Advances in Biological Activities of Functional Food (3rd Edition)

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Nutraceuticals, Functional Foods, and Novel Foods".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 289

Special Issue Editors


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Guest Editor
Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal
Interests: biochemistry, biomolecules, nutritional biochemistry; bioactive compounds; phenolic compounds; cholesterol intestinal absorption; herbal infusions; macroalga bioactivity; metabolomics; enzyme activity
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Special Issue Information

Dear Colleagues,

There has been a strong increase in the consumption of functional foods during the last decade, as people are becoming increasingly concerned about their health and about the relationship between nutrition and human well-being. Countless researchers have sought to determine the biological effects of several functional foods consumed in human diet, as well as that of their constituents, which differ from the nutritional components. To accept these foods as functional, they must demonstrate proven health benefits, mainly through in vivo studies and with the use of cutting-edge technologies. Research exploring the effect of functional foods and their bioactive molecules at cellular level is welcome.

The aim of this Special Issue is to identify the effect of these food’s entire matrix and bioactive compounds in several biochemical pathways in the cell metabolism of both healthy and laboratory model diseases cells. We endeavour for these studies to provide a better understanding of functional food claims and thus influence their consumption. The findings presented here will also support the development of new functional foods.

Dr. Maria Luisa Serralheiro
Dr. Rita Pacheco
Guest Editors

Manuscript Submission Information

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Keywords

  • bioactive compounds
  • post-digestion bioactivity
  • bioactive compounds bioavailability
  • disease prevention
  • health benefits
  • bioactivities
  • cell proteomic effect
  • cell metabolomic effect

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Published Papers (1 paper)

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Research

16 pages, 614 KiB  
Article
Bioactive Properties of Persea americana Peel Extract and Their Role in Hypercholesterolemia Management and Cardiovascular Health
by Laura M. Teixeira, Catarina P. Reis and Rita Pacheco
Foods 2025, 14(14), 2482; https://doi.org/10.3390/foods14142482 - 16 Jul 2025
Viewed by 109
Abstract
Cardiovascular diseases remain the leading cause of death worldwide, with hypercholesterolemia being a major contributing risk factor. Although cholesterol-lowering drugs are widely available, concerns about several adverse side effects have increased the demand for natural alternatives, with the most common approaches involving the [...] Read more.
Cardiovascular diseases remain the leading cause of death worldwide, with hypercholesterolemia being a major contributing risk factor. Although cholesterol-lowering drugs are widely available, concerns about several adverse side effects have increased the demand for natural alternatives, with the most common approaches involving the incorporation of foods rich in bioactive compounds into the diet. To explore this growing interest in food-based strategies for cardiovascular health, this study formulated and evaluated an aqueous peel extract of Persea americana to assess its potential role as a complementary approach to managing hypercholesterolemia. The extract was characterized, revealing the presence of various bioactive compounds, including pyridoxine-O-Hex, which was identified for the first time in a P. americana extract component. The safety profile of the extract was confirmed through in vivo assessment. Furthermore, the extract demonstrated protective effects against oxidative stress in HepG2 cells. Additionally, permeability studies using Caco-2 cells, as a model of the gastrointestinal barrier, indicated that the extract effectively reduced cholesterol’s permeation. In summary, these findings suggest that P. americana peel extract may serve as a promising natural product for functional foods for cardiovascular health and hypercholesterolemia management. Full article
(This article belongs to the Special Issue Advances in Biological Activities of Functional Food (3rd Edition))
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