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Diagnostics
Special Issues
Recent Advancements in the Diagnosis and Prognosis of Thoracic Diseases
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Recent Advancements in the Diagnosis and Prognosis of Thoracic Diseases

A Special Issue of Diagnostics (ISSN 2075-4418) belonging to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 30 September 2027 | Viewed by 601

Editor

Dr. Marco Andolfi

E-Mail Website
Guest Editor
Thoracic Surgery Unit, Azienda Ospedaliera of Perugia, Perugia, Italy
Interests: thoracic diseases; lung diseases; bronchoscopy

Special Issue Information

Dear Colleagues,

As widely reported, tailored patient management based on advanced diagnostic techniques and knowledge of prognostic factors capable of predicting the biological behavior of the diseases are of primary importance for enhancing the quality of life and prognosis of patients with thoracic diseases. Specifically, this Special Issue aims to highlight the impact of circulating and/or tissue biomarkers for disease detection, monitoring, classification, therapy selection, and prognostication, as well as the role of imaging for diagnosis and therapy planning.

New advances in each of these areas and the value of recent scientific achievements are herein collected.

Dr. Marco Andolfi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • quality of life
  • risk stratification
  • thoracic diseases
  • circulating biomarkers
  • tissue biomarkers

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

16 pages, 2197 KB  
Article
Prognostic Implications of Tumor Spread Through Air Spaces in Patients with Resected Lung Adenocarcinoma
by Marco Andolfi, Nicolò Scarsi, Martina Mandarano, Guido Bellezza, Renato Colella, Lucrezia Burico, Domenico Pourmolkara, Francesco Ferrante, Francesca Fratturelli and Jacopo Vannucci
Diagnostics 2026, 16(17), 2747; https://doi.org/10.3390/diagnostics16172747 - 27 Aug 2026
Viewed by 223
Abstract
Background: Spread through air spaces (STAS) consists of micropapillary clusters, solid nests, and/or single neoplastic cells into the air spaces of the lung parenchyma beyond the edge of the primary tumor. To date, its prognostic role in patients with lung adenocarcinoma is crucial, [...] Read more.
Background: Spread through air spaces (STAS) consists of micropapillary clusters, solid nests, and/or single neoplastic cells into the air spaces of the lung parenchyma beyond the edge of the primary tumor. To date, its prognostic role in patients with lung adenocarcinoma is crucial, resulting in an independent negative factor for both overall survival (OS) and disease-free survival (DFS). The study aims to assess the prognostic impact of STAS in patients with lung adenocarcinoma undergoing curative resection. Methods: A retrospective, observational single-center study enrolling consecutive patients who underwent lung resections for adenocarcinoma from January 2018 to December 2023 was performed. OS and DFS were analyzed. Univariable and multivariable Cox proportional hazard models, along with the inverse probability of treatment weight–adjusted Kaplan–Meier curves, were used to evaluate the prognostic impact of STAS. A logistic regression model was used to estimate the odds ratios and 95%-confidence intervals for clinical variables associated with the STAS status. Results: In total, 329 patients were enrolled, and two different groups were defined (STAS-present: 30; STAS-absent: 299). No statistically significant differences were observed in OS and DFS when comparing patients according to their STAS status. Conversely, STAS-present patients were more frequently associated with pN2-nodal involvement (22.7% vs. 77.3%, p = 0.022), stage IIIA disease (p = 0.003), and the presence of an adenocarcinoma-predominant micropapillary-pattern (p < 0.001). Female patients were associated with better outcomes than male patients in survival analysis, while stage IIIA disease and micropapillary-pattern emerged as statistically significant after the logistic regression. Conclusions: Our study provides relevant information on the relationship between STAS and clinicopathological characteristics, demonstrating its potential aggressive histological feature, due to the significant correlation with stage IIIA disease, and the adenocarcinoma micropapillary pattern. Therefore, STAS may identify a subgroup of patients in whom the prognostic implications should be further investigated. Full article
(This article belongs to the Special Issue Recent Advancements in the Diagnosis and Prognosis of Thoracic Diseases)
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