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Diagnostics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Diagnosis and Prognosis of Gynecological Diseases: Advances and Challenges

edited by Stefano Bettocchi and Stefania Carlucci

submission deadline 31 Aug 2026 | Viewed by 172 | Submission Open

Keywords: gynecological diseases; hysteroscopy; diagnostic technologies; prognostic evaluation; biomarkers; imaging techniques; artificial intelligence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Trends and Diagnosis of Autoimmune Diseases

edited by

Abdulla Watad

and

Yonatan Shneor Patt

submission deadline 31 Aug 2026 | Viewed by 162 | Submission Open

Keywords: autoimmunity; diagnosis; biomarkers; comorbidities; epidemiology; metabolic syndrome; autoinflammatory conditions; psoriasis; cardiovascular disease

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Innovations in Diagnostic and Interventional Cardiology: Bridging Imaging, Physiology, and Therapy

edited by Samit Shah and

Natalija Odanovic

submission deadline 31 Aug 2026 | Viewed by 104 | Submission Open

Keywords: EKG; CCTA; MRI; SPECT; PET; Echo; OCT; IVUS; QFR; angioIMR

(This special issue belongs to the Section Medical Imaging and Theranostics)

Innovations in Diagnostic Radiology: AI, Advanced Imaging and Precision Medicine

edited by

Thomas Frauenfelder

submission deadline 31 Aug 2026 | Viewed by 98 | Submission Open

Keywords: medical imaging; worklfow optimization; vision-language models; clinical decision support; diagnostic radiology; AI agents in healthcare; explainable AI

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Artificial Intelligence in Health Monitoring and Diagnosis: AI Meets Conventional Models—2nd Edition

edited by

Stanislav Makhanov

submission deadline 31 Aug 2026 | Viewed by 72 | Submission Open

Keywords: artificial intelligence; medical image processing; deep learning; machine learning; diagnostics; health monitoring

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Contemporary Achievements in Diagnosis and Treatment of Gynecological and Obstetric Conditions

edited by

Radmila Sparić

submission deadline 31 Aug 2026 | Viewed by 71 | Submission Open

Keywords: fibroid; endometriosis; pelvic pain; reproductive endocrinology; pregnancy complications; delivery; infertility; obstetrics; diagnosis; treatment

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Multimodality Cardiac Imaging: Enhancing Precision in Cardiology

edited by

Sanjeev Bhattacharyya

and Apostolos Vrettos

submission deadline 31 Aug 2026 | Viewed by 70 | Submission Open

Keywords: multimodality cardiac imaging; echocardiography; cardiac CT; cardiac MRI; transcatheter interventions; precision cardiology; imaging biomarkers

(This special issue belongs to the Section Medical Imaging and Theranostics)

Challenges in Urology: From the Diagnosis to the Management—2nd Edition

edited by

and

submission deadline 31 Aug 2026 | Viewed by 69 | Submission Open

Keywords: complications; rare; urologic cancer; urinary tract infections; urology

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Deep Learning, Generative AI, and Explainable AI in Medical Diagnostics: From Data to Decisions

edited by

Steven L. Fernandes

submission deadline 31 Aug 2026 | Viewed by 64 | Submission Open

Keywords: deep learning; machine learning; generative AI; explainable AI; medical diagnostics; medical imaging processing and analysis

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in Forensic Medicine and Postmortem Diagnosis

edited by

Hiroshi Ikegaya

submission deadline 31 Aug 2026 | Viewed by 63 | Submission Open

Keywords: forensic pathology; postmortem diagnosis; cause of death; postmortem imaging; forensic DNA analysis; forensic anthropology; toxicological analysis

Advances in Electrocardiology: Diagnostic Innovations and Clinical Applications

edited by

Branislav Milovanovic

submission deadline 31 Aug 2026 | Viewed by 62 | Submission Open

Keywords: heart rate variability (HRV); deceleration capacity; acceleration capacity; late potentials; artificial intelligence; machine learning; autonomic nervous system; electrocardiographic biomarkers; risk stratification; predictive analytics; signal processing

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advanced Radiomics in Precision Oncology

edited by

Shahin Zandieh

submission deadline 31 Aug 2026 | Viewed by 61 | Submission Open

Keywords: radiomics; deep radiomics; medical imaging; artificial intelligence (AI); precision medicine; quantitative imaging; deep learning; feature extraction; image analytics; big data

