed by 19 | Submission Open

Keywords: obesity; adipose tissue; immunometabolism; adipokines; metabolomics; gut microbiota; thermogenesis; NAFLD; inflammation; precision nutrition

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on Antimicrobial Nanomaterials

edited by

Nenad Filipovic

submission deadline 30 Jun 2026 | Viewed by 17 | Submission Open

Keywords: antimicrobial nanomaterials; metal/metal-oxide nanoparticles; stimuli-responsive platforms; photothermal/photodynamic mechanisms; biofilm inhibition

(This special issue belongs to the Section Materials Science)

Molecular and Metabolic Mechanisms Regulating Reproduction and Development in Animals

edited by Borhan Shokrollahi and Kimberly M. Davenport

submission deadline 30 Jun 2026 | Viewed by 16 | Submission Open

Keywords: molecular nutrition; metabolic signaling; reproductive physiology; epigenetic programming; placental biology; transcriptomics and metabolomics; mitochondrial function; oxidative stress pathways; developmental programming; ruminant health

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Therapeutic Strategies in Diabetic Retinopathy

edited by

Rosa Fernandes

submission deadline 30 Jun 2026 | Viewed by 15 | Submission Open

Keywords: diabetic retinopathy; neurovascular unit; molecular pathways; neuroinflammation; metabolic dysregulation; blood-retinal barrier; molecular biomarkers; multi-omics; molecular therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Translational Mechanisms of Cardiac Arrhythmias: From Oxidative Stress to Novel Therapeutic Strategies

edited by

Stefan Simović

submission deadline 30 Jun 2026 | Viewed by 15 | Submission Open

Keywords: cardiac arrhythmias; atrial fibrillation; oxidative stress; molecular mechanisms; translational research; antiarrhythmic therapy; cardiac remodeling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Multi-Omics in Cancer: Second Edition

edited by

Leo Kei Iwai

submission deadline 30 Jun 2026 | Viewed by 13 | Submission Open

Keywords: cancer; multi-omics; genomics; transcriptomics; proteomics; metabolomics; lipidomics; epigenomics; artificial intelligence; machine learning; systems biology; biomarkers; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Modern Approaches in Regenerative Therapy

edited by

Daria Chudakova

and

Vladimir P. Baklaushev

submission deadline 30 Jun 2026 | Viewed by 13 | Submission Open

Keywords: regenerative therapy; regeneration; neuroregeneration; cell reprogramming; cell therapy; regenerative bio-scaffolds; extracellular vesicles; mesenchymal stromal/stem cells (MSCs); cell differentiation; omics technologies

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Diabetic Nephropathy

edited by

Natalija Filipović

submission deadline 30 Jun 2026 | Viewed by 12 | Submission Open

Keywords: diabetic nephropathy; hyperglycemia; insulin resistance; oxidative stress; mitochondrial dysfunction; chronic kidney disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in the Bioactive Properties of Natural Products from Medicinal Plants: Antioxidant, Antibacterial, and Anticancer Activities

edited by Fhatuwani N. Mudau

submission deadline 30 Jun 2026 | Viewed by 12 | Submission Open

Keywords: antiproliferative properties; antimicrobial activity; medicinal plants; phytochemicals; metabolomics; natural products; cancer; therapeutic properties

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Pharmacological Effects of Bioactive Compounds Derived from Plants

edited by

Ibrahim Mssillou

submission deadline 30 Jun 2026 | Viewed by 11 | Submission Open

Keywords: bioactive compounds; wound healing; anti-cancer; anti-inflammatory; mechanism of action; antioxidants; neuroprotection; pharmacological properties

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Identification of Molecular Biomarkers Through Digital Pathology

edited by

Rafael Parra-Medina

submission deadline 30 Jun 2026 | Viewed by 10 | Submission Open

Keywords: digital pathology; molecular biomarkers; computational pathology; artificial intelligence; deep learning; spatial biology; multi-omics integration; tumor microenvironment; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mediators at the Crossroads of Microbes, the Microbiome, and Cancer

edited by

Syed Azmal Ali

submission deadline 30 Jun 2026 | Viewed by 9 | Submission Open

Keywords: molecular mediators; microbiome-cancer interface; proteomics; multi-omics; functional characterization

(This special issue belongs to the Section Molecular Microbiology)

