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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biomedical Applications of Mesenchymal Stem Cells

edited by

Giuliana Mannino

and

Debora Lo Furno

submission deadline 30 Dec 2025 | 8 articles | Viewed by 21019 | Submission Open

Keywords: mesenchymal stem cells; cell differentiation; cell therapy; regenerative medicine; tissue homeostasis; cartilage

(This special issue belongs to the Section Molecular Pharmacology)

Neurobiological Mechanisms of Addictive Disorders

edited by Liliana Marina Cancela

submission deadline 30 Dec 2025 | 7 articles | Viewed by 19869 | Submission Open

(This special issue belongs to the Section Molecular Neurobiology)

The Characterization and Application of Enzymes in Bioprocesses

edited by

Loredana Marcolongo

submission deadline 30 Dec 2025 | 9 articles | Viewed by 19372 | Submission Open

Keywords: biocatalysts; enzymatic characterization; enzymatic action; protein engineering; biocatalysts application; bioprocessing

(This special issue belongs to the Section Biochemistry)

Potential Prevention and Treatment of Neurodegenerative Disorders

edited by

Maria Paola Bertuccio

submission deadline 30 Dec 2025 | 5 articles | Viewed by 19170 | Submission Open

Keywords: neurodegenerative disorders; molecular biomarkers; oxidative stress; therapeutic strategies; disease prevention

(This special issue belongs to the Section Molecular Neurobiology)

Challenges and Innovation in Neurodegenerative Diseases, 2nd Edition

edited by

King-Ho Cheung

submission deadline 30 Dec 2025 | 7 articles | Viewed by 17659 | Submission Open

Keywords: neurodegenerative diseases; pathogenesis; biomarkers; disease model; natural product; new drug discovery; therapy; machine learning; stem cell therapy

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Signalling Pathways in Cardiovascular Pathophysiology

edited by Ernesto Alejandro Aiello

submission deadline 30 Dec 2025 | 5 articles | Viewed by 17297 | Submission Open

Keywords: heart; vascular; signaling; cardiovascular disease; mechanism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Animal Research Model for Neurological Diseases, 2nd Edition

edited by

Giuseppe Montalbano

and

Sepand Rastegar

submission deadline 30 Dec 2025 | 5 articles | Viewed by 15511 | Submission Open

Keywords: experimental models; mouse; rat; zebrafish; neurological disease; Alzheimer’ s disease; Parkinson’ s disease; neurodegeneration; neuroregeneration

(This special issue belongs to the Section Molecular Neurobiology)

Host-Pathogen Interaction, 6th Edition

edited by

Andreas Burkovski

submission deadline 30 Dec 2025 | 5 articles | Viewed by 13824 | Submission Open

Keywords: microorganisms; pathogen; bacteria; yeasts; protozoa; host organisms

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms and Therapeutic Innovations in Neurodegenerative Diseases: 2nd Edition

edited by Melania Maria Serafini and

Nicoletta Marchesi

submission deadline 30 Dec 2025 | 4 articles | Viewed by 12104 | Submission Open

Keywords: Alzheimer’ s disease; strokes; multiple sclerosis; amyotrophic lateral sclerosis; polyneuropathies; pain; diabetic retinopathy; neuroinflammation; dietary supplements; microbiome

(This special issue belongs to the Section Molecular Neurobiology)

Genetic and Molecular Mechanisms of Obesity

edited by

Maria Elisabeth Street

and

Giuseppina Rosaria Umano

submission deadline 30 Dec 2025 | 3 articles | Viewed by 11238 | Submission Open

Keywords: obesity; insulin signal transduction; insulin sensitivity; co-morbidities; genetics; epigenetics; miRNAs; DNA methylation; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Cancer and Cell Metabolism—2nd Edition

edited by

Maria Concetta Faniello

Maria Mesuraca

and

Barbara Quaresima

submission deadline 30 Dec 2025 | 7 articles | Viewed by 11135 | Submission Open

Keywords: cell metabolism; cancer metabolism; cancer cell; oxidative stress; gene expression; signaling pathways; metabolic regulation; tumor growth; energy metabolism; metabolic phenotype; metabolic substrates