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Diagnosis and Management of Lung Cancer—2nd Edition

edited by

Savvas Lampridis

and

Marco Scarci

submission deadline 31 Aug 2026 | Viewed by 59 | Submission Open

Keywords: lung cancer; diagnosis; screening; imaging; pathology; biomarkers

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Innovations in Neurovascular Disease Imaging and Treatment

edited by Gabriel Broocks

submission deadline 31 Aug 2026 | Viewed by 45 | Submission Open

Keywords: neurovascular imaging; ischemic stroke; endovascular therapy; CT/MR perfusion; vessel wall imaging; mechanical thrombectomy; cerebrovascular disease; neurointerventional radiology; stroke diagnostics; advanced image analysis

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advanced Diagnostic and Therapeutic Digestive Endoscopy

edited by Pier Alberto Testoni

submission deadline 31 Aug 2026 | Viewed by 39 | Submission Open

Keywords: gastroenterology; digestive tract diseases; gastrointestinal endoscopy; early diagnosis; endocavitary therapy

(This special issue belongs to the Section Medical Imaging and Theranostics)

Multidisciplinary Approaches to Oral Cancer Diagnosis

edited by

Siu Wai Choi

submission deadline 31 Aug 2026 | Viewed by 38 | Submission Open

Keywords: oral cancer diagnosis; oral cancer progression; machine learning; prediction models; biomarkers; early prediction

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Eye Disease: Diagnosis, Management, and Prognosis—2nd Edition

edited by

Adam Wylęgała

submission deadline 31 Aug 2026 | Viewed by 36 | Submission Open

Keywords: eye disease; diagnosis; prognosis; OCT

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

New Technologies in Advanced Cytopathological and Histopathological Diagnostics

edited by

Giuseppe Donato

and

Paolo Zaffino

submission deadline 31 Aug 2026 | Viewed by 36 | Submission Open

Keywords: digital pathology; molecular markers; cytopathology; histopathology; multimodal analysis

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Diagnosis and Management of Hypertrophic Cardiomyopathy

edited by Ibraim Masciarelli Francisco Pinto

submission deadline 31 Aug 2026 | Viewed by 31 | Submission Open

Keywords: hypertrophic cardiomyopathy; multimodality imaging; genetic testing; cardiac MRI; risk stratification; myosin inhibitor; septal reduction therapy; sudden cardiac death; echocardiography; precision cardiology

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advanced Diagnosis of Acute Kidney Injury

edited by

Rolando Claure-Del Granado

and Nuttha Lumlertgul

submission deadline 31 Aug 2026 | Viewed by 30 | Submission Open

Keywords: AKI biomarkers; point-of-care testing; multi-omics integration; machine learning risk prediction; urinary proteomics; biomarker-guided decision support; functional renal imaging

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Musculoskeletal Imaging and Exercise Metabolism

edited by Jimin Ren

submission deadline 31 Aug 2026 | Viewed by 30 | Submission Open

Keywords: quantitative musculoskeletal MRI/MRS; exercise physiology; muscle bioenergetics; pH and metabolic flux; oxygenation and perfusion; rehabilitation and training; aging and sarcopenia; mineral metabolism and lipid infiltration

(This special issue belongs to the Section Medical Imaging and Theranostics)

New Insights into the Diagnosis, Management, and Pathophysiology of Oropharyngeal Cancer

edited by Yung-An Tsou

submission deadline 31 Aug 2026 | Viewed by 28 | Submission Open

Keywords: oropharyngeal cancer; HPV; radiotherapy optimization; multidisciplinary approaches; transoral robotics surgery

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Expanding Horizons: Optical Coherence Tomography in Cross-Specialty Diagnostic Practice

edited by

Nicusor Iftimia

submission deadline 31 Aug 2026 | Viewed by 28 | Submission Open

Keywords: optical coherence tomography; cross-specialty diagnosis; AI-assisted OCT; OCT angiography; multimodal imaging

(This special issue belongs to the Section Biomedical Optics)

Advances in the Diagnosis and Management of Pediatric Diseases: 2nd Edition

edited by

Elena Tarca

submission deadline 31 Aug 2026 | Viewed by 27 | Submission Open

Keywords: pediatrics; neonatal medicine; congenital malformations; pediatric orthopedics and trauma; pediatric oncology; pediatric surgery; pediatric urology

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

AI and Computational Tools in Gastrointestinal Diagnostics: Shaping the Future of Clinical Practice

edited by

Chang Bang

submission deadline 31 Aug 2026 | Viewed by 12 | Submission Open

Keywords: artificial intelligence; machine learning; gastrointestinal endoscopy; computer-aided diagnosis (CAD); human-ai interaction; automation bias & neglect; digestive diseases; precision medicine; clinical decision support