Exploring Molecular Mechanisms Involved in Head and Neck Cancer

edited by Jae Won Chang

submission deadline 30 Jun 2026 | Viewed by 9 | Submission Open

Keywords: head and neck squamous cell carcinoma (HNSCC); molecular targeted therapy; tumor microenvironment (TME); therapeutic resistance; cancer stem cells (CSCs); immunotherapy; ferroptosis and cuproptosis; non-coding RNAs; microbiome and exosomes; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Advances in Amyloids: From Structure to Tailored Function

edited by Laurent Marichal

submission deadline 30 Jun 2026 | Viewed by 9 | Submission Open

Keywords: amyloid; aggregation; self-assembly; seeding; protein structure

(This special issue belongs to the Section Macromolecules)

Emerging Insights into Endothelial Biology and Metabolism

edited by

Hemant Giri

submission deadline 30 Jun 2026 | Viewed by 8 | Submission Open

Keywords: endothelial dysfunction; endothelial activation; vascular biology; endothelial migration; angiogenesis; vascular permeability; shear stress; microvascular and macrovascular remodeling; leukocyte trafficking; mitochondrial function

(This special issue belongs to the Section Molecular Biology)

Breast Cancer: From Pathophysiology to Novel Therapies, 2nd Edition

edited by Jennifer Sims-Mourtada

submission deadline 30 Jun 2026 | Viewed by 8 | Submission Open

Keywords: breast cancer; genetics; tumor microenvironment; model systems; organoids; immune cells; tumor stroma; therapeutic resistance; novel therapies

(This special issue belongs to the Section Molecular Oncology)

Molecular and Bioactive Properties of Novel and Functional Food Ingredients

edited by

Ewelina Zielińska

submission deadline 30 Jun 2026 | Viewed by 7 | Submission Open

Keywords: functional food; bioactive compounds; novel food; molecular properties; peptides; edible insects; metabolomics; health-promoting ingredients; oxidative stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Thyroid Disease: From Molecular Mechanisms to Diagnosis and Therapeutic Advances

edited by

Mariana Lorena Tellechea

and Juan Nicola

submission deadline 30 Jun 2026 | Viewed by 7 | Submission Open

Keywords: thyroid disease; hypothyroidism; hyperthyroidism; autoimmune thyroid disease; thyroid nodules; thyroid cancer

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Emerging Molecular Research on Photocatalytic Functional Materials

edited by Yifan Chen

submission deadline 30 Jun 2026 | Viewed by 7 | Submission Open

Keywords: photocatalytic materials; molecular level; functional optimization; mechanism; synergistic effects

(This special issue belongs to the Section Materials Science)

New Advances in Bioactive Compounds

edited by

Samuel Cota Teixeira

submission deadline 30 Jun 2026 | Viewed by 6 | Submission Open

Keywords: bioactive compound; natural products; polyphenols; carotenoids; alkaloids

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Rare Diseases Associated with Short Stature: Genetics, Pathogenesis and Therapy, 2nd Edition

edited by

Michal Ordak

submission deadline 30 Jun 2026 | Viewed by 6 | Submission Open

Keywords: skeletal disorders; dwarfism; skeletal dysplasias; short stature; biomarkers; mutations; rare disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Effects of Bioactive Compounds in Cardiovascular and Neurological Diseases

edited by

Paul-Mihai Boarescu

submission deadline 30 Jun 2026 | Viewed by 5 | Submission Open

Keywords: inflammation; oxidative stress; bioactive compounds; cardiovascular diseases; neurological diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Natural Products in Drug Discovery: 2nd Edition

edited by

Luciana Scotti

and

Marcus Tullius Scotti

submission deadline 30 Jun 2026 | Viewed by 5 | Submission Open

Keywords: natural product; medicinal chemistry; drug design; drug discovery; pharmacy; chemistry

(This special issue belongs to the Section Molecular Pharmacology)

Autophagy in Physiology and Pathophysiology: Recent Advances

edited by

María Isabel Colombo

and Claudio Marcelo Fader

submission deadline 30 Jun 2026 | Viewed by 5 | Submission Open

Keywords: macroautophagy; microautophagy; chaperone-mediated autophagy (CMA); autophagy-related genes (ATG); xenophagy; mitophagy; pexophagy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetics- and Genomics-Based Wheat Improvement and Breeding

edited by Jian Ma

submission deadline 30 Jun 2026 | Viewed by 5 | Submission Open

Keywords: wheat crop; germplasm; genetics; genomics; breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Smart and Sustainable Delivery Systems for Natural Compounds in Health and Nutrition

edited by Raffaele Conte

submission deadline 30 Jun 2026 | Viewed by 4 | Submission Open

Keywords: natural bioactive compounds; smart delivery systems; sustainable nutrition; biopolymer-based carriers; microfluidics and green technologies; controlled and targeted release; functional foods and nutraceuticals; one health approach