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Plant Natural Products for Human Health and Disease

edited by

Rumyana Simeonova

submission deadline 30 Dec 2025 | 2 articles | Viewed by 9614 | Submission Open

Keywords: medicinal plants; phytochemistry; bioactive compounds; metabolomics; proteomics; antioxidants; signal transduction; immunomodulation; phytopharmacology; ethnopharmacology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

IJMS 25th Anniversary: Updates and Progress on Bioactives and Nutraceuticals

edited by

Maurizio Battino

submission deadline 30 Dec 2025 | 6 articles | Viewed by 9409 | Submission Open

Keywords: natural products; bioactive; nutraceutical; nutrient; health; dietary; functional food; vitamins; phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mitochondrial Biology and Human Diseases

edited by

Francesco Bruni

and

Paola Loguercio Polosa

submission deadline 30 Dec 2025 | 4 articles | Viewed by 9409 | Submission Open

Keywords: mitochondria; mitochondrial gene expression; bioenergetics; mitochondriopathies; human diseases

(This special issue belongs to the Section Molecular Biology)

25th Anniversary of IJMS: Updates and Advances in Molecular Microbiology

edited by

Shu Yuan

submission deadline 30 Dec 2025 | 8 articles | Viewed by 9180 | Submission Open

Keywords: bacteria fungi; bacteriophages; microalgae; microbiome; gut microbiota; environmental microbiome; microbiome– brain– gut axis; virus– host interactions; emerging viruses re-emerging viruses; virus mutation; biofilm antimicrobial; SARS-CoV-2 (COVID-19)

(This special issue belongs to the Section Molecular Microbiology)

Pathogenicity and Antibiotic Resistance of Helicobacter pylori

edited by

Paweł Krzyżek

submission deadline 30 Dec 2025 | 2 articles | Viewed by 9130 | Submission Open

Keywords: Helicobacter pylori; antibiotic resistance; antibiotic tolerance; point mutations; efflux pumps; biofilm formation; coccoid forms; membrane vesicles; virulence factors

(This special issue belongs to the Section Molecular Microbiology)

Central and Local Modulators of Reproduction and Fertility: An Update (4th Edition)

edited by

Rosaria Meccariello

submission deadline 30 Dec 2025 | 4 articles | Viewed by 9065 | Submission Open

Keywords: reproduction; fertility; HPG axis; testis; ovary; spermatogenesis; ovogenesis; gametes; GnRH; gonadotropins; sex steroids; kisspeptins; GnIH; metabolic sensors; leptin; endocannabinoids; autocrine/paracrine regulators; protein/peptide hormones; lipid mediators; epigenetics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Molecular Research on Autoimmune Diseases, 2nd Edition

edited by

Davide Cossu

submission deadline 30 Dec 2025 | 5 articles | Viewed by 8476 | Submission Open

Keywords: autoimmune markers; immunology; pathogenesis; immunogenetics; animal models; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Omics Technologies in Molecular Biology

edited by

Andrés J. Cortés

submission deadline 30 Dec 2025 | 3 articles | Viewed by 8443 | Submission Open

Keywords: omics technologies; genomics; transcriptomics; proteomics; metabolomics; lipidomics; phenomics; enviromics; big data; machine learning; molecular biology

(This special issue belongs to the Section Molecular Biology)

Plant and Environmental Interactions (Abiotic Stress)

edited by

Lixin Li

submission deadline 30 Dec 2025 | 5 articles | Viewed by 7392 | Submission Open

Keywords: stress response; signal transduction; metabolism and secondary metabolism; material/vesicle transportation; rhizospheric microorganism; interactions between plants and microorganisms

(This special issue belongs to the Section Molecular Plant Sciences)

Non-small Cell Lung Cancer: From Molecular Mechanisms to Therapeutic Strategies

edited by

Lorenzo Belluomini

submission deadline 30 Dec 2025 | 3 articles | Viewed by 7350 | Submission Open

Keywords: NSCLC; predictive and prognostic biomarkers; immunotherapy; targeted therapy; special populations

