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Diagnostics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Diagnostic Innovations in Metabolic Diseases Management

edited by

Teodora Alexescu

and Angela Cozma

submission deadline 30 Sep 2026 | Viewed by 39 | Submission Open

Keywords: metabolic diseases; cardio-reno-metabolic syndrome; obesity; metabolic syndrome

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Clinical Advances in Diagnosis and Prognosis of Urological Diseases

edited by

Xiuheng Liu

submission deadline 30 Sep 2026 | Viewed by 37 | Submission Open

Keywords: urological diagnostics; prognostic biomarkers; artificial intelligence in urology; precision medicine; liquid biopsy; advanced imaging; prostate cancer; bladder cancer; kidney cancer; clinical risk stratification

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Periodontal Disease: Diagnosis and Management, 2nd Edition

edited by

Francesco D’Ambrosio

submission deadline 30 Sep 2026 | Viewed by 28 | Submission Open

Keywords: periodontal disease ; periodontitis ; management ; diagnosis ; biomarker ; periodontology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Allergy and Asthma: Clinical Diagnostics and Management

edited by Askin Gulsen

submission deadline 30 Sep 2026 | Viewed by 20 | Submission Open

Keywords: allergy; asthma; precision medicine; biomarkers; airway inflammation; clinical diagnostics; biologic therapies; phenotyping; disease management; immunology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Laboratory Diagnosis of Cardiovascular Diseases

edited by Ibrahim A. Hashim

submission deadline 30 Sep 2026 | Viewed by 14 | Submission Open

Keywords: laboratory diagnostics; cardiovascular diseases; biomarkers; metabolomics; point-of-care testing; artificial intelligence

(This special issue belongs to the Section Clinical Laboratory Medicine)

Complex Digestive Diseases: Diagnosis and Management

edited by

Dong Wu

submission deadline 30 Sep 2026 | Viewed by 12 | Submission Open

Keywords: complex digestive diseases; precision diagnosis; advanced endoscopy; personalized management; artificial intelligence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Diagnostic Testing for Esophageal Diseases

edited by

Micheal Tadros

submission deadline 30 Sep 2026 | Viewed by 2 | Submission Open

Keywords: esophageal diseases; endoscopy; diagnostic tools; diagnostic testing; artificial intelligence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Autopsy Pathology's Paradigm Shift: Are AI and New Technologies Forging a New Era?

edited by

Vincenzo Arena

submission deadline 30 Sep 2026 | Viewed by 1 | Submission Open

Keywords: autopsy pathology; AI; artificial intelligence; immunohistochemistry; molecular pathology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Ocular Inflammation: Progress and Pitfalls in Diagnosis, Imaging and Management

edited by

Carl P. Herbort, Jr.

and

Ioannis Papasavvas

submission deadline 1 Oct 2026 | Viewed by 33 | Submission Open

Keywords: uveitis; intraocular inflammation; fluorescein angiography (FA); indocyanine green angiography (ICGA); optical coherence tomography (OCT); enhanced depth imaging OCT (EDI-OCT); optical coherence tomography angiography (OCT-A); fundus autofluorescence (FAF); uveitis masquerades; intraocular interleukin assays; Vogt– Koyanagi– Harada disease (VKH); multiple evanescent white dot syndrome (MEWDS); consensus definitions

(This special issue belongs to the Section Medical Imaging and Theranostics)

Beyond the Joint: Advances in Musculoskeletal Imaging and Sports Radiology

edited by

Francesco Feletti

submission deadline 30 Oct 2026 | Viewed by 160 | Submission Open

Keywords: sports radiology; musculoskeletal imaging; diagnostic imaging; artificial intelligence; orthopaedics; extreme sports; outdoor sports; outdoor physical activity; one health; health policy

(This special issue belongs to the Section Medical Imaging and Theranostics)

AI for Precision Diagnostics: Enhancing Accuracy, Accessibility, and Outcomes

edited by

Shereen Afifi

and Mirza Mansoor Baig

submission deadline 30 Oct 2026 | Viewed by 44 | Submission Open

Keywords: precision diagnostics; medical imaging and radiology; machine learning; deep learning; and transformers; biosensors and wearable health devices; explainable AI; point-of-care and remote diagnostic systems; digital health; edge AI and computing; bioinformatics; personalized medicine and health; healthcare accessibility

