Autopsy Pathology's Paradigm Shift: Are AI and New Technologies Forging a New Era?

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 1091

Special Issue Editor


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Guest Editor
U.O.S. Coordinamento delle Attività di Settorato—Pathology Unit, Department of Woman, Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy
Interests: cardiovascular pathology; autopsy pathology; placental pathology; surgical pathology
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Special Issue Information

Dear Colleagues,

We are pleased to announce the launch of a new Special Issue, entitled "Autopsy Pathology's Paradigm Shift: Are AI and New Technologies Forging a New Era?". This Special Issue provides the opportunity to contribute to the most relevant topics in autopsy pathology, providing a comprehensive appraisal of this diagnostic field in the era of AI.

Over the years, there has been a growing interest in research on immunohistochemical and molecular markers that can resolve, or help to resolve, even the most complex cases by revealing the presence or absence of specific molecules.

The search for new markers is of fundamental importance for anatomic pathology, for diagnostic, prognostic, and theranostic purposes. The inevitable variables related to the postmortem interval, the manner of death, and the circumstances of death all preclude the straightforward application of single-molecule expression testing to autopsy (forensic or non-forensic).

The macroscopic and microscopic knowledge acquired over centuries in autopsy pathology (even beyond strictly forensic contexts) remains a cornerstone of the discipline.

To better understand the potential role of AI in this field, we invite authors to submit articles exploring various aspects of autopsy pathology, assessing the current state of the art and give particular attention to the body of knowledge consolidated in the existing literature.

This systematic collection will provide a valuable tool for new generations of pathologists.

Articles on the sensitive topic of asphyxial deaths, arrhythmic deaths, and sudden deaths (adult and pediatric cases), as well as articles on fetoplacental pathology, are welcome.

For each paper submitted, the authors will need to demonstrate and compare the degree to which AI has contributed to the topic at hand as well as the purpose and extent that AI can be of help.

For this Special Issue, we invite investigators from different disciplines to contribute original research articles and reviews of key diagnostic topics, taking into account the solid evidence accumulated over centuries of research on the subject, and to propose the potential role of AI in the near future for this discipline.

Prof. Dr. Vincenzo Arena
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • autopsy pathology
  • AI
  • artificial intelligence
  • immunohistochemistry
  • molecular pathology

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Published Papers (1 paper)

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Research

12 pages, 1314 KB  
Article
Prevalence and Morphological Classification of Persistent Metopic Suture in Adult Autopsy Cases: A Forensic Anatomical Study from Western Türkiye
by Gökmen Karabağ, Volkan Zeybek, Ahmet Küpeli, Mehmet Sunay Yavuz, Mahmut Aşırdizer, Ertuğrul Tatlısumak and Aslıhan Teyin
Diagnostics 2026, 16(3), 415; https://doi.org/10.3390/diagnostics16030415 - 30 Jan 2026
Viewed by 657
Abstract
Background: Persistent metopic suture represents a normal anatomical variant that may persist into adulthood and can be misinterpreted as a frontal skull fracture, particularly in trauma-related forensic cases. Despite its clinical and medico-legal relevance, data derived from autopsy-based evaluations remain limited, with most [...] Read more.
Background: Persistent metopic suture represents a normal anatomical variant that may persist into adulthood and can be misinterpreted as a frontal skull fracture, particularly in trauma-related forensic cases. Despite its clinical and medico-legal relevance, data derived from autopsy-based evaluations remain limited, with most prevalence studies relying on dry skull collections or radiological series. This study aimed to determine the prevalence and morphological characteristics of persistent metopic suture in adult autopsy cases and to evaluate its distribution according to age, sex, and cause of death. Methods: This cross-sectional study included 500 consecutive adult autopsy cases (≥18 years). The frontal bone was directly inspected during autopsy for the presence of metopic suture, which was classified as complete or incomplete. Descriptive statistics were applied, and associations between metopism and sex, age group, and cause of death were analyzed using chi-square or Fisher’s exact test, as appropriate. Results: Complete metopism was identified in 7 of 500 cases, corresponding to a prevalence of 1.4% (95% confidence interval: approximately 0.6–2.9%). No incomplete metopic sutures were observed. Metopism was slightly more frequent in females than males; however, no statistically significant association was found between metopism and sex, age group, or cause of death (p > 0.05). Conclusions: Persistent metopic suture is an uncommon but clinically and forensically relevant anatomical variant in adults. Its recognition during forensic autopsy is essential to avoid misinterpretation as a cranial fracture, particularly in trauma-related deaths, thereby preventing diagnostic and medico-legal errors. Full article
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