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Diagnostics
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Diagnosis and Management of Colorectal Diseases, 2nd Edition
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Diagnosis and Management of Colorectal Diseases, 2nd Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1978

Special Issue Editors

Dr. Filippo Carannante

E-Mail Website
Guest Editor
Unit of Colorectal Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Roma, Italy
Interests: abdominal surgery; minimally invasive surgery; colorectal surgery; colorectal cancer; IBD; image-guided surgery; rectal functional disorders; ERAS
Special Issues, Collections and Topics in MDPI journals
Dr. Guglielmo Niccolò Piozzi

E-Mail Website
Guest Editor
Department of Colorectal Surgery, Portsmouth Hospitals University NHS Trust, Queen Alexandra Hospital, Southwick Hill Road, Cosham, Portsmouth PO6 3LY, UK
Interests: colorectal cancer; robotic surgery; intersphincteric resection; complete mesocolic excision; advanced lymphadenectomy; surgical techniques
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, entitled “Diagnosis and Management of Colorectal Diseases, 2nd Edition”, delves into the latest advancements and challenges in this field of research. It will showcase cutting-edge research relating to early detection methods, innovative surgical techniques, and non-invasive therapeutic options for a broad spectrum of colorectal conditions. The contributors, comprising renowned experts and emerging scholars, will provide comprehensive insights into etiology, diagnosis, and management strategies tailored to enhance patient outcomes and quality of life. This comprehensive collection seeks to serve as a vital resource for clinicians, researchers, and healthcare professionals alike, fostering a deeper understanding and improved care for those affected by colorectal diseases.

Dr. Filippo Carannante
Dr. Guglielmo Niccolò Piozzi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • colorectal diseases
  • markers
  • diagnosis
  • prognosis
  • screening

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Published Papers (2 papers)

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Research

23 pages, 1189 KB  
Article
Atherogenic Lipid Indices in Colorectal Cancer: Metabolic Associations and Survival Outcomes
by Răzvan Alexandru Marinescu, Daniela Marinescu, Lidia Boldeanu, Ana-Maria Ciurea, Marius Bică, Ștefan Pătrașcu, Victor Dan Eugen Strâmbu, Petru Adrian Radu, Petrica Popa, Mohamed-Zakaria Assani, Mihail Virgil Boldeanu and Valeriu Șurlin
Diagnostics 2026, 16(5), 810; https://doi.org/10.3390/diagnostics16050810 - 9 Mar 2026
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Abstract
Background/Objectives: Type 2 diabetes mellitus (T2DM) and atherogenic dyslipidemia have been implicated in colorectal cancer (CRC) development, but their prognostic relevance after cancer diagnosis remains unclear. This study aimed to evaluate the association between T2DM, lipid-derived atherogenic indices, and survival outcomes in patients [...] Read more.
Background/Objectives: Type 2 diabetes mellitus (T2DM) and atherogenic dyslipidemia have been implicated in colorectal cancer (CRC) development, but their prognostic relevance after cancer diagnosis remains unclear. This study aimed to evaluate the association between T2DM, lipid-derived atherogenic indices, and survival outcomes in patients with CRC. Methods: We conducted a retrospective cohort study including 240 CRC patients, of whom 60 had coexisting T2DM. Overall survival (OS) and disease-free survival (DFS) were analyzed using the Kaplan–Meier (KM) method and log-rank tests. In the absence of recurrence-specific data, DFS was defined as time to death or last follow-up. Lipid-related indices, including the atherogenic index of plasma (AIP), atherogenic coefficient (AC), remnant cholesterol (RC), non-high-density lipoprotein cholesterol (non-HDL-C), triglyceride–glucose (TyG) index, and triglyceride-to-HDL cholesterol ratio (TG/HDL-C), were evaluated by tertiles in KM analyses. Multivariable Cox proportional hazards models were constructed to assess the independent prognostic value of AIP, AC, and RC (entered separately as a continuous variable standardized to 1 standard deviation), adjusted for age, sex, adjuvant chemotherapy, radiotherapy, and T2DM status. Sensitivity analyses were performed in stage III–IV patients. Results: During follow-up, 28 deaths occurred. OS did not differ significantly between CRC patients and those with CRC coexisting with T2DM (log-rank p-values = 0.220). DFS analyses showed no significant differences across tertiles of any lipid-related index (all log-rank p-values > 0.05), with overlapping survival curves and no consistent dose–response patterns. In adjusted Cox models, AIP (hazard ratio [HR] per 1 SD = 0.71, 95% CI 0.48–1.06), AC (HR = 0.72, 95% CI 0.44–1.20), and RC (HR = 0.66, 95% CI 0.39–1.12) were not independently associated with DFS. Results were consistent in advanced-stage disease (stage III–IV). Conclusions: In this cohort of patients with CRC, neither T2DM nor lipid-derived indices reflecting atherogenic dyslipidemia and insulin resistance were independently associated with OS or DFS. These findings help refine the clinical interpretation of lipid-derived biomarkers in CRC, suggesting limited prognostic utility beyond established oncologic factors. Full article
(This article belongs to the Special Issue Diagnosis and Management of Colorectal Diseases, 2nd Edition)
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15 pages, 5699 KB  
Article
Short-Term Efficacy and Safety of Elobixibat for Chronic Constipation Assessed by Rectal Ultrasonography: A Retrospective Observational Study
by Momoko Tsuda, Tomoyuki Onodera, Kanako Konishi, Norishige Maiya, Mio Matsumoto, Kimitoshi Kubo, Sayaka Kudo, Yoshiyuki Hosoi and Mototsugu Kato
Diagnostics 2026, 16(2), 354; https://doi.org/10.3390/diagnostics16020354 - 21 Jan 2026
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Abstract
Background/Objectives: Ultrasonography (US) is a non-invasive and repeatable examination for evaluating chronic constipation. However, few studies have explored treatment decisions based on rectal US findings. To date, the efficacy and safety of elobixibat have not been evaluated using rectal US classification in patients [...] Read more.
Background/Objectives: Ultrasonography (US) is a non-invasive and repeatable examination for evaluating chronic constipation. However, few studies have explored treatment decisions based on rectal US findings. To date, the efficacy and safety of elobixibat have not been evaluated using rectal US classification in patients with chronic constipation. This study aimed to evaluate the short-term efficacy and safety of elobixibat in patients with chronic constipation classified as “no fecal retention” by rectal US. Methods: We retrospectively analyzed 32 patients with chronic constipation who underwent rectal US and received elobixibat (10 mg/day) between May 2019 and December 2024. Rectal US findings classified patients into four groups: no fecal retention, fecal retention without hard stools, fecal retention with hard stools, and gas retention. The primary endpoint was the response rate of spontaneous bowel movements (SBMs) within 3 days after starting elobixibat in the “no fecal retention” group. Results: Among 18 patients in the “no fecal retention” group, 94.4% achieved SBMs within 3 days, indicating a favorable short-term response. Adverse events included abdominal distension and abdominal pain, each observed in one patient (3.1%). Conclusions: Elobixibat was effective and well tolerated in patients with chronic constipation classified by rectal US findings. Full article
(This article belongs to the Special Issue Diagnosis and Management of Colorectal Diseases, 2nd Edition)
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