(This special issue belongs to the Section Molecular Oncology)

Biophysical Perspectives on Bone Physiology and Pathology

edited by Atsuhiko Ichimura and Yohei Ueda

submission deadline 30 Dec 2025 | 1 articles | Viewed by 7183 | Submission Open

Keywords: bone formation; bone disorders; physiology; pathology; stem cells; osteoblasts; osteoclasts

(This special issue belongs to the Section Molecular Biophysics)

Molecular Pathogenesis and Therapies for Retinal and Optic Nerve Diseases

edited by

Toshiyuki Oshitari

submission deadline 30 Dec 2025 | 1 articles | Viewed by 6879 | Submission Open

Keywords: neurovascular unit; neurovascular cell death; neuroprotection; vasoprotection; regeneration; molecular and cellular pathologies; current and future therapies; drug delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Phenolic Accumulation and Application in Human Diseases

edited by

Izabela Grzegorczyk-Karolak

submission deadline 30 Dec 2025 | 3 articles | Viewed by 6825 | Submission Open

Keywords: antioxidant effects; anticancer/antiproliferative activity; anti-inflammatory activity; antimicrobial effects bioactive polyphenols; chemical identification of plant compounds; chemistry and mechanisms of action; health beneficial effect; medicinal plant; molecular targets; natural products; phytochemicals; structure– activity relationship

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Effect of Food-Derived Compounds on Brown Fat Cell Function

edited by

Nobuyuki Takahashi

submission deadline 30 Dec 2025 | 3 articles | Viewed by 6650 | Submission Open

Keywords: brown adipocyte; beige adipocyte; nutrients; food-derived components; thermogenesis; energy homeostasis; inflammation; obesity; diabetes; insulin resistance; metabolic syndrome; adipokines; lipid and carbohydrate metabolism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Reproductive Toxicity of Chemicals

edited by

Maria Laura Zenclussen

submission deadline 30 Dec 2025 | 6 articles | Viewed by 6640 | Submission Open

Keywords: reproductive health; fertility; anthropogenic chemicals; impaired fertility; reproductive toxicity; embryo; toxicants; hormone disruption; chemical exposure

(This special issue belongs to the Section Molecular Toxicology)

Molecular Mechanisms of Bone Development and Differentiation in Health and Disease

edited by

Cristina Sánchez-De-Diego

submission deadline 30 Dec 2025 | 3 articles | Viewed by 6345 | Submission Open

Keywords: bone differentiation; signaling pathways; bone diseases; bone formation; osteoblast; osteocyte; osteoclast

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Influence of Environmental Factors on Disease and Health Outcomes

edited by

Piotr Kaminski

submission deadline 30 Dec 2025 | 3 articles | Viewed by 5850 | Submission Open

Keywords: environmental factors; ecophysiological determinations; genetic predispositions; gene expression; defensive responses; pathophysiological abnormalities; lifestyle diseases; polymorphisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immune Regulation and T Cell Dynamics

edited by Tatiana Akimova

submission deadline 30 Dec 2025 | 2 articles | Viewed by 5352 | Submission Open

Keywords: autoimmunity; T cells; FOXP3; Treg; regulatory T cells; transplantation; tolerance; T cell activation; exhaustion; T cell-mediated immunity; T cell immunotherapy

(This special issue belongs to the Section Molecular Immunology)

The Role of Extracellular Matrix in Cancer

edited by

José M. Muñoz-Félix

submission deadline 30 Dec 2025 | 1 articles | Viewed by 5149 | Submission Open

Keywords: extracellular matrix; cancer; collagen; integrins; metastasis

(This special issue belongs to the Section Molecular Oncology)