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Challenges in Monitoring and Diagnosis in Medical Sciences

edited by

Mihaela Badea

and

Laura Gaman

submission deadline 31 Oct 2026 | 3 articles | Viewed by 7027 | Submission Open

Keywords: diagnostic; monitoring; medical sciences

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Integrative Approaches in Head and Neck Cancer Imaging

edited by

Calin G. Buzea

submission deadline 31 Oct 2026 | 3 articles | Viewed by 5646 | Submission Open

Keywords: head and neck cancer; imaging technologies; multimodal imaging; image-guided therapy; artificial intelligence in imaging

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Diagnosis and Prognosis of Abdominal Diseases

edited by

Filippo Carannante

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3105 | Submission Open

Keywords: diagnosis; prognosis; abdominal diseases; markers; screening

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

New Insights into Gastrointestinal Endoscopy

edited by

Paraskevas Gkolfakis

and

Apostolis Papaefthymiou

submission deadline 31 Oct 2026 | 3 articles | Viewed by 3051 | Submission Open

Keywords: diagnosis; prognosis; gastrointestinal endoscopy; markers; clinical practice and patient care

(This special issue belongs to the Section Biomedical Optics)

Optical Coherence Tomography in Non-Invasive Diagnostic Imaging

edited by

Carmen Cantisani

and

Sandra Schuh

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2327 | Submission Open

Keywords: diagnosis; screening; marker; prognosis; optical coherence tomography; non-invasive diagnostic imaging

(This special issue belongs to the Section Biomedical Optics)

Clinical Diagnosis and Prognosis of Steatotic Liver Disease

edited by

Helma Pinchemel Cotrim

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1674 | Submission Open

Keywords: steatotic liver disease— SLD; steatohepatitis; steatosis; diagnosis; prognosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Clinical Diagnosis and Management of Metabolic Bone Diseases

edited by Maria Lucia Fleiuss Farias

submission deadline 31 Oct 2026 | Viewed by 1533 | Submission Open

Keywords: bone; PTH; hyperparathyroidism; chronic kidney disease-metabolic bone disorder; osteoporosis; DXA; HR-pQCT

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Clinical Diagnostics and Management of Stroke

edited by

Qiwen Deng

submission deadline 31 Oct 2026 | Viewed by 1429 | Submission Open

Keywords: ischemic stroke; diagnostic; thrombolysis; endovascular thrombectomy; post-stroke cognitive impairment; secondary prevention; neuroinflammation; neuroprotection

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Neurological Diseases: Novel Biomarkers for Diagnosis and Management

edited by

Costanza Maria Cristiani

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1227 | Submission Open

Keywords: biomarkers; laboratory medicine; neuroimaging; neurological diseases; treatment; management; clinical diagnostics

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis and Prognosis in Otorhinolaryngology and Head and Neck Surgery

edited by

Leandro Luongo Matos

submission deadline 31 Oct 2026 | Viewed by 877 | Submission Open

Keywords: otorhinolaryngologic neoplasms; head and neck neoplasms; diagnostic techniques and procedures; prognosis; biomarkers; tumor; precision medicine; artificial intelligence; radiomics; molecular diagnostic techniques; disease progression

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Novel Optical Imaging Technologies in Ophthalmology and Neuroscience: Advances and Applications

edited by

Jae-Ho Han

submission deadline 31 Oct 2026 | 1 articles | Viewed by 714 | Submission Open

Keywords: optical imaging; ophthalmology; neuroscience; diagnosis; prognosis

(This special issue belongs to the Section Biomedical Optics)

Clinical Advances in Fetal Medicine: Diagnosis and Management

edited by

Felix Rafael De Bie

submission deadline 31 Oct 2026 | Viewed by 577 | Submission Open

Keywords: prenatal diagnosis; fetal therapy; congenital anomalies; imaging; molecular diagnostics; fetal intervention; ethics; precision fetal medicine; congenital diaphragmatic hernia; spina bifida; gastroschisis; sacro-coccygeal teratoma; vein of galen; twin– twin transfusion syndrome; congenital cardiac malformation; congenital pulmonary airway malformation; lower urinary tract obstruction

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Wearable Devices for Health Monitoring and Disease Diagnosis

edited by Robert LeMoyne

submission deadline 31 Oct 2026 | Viewed by 321 | Submission Open

Keywords: wearable devices; health monitoring; diagnosis; sensors; artificial intelligence

(This special issue belongs to the Section Point-of-Care Diagnostics and Devices)

The Future of Diagnostics: Exploring the Role of Artificial Intelligence in Medicine 2026

edited by

Shang-Ming Zhou

, Neil Vaughan and Jiaxiang Zhang

submission deadline 31 Oct 2026 | Viewed by 155 | Submission Open

Keywords: diagnostics; artificial intelligence; medicine; healthcare; future

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Machine Learning for Medical Image Processing and Analysis in 2026

edited by Wei Shao

submission deadline 31 Oct 2026 | Viewed by 112 | Submission Open

Keywords: machine learning; medical image processing; diagnostic accuracy; healthcare; algorithms