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Diagnostic Approaches to Temporomandibular Disorders

edited by

Yiu Yan Leung

submission deadline 31 Aug 2026 | Viewed by 2 | Submission Open

Keywords: temporomandibular disorders; TMD; diagnostic approaches; imaging modalities; clinical assessment; TMJ; facial pain; MRI; CBCT; orofacial pain

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Infectious Disease Diagnosis Technologies

edited by

Dakai Liu

and Fermina Maria Mazzella

submission deadline 30 Sep 2026 | 3 articles | Viewed by 6100 | Submission Open

Keywords: molecular diagnosis; biomarkers; microbial culture and identification; high-throughput sequencing; infectious diseases; artificial intelligence; digital image; radiological imaging; point-of-care testing

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Radiomics and Artificial Intelligence Applications in the Diagnosis of Brain Lesions

edited by

Calin G. Buzea

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3139 | Submission Open

Keywords: brain lesions; biomarker; prognosis; diagnosis; radiomics; artificial intelligence

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in Sleep and Respiratory Medicine

edited by Cheng-Yu Tsai

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2852 | Submission Open

Keywords: sleep and respiratory disorders; chest medicine; AI in healthcare; digital technology; precision diagnostics

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Digital Innovation in Salivary Diagnostics for Oral and Systemic Health

edited by

Corina Marilena Cristache

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2719 | Submission Open

Keywords: saliva diagnosis; oral disease; systemic diseases; artificial intelligence; AI driven diagnosis

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Applications of Optical Coherence Tomography and Optical Coherence Tomography Angiography in Ophthalmology

edited by

Daniela Bacherini

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2441 | Submission Open

Keywords: OCT; OCTA; ophthalmology; diagnostics; clinical applications

(This special issue belongs to the Section Biomedical Optics)

Diagnosis and Treatment of Kidney Disease—2nd Edition

edited by

Giuseppe Stefano Netti

submission deadline 30 Sep 2026 | 1 articles | Viewed by 757 | Submission Open

Keywords: kidney diseases; acute kidney injury; nephropathy; biomarkers; diagnosis; chronic renal failure

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Revolutionizing Male Infertility: Novel Mechanistic Insights, Diagnostic Innovations, and Management Strategies

edited by

Athanasios Zachariou

submission deadline 30 Sep 2026 | 1 articles | Viewed by 681 | Submission Open

Keywords: male infertility; andrology; reproductive health; testis; spermatozoa; semen analysis; TESE; mTESE; ultrasound; artificial intelligence; IVF

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Gastrointestinal Pathology

edited by

Ivan R. Ilić

and

Pavle Randjelovic

submission deadline 30 Sep 2026 | 1 articles | Viewed by 520 | Submission Open

Keywords: gastroesophageal reflux disease; gastritis; dysplasia; gastric cancer; inflammatory bowel disease; microscopic colitis; microbiota; celiac disease; colorectal cancer

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in Diagnosis and Management of Liver Diseases

edited by

Po-Heng Chuang

submission deadline 30 Sep 2026 | 1 articles | Viewed by 513 | Submission Open

Keywords: liver parenchyma diseases; fatty liver; hepatitis; intrahepatic space-occupying lesions; abscess liver cancer; biomarkers; artificial intelligence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Hematology Laboratory—2nd Edition

edited by

Eloisa Urrechaga

submission deadline 30 Sep 2026 | Viewed by 282 | Submission Open

Keywords: complete blood counts; leukocyte differential; reticulocyte indices; immature platelet fraction; cell population data; blood cell analyzers

(This special issue belongs to the Section Clinical Laboratory Medicine)

Soft Tissue and Bone Sarcomas: Advances in Diagnosis, Treatment, and Prognosis

edited by

Andrea Angelini

submission deadline 30 Sep 2026 | Viewed by 237 | Submission Open

Keywords: soft tissue sarcomas; bone sarcomas; diagnosis; prognosis; biomarkers

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

New Advances in Gastrointestinal Endoscopy

edited by

Gwang Ha Kim

submission deadline 30 Sep 2026 | Viewed by 108 | Submission Open

Keywords: artificial intelligence; bariatric endoscopy; gastrointestinal bleeding; endoscopic imaging; endoscopic resection; endoscopic ultrasonography; gastrointestinal tumor; third-space endoscopy

(This special issue belongs to the Section Biomedical Optics)

Advances in Laboratory Markers of Human Disease—2nd Edition

edited by

Mina Hur

submission deadline 30 Sep 2026 | Viewed by 97 | Submission Open

Keywords: laboratory biomarkers; genomics; proteomics; molecular diagnostics; clinical chemistry