Heart Failure: From Molecular Mechanisms to Clinically Translational Innovations

edited by

Carmela Rita Balistreri

submission deadline 30 Dec 2025 | 1 articles | Viewed by 4728 | Submission Open

Keywords: heart failure; pathophysiology; cellular and molecular mechanisms; traditional biomarkers: limits and benefits; emerging molecular biomarkers; innovative therapies; i.e.; personalized therapies; targeted therapies; etc.; the application of artificial intelligence; multi-omics technologies; imaging innovative biomarkers; clinical translation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in the Genetic Research on Psychiatric Disorders

edited by Lawrence Shih-Hsin Wu

submission deadline 30 Dec 2025 | 1 articles | Viewed by 4070 | Submission Open

Keywords: genetics; bipolar disorder; schizophrenia; major depressive disorder; autism; substance abuse; genomics

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Primary Nephropathies: Pathogenesis, Inflammatory Response and Advanced Treatments

edited by

Joan Torras-Ambròs

and Juliana Bordignon-Draibe

submission deadline 30 Dec 2025 | 2 articles | Viewed by 4031 | Submission Open

Keywords: primary glomerular diseases; membranous nephropathy; IgA nephropathy; glomerular inflammatory mechanisms; aberrantly glycosylated IgA1; galactose-deficient IgA1 (Gd-IgA1); alternative complement pathway; C5; factor B; factor D; APRIL; BAFF; phospholipase A2 receptor (PLA2R); thrombospondin type I domain-containing 7A (THSD7A); exostosins 1 and 2 (EXT1/2); neural epidermal growth factor-like 1 protein (NELL-1); semaphorin 3B (Sema3B); neural cell adhesion molecule 1 (NCAM1)

(This special issue belongs to the Section Molecular Immunology)

Neuroimmune Axis in Cancer and Inflammatory Diseases

edited by

Patrick Ming-Kuen Tang

submission deadline 30 Dec 2025 | 1 articles | Viewed by 3923 | Submission Open

Keywords: neuro-immune axis; cancer progression; drug resistance; cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Neurogenetic Disorders: Neurogenetics, Pathogenesis, and Gene Therapy

edited by

Paschalis Theotokis

submission deadline 30 Dec 2025 | 1 articles | Viewed by 3665 | Submission Open

Keywords: precision medicine; gene therapy; neurogenetics; rare monogenic diseases; inherited nervous system disorders; mitochondrial diseases (e.g.; LHON; MELAS); lysosomal storage disorders (e.g.; Tay– Sachs; Gaucher); hereditary neuropathies (e.g.; CMT; hATTR); motor neuron diseases (e.g.; SMA; ALS); spinocerebellar ataxias (e.g.; SCA); biomarkers in neurology

(This special issue belongs to the Section Molecular Neurobiology)

The Emerging Role of Quantum Sciences and Radiation Biology in Biomedical Applications, 2nd Edition

edited by

Livio Giuliani

Pierre Madl

and

Nikolaj Sorgenfrei Blom

submission deadline 30 Dec 2025 | 2 articles | Viewed by 3546 | Submission Open

Keywords: quantum sciences; radiation biology; biomedical applications

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advances in Drug Delivery Systems: From Nanoparticles to Precision Medicine

edited by

Satya Prakash

submission deadline 30 Dec 2025 | 1 articles | Viewed by 3268 | Submission Open

Keywords: polymer-based nanoparticles; lipid nanoparticles; PLGA and chitosan nano/microparticles for gene therapy; targeted drug delivery; nucleic acid-loaded nanoparticles; siRNA nanoparticles; nanoparticle-mediated mirna delivery; nanoparticles in cancer therapy; nanoparticles in vaccine design; nanoparticle-mediated gene therapy

(This special issue belongs to the Section Molecular Pharmacology)

Insights into Mitochondrial Iron Metabolism: Connections to Cancer and Other Pathologies

edited by Michael Petronek

submission deadline 30 Dec 2025 | 1 articles | Viewed by 3180 | Submission Open

Keywords: iron metabolism; mitochondrial iron; cellular homeostasis; iron– sulfur cluster biogenesis; heme synthesis; mitochondrial ferritin; cancer biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innate Immunity: New Insights into Genetic and Signaling Networks

edited by

Styliani Sarrou

submission deadline 30 Dec 2025 | 2 articles | Viewed by 3153 | Submission Open

Keywords: innate immunity; innate immune response; signaling pathways; genetic variations

