Molecular Mechanisms of Bone Development and Differentiation in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 July 2025 | Viewed by 346
Special Issue Editor
Interests: bone; osteocyte differentiation; bone marrow microenvironment; bone metabolism; oxidative stress; cancer research; bone metastasis; microfluidics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue, "Molecular Mechanisms of Bone Development and Differentiation in Health and Disease," provides an in-depth exploration of the molecular pathways and genetic factors crucial to bone formation, growth, and remodeling. Bone is a dynamic tissue that undergoes continuous turnover, balancing between bone formation by osteoblasts and bone resorption by osteoclasts. This balance is essential for maintaining bone health and function. This Special Issue gathers a wide range of research studies that shed light on the complex biological processes governing bone development and differentiation.
Key topics include the role of signaling pathways such as Wnt, BMP, and Notch in regulating osteoblast, osteocyte, and osteoclast activity. This Special Issue also examines how genetic mutations and variations impact these pathways, leading to various bone diseases such as osteoporosis, osteopetrosis, and skeletal dysplasia. Researchers explore how epigenetic factors and microRNAs contribute to the regulation of bone cell differentiation and function.
Additionally, this Special Issue addresses the interplay between systemic factors, such as hormones and nutrients, and local factors within the bone microenvironment that influence bone remodeling. Studies on the molecular mechanisms underlying bone healing and regeneration are also highlighted, offering insights into potential therapeutic approaches for bone repair.
By comprehensively examining these molecular and genetic factors, this Special Issue aims to enhance the understanding of bone biology. This knowledge is crucial for developing innovative strategies to diagnose, prevent, and treat bone-related disorders, ultimately improving bone health and quality of life for individuals affected by these conditions.
Dr. Cristina Sánchez-De-Diego
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- bone differentiation
- signaling pathways
- bone diseases
- bone formation
- osteoblast
- osteocyte
- osteoclast
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