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Diagnostics
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Diagnosis and Management of Retinopathy—2nd Edition
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Diagnosis and Management of Retinopathy—2nd Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1507

Special Issue Editor

Prof. Dr. Joanna Gołȩbiewska

E-Mail Website
Guest Editor
1. Department of Ophthalmology, Military Institute of Aviation Medicine, 01-755 Warsaw, Poland
2. Faculty of Medicine, Lazarski University, 02-662 Warsaw, Poland
Interests: OCT; OCTA; multimodal imaging; retinal diseases; macular degeneration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Retinopathy is a term used to describe a group of disorders that affect the retina and are usually caused by damage to tiny blood vessels.

Modern ophthalmological imaging methods provide important information on the pathogenesis of diseases such as retinal abnormalities due to diabetic retinopathy or vascular occlusion. Moreover, there is an increasing number of studies on diagnostic methods and treatment patterns for these diseases.

The purpose of the Diagnostics Special Issue on retinopathy is to provide readers with an overview of this ocular disorder—its causes, symptoms, risk factors, diagnostic methods and treatment options. We hope that articles contained in this issue will empower readers with the knowledge and information that can help them effectively prevent and manage retinopathy.

This Special Issue aims to explore recent scientific discoveries in the following research areas:

  • Diabetic retinopathy;
  • Retinopathy of prematurity;
  • Hypertensive retinopathy;
  • Retinal vein/artery occlusion;
  • Inherited retinal diseases, i.e., Coats disease.

Original research articles that focus on multimodal imaging findings in the diagnostics of retinopathy are welcome. In this research topic, we are looking for original papers and review articles focusing on updated diagnostic patterns and innovative multidisciplinary treatment protocols. Interesting case reports will also be considered for publication.

Prof. Dr. Joanna Gołȩbiewska
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetic retinopathy
  • hypertensive retinopathy
  • inherited retinal diseases
  • imaging
  • OCT

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Published Papers (2 papers)

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Research

11 pages, 1328 KB  
Article
Non-Exudative Macular Neovascularization in Various Acquired Macular Degenerations with Double- and Triple-Layer Sign on OCT
by Joanna Gołębiewska, Ilona Katarzyna Jędrzejewska, Justyna Mędrzycka, Mariusz Przybyś and Radosław Różycki
Diagnostics 2026, 16(3), 497; https://doi.org/10.3390/diagnostics16030497 - 6 Feb 2026
Viewed by 448
Abstract
Background/Objectives: To investigate the rate of exudative progression over time in patients with non-exudative macular neovascularization (NE-MNV) associated with various acquired macular degenerations presenting with a double-layer sign (DLS) or triple-layer sign (TLS) on optical coherence tomography (OCT), and to identify potential [...] Read more.
Background/Objectives: To investigate the rate of exudative progression over time in patients with non-exudative macular neovascularization (NE-MNV) associated with various acquired macular degenerations presenting with a double-layer sign (DLS) or triple-layer sign (TLS) on optical coherence tomography (OCT), and to identify potential predictors of this progression. Methods: Fifty-one eyes of fourty-nine patients with a DLS or TLS on OCT images were identified. OCT angiography (OCTA) was performed to detect NE-MNV, and only eyes with confirmed NE-MNV were included in the final analysis. Central macular thickness (CMT), choroidal thickness (CT), morphology of the abnormal vessels, the duration of follow-up, progression to active exudative MNV, and the status of the contralateral eye were assessed. Results: The final analysis included 32 eyes of 30 participants with NE-MNV. The median observation period was 46 months. The causes of NE-MNV were age- related macular degeneration (AMD) in 59.38% of eyes, pachychoroid epitheliopathy (PPE) in 37.50%, and other causes in 3.12%. Exudation developed in 15.62% of eyes (median time to onset: 24 months), predominantly in the AMD subgroup. Abnormalities in the fellow eye were present in 59.38% of cases. Neither age nor other factors, including sex, cause of MNV, CMT, CT, MNV morphology, or fellow eye status, were statistically significant predictors of progression to active MNV (p = 0.67, p > 0.99, p = 0.62, p = 0.09, p = 0.09, p = 0.2, p = 0.62, resp.). Conclusions: NE-MNV is an asymptomatic condition that may occur in the course of various retinal diseases. While DLS and TLS demonstrate high sensitivity and specificity for the diagnosis of NE-MNV, their presence does not always indicate concurrent MNV. Multimodal imaging is essential for accurate monitoring of these patients and detection of potential disease progression. Full article
(This article belongs to the Special Issue Diagnosis and Management of Retinopathy—2nd Edition)
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11 pages, 7165 KB  
Article
Diagnosis and Monitoring of Retinal Vasculitis by Widefield Swept Source OCT Angiography
by Manish Harrigill, Matthew Nguyen and Jila Noori
Diagnostics 2025, 15(24), 3129; https://doi.org/10.3390/diagnostics15243129 - 9 Dec 2025
Viewed by 573
Abstract
Objectives: To evaluate the utility of widefield montage swept-source OCT angiography (SS-OCTA) in detecting and monitoring retinal vasculitis beyond the posterior pole. Methods: Prospective case series. Patients with clinically diagnosed retinal vasculitis imaged with a same-day widefield SS-OCTA montage and ultra-widefield fluorescein angiography [...] Read more.
Objectives: To evaluate the utility of widefield montage swept-source OCT angiography (SS-OCTA) in detecting and monitoring retinal vasculitis beyond the posterior pole. Methods: Prospective case series. Patients with clinically diagnosed retinal vasculitis imaged with a same-day widefield SS-OCTA montage and ultra-widefield fluorescein angiography (FA) at 2 or more visits. Five overlapping 12 × 12 mm SS-OCTA scans were acquired to provide imaging of the posterior pole and each quadrant of the near periphery. A color retinal thickness map was superimposed on each 12 × 12 mm en-face flow scan with a customized segmentation to demonstrate perivascular retinal thickening. A composite “montage” image was then created by combining the scans to allow for analysis of the macula and near periphery. Findings were then correlated with the same-day FA, the current “gold standard” diagnostic tool for retinal vasculitis, to assess diagnostic efficacy. Results: SS-OCTA demonstrated perivascular thickening in both the posterior pole and peripheral retina in 30 eyes of 16 patients and was found to be an effective diagnostic tool with good correlation to findings on fluorescein angiography for monitoring retinal vasculitis over time. Conclusions: The widefield SS-OCTA montage expands the visualization of retinal vasculitis into the near periphery, providing a noninvasive tool that may complement FA in the diagnosis and monitoring of retinal vasculitis. Full article
(This article belongs to the Special Issue Diagnosis and Management of Retinopathy—2nd Edition)
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