(This special issue belongs to the Section Molecular Immunology)

Advances in the Pathogenesis and Treatment of Heart Failure

edited by

Wioletta Szczurek-Wasilewicz

and

Bożena Szyguła-Jurkiewicz

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2814 | Submission Open

Keywords: heart failure; biomarkers; pathways of heart failure; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Hypertension and Cardiovascular Disease: 2nd Edition

edited by

Edyta Zbroch

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2785 | Submission Open

Keywords: hypertension; hypertension pathophysiology; hypertension molecular mechanisms; cardiovascular disease; cardiovascular pathophysiology; cardiovascular molecular mechanisms; cardiovascular biomarkers; heart failure; coronary artery disease; chronic kidney disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Cancer Stem Cell Research: 2nd Edition

edited by

Tomoyasu Sugiyama

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2745 | Submission Open

Keywords: cancer stem cell; biomarker; signaling; cancer-associated fibroblast; artificial intelligence; cell therapy; antibody therapy; cell therapy; gene expression

(This special issue belongs to the Section Molecular Oncology)

Plant Stress Biology

edited by Rui Li

submission deadline 30 Dec 2025 | 3 articles | Viewed by 2645 | Submission Open

Keywords: abiotic stress; biotic stress; stress response mechanisms; oxidative stress; phytohormones signaling; stress tolerance

(This special issue belongs to the Section Molecular Plant Sciences)

Mechanisms of Diabetic Cardiomyopathy

edited by Martin Michel

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2540 | Submission Open

Keywords: diabetes; cardiomyopathy; animal models; novel treatments; pathophyiology; SGLT2 inhibitors; neprilysin inhibitors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Anti-Cancer Drugs, 2nd Edition

edited by

Christiana Neophytou

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2354 | Submission Open

Keywords: combination therapy in cancer; small-molecule inhibitors in cancer; anti-cancer agents derived from natural sources; immunotherapy advances in cancer therapy; targeting metastatic dormancy; modulation of the tumor microenvironment; 3D model approaches in cancer research; predictive biomarkers for cancer chemoresistance

(This special issue belongs to the Section Molecular Oncology)

25th Anniversary of IJMS: Updates and Advances in Molecular Plant Sciences

edited by

Andrei Smertenko

submission deadline 30 Dec 2025 | 4 articles | Viewed by 2283 | Submission Open

Keywords: plant science; plant biochemistry; mechanisms; plant development; stress responses; plant physiology; genetics

(This special issue belongs to the Section Molecular Plant Sciences)

Cutting-Edge Advances in Natural Bioactive Compounds

edited by

Luisa M. P. F. Amaral

and

Romeu A. Videira

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2276 | Submission Open

Keywords: natural bioactive compounds; discovery and isolation; chemical characterization; biological activities; mechanisms of action; pharmaceuticals; nutraceuticals; agricultural applications; cosmetic innovations

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Neutrophil Extracellular Traps (NETs) in Human Disease: Mechanisms, Pathophysiology and Therapeutic Potential

edited by

Rachel Shukrun

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1949 | Submission Open

Keywords: neutrophil extracellular traps (NETs) ; NETosis ; inflammation ; cancer microenvironment ; autoimmune disease ; thrombosis ; molecular signaling ; innate immunity ; biomarkers ; targeted therapy

(This special issue belongs to the Section Molecular Immunology)

Dietary Antioxidants in Human Health

edited by

Marika Cordaro

Roberta Fusco

and

Rosanna Di Paola

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1948 | Submission Open

Keywords: diet; functional food; oxidative stress; mitochondrial disfunction; human health; animal models; nutrition; molecular pathways; human pathology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Stroke: Novel Molecular Mechanisms and Therapeutic Approaches

edited by Kang-Ho Choi

submission deadline 30 Dec 2025 | 2 articles | Viewed by 1889 | Submission Open

Keywords: stroke; cerebrovascular disease; mechanisms; treatment; diagnosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 251-300 on page 6 of 68.

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