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Biological Rhythms in Laboratory Medicine

edited by

Fernando Marques-Garcia

and

Rubén Fossión

submission deadline 31 Oct 2026 | Viewed by 106 | Submission Open

Keywords: biological rhythms; laboratory medicine; biomarkers; physiology

(This special issue belongs to the Section Clinical Laboratory Medicine)

From Mystery to Diagnosis: Redefining Medical Practice Through Rare Disease Diagnostics

edited by

Emilia Severin

submission deadline 31 Oct 2026 | Viewed by 62 | Submission Open

Keywords: rare disease; diagnostics; molecular testing; advanced imaging; artificial intelligence

Diagnosis and Prognosis of Heart Disease, 3rd Edition

edited by

Yuli Huang

submission deadline 31 Oct 2026 | Viewed by 47 | Submission Open

Keywords: heart disease; coronary artery disease; arrhythmia; heart failure; diagnosis; prognosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Hematology: Diagnostic Techniques and Assays, 2nd Edition

edited by Chihyun Cho

submission deadline 31 Oct 2026 | Viewed by 43 | Submission Open

Keywords: diagnostic; hematology; technique; assay; biomarkers

(This special issue belongs to the Section Clinical Laboratory Medicine)

Precision Medicine for Cerebellar Disorders: From Bench to Bedside

edited by Mario Manto and

Hiroshi Mitoma

submission deadline 31 Oct 2026 | Viewed by 35 | Submission Open

Keywords: cerebellum; cerebellar disorders; ataxia/cerebellar ataxia; preclinical research; precision medicine

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in the Diagnosis and Management of Vasculitis—2nd Edition

edited by

Alicia Rodríguez-Pla

submission deadline 31 Oct 2026 | Viewed by 34 | Submission Open

Keywords: vasculitis; advances; updates; management; treatment; therapy

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis and Management of Esophageal Disorders: Modern Approaches

edited by

Wojciech Blonski

submission deadline 31 Oct 2026 | Viewed by 28 | Submission Open

Keywords: eosinophilic esophagitis; GERD; achalasia; esophagogastric junction outflow obstruction; lichen planus

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advancements and Innovations in the Diagnosis of Lung Cancer

edited by

Houssein A. Youness

submission deadline 31 Oct 2026 | Viewed by 13 | Submission Open

Keywords: lung cancer; diagnosis; biomarkers; artificial intelligence; robotic bronchoscopy; bronchoscopic imaging; endobronchial ultrasound; molecular profiling; genetic profiling; next-generation sequencing; tissue acquisition; low-dose CT screening; personalized medicine; medical imaging; lung nodules

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Artificial Intelligence and Pattern Recognition Methods for the Automatic Detection and Evaluation of Neurological Disorders, 3rd Edition

edited by

Juan Rafael Orozco-Arroyave

submission deadline 31 Oct 2026 | Viewed by 12 | Submission Open

Keywords: machine learning; neurodegenerative diseases; diagnosis; detection and evaluation; monitoring

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Novel Technologies in Orthopedic Surgery: Diagnosis and Management, 2nd Edition

edited by Giuseppe Salvatore

submission deadline 31 Oct 2026 | Viewed by 2 | Submission Open

Keywords: orthopedic surgery; orthopedic diagnosis; orthopedics; computer navigation and augmented reality; robotics; digital templating; 3D printing; artificial intelligence; machine learning; deep learning

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Innovations and Challenges in Breast Imaging

edited by

Gary J. Whitman

submission deadline 31 Oct 2026 | Viewed by 1 | Submission Open

Keywords: breast imaging; breast ultrasound; mammography; digital breast tomosynthesis; digital mammography; contrast-enhanced mammography; breast MRI; molecular breast imaging; imaging-guided interventional breast procedures; artificial intelligence in imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Neurosurgical Diagnostics: Imaging, Intraoperative Monitoring, and Prognostic Assessment

edited by Janez Ravnik

submission deadline 31 Oct 2026 | Submission Open

Keywords: diagnostics; MR imaging; function imaging; neurosurgery; brain; spine

(This special issue belongs to the Section Medical Imaging and Theranostics)

