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Diagnostics
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Novel Optical Imaging Technologies in Ophthalmology and Neuroscience: Advances and...
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Novel Optical Imaging Technologies in Ophthalmology and Neuroscience: Advances and Applications

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Biomedical Optics".

Deadline for manuscript submissions: closed (30 November 2025) | Viewed by 549

Special Issue Editor

Prof. Dr. Jae-Ho Han

E-Mail Website
Guest Editor
1. Department of Brain and Cognitive Engineering (Primary), Korea University, Seoul 136-701, Republic of Korea
2. Department of Artificial Intelligence (Secondary), Korea University, Seoul 136-701, Republic of Korea
Interests: artificial intelligence in biomedicine; diagnosis of retinal diseases; deep learning for ophthalmology images; neuroscience research
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Advances in optical imaging technologies have revolutionized our understanding of the eye and brain, enabling unprecedented visualization of cellular and molecular processes in health and disease. This Special Issue, "Novel Optical Imaging Technologies in Ophthalmology and Neuroscience: Advances and Applications", highlights cutting-edge innovations. These technologies offer transformative potential for diagnosing and monitoring conditions such as glaucoma, retinal degeneration, and neurodegenerative disorders.

We invite researchers and clinicians to contribute original research articles, reviews, case reports, brief reports, and communications that explore the development, validation, and clinical application of these imaging modalities. By fostering interdisciplinary collaboration, this issue aims to accelerate progress in vision science and neuroimaging.

We look forward to hearing from you.

Prof. Dr. Jae-Ho Han
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical imaging
  • ophthalmology
  • neuroscience
  • diagnosis
  • prognosis

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Published Papers (1 paper)

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Research

14 pages, 3548 KB  
Article
Characterization of Peripheral Retinal Degenerations and Rhegmatogenous Lesions Using Ultra-Widefield Swept Source OCT Integrated with a Novel Scanning Laser Ophthalmoscope
by Daniela Bacherini, Clara Rizzo, Giulio Vicini, Diego Luciani, Lorenzo Vannozzi, Gianni Virgili, Fabrizio Giansanti and Cristina Nicolosi
Diagnostics 2025, 15(22), 2930; https://doi.org/10.3390/diagnostics15222930 - 20 Nov 2025
Viewed by 349
Abstract
Background/Objectives: The purpose of this study was to evaluate the implementation of ultra-widefield swept-source optical coherence tomography (SS-OCT) in characterizing peripheral retinal degenerations and rhegmatogenous lesions, and to assess its potential implications for clinical management. These lesions are often challenging to visualize [...] Read more.
Background/Objectives: The purpose of this study was to evaluate the implementation of ultra-widefield swept-source optical coherence tomography (SS-OCT) in characterizing peripheral retinal degenerations and rhegmatogenous lesions, and to assess its potential implications for clinical management. These lesions are often challenging to visualize with conventional techniques, highlighting the need for advanced imaging modalities to improve detection and characterization. Methods: We conducted a retrospective observational study involving patients diagnosed with peripheral retinal degenerations and/or rhegmatogenous lesions referred to our center. All participants underwent comprehensive ophthalmological evaluation, including slit-lamp biomicroscopy, dilated fundus examination, and peripheral SS-OCT imaging. Key parameters assessed included the presence of vitreoretinal attachment, vitreous traction, full-thickness retinal defects, and subretinal fluid associated with the peripheral lesions under investigation. Results: A total of 107 eyes from 95 patients were included. The mean spherical equivalent was −2.18 ± 2.5 diopters, and mean BCVA was 0.03 ± 0.11. Peripheral SS-OCT imaging successfully captured and characterized 130 retinal lesions, including retinal tears (n = 34), lattice degeneration (n = 25), retinal holes (n = 21), peripheral retinoschisis (n = 17), and schisis/detachment (n = 7). Less commonly observed lesions were snail track degeneration (n = 4), white without pressure (n = 4) microcystic degeneration (n = 2), dialysis (n = 2), condensed vitreous (n = 2), and paving stone degeneration (n = 1). SS-OCT provided high-resolution visualization of the peripheral retina and vitreoretinal interface, revealing findings such as vitreous traction, everted edges in retinal holes, and associated subretinal fluid, some of which were not clinically detectable and, in several cases, directly influenced management decisions. Conclusions: Ultra-widefield SS-OCT significantly enhanced the visualization of peripheral retinal degenerations and rhegmatogenous lesions, providing clinically meaningful details that may influence diagnosis and clinical decision-making. Full article
(This article belongs to the Special Issue Novel Optical Imaging Technologies in Ophthalmology and Neuroscience: Advances and Applications)
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