(This special issue belongs to the Section Clinical Laboratory Medicine)

Advancing Blood-Based Diagnostics: Innovations, Challenges and Clinical Impact

edited by Sapha Shibeeb

submission deadline 30 Sep 2026 | 1 articles | Viewed by 91 | Submission Open

Keywords: diagnostic biomarkers; analytical performance; test interpretability; prognostic markers; translational diagnostics; artificial intelligence in diagnostics; precision medicine; clinical decision-making

(This special issue belongs to the Section Clinical Laboratory Medicine)

Advancing Diagnostics in Neuroimaging

edited by

Ali Y Mian

submission deadline 30 Sep 2026 | Viewed by 87 | Submission Open

Keywords: neuroimaging; magnetic resonance imaging (MRI); positron emission tomography (PET); radiomics; neurological disorders; precision medicine; quantitative biomarkers; multimodal integration

(This special issue belongs to the Section Medical Imaging and Theranostics)

Machine Learning Approaches for the Diagnosis of Sleep and Respiratory Disorders

edited by

Alaa Sheta

, Shyam Subramanian and

Salim R. Surani

submission deadline 30 Sep 2026 | Viewed by 79 | Submission Open

Keywords: diagnostics; artificial intelligence; sleep; respiratory disorders; healthcare

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Recent Achievements in Oral and Maxillofacial Radiology

edited by

Svetlana Antic

submission deadline 30 Sep 2026 | Viewed by 76 | Submission Open

Keywords: cone-beam computed tomography (CBCT); artificial intelligence (AI) in radiology; maxillofacial pathology detection and evaluation; image-guided surgery; radiation dose optimization; radiographic interpretation; virtual surgical planning; temporomandibular joint imaging; temporomandibular joint and temporal bone diagnostics; oral cancer detection and evaluation

(This special issue belongs to the Section Medical Imaging and Theranostics)

Integrative Computational Neuropathology: Multimodal Approaches for Precision Diagnosis

edited by Timothy E. van Meter

submission deadline 30 Sep 2026 | Viewed by 70 | Submission Open

Keywords: computational neuropathology; neurology; brain; spinal cord; multiplex; biomarkers; automated imaging; artificial intelligence; automated diagnosis; machine learning; precision medicine

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

EEG Analysis in Diagnostics, 2nd Edition

edited by

Jae-Ho Han

submission deadline 30 Sep 2026 | Viewed by 61 | Submission Open

Keywords: advanced EEG Techniques; the characterization of EEG signal patterns; the identification of EEG signal abnormalities; functional connectivity analysis in EEG; sleep studies based on EEG; EEG in epilepsy diagnosis and monitoring; neurofeedback and EEG in cognitive enhancement; event-related potentials in clinical EEG; understanding pathophysiology via EEG

(This special issue belongs to the Section Medical Imaging and Theranostics)

Applications of Optical Coherence Tomography in the Ocular Diagnosis: From the Tear Film to the Sclera 2.0

edited by

Claudio Iovino

Jay Chhablani

and

Giuseppe Giannaccare

submission deadline 30 Sep 2026 | Viewed by 60 | Submission Open

Keywords: optical coherence tomography; optical coherence tomography angiography; corneal curvature; tear film; central corneal thickness; glaucoma; anterior chamber; iris angiography; macular thickness; choroidal thickness; axial length measurement; retinal vascular plexuses; choroidal vasculature; macular surgery

(This special issue belongs to the Section Biomedical Optics)

Deep Learning Applications in Medical Image Analysis and Diagnosis

edited by Jorge M. Núñez-Córdoba

submission deadline 30 Sep 2026 | Viewed by 48 | Submission Open

Keywords: deep learning; machine learning; artificial intelligence; medical imaging; diagnostic imaging; clinical validation; accuracy

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Maternal-Fetal Medicine: Diagnosis, Prognosis and Clinical Features

edited by Antonio Braga

submission deadline 30 Sep 2026 | Viewed by 47 | Submission Open

Keywords: maternal– fetal medicine; prenatal diagnosis; fetal ultrasound and doppler; prediction models; high-risk pregnancy; perinatal outcomes

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis and Management of Pulmonary Fibrosis

edited by Yi Wang

submission deadline 30 Sep 2026 | Viewed by 44 | Submission Open

Keywords: pulmonary fibrosis; idiopathic pulmonary fibrosis; interstitial lung disease; diagnosis; biomarkers; antifibrotic therapy; imaging; disease management

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnostic Innovations in Metabolic Diseases Management

edited by