Application of Artificial Intelligence to Advance Individualized Diagnosis and Treatment in Emergency and Critical Care Medicine, 2nd Edition

edited by

Zhongheng Zhang

submission deadline 30 Nov 2026 | 3 articles | Viewed by 7073 | Submission Open

Keywords: critical care; sepsis; artificial intelligence; predictive analytics; clustering; acute kidney injury; emergency medicine; transcriptome

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Diagnostic Advances in Obstetrics and Gynecology, Breast Disease and Women’s Health

edited by Menelaos Zafrakas

submission deadline 30 Nov 2026 | 2 articles | Viewed by 6846 | Submission Open

Keywords: obstetrics; gynecology; maternal– fetal medicine; breast; women’ s health; diagnostics

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Diagnostics of Chronic Kidney Disease

edited by

Tomasz Gołębiowski

and

Andrzej Konieczny

submission deadline 30 Nov 2026 | 2 articles | Viewed by 5737 | Submission Open

Keywords: chronic kidney disease; diabetic nephropathy; glomerulonephritis; acid– base disorders; uremic toxin; artificial intelligence; metabolic bone disease; vascular access; arteriovenous fistula; catheter; hemodialysis

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in the Application of Ultrasound Technology in the Diagnosis of Skin Diseases

edited by

Priscila Giavedoni

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1283 | Submission Open

Keywords: skin ultrasound; cutaneous imaging; inflammatory skin diseases; skin tumors; high-frequency ultrasound; diagnostic imaging; medical imaging; ultrasound-guided procedures; dermatology; skin assessment

(This special issue belongs to the Section Medical Imaging and Theranostics)

Innovations in Kidney Disease Diagnostics: Organoids, Pathology, and Clinical Insights

edited by

Kenji Tsuji

submission deadline 30 Nov 2026 | Viewed by 1163 | Submission Open

Keywords: chronic kidney disease; diabetic kidney disease; glomerulonephritis; polycystic kidney diseases; renal pathology; biomarker; kidney regeneration; hemodialysis; peritoneal dialysis; diagnosis

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Global Advances in EGD and Colonoscopy: The Convergence of Advanced Imaging and AI

edited by

Naohisa Yoshida

submission deadline 30 Nov 2026 | Viewed by 1135 | Submission Open

Keywords: esophagogastroduodenoscopy (EGD); colonoscopy; artificial intelligence; image-enhanced endoscopy; optical biopsy

(This special issue belongs to the Section Biomedical Optics)

New Radiological, Electrocardiographic and Biochemical Cardiovascular Risk Factors in 2026

edited by

Paweł Gać

submission deadline 30 Nov 2026 | Viewed by 25 | Submission Open

Keywords: cardiovascular medicine; risk factors; heart and vascular biology; imaging diagnostics; electrocardiogram; biochemistry; toxicology; experimental medicine

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Rheumatic Diseases: From Macroscopic Diagnosis to Molecular Mechanisms

edited by

Cristina Pamfil

submission deadline 30 Nov 2026 | Viewed by 23 | Submission Open

Keywords: rheumatology diagnostics; imaging and radiomics; autoantibodies and biomarkers; multi-omics (proteomics/metabolomics/genomics); machine learning/artificial intelligence; disease activity and prognosis; precision medicine; interstitial lung disease in rheumatology; vasculitis and connective tissue diseases; diagnostic pathways

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Progress in Chronic Pain: Bridging Basic and Clinical Research

edited by

Helder Cardoso-Cruz

and

Clara Monteiro

submission deadline 31 Dec 2026 | 2 articles | Viewed by 4006 | Submission Open

Keywords: chronic pain; pain prevention; new biomarkers in chronic pain; personalized treatment approaches; sensory and cognitive dimensions; neuropathic pain; inflammatory pain

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Cardiovascular Diseases: Advances in Diagnosis and Management

edited by

Thien Tan Tri Tai Truyen

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3023 | Submission Open

Keywords: cardiovascular diseases; predictive risk score; mortality; prognosis; artificial intelligence; machine learning; large language models

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

(Bio)sensors for Medical Diagnostics

edited by

Mihaela Badea

Akhtar Hayat

and Sehrish Bilal

submission deadline 31 Dec 2026 | Viewed by 479 | Submission Open

Keywords: sensors and biosensors; medical diagnostics; biomarker detection; point-of-care testing; lab-on-a-chip; wearable health technology; nanotechnology; signal transduction; early disease detection; clinical monitoring

(This special issue belongs to the Section Point-of-Care Diagnostics and Devices)

Gastrointestinal Endoscopy: Diagnostic Applications and Safety Evaluation

edited by

Giacomo Emanuele Maria Rizzo