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Thyroid Hormone Signaling: Mechanisms and Pathophysiological Implications

edited by María Laura Barreiro Arcos and Horacio Eduardo Romeo

submission deadline 30 Jun 2026 | Viewed by 4 | Submission Open

Keywords: thyroid hormones; mitochondrial function; oxidative stress; redox signaling; metabolic disorders; immune modulation; cardiovascular pathology; neurodevelopment and aging; cancer progression

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Metabolic Features of Breast Cancer: From Understanding Heterogeneous Biology to Developing New Therapies

edited by

Lyudmila Bel'skaya

submission deadline 30 Jun 2026 | Viewed by 4 | Submission Open

Keywords: breast cancer; heterogeneity; metabolic processes; metabolites; proteins; gene expression; diagnosis; prognosis; treatment response

(This special issue belongs to the Section Molecular Oncology)

The Role of Gut Microbiome Regulation in Immunity and Inflammation

edited by Lei Deng

submission deadline 30 Jun 2026 | Viewed by 4 | Submission Open

Keywords: gut microbiome; adaptive immunity; IBD; inflammation; innate immunity; enteric infections; salmonella; intestine barrier; mucosal immunity

(This special issue belongs to the Section Molecular Microbiology)

Organoid Models: Advancing the Study of Disease Mechanisms and Nutritional Regulations

edited by

Xi Lin

and Pinghuang Liu

submission deadline 30 Jun 2026 | Viewed by 4 | Submission Open

Keywords: organoids; disease mechanisms; nutritional regulation; disease modeling; stem cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Retinal Diseases: 3rd Edition

edited by Minzhong Yu

submission deadline 30 Jun 2026 | Viewed by 3 | Submission Open

Keywords: retina; optic nerve; ocular disorder; retinal disease; genetic mutation; aging; drug side effects; novel mutations/biomarkers; signaling pathways; spectral domain optical coherence tomography; stem cells; gene therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Characterization and Biological Function of Marine Biopolymers

edited by

Zahira Belattmania

submission deadline 30 Jun 2026 | Viewed by 2 | Submission Open

Keywords: marine-based biopolymers; sustainable extractions; polymer characterization; biological functions; marine resources

(This special issue belongs to the Section Materials Science)

Aptamers in Cancer Therapy: Mechanisms, Applications, and Translational Perspectives

edited by

Gabor I. Csonka

submission deadline 30 Jun 2026 | Viewed by 2 | Submission Open

Keywords: aptamers; targeted drug delivery; cancer immunotherapy; molecular imaging; biomarkers; precision oncology; SELEX; theranostics; translational oncology; mechanistic insights

(This special issue belongs to the Section Molecular Oncology)

Alcohol Metabolism: Molecular, Physiological, and Behavioral Consequences from Basic Research to Translational Applications

edited by Analia G. Karadayian

submission deadline 30 Jun 2026 | Viewed by 2 | Submission Open

Keywords: alcohol metabolism; acetaldehyde; mitochondrial dysfunction; oxidative stress; behavioral outcomes; animal models; translational research

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Interactions Between Microbes and Hosts: Physiology, Pathology and Treatment—Second Edition

edited by

Emira D’Amico

submission deadline 30 Jun 2026 | Viewed by 2 | Submission Open

Keywords: microbial infection; microbes– host interaction; virulence factors; molecular and cell biology; antimicrobial therapy; antibiotics; antimicrobial peptides; resistance mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Plant and Lichen Metabolites: Characterization and Applications

edited by

Agnieszka Hanaka

submission deadline 30 Jun 2026 | Viewed by 2 | Submission Open

Keywords: phytochemicals; secondary metabolites; bioactive compounds; bioactivity evaluation; synthesis optimization; metabolite application; metabolite extraction; elicitors; stress physiology; plant biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Displaying special issue 3051-3100 on page 62 of 65.

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